DK0778348T3 - Fremgangsmåde til fremstilling af et protein ved anvendelse af en svamp transformeret ved multikopi-integration af en ekspr - Google Patents
Fremgangsmåde til fremstilling af et protein ved anvendelse af en svamp transformeret ved multikopi-integration af en eksprInfo
- Publication number
- DK0778348T3 DK0778348T3 DK97200631T DK97200631T DK0778348T3 DK 0778348 T3 DK0778348 T3 DK 0778348T3 DK 97200631 T DK97200631 T DK 97200631T DK 97200631 T DK97200631 T DK 97200631T DK 0778348 T3 DK0778348 T3 DK 0778348T3
- Authority
- DK
- Denmark
- Prior art keywords
- protein
- preparing
- multicopy integration
- integration
- yeast
- Prior art date
Links
- 108090000623 proteins and genes Proteins 0.000 title abstract 6
- 230000010354 integration Effects 0.000 title abstract 4
- 102000004169 proteins and genes Human genes 0.000 title abstract 4
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 241000233866 Fungi Species 0.000 title 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 abstract 2
- 239000013604 expression vector Substances 0.000 abstract 2
- 241000228212 Aspergillus Species 0.000 abstract 1
- 244000303965 Cyamopsis psoralioides Species 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 241000206602 Eukaryota Species 0.000 abstract 1
- 241000235649 Kluyveromyces Species 0.000 abstract 1
- 102000004882 Lipase Human genes 0.000 abstract 1
- 108090001060 Lipase Proteins 0.000 abstract 1
- 239000004367 Lipase Substances 0.000 abstract 1
- 102000004316 Oxidoreductases Human genes 0.000 abstract 1
- 108090000854 Oxidoreductases Proteins 0.000 abstract 1
- 241000235648 Pichia Species 0.000 abstract 1
- 241000235527 Rhizopus Species 0.000 abstract 1
- 108020001027 Ribosomal DNA Proteins 0.000 abstract 1
- 241000235070 Saccharomyces Species 0.000 abstract 1
- 241000223259 Trichoderma Species 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 230000002950 deficient Effects 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 235000019421 lipase Nutrition 0.000 abstract 1
- 239000003550 marker Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2465—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1) acting on alpha-galactose-glycoside bonds, e.g. alpha-galactosidase (3.2.1.22)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
- C12N15/815—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts for yeasts other than Saccharomyces
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/18—Carboxylic ester hydrolases (3.1.1)
- C12N9/20—Triglyceride splitting, e.g. by means of lipase
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB898915659A GB8915659D0 (en) | 1989-07-07 | 1989-07-07 | Enzymes,their production and use |
| EP90201007 | 1990-04-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0778348T3 true DK0778348T3 (da) | 2000-12-04 |
Family
ID=26125849
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK90911878.8T DK0481008T3 (da) | 1989-07-07 | 1990-07-09 | Fremgangsmåde til fremstilling af et protein ved anvendelse af en svamp transformeret ved multikopiintegration af en ekspressionsvektor. |
| DK97200631T DK0778348T3 (da) | 1989-07-07 | 1990-07-09 | Fremgangsmåde til fremstilling af et protein ved anvendelse af en svamp transformeret ved multikopi-integration af en ekspr |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK90911878.8T DK0481008T3 (da) | 1989-07-07 | 1990-07-09 | Fremgangsmåde til fremstilling af et protein ved anvendelse af en svamp transformeret ved multikopiintegration af en ekspressionsvektor. |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6090574A (da) |
| EP (2) | EP0778348B1 (da) |
| JP (1) | JP3273609B2 (da) |
| AT (2) | ATE160176T1 (da) |
| CA (1) | CA2063592C (da) |
| DE (2) | DE69033633T2 (da) |
| DK (2) | DK0481008T3 (da) |
| ES (2) | ES2150188T3 (da) |
| IE (1) | IE81016B1 (da) |
| WO (1) | WO1991000920A2 (da) |
Families Citing this family (106)
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| WO1991014781A1 (en) * | 1990-03-19 | 1991-10-03 | Henkel Research Corporation | METHOD FOR INCREASING THE OMEGA-HYDROXYLASE ACTIVITY IN $i(CANDIDA TROPICALIS) |
| JP3133774B2 (ja) * | 1990-10-04 | 2001-02-13 | 日本食品化工株式会社 | 新規な宿主−ベクター系 |
| ATE140974T1 (de) * | 1990-10-04 | 1996-08-15 | Japan Maize Prod | Wirt-vektor-system |
| IT1251435B (it) * | 1991-09-04 | 1995-05-09 | Sclavo Spa | Vettore genetico per la integrazione multipla stabile di sequenze di dna nel genoma dei lieviti kluyveromyces lactis e saccharomyces cerevisiae e plasmidi che lo contengono. |
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| CA2169942C (en) * | 1993-09-02 | 1999-04-13 | Larry C. James | Multiple integrative vectors and yarrowia lipolytica transformants |
| US6936289B2 (en) | 1995-06-07 | 2005-08-30 | Danisco A/S | Method of improving the properties of a flour dough, a flour dough improving composition and improved food products |
| AU725390B2 (en) * | 1996-09-24 | 2000-10-12 | Andreas Bachmair | DNA-constructs comprising intergenic ribosomal DNA and methods to produce proteins using these DNA-constructs |
| US7883872B2 (en) | 1996-10-10 | 2011-02-08 | Dyadic International (Usa), Inc. | Construction of highly efficient cellulase compositions for enzymatic hydrolysis of cellulose |
| WO2000020555A2 (en) | 1998-10-06 | 2000-04-13 | Aarl Inc | Transformation system in the field of filamentous fungal hosts: in chrysosporium |
| EP0870835A1 (en) * | 1997-04-07 | 1998-10-14 | Unilever N.V. | Agrobacterium mediated transformation of moulds, in particular those belonging to the genus Aspergillus |
| JP4307563B2 (ja) | 1997-04-07 | 2009-08-05 | ユニリーバー・ナームローゼ・ベンノートシャープ | 糸状菌、特にアスペルギルス属に属する糸状菌のアグロバクテリウム媒介性形質転換 |
| EP1433852B1 (en) | 1997-04-09 | 2006-06-28 | Danisco A/S | Use of lipase for improving doughs and baked products |
| JP4531868B2 (ja) * | 1997-04-11 | 2010-08-25 | コニンクリーケ デーエスエム ナムローゼ フェンノートシャップ | １を超える非リボソームｒｎａをコードしているドメインの染色体ゲノムに組込まれた少なくとも２コピーの所望遺伝子を含む、特にクルイベロミセスによる酵母細胞 |
| US6265186B1 (en) | 1997-04-11 | 2001-07-24 | Dsm N.V. | Yeast cells comprising at least two copies of a desired gene integrated into the chromosomal genome at more than one non-ribosomal RNA encoding domain, particularly with Kluyveromyces |
| EP0979294B1 (en) * | 1997-04-11 | 2015-05-27 | DSM IP Assets B.V. | Gene conversion as a tool for the construction of recombinant industrial filamentous fungi |
| US6391585B1 (en) * | 1997-05-27 | 2002-05-21 | Hanil Synthetic Fiber Co., Ltd. | Process for preparing recombinant proteins using highly efficient expression vector from saccharomyces cerevisiae |
| US6228583B1 (en) | 1997-08-04 | 2001-05-08 | Massachusetts Institute Of Technology | Assays for compounds which extend life span |
| PL341760A1 (en) * | 1997-12-22 | 2001-05-07 | Dsm Nv | Expression cloning in mildew fungi |
| EP1040197A1 (en) * | 1997-12-22 | 2000-10-04 | Unilever N.V. | A process for site-directed integration of multiple copies of a gene in a mould |
| EP1073755A2 (en) * | 1998-04-28 | 2001-02-07 | Axys Pharmaceuticals, Inc. | Novel serine protease capable of selective cleavage of insulin-like growth factor binding protein |
| US7220542B2 (en) | 2000-07-17 | 2007-05-22 | Van Den Brink Johannes Maarten | Expression cloning in filamentous fungi |
| AU7398100A (en) * | 1999-09-13 | 2001-04-17 | Concordia University | A multifunctional system for the efficient manipulation of protein expression infilamentous fungi and method using same |
| DE19963690A1 (de) * | 1999-11-23 | 2001-06-13 | Rhein Biotech Proz & Prod Gmbh | Vektoren und Verfahren zur Herstellung rekombinanter Proteine in Pilzen |
| WO2002092757A2 (en) * | 2000-11-15 | 2002-11-21 | Kemin Industries, Inc. | Enzyme over-producing transgenic microorganisms |
| JP4494716B2 (ja) * | 2000-12-13 | 2010-06-30 | ユニリーバー・ナームローゼ・ベンノートシヤープ | 菌類による異種たんぱく質の生産方法 |
| CA2474172C (en) | 2001-01-25 | 2012-07-10 | Evolva Ltd. | A library of a collection of cells |
| AU2002226307A1 (en) * | 2001-01-25 | 2002-08-06 | Evolva Biotech A/S | Artificial chromosomes comprising concatemers of expressible nucleotide sequences |
| NZ528260A (en) | 2001-05-18 | 2005-09-30 | Danisco | Method of improving dough and bread quality with the addition of an enzyme that hydrolyses a glycolipid and a phospholipid and incapable of hydrolysing a triglyceride or monoglyceride |
| ITMI20011728A1 (it) * | 2001-08-06 | 2003-02-06 | Consorzio Per Le Ricerche E Lo | Vettore per l'integrazione sito-specifica di sequenze di dna eterologhe in lieviti metilotrofi |
| MXPA05007654A (es) | 2003-01-17 | 2005-09-30 | Danisco | Metodo. |
| WO2004072225A2 (en) * | 2003-02-12 | 2004-08-26 | Ramot At Tel Aviv University Ltd. | Transgenic fungi expressing bcl-2 and methods of using bcl-2 or portions thereof for improving biomass production, survival, longevity, stress resistance and pathogenicity of fungi |
| GB0405637D0 (en) | 2004-03-12 | 2004-04-21 | Danisco | Protein |
| EA014985B1 (ru) | 2004-07-16 | 2011-04-29 | Даниско А/С | Способ ферментативного рафинирования пищевых масел гидратацией и применение липидацилтрансферазы для осуществления способа |
| US8680252B2 (en) | 2006-12-10 | 2014-03-25 | Dyadic International (Usa), Inc. | Expression and high-throughput screening of complex expressed DNA libraries in filamentous fungi |
| CA2736661A1 (en) | 2007-09-07 | 2009-03-12 | Dyadic International, Inc. | Novel fungal enzymes |
| WO2009065778A1 (en) | 2007-11-20 | 2009-05-28 | Dsm Ip Assets B.V. | Succinic acid production in a eukaryotic cell |
| US8735112B2 (en) | 2007-11-20 | 2014-05-27 | Dsm Ip Assets B.V. | Dicarboxylic acid production in a recombinant yeast |
| WO2009065777A1 (en) | 2007-11-20 | 2009-05-28 | Dsm Ip Assets B.V. | Dicarboxylic acid production in a filamentous fungus |
| EP2116136A1 (en) | 2008-05-08 | 2009-11-11 | Nederlandse Organisatie voor toegepast- natuurwetenschappelijk onderzoek TNO | Novel phytases |
| NZ591972A (en) * | 2008-10-03 | 2013-04-26 | Agrisoma Biosciences Inc | Production of modified fatty acids in plants |
| US8735100B2 (en) | 2009-03-17 | 2014-05-27 | Nederlandse Organisatie Voor Toegepast -Natuurwetenschappelijk Onderzoek Tno | Cellulose and ligno-cellulose active proteins |
| EP2419518A1 (en) | 2009-04-15 | 2012-02-22 | DSM IP Assets B.V. | Dicarboxylic acid production process |
| RU2439157C2 (ru) * | 2009-06-18 | 2012-01-10 | Федеральное государственное унитарное предприятие "Государственный научно-исследовательский институт генетики и селекции промышленных микроорганизмов" (ФГУП ГосНИИгенетика) | ГЕНЕТИЧЕСКАЯ КОНСТРУКЦИЯ ДЛЯ ПОЛУЧЕНИЯ СТАБИЛЬНЫХ ТРАНСФОРМАНТОВ ГРИБОВ РОДА Rhizopus |
| UA108853C2 (uk) | 2009-07-10 | 2015-06-25 | Спосіб ферментації галактози | |
| DE102009035671A1 (de) * | 2009-07-30 | 2011-02-03 | Dechema Gesellschaft Für Chemische Technik Und Biotechnologie E.V. | Verfahren zur Expression von homologen Proteinen und/oder Peptiden in Pilzen der Klasse Dothideomycetes |
| RU2420567C1 (ru) * | 2009-12-09 | 2011-06-10 | Федеральное государственное унитарное предприятие "Государственный научно-исследовательский институт генетики и селекции промышленных микроорганизмов" (ФГУП ГосНИИгенетика) | СПОСОБ КОНСТРУИРОВАНИЯ ШТАММОВ ДРОЖЖЕЙ Saccharomyces cerevisiae - СТАБИЛЬНЫХ ПРОДУЦЕНТОВ СОМАТОТРОПИНА ЧЕЛОВЕКА, ШТАММ ДРОЖЖЕЙ Saccharomyces cerevisiae - СТАБИЛЬНЫЙ ПРОДУЦЕНТ СОМАТОТРОПИНА ЧЕЛОВЕКА (ВАРИАНТЫ) |
| JP2013524797A (ja) | 2010-04-21 | 2013-06-20 | ディーエスエム アイピー アセッツ ビー．ブイ． | アラビノースを転化できる細胞を製造する方法 |
| EP2388331A1 (en) | 2010-05-21 | 2011-11-23 | Nederlandse Organisatie voor toegepast -natuurwetenschappelijk onderzoek TNO | Constitutive promoter |
| JP5961886B2 (ja) | 2010-10-13 | 2016-08-03 | ディーエスエム アイピー アセッツ ビー．ブイ． | ペントースおよびグルコース発酵酵母細胞 |
| WO2012143513A2 (en) | 2011-04-22 | 2012-10-26 | Dsm Ip Assets B.V. | Yeast cell capable of converting sugars including arabinose and xylose |
| AR087423A1 (es) | 2011-08-04 | 2014-03-19 | Dsm Ip Assets Bv | Celula capaz de fermentar azucares pentosas |
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| US20130273619A1 (en) | 2012-04-16 | 2013-10-17 | Basf Se | Process for the Preparation of (3E, 7E)-Homofarnesol |
| ES2717682T3 (es) | 2012-10-16 | 2019-06-24 | Dsm Ip Assets Bv | Células con conversión mejorada de pentosas |
| EP2772545A1 (en) | 2013-03-01 | 2014-09-03 | Nederlandse Organisatie voor toegepast -natuurwetenschappelijk onderzoek TNO | Starch active proteins |
| BR112015027609A2 (pt) | 2013-05-02 | 2017-12-05 | Dutch Dna Biotech B V | uso de uma proteína, vetor para transformação de um microrganismo, organismo transgênico, e, métodos para produção de um ácido cítrico, de um ácido itacônico e de um derivado de ácido cítrico |
| BR112015029580A2 (pt) | 2013-05-31 | 2017-09-19 | Dsm Ip Assets Bv | Microrganismo recombinante, processo para a preparação de um diterpeno ou diterpeno glicosilado, diterpeno ou diterpeno glicosilado, gêneros alimentícios, alimentos para animais ou bebidas e método para converter um primeiro diterpeno glicosilado em um segundo diterpeno glicosilado |
| BR112016000745B1 (pt) | 2013-07-15 | 2021-01-05 | Dsm Ip Assets B.V. | processo para a preparação de rebaudiosídeo m |
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| CN107666834B (zh) | 2015-04-03 | 2021-08-24 | 帝斯曼知识产权资产管理有限公司 | 甜菊醇糖苷 |
| CA2980649A1 (en) | 2015-04-21 | 2016-10-27 | Dsm Ip Assets B.V. | Geranylgeranyl pyrophosphate synthase |
| WO2016188813A1 (en) | 2015-05-22 | 2016-12-01 | Dsm Ip Assets B.V. | Acetate consuming yeast cell |
| CA2991651A1 (en) | 2015-07-10 | 2017-01-19 | Dsm Ip Assets B.V. | Steviol glycoside composition |
| US20180230505A1 (en) | 2015-08-13 | 2018-08-16 | Dsm Ip Assets B.V. | Steviol glycoside transport |
| WO2017050652A1 (en) | 2015-09-25 | 2017-03-30 | Dsm Ip Assets B.V. | Asparaginase |
| PL3359655T3 (pl) | 2015-10-06 | 2020-05-18 | Dsm Ip Assets B.V. | Komórka eukariotyczna ze zwiększonym wytwarzaniem produktu fermentacji |
| EP3435772A1 (en) | 2016-03-31 | 2019-02-06 | DSM IP Assets B.V. | Enzyme composition and preparation of a dairy product with improved properties |
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| CN111254127B (zh) * | 2018-11-30 | 2022-06-10 | 康码（上海）生物科技有限公司 | 蛋白激酶a催化亚基tpk2基因改造方法及其应用 |
| US20250290081A1 (en) | 2020-10-22 | 2025-09-18 | Dsm Ip Assets B.V. | Microorganisms for diterpene production |
| FR3122436B1 (fr) * | 2021-04-30 | 2025-04-11 | Ifp Energies Now | Insertion multicopies d’un gène d’intérêt dans le génome d’un champignon |
| EP4359426A2 (en) | 2021-06-24 | 2024-05-01 | Fonterra Co-Operative Group Limited | Recombinant beta-lactoglobulin |
| EP4370691A1 (en) | 2021-07-12 | 2024-05-22 | Danisco US Inc. | Recombinant yeast cell |
| MX2024000509A (es) | 2021-07-12 | 2024-03-15 | Danisco Us Inc | Celula de levadura recombinante. |
| EP4370690A1 (en) | 2021-07-12 | 2024-05-22 | Danisco Us Inc | Recombinant yeast cell |
| MX2024000511A (es) | 2021-07-12 | 2024-03-11 | Danisco Us Inc | Celula de levadura recombinante. |
| EP4370688A1 (en) | 2021-07-12 | 2024-05-22 | Danisco Us Inc | Recombinant yeast cell |
| WO2023285297A1 (en) | 2021-07-12 | 2023-01-19 | Dsm Ip Assets B.V. | Recombinant yeast cell |
| CN113564206B (zh) * | 2021-07-29 | 2023-09-26 | 山东大学 | 一种目的基因多拷贝整合到酿酒酵母染色体rDNA的方法 |
| CN118234857A (zh) | 2021-11-04 | 2024-06-21 | 丹尼斯科美国公司 | 变体多肽和重组酵母细胞 |
| EP4426848A1 (en) | 2021-11-04 | 2024-09-11 | Danisco Us Inc | Process for the production of ethanol and recombinant yeast cell |
| MX2024005281A (es) | 2021-11-04 | 2024-05-17 | Danisco Us Inc | Celula de levadura recombinante. |
| TW202325853A (zh) | 2021-11-09 | 2023-07-01 | 美商安進公司 | 治療性蛋白之生產 |
| US20250304938A1 (en) | 2022-05-16 | 2025-10-02 | Dsm Ip Assets B.V. | Lipolytic enzyme variants |
| WO2025012325A1 (en) | 2023-07-11 | 2025-01-16 | Dsm Ip Assets B.V. | Protein arginine deiminase |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| AU600885B2 (en) * | 1984-05-25 | 1990-08-30 | Zymogenetics Inc. | Stable DNA constructs |
| GB8415186D0 (en) * | 1984-06-14 | 1984-07-18 | Ciba Geigy Ag | Polypeptides |
| CA1341130C (en) * | 1984-07-27 | 2000-10-31 | Adrianus Marinus Ledeboer | Use of oxidoreductases in bleaching and/or detergent compositions and their preparation by microorganisms engineered by recombinant dna technology |
| JPS61134325A (ja) * | 1984-12-04 | 1986-06-21 | Teijin Ltd | ハイブリツド抗体遺伝子の発現方法 |
| JPH0614865B2 (ja) * | 1985-12-13 | 1994-03-02 | 麒麟麦酒株式会社 | α―アセト乳酸脱炭酸酵素をコードするＤＮＡ鎖およびこのＤＮＡ鎖により形質転換された酵母 |
| US5003406A (en) | 1986-05-28 | 1991-03-26 | Mitsubishi Denki Kabushiki Kaisha | Video image reproducing apparatus which eliminates a noise bar in the image by using a field memory |
| CA1339101C (en) * | 1986-06-03 | 1997-07-29 | Nicolaas Overbeeke | Production of guar alpha-galactosidase and immunologically related alpha-galactosidases by host organisms transformed with recombinant dna methods |
| GB8629536D0 (en) | 1986-12-10 | 1987-01-21 | Unilever Plc | Enzymatic detergent composition |
| PT88556B (pt) * | 1987-09-28 | 1992-11-30 | Smithkline Biolog | Processo de integracao genomica estavel e de expressao de uma sequencia de cadificacao estranha, em leveduras |
| DK571587D0 (da) | 1987-11-02 | 1987-11-02 | Novo Industri As | Enzymatisk detergentsammensaetning |
| EP0318775B1 (en) * | 1987-12-03 | 1994-02-02 | Chisso Corporation | A lipase gene |
| US5001230A (en) * | 1988-02-18 | 1991-03-19 | Schering Corporation | T cell activation markers |
| JP3079276B2 (ja) * | 1988-02-28 | 2000-08-21 | 天野製薬株式会社 | 組換え体ｄｎａ、それを含むシュードモナス属菌及びそれを用いたリパーゼの製造法 |
| JP2639677B2 (ja) * | 1988-03-14 | 1997-08-13 | 旭化成工業株式会社 | リパーゼの遺伝情報を有するｄｎａ |
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1990
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- 1990-07-09 IE IE249690A patent/IE81016B1/en not_active IP Right Cessation
- 1990-07-09 ES ES97200631T patent/ES2150188T3/es not_active Expired - Lifetime
- 1990-07-09 EP EP97200631A patent/EP0778348B1/en not_active Expired - Lifetime
- 1990-07-09 JP JP51119190A patent/JP3273609B2/ja not_active Expired - Fee Related
- 1990-07-09 EP EP90911878A patent/EP0481008B1/en not_active Expired - Lifetime
- 1990-07-09 AT AT97200631T patent/ATE196505T1/de not_active IP Right Cessation
- 1990-07-09 DE DE69033633T patent/DE69033633T2/de not_active Expired - Lifetime
- 1990-07-09 DE DE69031710T patent/DE69031710T2/de not_active Expired - Lifetime
- 1990-07-09 DK DK90911878.8T patent/DK0481008T3/da active
- 1990-07-09 ES ES90911878T patent/ES2109238T3/es not_active Expired - Lifetime
- 1990-07-09 WO PCT/EP1990/001138 patent/WO1991000920A2/en not_active Ceased
- 1990-07-09 CA CA002063592A patent/CA2063592C/en not_active Expired - Lifetime
- 1990-07-09 DK DK97200631T patent/DK0778348T3/da active
-
1994
- 1994-12-27 US US08/364,010 patent/US6090574A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP0481008A1 (en) | 1992-04-22 |
| DK0481008T3 (da) | 1998-05-04 |
| DE69031710T2 (de) | 1998-03-05 |
| US6090574A (en) | 2000-07-18 |
| JPH05501949A (ja) | 1993-04-15 |
| IE902496A1 (en) | 1991-02-13 |
| WO1991000920A2 (en) | 1991-01-24 |
| WO1991000920A3 (en) | 1991-03-07 |
| CA2063592A1 (en) | 1991-01-08 |
| ATE160176T1 (de) | 1997-11-15 |
| DE69033633T2 (de) | 2001-05-03 |
| EP0778348A1 (en) | 1997-06-11 |
| EP0481008B1 (en) | 1997-11-12 |
| JP3273609B2 (ja) | 2002-04-08 |
| CA2063592C (en) | 2003-01-21 |
| ATE196505T1 (de) | 2000-10-15 |
| ES2109238T3 (es) | 1998-01-16 |
| IE81016B1 (en) | 1999-09-22 |
| DE69033633D1 (de) | 2000-10-26 |
| EP0778348B1 (en) | 2000-09-20 |
| DE69031710D1 (de) | 1997-12-18 |
| ES2150188T3 (es) | 2000-11-16 |
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