ATE395336T1 - Chinolinderivate zur verwendung als inhibitoren von mycobakterien - Google Patents

Chinolinderivate zur verwendung als inhibitoren von mycobakterien

Info

Publication number
ATE395336T1
ATE395336T1 AT05707886T AT05707886T ATE395336T1 AT E395336 T1 ATE395336 T1 AT E395336T1 AT 05707886 T AT05707886 T AT 05707886T AT 05707886 T AT05707886 T AT 05707886T AT E395336 T1 ATE395336 T1 AT E395336T1
Authority
AT
Austria
Prior art keywords
mycobacteria
inhibitors
quinoline derivatives
quinoline
derivatives
Prior art date
Application number
AT05707886T
Other languages
English (en)
Inventor
J E G Guillemont
E T J Pasquier
D F A Lancois
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Application granted granted Critical
Publication of ATE395336T1 publication Critical patent/ATE395336T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
AT05707886T 2004-01-29 2005-01-28 Chinolinderivate zur verwendung als inhibitoren von mycobakterien ATE395336T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP04075286 2004-01-29

Publications (1)

Publication Number Publication Date
ATE395336T1 true ATE395336T1 (de) 2008-05-15

Family

ID=34833674

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05707886T ATE395336T1 (de) 2004-01-29 2005-01-28 Chinolinderivate zur verwendung als inhibitoren von mycobakterien

Country Status (20)

Country Link
US (1) US7790894B2 (de)
EP (1) EP1713776B1 (de)
JP (1) JP4919810B2 (de)
KR (1) KR101160183B1 (de)
CN (1) CN1910154B (de)
AP (1) AP2321A (de)
AT (1) ATE395336T1 (de)
AU (1) AU2005210036B2 (de)
BR (1) BRPI0507312A (de)
CA (1) CA2554049C (de)
DE (1) DE602005006744D1 (de)
EA (1) EA011572B9 (de)
ES (1) ES2306098T3 (de)
IL (1) IL177101A (de)
MX (1) MXPA06008596A (de)
NO (1) NO337253B1 (de)
NZ (1) NZ547614A (de)
UA (1) UA83875C2 (de)
WO (1) WO2005075428A1 (de)
ZA (1) ZA200606291B (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO2855B1 (en) * 2005-08-03 2015-03-15 شركة جانسين فارماسوتيكا ان. في Quinoline derivatives acting as antibacterial agents
JO2683B1 (en) * 2006-12-06 2013-03-03 جانسين فارماسوتيكا ان. في Quinoline antibacterial derivatives
JO2970B1 (en) 2006-12-06 2016-03-15 جانسين فارماسوتيكا ان. في Quinoline antibacterial derivatives
JO2685B1 (en) * 2006-12-06 2013-03-03 جانسين فارماسوتيكا ان في Quinoline antibacterial derivatives
JO2684B1 (en) * 2006-12-06 2013-03-03 جانسين فارماسوتيكا ان في Quinoline antibacterial derivatives
JO3271B1 (ar) 2006-12-06 2018-09-16 Janssen Pharmaceutica Nv مشتقات الكوينولين المضادة للجراثيم
CA2751892A1 (en) 2009-01-15 2010-07-22 Rutgers, The State University Of New Jersey Benzo [c] phenanthridines as antimicrobial agents
CA2760526A1 (en) 2009-04-30 2010-11-04 Rutgers, The State University Of New Jersey Antimicrobial agents
US8933096B2 (en) 2010-06-09 2015-01-13 Rugers, The State University of New Jersey Antimicrobial agents
WO2011163610A2 (en) * 2010-06-25 2011-12-29 Rutgers, The State University Of New Jersey Antimicrobial agents
RU2486175C2 (ru) * 2011-09-12 2013-06-27 Закрытое Акционерное Общество "Фарм-Синтез" Производные хинолина, в частности 5,6,7-замещенные 1-(2-хлорхинолин-3-ил)-4-диметиламино-2-(нафталин-1-ил)-1-фенилбутан-2-олы, способ получения и применение соединений
WO2013106756A2 (en) 2012-01-13 2013-07-18 Rutgers, The State University Of New Jersey Antimicrobial agents
EP2828245A1 (de) 2012-03-21 2015-01-28 Rutgers, The State University of New Jersey Antimikrobiotika
ES2576491T3 (es) 2012-04-27 2016-07-07 Janssen Pharmaceutica, N.V. Derivados de quinolina antibacterianos
AU2013254670B2 (en) 2012-04-27 2017-03-30 Janssen Pharmaceutica Nv Antibacterial quinoline derivatives
MY189505A (en) 2012-10-16 2022-02-16 Janssen Pharmaceutica Nv Methylene linked quinolinyl modulators of roryt
HK1213887A1 (zh) 2012-10-16 2016-07-15 Janssen Pharmaceutica N.V. RORγt的苯基连接的喹啉基调节剂
WO2014062655A1 (en) 2012-10-16 2014-04-24 Janssen Pharmaceutica Nv HETEROARYL LINKED QUINOLINYL MODULATORS OF RORyt
CA2926339A1 (en) 2013-10-15 2015-04-23 Janssen Pharmaceutica Nv Alkyl linked quinolinyl modulators of roryt
US10555941B2 (en) 2013-10-15 2020-02-11 Janssen Pharmaceutica Nv Alkyl linked quinolinyl modulators of RORγt
US9284308B2 (en) 2013-10-15 2016-03-15 Janssen Pharmaceutica Nv Methylene linked quinolinyl modulators of RORγt
US9221804B2 (en) 2013-10-15 2015-12-29 Janssen Pharmaceutica Nv Secondary alcohol quinolinyl modulators of RORγt
US9328095B2 (en) 2013-10-15 2016-05-03 Janssen Pharmaceutica Nv Heteroaryl linked quinolinyl modulators of RORgammat
CA2927182A1 (en) * 2013-10-15 2015-04-23 Janssen Pharmaceutica Nv Quinolinyl modulators of ror.gamma.t
US9403816B2 (en) 2013-10-15 2016-08-02 Janssen Pharmaceutica Nv Phenyl linked quinolinyl modulators of RORγt
US9458150B2 (en) 2013-11-08 2016-10-04 Rutgers, The State University Of New Jersey Antimicrobial agents
WO2017147316A1 (en) 2016-02-25 2017-08-31 Taxis Pharmaceuticals, Inc. Synthetic processes and intermediates
CN110891566B (zh) 2017-03-30 2023-12-19 塔克西斯医药股份有限公司 合成方法和合成中间体

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5965572A (en) * 1996-10-28 1999-10-12 The United States Of America As Respresented By The Secretary Of The Army Methods for treating antibiotic-resistant infections
AU757059B2 (en) * 1997-06-19 2003-01-30 Sepracor, Inc. Quinoline-indole antimicrobial agents, uses and compositions related thereto
US6103905A (en) 1997-06-19 2000-08-15 Sepracor, Inc. Quinoline-indole antimicrobial agents, uses and compositions related thereto
AU2717899A (en) * 1998-01-26 1999-08-09 Smithkline Beecham Plc Quinoline derivatives as antibacterials
SI1527050T1 (sl) * 2002-07-25 2010-08-31 Janssen Pharmaceutica Nv Kinolinski derivati in njihova uporaba kot mikobakterijski inhibitorji
BRPI0507076B8 (pt) * 2004-01-23 2021-05-25 Janssen Pharmaceutica Nv quinolinas substituídas, seu processo de preparação, composição farmacêutica que as compreende e seu uso como inibidores micobacterianos

Also Published As

Publication number Publication date
ES2306098T3 (es) 2008-11-01
EP1713776B1 (de) 2008-05-14
JP4919810B2 (ja) 2012-04-18
EA011572B1 (ru) 2009-04-28
CA2554049C (en) 2012-12-18
NO337253B1 (no) 2016-02-22
HK1099297A1 (en) 2007-08-10
KR101160183B1 (ko) 2012-06-26
AP2006003705A0 (en) 2006-08-31
IL177101A (en) 2012-01-31
EA200601391A1 (ru) 2006-12-29
CA2554049A1 (en) 2005-08-18
AP2321A (en) 2011-11-16
KR20070004597A (ko) 2007-01-09
NO20063821L (no) 2006-08-28
AU2005210036B2 (en) 2010-12-23
EP1713776A1 (de) 2006-10-25
US7790894B2 (en) 2010-09-07
BRPI0507312A (pt) 2007-06-26
EA011572B9 (ru) 2018-01-31
ZA200606291B (en) 2008-02-27
CN1910154A (zh) 2007-02-07
NZ547614A (en) 2009-04-30
IL177101A0 (en) 2006-12-10
CN1910154B (zh) 2011-08-17
JP2007519687A (ja) 2007-07-19
DE602005006744D1 (de) 2008-06-26
UA83875C2 (ru) 2008-08-26
US20070299106A1 (en) 2007-12-27
MXPA06008596A (es) 2006-08-28
WO2005075428A1 (en) 2005-08-18
AU2005210036A1 (en) 2005-08-18

Similar Documents

Publication Publication Date Title
DE602005006744D1 (de) Chinolinderivate zur verwendung als inhibitoren von mycobakterien
DE602005013819D1 (de) Pyridincarbonsäureamidderivate zur verwendung als antikrebsmittel
ATE444068T1 (de) Chinolinderivate und ihre verwendung als mycobakterielle inhibitoren
ATE400271T1 (de) Aryl-pyridinderivate als 11-beta-hsd1-hemmer
ATE524467T1 (de) Neuartige aza-heterozyklen als kinase-inhibitoren
ATE520671T1 (de) Pyrimidin-harnstoff-derivate als kinase-hemmer
ATE420076T1 (de) Indozolonderivate als 11b-hsd1-inhibitoren
DE602007013295D1 (de) Substituierte isochinoline und ihre verwendung als rho-kinase-inhibitoren
ATE529421T1 (de) Chinolinderivate als phosphodiesterase-hemmer
DE602007008837D1 (de) Als protein-kinase-inhibitoren nutzbare dyhydrodiazepine
EP1737811A4 (de) Cetp-inhibitoren
ATE452631T1 (de) N-2-adamantanyl-2-phenoxy-acetamid-derivate als 11-betahydroxysteroid-dehydrogenase-hemmer
DE602005022115D1 (de) Heteroaromatische chinolinverbindungen und deren verwendung als pde10-inhibitoren
ATE543816T1 (de) Azacycloalkanderivate als inhibitoren von stearoyl-coenzym-a-delta-9-desaturase
ATE446090T1 (de) Thiadiazolidinone als gsk3-inhibitoren
ATE423121T1 (de) Diphenylimidazopyrimidin- und -imidazolamine als b-sekretase-inhibitoren
ATE478064T1 (de) Als pi-3-kinaseinhibitoren verwendete pyrimidinderivate
ATE518860T1 (de) Pyrroloä2,3-büpyridinderivate als proteinkinaseinhibitoren
EP1973889A4 (de) Cetp-inhibitoren
DE602004025258D1 (de) Aminotriazol-verbindungen als proteinkinase-hemmer
ATE441641T1 (de) Isochinolinderivate als inhibitoren von rho- kinase
ATE530545T1 (de) Als kinaseinhibitoren geeignete pyrazolylaminopyridinderivate
DE602004022170D1 (de) 2-imino-4-(thio)oxo-5-polycyclovinylazoline zur verwendung als pi3-kinase-inhibtoren
ATE509011T1 (de) Pyrimidinderivate als 11beta-hsd1-inhibitoren
DE602005014646D1 (de) Substituierte propenylpiperazinderivate als neue inhibitoren von histondeacetylase

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1713776

Country of ref document: EP