ATE394409T1 - Verfahren zur herstellung von purinnukleosiden - Google Patents
Verfahren zur herstellung von purinnukleosidenInfo
- Publication number
- ATE394409T1 ATE394409T1 AT02768391T AT02768391T ATE394409T1 AT E394409 T1 ATE394409 T1 AT E394409T1 AT 02768391 T AT02768391 T AT 02768391T AT 02768391 T AT02768391 T AT 02768391T AT E394409 T1 ATE394409 T1 AT E394409T1
- Authority
- AT
- Austria
- Prior art keywords
- adenine
- beta
- present
- preparation
- derivative
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000002212 purine nucleoside Substances 0.000 title 1
- FCZOVUJWOBSMSS-UHFFFAOYSA-N 5-[(6-aminopurin-9-yl)methyl]-5-methyl-3-methylideneoxolan-2-one Chemical compound C1=NC2=C(N)N=CN=C2N1CC1(C)CC(=C)C(=O)O1 FCZOVUJWOBSMSS-UHFFFAOYSA-N 0.000 abstract 2
- 229960000643 adenine Drugs 0.000 abstract 2
- 239000002777 nucleoside Substances 0.000 abstract 2
- -1 2-deoxy-alpha-D-arabinofuranosyl halide Chemical class 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 125000000328 arabinofuranosyl group Chemical group C1([C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 abstract 1
- WDDPHFBMKLOVOX-AYQXTPAHSA-N clofarabine Chemical compound C1=NC=2C(N)=NC(Cl)=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1F WDDPHFBMKLOVOX-AYQXTPAHSA-N 0.000 abstract 1
- 229960000928 clofarabine Drugs 0.000 abstract 1
- 230000008878 coupling Effects 0.000 abstract 1
- 238000010168 coupling process Methods 0.000 abstract 1
- 238000005859 coupling reaction Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 230000000707 stereoselective effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30959001P | 2001-08-02 | 2001-08-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE394409T1 true ATE394409T1 (de) | 2008-05-15 |
Family
ID=23198848
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02768391T ATE394409T1 (de) | 2001-08-02 | 2002-08-01 | Verfahren zur herstellung von purinnukleosiden |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6680382B2 (de) |
| EP (1) | EP1412369B1 (de) |
| JP (1) | JP4593917B2 (de) |
| AT (1) | ATE394409T1 (de) |
| CA (1) | CA2449561A1 (de) |
| DE (1) | DE60226447D1 (de) |
| ES (1) | ES2306783T3 (de) |
| WO (1) | WO2003011877A2 (de) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7528247B2 (en) * | 2001-08-02 | 2009-05-05 | Genzyme Corporation | Process for preparing purine nucleosides |
| US7214791B2 (en) * | 2004-07-01 | 2007-05-08 | Shenzhen Hande Technology Co., Ltd. | Method for preparation of 2′-deoxy-2′, 2′-difluoro-β-cytidine or pharmaceutically acceptable salts thereof by using 1,6-anhydro-β-d-glucose as raw material |
| US8741858B2 (en) | 2007-09-21 | 2014-06-03 | Zhongxu Ren | Oligomer-nucleoside phosphate conjugates |
| EP2070938A1 (de) | 2007-12-13 | 2009-06-17 | Heidelberg Pharma AG | Clofarabin-Dietherphospholipid-Derivate |
| CN101240003B (zh) * | 2008-03-12 | 2011-05-25 | 广州仁心医药科技有限公司 | 一种克罗拉滨原料药的制备方法 |
| CL2009002206A1 (es) | 2008-12-23 | 2011-08-26 | Gilead Pharmasset Llc | Compuestos derivados de pirrolo -(2-3-d]-pirimidin-7(6h)-tetrahidrofuran-2-il fosfonamidato, composicion farmaceutica; y su uso en el tratamiento de enfermedades virales. |
| AR074897A1 (es) | 2008-12-23 | 2011-02-23 | Pharmasset Inc | Fosforamidatos de nucleosidos |
| MX2011006890A (es) | 2008-12-23 | 2011-07-20 | Pharmasset Inc | Analogos de nucleosidos. |
| CN101830955B (zh) * | 2009-03-13 | 2013-09-11 | 浙江海正药业股份有限公司 | 抗肿瘤药物氯法拉宾的合成工艺 |
| CN102438588B (zh) | 2009-03-23 | 2015-04-01 | 埃姆比特生物科学公司 | 使用联合治疗法治疗疾病的方法 |
| TWI399381B (zh) * | 2009-08-18 | 2013-06-21 | Scinopharm Taiwan Ltd | 克拉屈濱（ｃｌａｄｒｉｂｉｎｅ）的製備方法 |
| AP2012006535A0 (en) | 2010-03-31 | 2012-10-31 | Gilead Pharmasset Llc | Stereoselective synthesis of phosphorous containing actives |
| CN102311472B (zh) * | 2010-07-09 | 2014-09-03 | 神隆(昆山)生化科技有限公司 | 2-氯-9-(2’-脱氧-2’-氟-β-D-阿拉伯呋喃糖基)-腺嘌呤的制备 |
| ES2716158T3 (es) | 2010-11-30 | 2019-06-10 | Gilead Pharmasset Llc | 2'-spiro-nucleótidos para el tratamiento de hepatitis C |
| IN2014CH00518A (de) * | 2014-02-04 | 2015-08-07 | Msn Lab Private Ltd | |
| EP2937420A1 (de) | 2014-04-23 | 2015-10-28 | Synbias Pharma AG | Verfahren zur Synthese von Clofarabin |
| CN105601688A (zh) * | 2015-12-23 | 2016-05-25 | 国药一心制药有限公司 | 一种氯法拉滨中间体及氯法拉滨的制备方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4751221A (en) | 1985-10-18 | 1988-06-14 | Sloan-Kettering Institute For Cancer Research | 2-fluoro-arabinofuranosyl purine nucleosides |
| US5459256A (en) | 1987-04-17 | 1995-10-17 | The Government Of The United States Of America As Represented By The Department Of Health And Human Services | Lipophilic, aminohydrolase-activated prodrugs |
| JPH0217199A (ja) | 1988-07-05 | 1990-01-22 | Japan Tobacco Inc | ２’−デオキシ−β−アデノシンの製造方法 |
| US5384310A (en) | 1989-05-23 | 1995-01-24 | Southern Research Institute | 2'-fluoro-2-haloarabinoadinosines and their pharmaceutical compositions |
| HU906976D0 (en) | 1989-11-13 | 1991-05-28 | Bristol Myers Squibb Co | Process for producing 2', 3'-didesoxy-2'-fluoarabinonucleoside analogues |
| US5206351A (en) * | 1990-06-15 | 1993-04-27 | Ash Stevens, Inc. | Process for the preparation of 2-amino (2,3,5-tri-o-benzyl-beta-d-arabinofuranosyl)adenine |
| BR9302431A (pt) * | 1992-06-22 | 1994-01-11 | Lilly Co Eli | Processo de glicosilacao de anion estereosseletivo |
| UA41261C2 (uk) * | 1992-06-22 | 2001-09-17 | Елі Ліллі Енд Компані | Спосіб одержання збагачених бета-аномером нуклеозидів |
| US5821357A (en) * | 1992-06-22 | 1998-10-13 | Eli Lilly And Company | Stereoselective glycosylation process for preparing 2'-deoxy-2',2'-difluoropurine and triazole nucleosides |
| AU3851601A (en) | 2000-02-18 | 2001-08-27 | Southern Res Inst | Methods for synthesizing 2-chloro-9-(2-deoxy-2-fluoro-beta-d-arabinofuranosyl)-9h- purin-6-amine |
-
2002
- 2002-08-01 AT AT02768391T patent/ATE394409T1/de not_active IP Right Cessation
- 2002-08-01 ES ES02768391T patent/ES2306783T3/es not_active Expired - Lifetime
- 2002-08-01 DE DE60226447T patent/DE60226447D1/de not_active Expired - Lifetime
- 2002-08-01 JP JP2003517068A patent/JP4593917B2/ja not_active Expired - Lifetime
- 2002-08-01 CA CA002449561A patent/CA2449561A1/en not_active Abandoned
- 2002-08-01 WO PCT/US2002/024392 patent/WO2003011877A2/en not_active Ceased
- 2002-08-01 US US10/209,808 patent/US6680382B2/en not_active Expired - Lifetime
- 2002-08-01 EP EP02768391A patent/EP1412369B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| WO2003011877A3 (en) | 2003-04-17 |
| DE60226447D1 (de) | 2008-06-19 |
| WO2003011877A2 (en) | 2003-02-13 |
| JP4593917B2 (ja) | 2010-12-08 |
| EP1412369B1 (de) | 2008-05-07 |
| CA2449561A1 (en) | 2003-02-13 |
| US6680382B2 (en) | 2004-01-20 |
| JP2005504036A (ja) | 2005-02-10 |
| US20030114663A1 (en) | 2003-06-19 |
| ES2306783T3 (es) | 2008-11-16 |
| EP1412369A2 (de) | 2004-04-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |