ATE395075T1 - Verwendung von il-18 inhibitoren zur behandlung und/oder prävention von atherosklerose - Google Patents

Verwendung von il-18 inhibitoren zur behandlung und/oder prävention von atherosklerose

Info

Publication number
ATE395075T1
ATE395075T1 AT01945064T AT01945064T ATE395075T1 AT E395075 T1 ATE395075 T1 AT E395075T1 AT 01945064 T AT01945064 T AT 01945064T AT 01945064 T AT01945064 T AT 01945064T AT E395075 T1 ATE395075 T1 AT E395075T1
Authority
AT
Austria
Prior art keywords
inhibitors
treat
prevent atherosclerosis
atherosclerosis
prevent
Prior art date
Application number
AT01945064T
Other languages
English (en)
Inventor
Yolande Chvatchko
Alain Tedgui
Ziad Mallat
Original Assignee
Serono Lab
Inst Nat Sante Rech Med
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Serono Lab, Inst Nat Sante Rech Med filed Critical Serono Lab
Application granted granted Critical
Publication of ATE395075T1 publication Critical patent/ATE395075T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Cardiology (AREA)
  • Mycology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
AT01945064T 2000-05-05 2001-04-30 Verwendung von il-18 inhibitoren zur behandlung und/oder prävention von atherosklerose ATE395075T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP00109606 2000-05-05

Publications (1)

Publication Number Publication Date
ATE395075T1 true ATE395075T1 (de) 2008-05-15

Family

ID=8168631

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01945064T ATE395075T1 (de) 2000-05-05 2001-04-30 Verwendung von il-18 inhibitoren zur behandlung und/oder prävention von atherosklerose

Country Status (32)

Country Link
US (1) US20040076628A1 (de)
EP (1) EP1278540B1 (de)
JP (1) JP5122053B2 (de)
KR (2) KR100798545B1 (de)
CN (2) CN1841066B (de)
AR (1) AR035640A1 (de)
AT (1) ATE395075T1 (de)
AU (2) AU2001267390B2 (de)
BG (1) BG65881B1 (de)
BR (1) BRPI0110506B8 (de)
CA (1) CA2407895C (de)
CY (1) CY1110385T1 (de)
CZ (1) CZ300792B6 (de)
DE (1) DE60134009D1 (de)
DK (1) DK1278540T3 (de)
EA (2) EA007014B1 (de)
EE (1) EE05056B1 (de)
ES (1) ES2305082T3 (de)
HR (1) HRP20020828A2 (de)
HU (1) HU229375B1 (de)
IL (2) IL152567A0 (de)
ME (1) ME00554B (de)
MX (1) MXPA02010895A (de)
NO (1) NO329821B1 (de)
PL (1) PL209371B1 (de)
PT (1) PT1278540E (de)
RS (1) RS50926B (de)
SI (1) SI1278540T1 (de)
SK (1) SK287761B6 (de)
UA (2) UA78492C2 (de)
WO (1) WO2001085201A2 (de)
ZA (1) ZA200208228B (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK12942002A3 (sk) * 2000-02-10 2003-05-02 Abbott Laboratories Protilátky viažuce ľudský interleukín-18, spôsoby ich výroby a použitia
IL157024A0 (en) * 2001-01-29 2004-02-08 Applied Research Systems Il-18 inhibitors in heart disease
US7655616B2 (en) * 2001-05-25 2010-02-02 Ares Trading S.A. Use of IL-18 inhibitors for treating head injuries
US6797727B2 (en) 2001-07-16 2004-09-28 Transition Therapeutics Inc. Use of rhein or diacerhein compounds for the treatment or prevention of vascular diseases
GB0210212D0 (en) * 2002-05-03 2002-06-12 Univ Southampton Effects of dietary N-3 and N-6 pufa intake on atheromatous plaque stability
US8729124B2 (en) 2002-03-05 2014-05-20 Pronova Biopharma Norge As Use of EPA and DHA in secondary prevention
US9592267B2 (en) * 2002-03-22 2017-03-14 Merck Serono Sa Use of IL-18BP for treatment of peripheral vascular diseases
ATE399872T1 (de) * 2003-03-11 2008-07-15 Serono Lab Expressionvektoren, die den promotor des ie2-gens des maus cytomegalovirus enthalten
AU2004238524B2 (en) 2003-05-13 2011-06-23 Merck Serono Sa Active variants of the IL-18 binding protein and medical uses thereof
US7968684B2 (en) * 2003-11-12 2011-06-28 Abbott Laboratories IL-18 binding proteins
ES2356364T3 (es) * 2004-04-15 2011-04-07 Athera Biotechnologies Ab Anexina v para prevenir la ruptura de la placa.
CN101219208B (zh) * 2005-01-04 2010-08-11 健能隆医药技术（上海）有限公司 白介素-22的医药用途
CA2609060C (en) 2005-06-03 2014-07-15 Urs Weber Production of recombinant il-18 binding protein
PT1891088E (pt) 2005-06-10 2011-12-19 Ares Trading Sa Processo para a purificação da proteína de ligação il-18
KR101603001B1 (ko) 2010-08-25 2016-03-11 에프. 호프만-라 로슈 아게 Il-18r1에 대한 항체 및 그의 용도
US9376489B2 (en) 2012-09-07 2016-06-28 Novartis Ag IL-18 binding molecules
MD707Z (ro) * 2013-01-18 2014-07-31 Институт Зоологии Академии Наук Молдовы Metodă de identificare a secvenţelor polimorfe 4a/4b ale genei sintetazei endoteliale a oxidului nitric
WO2015032932A1 (en) 2013-09-05 2015-03-12 Ab2 Bio Sa Il-18 binding protein (il-18bp) in inflammatory diseases
CN107660150B (zh) 2015-03-05 2023-10-24 Ab2生物股份有限公司 Il-18结合蛋白(il-18bp)和抗体在炎性疾病中
TW202233675A (zh) 2020-10-29 2022-09-01 瑞士商諾華公司 Ｉｌ－１８拮抗劑用於治療和／或預防異位性皮炎或相關病症之用途
CN112972655A (zh) * 2021-04-16 2021-06-18 武汉大学 白细胞介素12在制备预防、缓解和/或治疗主动脉瘤药物中的应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5985863A (en) * 1996-09-12 1999-11-16 Vertex Pharmaceuticals, Inc. Compositions and methods for decreasing IGIF and IFN-γ production by administering an ICE inhibitor
US5877197A (en) * 1996-12-16 1999-03-02 Karanewsky; Donald S. C-terminal modified (N-substituted)-2-indolyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases
IL121860A0 (en) * 1997-08-14 1998-02-22 Yeda Res & Dev Interleukin-18 binding proteins their preparation and use
CA2276216A1 (en) * 1998-06-24 1999-12-24 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo An artificial peptide capable of neutralizing the biological activity of interleukin-18
EP0987552A3 (de) * 1998-08-31 2000-06-07 Pfizer Products Inc. Diarylsulphonylharnstoff-Bindungsproteine
CA2340579A1 (en) * 1998-09-01 2000-03-09 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Interleukin 18-binding protein

Also Published As

Publication number Publication date
SK287761B6 (en) 2011-09-05
HUP0301991A2 (hu) 2003-09-29
SI1278540T1 (sl) 2008-10-31
RS50926B (sr) 2010-08-31
SK15562002A3 (sk) 2003-05-02
EP1278540B1 (de) 2008-05-14
ME00554B (me) 2012-03-20
CN1841066B (zh) 2012-08-29
MEP64008A (en) 2011-12-20
ZA200208228B (en) 2005-07-27
KR20030016254A (ko) 2003-02-26
DK1278540T3 (da) 2008-07-21
EA005410B1 (ru) 2005-02-24
CZ300792B6 (cs) 2009-08-12
BRPI0110506B1 (pt) 2015-05-19
KR20070073989A (ko) 2007-07-10
PL209371B1 (pl) 2011-08-31
NO329821B1 (no) 2010-12-27
DE60134009D1 (de) 2008-06-26
WO2001085201A3 (en) 2002-05-10
US20040076628A1 (en) 2004-04-22
HK1055681A1 (en) 2004-01-21
YU82602A (sh) 2006-01-16
PL365697A1 (en) 2005-01-10
IL152567A (en) 2010-12-30
KR100798545B1 (ko) 2008-01-28
HK1094909A1 (en) 2007-04-13
EE05056B1 (et) 2008-08-15
AU2001267390B2 (en) 2005-09-22
UA87658C2 (uk) 2009-08-10
AU6739001A (en) 2001-11-20
PT1278540E (pt) 2008-07-03
HRP20020828A2 (en) 2004-12-31
BRPI0110506B8 (pt) 2021-05-25
HUP0301991A3 (en) 2006-11-28
CZ20023644A3 (cs) 2003-03-12
WO2001085201A2 (en) 2001-11-15
UA78492C2 (en) 2007-04-10
CA2407895A1 (en) 2001-11-15
NO20025307L (no) 2002-12-18
BG65881B1 (bg) 2010-04-30
EP1278540A2 (de) 2003-01-29
IL152567A0 (en) 2003-05-29
EA200401183A1 (ru) 2004-12-30
AR035640A1 (es) 2004-06-23
JP5122053B2 (ja) 2013-01-16
NO20025307D0 (no) 2002-11-05
BG107218A (bg) 2003-06-30
CA2407895C (en) 2012-12-18
MXPA02010895A (es) 2003-03-27
CN1250286C (zh) 2006-04-12
JP2003532685A (ja) 2003-11-05
EE200200620A (et) 2004-06-15
CN1434722A (zh) 2003-08-06
EA007014B1 (ru) 2006-06-30
BR0110506A (pt) 2003-04-01
ES2305082T3 (es) 2008-11-01
HU229375B1 (en) 2013-11-28
CN1841066A (zh) 2006-10-04
EA200201175A1 (ru) 2003-04-24
CY1110385T1 (el) 2015-04-29

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