BRPI0507312A - derivados de quinolina para uso como inibidores micobacterianos - Google Patents

derivados de quinolina para uso como inibidores micobacterianos

Info

Publication number
BRPI0507312A
BRPI0507312A BRPI0507312-0A BRPI0507312A BRPI0507312A BR PI0507312 A BRPI0507312 A BR PI0507312A BR PI0507312 A BRPI0507312 A BR PI0507312A BR PI0507312 A BRPI0507312 A BR PI0507312A
Authority
BR
Brazil
Prior art keywords
quinoline derivatives
mycobacterial
inhibitors
mycobacterial inhibitors
useful
Prior art date
Application number
BRPI0507312-0A
Other languages
English (en)
Inventor
Jerome Emile George Guillemont
Elisabeth Ther Se Jea Pasquier
David Francis Alain Lancois
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of BRPI0507312A publication Critical patent/BRPI0507312A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)

Abstract

DERIVADOS DE QUINOLINA PARA USO COMO INIBIDORES MICOBACTERIANOS. A presente invenção refere-se a derivados de quinolina substituídos de acordo com a fórmula geral (l) úteis no tratamento de doenças micobacterianas tal como TB.
BRPI0507312-0A 2004-01-29 2005-01-28 derivados de quinolina para uso como inibidores micobacterianos BRPI0507312A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04075286 2004-01-29
PCT/EP2005/050375 WO2005075428A1 (en) 2004-01-29 2005-01-28 Quinoline derivatives for use as mycobacterial inhibitors

Publications (1)

Publication Number Publication Date
BRPI0507312A true BRPI0507312A (pt) 2007-06-26

Family

ID=34833674

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0507312-0A BRPI0507312A (pt) 2004-01-29 2005-01-28 derivados de quinolina para uso como inibidores micobacterianos

Country Status (20)

Country Link
US (1) US7790894B2 (pt)
EP (1) EP1713776B1 (pt)
JP (1) JP4919810B2 (pt)
KR (1) KR101160183B1 (pt)
CN (1) CN1910154B (pt)
AP (1) AP2321A (pt)
AT (1) ATE395336T1 (pt)
AU (1) AU2005210036B2 (pt)
BR (1) BRPI0507312A (pt)
CA (1) CA2554049C (pt)
DE (1) DE602005006744D1 (pt)
EA (1) EA011572B9 (pt)
ES (1) ES2306098T3 (pt)
IL (1) IL177101A (pt)
MX (1) MXPA06008596A (pt)
NO (1) NO337253B1 (pt)
NZ (1) NZ547614A (pt)
UA (1) UA83875C2 (pt)
WO (1) WO2005075428A1 (pt)
ZA (1) ZA200606291B (pt)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO2855B1 (en) 2005-08-03 2015-03-15 شركة جانسين فارماسوتيكا ان. في Quinoline derivatives acting as antibacterial agents
JO2683B1 (en) * 2006-12-06 2013-03-03 جانسين فارماسوتيكا ان. في Quinoline antibacterial derivatives
JO2684B1 (en) * 2006-12-06 2013-03-03 جانسين فارماسوتيكا ان في Quinoline antibacterial derivatives
JO2685B1 (en) 2006-12-06 2013-03-03 جانسين فارماسوتيكا ان في Quinoline antibacterial derivatives
JO2970B1 (en) 2006-12-06 2016-03-15 جانسين فارماسوتيكا ان. في Quinoline antibacterial derivatives
JO3271B1 (ar) 2006-12-06 2018-09-16 Janssen Pharmaceutica Nv مشتقات الكوينولين المضادة للجراثيم
US8741917B2 (en) 2009-01-15 2014-06-03 Rutgers, The State University Of New Jersey Benzo [C] phenanthridines as antimicrobial agents
US20120059026A1 (en) 2009-04-30 2012-03-08 University Of Medicine And Dentistry Of New Jersey Antimicrobial agents
WO2011156626A1 (en) 2010-06-09 2011-12-15 Rutgers, The State University Of New Jersey Antimicrobial agents
CA2803890A1 (en) 2010-06-25 2011-12-29 Rutgers, The State University Of New Jersey Antimicrobial agents
RU2486175C2 (ru) * 2011-09-12 2013-06-27 Закрытое Акционерное Общество "Фарм-Синтез" Производные хинолина, в частности 5,6,7-замещенные 1-(2-хлорхинолин-3-ил)-4-диметиламино-2-(нафталин-1-ил)-1-фенилбутан-2-олы, способ получения и применение соединений
WO2013106756A2 (en) 2012-01-13 2013-07-18 Rutgers, The State University Of New Jersey Antimicrobial agents
AU2013235038A1 (en) 2012-03-21 2014-10-09 Malvika Kaul Antimicrobial agents
US9133167B2 (en) 2012-04-27 2015-09-15 Janssen Pharmaceutica Nv Antibacterial quinoline derivatives
KR102110366B1 (ko) 2012-04-27 2020-05-14 얀센 파마슈티카 엔.브이. 항균성 퀴놀린 유도체
JP6466335B2 (ja) 2012-10-16 2019-02-06 ヤンセン ファーマシューティカ エヌ．ベー． ＲＯＲ−γ−Ｔのメチレン連結キノリニルモジュレーター
CN104884448A (zh) 2012-10-16 2015-09-02 詹森药业有限公司 Rorγt的杂芳基连接的喹啉基调节剂
US9309222B2 (en) 2012-10-16 2016-04-12 Janssen Pharmaceutica Nv Phenyl linked quinolinyl modulators of RORγt
CN105873439A (zh) 2013-10-15 2016-08-17 詹森药业有限公司 RORγt的烷基连接的喹啉基调节剂
KR20160068956A (ko) 2013-10-15 2016-06-15 얀센 파마슈티카 엔.브이. RORyT의 퀴놀리닐 조절제
US10555941B2 (en) 2013-10-15 2020-02-11 Janssen Pharmaceutica Nv Alkyl linked quinolinyl modulators of RORγt
US9328095B2 (en) 2013-10-15 2016-05-03 Janssen Pharmaceutica Nv Heteroaryl linked quinolinyl modulators of RORgammat
US9221804B2 (en) 2013-10-15 2015-12-29 Janssen Pharmaceutica Nv Secondary alcohol quinolinyl modulators of RORγt
US9403816B2 (en) 2013-10-15 2016-08-02 Janssen Pharmaceutica Nv Phenyl linked quinolinyl modulators of RORγt
US9284308B2 (en) 2013-10-15 2016-03-15 Janssen Pharmaceutica Nv Methylene linked quinolinyl modulators of RORγt
US9458150B2 (en) 2013-11-08 2016-10-04 Rutgers, The State University Of New Jersey Antimicrobial agents
CN109195957A (zh) 2016-02-25 2019-01-11 塔克西斯医药股份有限公司 合成方法和中间体
CA3058183A1 (en) 2017-03-30 2018-10-04 Taxis Pharmaceuticals, Inc. Synthetic processes and synthetic intermediates towardthe production of txa709

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5965572A (en) * 1996-10-28 1999-10-12 The United States Of America As Respresented By The Secretary Of The Army Methods for treating antibiotic-resistant infections
WO1998057931A2 (en) * 1997-06-19 1998-12-23 Sepracor Inc. Quinoline-indole antimicrobial agents, uses and compositions related thereto
US6103905A (en) 1997-06-19 2000-08-15 Sepracor, Inc. Quinoline-indole antimicrobial agents, uses and compositions related thereto
DE69908555T2 (de) * 1998-01-26 2004-05-06 Smithkline Beecham P.L.C., Brentford Chinolinderivate als antibakterielles arzneimittel
PT1527050E (pt) * 2002-07-25 2010-06-22 Janssen Pharmaceutica Nv Derivados de quinolina e sua utilização como inibidores de micobactérias
KR101150172B1 (ko) * 2004-01-23 2012-05-25 얀센 파마슈티카 엔.브이. 치환된 퀴놀린 및 마이코박테리아 저해제로서의 용도

Also Published As

Publication number Publication date
NO337253B1 (no) 2016-02-22
WO2005075428A1 (en) 2005-08-18
IL177101A0 (en) 2006-12-10
CA2554049C (en) 2012-12-18
JP2007519687A (ja) 2007-07-19
CN1910154B (zh) 2011-08-17
US20070299106A1 (en) 2007-12-27
US7790894B2 (en) 2010-09-07
KR20070004597A (ko) 2007-01-09
EA011572B9 (ru) 2018-01-31
ZA200606291B (en) 2008-02-27
MXPA06008596A (es) 2006-08-28
NO20063821L (no) 2006-08-28
CN1910154A (zh) 2007-02-07
HK1099297A1 (en) 2007-08-10
IL177101A (en) 2012-01-31
AP2006003705A0 (en) 2006-08-31
ES2306098T3 (es) 2008-11-01
AU2005210036A1 (en) 2005-08-18
ATE395336T1 (de) 2008-05-15
CA2554049A1 (en) 2005-08-18
DE602005006744D1 (de) 2008-06-26
UA83875C2 (ru) 2008-08-26
EP1713776B1 (en) 2008-05-14
EA011572B1 (ru) 2009-04-28
NZ547614A (en) 2009-04-30
EA200601391A1 (ru) 2006-12-29
JP4919810B2 (ja) 2012-04-18
AU2005210036B2 (en) 2010-12-23
KR101160183B1 (ko) 2012-06-26
EP1713776A1 (en) 2006-10-25
AP2321A (en) 2011-11-16

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL