ATE395086T1 - Verfahren zur herstellung von einschlussverbindungen zwischen einem nichtsteroidalen antirheumatikum und betacyclodextrin durch mikrowellenbehandlung - Google Patents
Verfahren zur herstellung von einschlussverbindungen zwischen einem nichtsteroidalen antirheumatikum und betacyclodextrin durch mikrowellenbehandlungInfo
- Publication number
- ATE395086T1 ATE395086T1 AT02805328T AT02805328T ATE395086T1 AT E395086 T1 ATE395086 T1 AT E395086T1 AT 02805328 T AT02805328 T AT 02805328T AT 02805328 T AT02805328 T AT 02805328T AT E395086 T1 ATE395086 T1 AT E395086T1
- Authority
- AT
- Austria
- Prior art keywords
- betacyclodextrin
- microwave treatment
- inclusion compounds
- antirheumatic drug
- drug
- Prior art date
Links
- 229920000858 Cyclodextrin Polymers 0.000 title abstract 3
- 239000001116 FEMA 4028 Substances 0.000 title 1
- 239000003435 antirheumatic agent Substances 0.000 title 1
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 title 1
- 235000011175 beta-cyclodextrine Nutrition 0.000 title 1
- 229960004853 betadex Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 229940079593 drug Drugs 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 abstract 2
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 235000011114 ammonium hydroxide Nutrition 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 229960001680 ibuprofen Drugs 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229960002702 piroxicam Drugs 0.000 abstract 1
- QYSPLQLAKJAUJT-UHFFFAOYSA-N piroxicam Chemical compound OC=1C2=CC=CC=C2S(=O)(=O)N(C)C=1C(=O)NC1=CC=CC=N1 QYSPLQLAKJAUJT-UHFFFAOYSA-N 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
- A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/4935—Impregnated naturally solid product [e.g., leather, stone, etc.]
- Y10T428/662—Wood timber product [e.g., piling, post, veneer, etc.]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nanotechnology (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Public Health (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Adornments (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2001MI002749A ITMI20012749A1 (it) | 2001-12-21 | 2001-12-21 | Procedimento per la preparazione mediante trattamento con microonde di composti di inclusione tra farmaco e ciclodestrine e prodotti ottenut |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE395086T1 true ATE395086T1 (de) | 2008-05-15 |
Family
ID=11448736
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02805328T ATE395086T1 (de) | 2001-12-21 | 2002-12-17 | Verfahren zur herstellung von einschlussverbindungen zwischen einem nichtsteroidalen antirheumatikum und betacyclodextrin durch mikrowellenbehandlung |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US7935685B2 (de) |
| EP (1) | EP1455838B1 (de) |
| CN (1) | CN100528236C (de) |
| AT (1) | ATE395086T1 (de) |
| AU (1) | AU2002356663A1 (de) |
| BR (1) | BR0207630A (de) |
| CA (1) | CA2470992A1 (de) |
| DE (1) | DE60226637D1 (de) |
| HR (1) | HRP20040570A2 (de) |
| IT (1) | ITMI20012749A1 (de) |
| MX (1) | MXPA04005883A (de) |
| NO (1) | NO20033669L (de) |
| PL (1) | PL370706A1 (de) |
| WO (1) | WO2003053475A1 (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008539240A (ja) * | 2005-04-25 | 2008-11-13 | テバ ファーマシュ−ティカルズ ユーエスエー， インコーポレイテッド | 持続放出性処方物 |
| CN100443839C (zh) * | 2005-08-06 | 2008-12-17 | 天水华圆制药设备科技有限责任公司 | 安全节能的微波真空自动连续干燥机 |
| CN100424453C (zh) * | 2005-08-06 | 2008-10-08 | 天水华圆制药设备科技有限责任公司 | 带有双干燥室的微波真空连续干燥机及其使用方法 |
| US7781572B2 (en) * | 2005-10-05 | 2010-08-24 | Nse Products, Inc. | Nanosized carotenoid cyclodextrin complexes |
| US7658913B2 (en) | 2005-11-28 | 2010-02-09 | Verrow Pharmaceuticals, Inc. | Compositions useful for reducing nephrotoxicity and methods of use thereof |
| US8192721B2 (en) * | 2007-12-13 | 2012-06-05 | Verrow Pharmaceuticals, Inc. | Compositions useful for reducing toxicity associated with gadolinium-based contrast agents |
| CN102181078A (zh) * | 2010-12-29 | 2011-09-14 | 天津科技大学 | 一种提高沃氏氧化物生物催化效率的包合物制备方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1241088B (it) * | 1990-03-27 | 1993-12-29 | Chiesi Farma Spa | Procedimento per la preparazione di complessi piroxicam/ciclodestrina,prodotti ottenuti e loro composizioni farmaceutiche |
| US5472954A (en) * | 1992-07-14 | 1995-12-05 | Cyclops H.F. | Cyclodextrin complexation |
| ZA941544B (en) * | 1993-03-05 | 1994-10-31 | Hexal Pharma Gmbh | Crystalline cyclodextrin complexes of ranitidine hydrochloride, process for their preparation and pharmaceutical compositions containing the same. |
| EP0760680A1 (de) * | 1994-05-27 | 1997-03-12 | Farmarc Nederland Bv | Pharmazeutische zusammensetzungen |
| DE4428654A1 (de) * | 1994-08-12 | 1996-02-15 | Consortium Elektrochem Ind | Wasserlösliche Cyclodextrinderivate mit lipophilen Substituenten und Verfahren zu ihrer Herstellung |
| ZA959469B (en) * | 1994-11-15 | 1996-05-15 | South African Druggists Ltd | Pharmaceutical composition |
| TW487582B (en) | 1995-08-11 | 2002-05-21 | Nissan Chemical Ind Ltd | Method for converting sparingly water-soluble medical substance to amorphous state |
| CA2418490A1 (en) | 2000-08-11 | 2002-02-21 | Eisai Co., Ltd. | Drug-containing solid dispersion having improved solubility |
-
2001
- 2001-12-21 IT IT2001MI002749A patent/ITMI20012749A1/it unknown
-
2002
- 2002-12-17 WO PCT/EP2002/014349 patent/WO2003053475A1/en not_active Ceased
- 2002-12-17 CA CA002470992A patent/CA2470992A1/en not_active Abandoned
- 2002-12-17 PL PL02370706A patent/PL370706A1/xx not_active Application Discontinuation
- 2002-12-17 US US10/499,338 patent/US7935685B2/en not_active Expired - Fee Related
- 2002-12-17 BR BR0207630-6A patent/BR0207630A/pt not_active IP Right Cessation
- 2002-12-17 HR HR20040570A patent/HRP20040570A2/xx not_active Application Discontinuation
- 2002-12-17 MX MXPA04005883A patent/MXPA04005883A/es active IP Right Grant
- 2002-12-17 DE DE60226637T patent/DE60226637D1/de not_active Expired - Lifetime
- 2002-12-17 AU AU2002356663A patent/AU2002356663A1/en not_active Abandoned
- 2002-12-17 EP EP02805328A patent/EP1455838B1/de not_active Expired - Lifetime
- 2002-12-17 CN CNB028268792A patent/CN100528236C/zh not_active Expired - Fee Related
- 2002-12-17 AT AT02805328T patent/ATE395086T1/de not_active IP Right Cessation
-
2003
- 2003-08-19 NO NO20033669A patent/NO20033669L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CN100528236C (zh) | 2009-08-19 |
| HRP20040570A2 (en) | 2004-10-31 |
| WO2003053475A1 (en) | 2003-07-03 |
| ITMI20012749A1 (it) | 2003-06-21 |
| HK1079992A1 (zh) | 2006-04-21 |
| CN1638806A (zh) | 2005-07-13 |
| AU2002356663A1 (en) | 2003-07-09 |
| EP1455838B1 (de) | 2008-05-14 |
| BR0207630A (pt) | 2004-06-01 |
| NO20033669D0 (no) | 2003-08-19 |
| US7935685B2 (en) | 2011-05-03 |
| EP1455838A1 (de) | 2004-09-15 |
| CA2470992A1 (en) | 2003-07-03 |
| DE60226637D1 (de) | 2008-06-26 |
| US20050042471A1 (en) | 2005-02-24 |
| NO20033669L (no) | 2003-10-17 |
| MXPA04005883A (es) | 2004-11-01 |
| US20070059547A9 (en) | 2007-03-15 |
| PL370706A1 (en) | 2005-05-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |