ATE394496T1 - Herstellung von sekretierten proteinen durch rekombinante eukaryotische zellen - Google Patents

Herstellung von sekretierten proteinen durch rekombinante eukaryotische zellen

Info

Publication number
ATE394496T1
ATE394496T1 AT01924287T AT01924287T ATE394496T1 AT E394496 T1 ATE394496 T1 AT E394496T1 AT 01924287 T AT01924287 T AT 01924287T AT 01924287 T AT01924287 T AT 01924287T AT E394496 T1 ATE394496 T1 AT E394496T1
Authority
AT
Austria
Prior art keywords
protein
secreted
production
eukaryotic cells
secreted proteins
Prior art date
Application number
AT01924287T
Other languages
English (en)
Inventor
Merja Penttila
Michael Ward
Huaming Wang
Mari Valkonen
Markku Saloheimo
Original Assignee
Genencor Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genencor Int filed Critical Genencor Int
Application granted granted Critical
Publication of ATE394496T1 publication Critical patent/ATE394496T1/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/11—Protein-serine/threonine kinases (2.7.11)
    • C12Y207/11001—Non-specific serine/threonine protein kinase (2.7.11.1), i.e. casein kinase or checkpoint kinase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/03—Phosphoric monoester hydrolases (3.1.3)
    • C12Y301/03016—Phosphoprotein phosphatase (3.1.3.16), i.e. calcineurin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Mycology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT01924287T 2000-03-24 2001-03-23 Herstellung von sekretierten proteinen durch rekombinante eukaryotische zellen ATE394496T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US53469200A 2000-03-24 2000-03-24

Publications (1)

Publication Number Publication Date
ATE394496T1 true ATE394496T1 (de) 2008-05-15

Family

ID=24131126

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01924287T ATE394496T1 (de) 2000-03-24 2001-03-23 Herstellung von sekretierten proteinen durch rekombinante eukaryotische zellen

Country Status (8)

Country Link
US (4) US20010034045A1 (de)
EP (1) EP1266018B1 (de)
AT (1) ATE394496T1 (de)
AU (1) AU2001250954A1 (de)
CA (1) CA2403842C (de)
DE (1) DE60133884D1 (de)
DK (1) DK1266018T3 (de)
WO (1) WO2001072783A2 (de)

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FI20105632A0 (fi) * 2010-06-04 2010-06-04 Valtion Teknillinen Menetelmä proteiinien tuottamiseksi rihmamaisilla sienillä
FI20105633A0 (fi) * 2010-06-04 2010-06-04 Valtion Teknillinen Parannettu menetelmä proteiinien tuottamiseksi
FI20105634A0 (fi) 2010-06-04 2010-06-04 Valtion Teknillinen Proteiinien parannettu tuotto rihmamaisilla sienillä
US20130280269A1 (en) * 2010-06-08 2013-10-24 National University Of Ireland Manipulation of HSP70 and IRE1Alpha Protein Interactions
BR112012033404B1 (pt) 2010-06-29 2021-05-18 Dsm Ip Assets B.V. célula recombinante, método para a preparação de um polipeptídeo, composição, método para o tratamento de um substrato que compreende material de carboidrato e uso de um polipeptídeo
US9175050B2 (en) 2010-06-29 2015-11-03 Dsm Ip Assets B.V. Polypeptide having swollenin activity and uses thereof
WO2012000891A1 (en) 2010-06-29 2012-01-05 Dsm Ip Assets B.V. Polypeptide having carbohydrate degrading activity and uses thereof
DK2588494T3 (en) 2010-06-29 2018-06-14 Dsm Ip Assets Bv POLYPEPTIDE WITH BETA-GLUCOSIDASE ACTIVITY AND APPLICATIONS THEREOF
CA2803513A1 (en) 2010-06-29 2012-01-05 Margot Elisabeth Francoise Schooneveld-Bergmans Polypeptide having acetyl xylan esterase activity and uses thereof
CA2802128A1 (en) 2010-06-29 2012-01-05 Margot Elisabeth Francoise Schooneveld-Bergmans Polypeptide having beta-glucosidase activity and uses thereof
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KR20130132789A (ko) * 2010-11-05 2013-12-05 아사히 가라스 가부시키가이샤 스키조사카로미세스속 효모의 형질 전환체 및 그 제조 방법
CN105821078A (zh) * 2010-12-09 2016-08-03 巴斯德研究所 用于获得高产量重组蛋白表达的基于mgmt的方法
WO2012109238A2 (en) 2011-02-07 2012-08-16 President And Fellows Of Harvard College Methods for increasing immune responses using agents that directly bind to and activate ire-1
WO2013134774A1 (en) 2012-03-09 2013-09-12 Cornell University Modulation of breast cancer growth by modulation of xbp1 activity
CN102604913B (zh) * 2012-04-05 2013-08-14 湖南尤特尔生化有限公司 一种疏棉状嗜热丝孢菌脂肪酶的制备方法和应用
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CN102994541B (zh) * 2012-12-19 2015-04-15 江南大学 一种共表达upr关键基因和下游靶基因增强葡萄糖氧化酶分泌的方法
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AU2015248815B2 (en) 2014-04-17 2021-07-08 Boehringer Ingelheim Rcv Gmbh & Co Kg Recombinant host cell engineered to overexpress helper proteins
CN105112303B (zh) * 2015-09-06 2018-10-16 江南大学 一种产酒用复合酶的黑曲霉菌株
CN109476714A (zh) * 2016-07-22 2019-03-15 诺维信公司 改善的丝状真菌宿主
CN110431224A (zh) 2017-03-13 2019-11-08 帝斯曼知识产权资产管理有限公司 锌双核簇转录调控因子缺陷型菌株
CN107723253B (zh) * 2017-09-29 2021-10-15 天津昕因达生物技术有限公司 一种双质粒共转化外源基因高表达基因工程菌
US20210032642A1 (en) * 2018-04-06 2021-02-04 Danisco Us Inc. Increased alcohol production from yeast producing an increased amount of active hac1 protein
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CN118879519A (zh) 2018-05-25 2024-11-01 丹尼斯科美国公司 富马酸还原酶过表达导致酵母中增加的发酵速率
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Also Published As

Publication number Publication date
US7662584B2 (en) 2010-02-16
DK1266018T3 (da) 2008-09-01
CA2403842C (en) 2012-09-25
AU2001250954A1 (en) 2001-10-08
WO2001072783A2 (en) 2001-10-04
US20040186070A1 (en) 2004-09-23
US8753866B2 (en) 2014-06-17
US20140335591A1 (en) 2014-11-13
EP1266018A2 (de) 2002-12-18
CA2403842A1 (en) 2001-10-04
WO2001072783A3 (en) 2002-07-18
DE60133884D1 (de) 2008-06-19
US20010034045A1 (en) 2001-10-25
EP1266018B1 (de) 2008-05-07
US20100221775A1 (en) 2010-09-02

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