ATE396189T1 - Cyanopyrrolhaltige cyclische carbamat- und thiocarbamatbiaryle und verfahren zu deren herstellung - Google Patents
Cyanopyrrolhaltige cyclische carbamat- und thiocarbamatbiaryle und verfahren zu deren herstellungInfo
- Publication number
- ATE396189T1 ATE396189T1 AT05740218T AT05740218T ATE396189T1 AT E396189 T1 ATE396189 T1 AT E396189T1 AT 05740218 T AT05740218 T AT 05740218T AT 05740218 T AT05740218 T AT 05740218T AT E396189 T1 ATE396189 T1 AT E396189T1
- Authority
- AT
- Austria
- Prior art keywords
- optionally substituted
- methyl
- alkyl
- cyanopyrrole
- aminoalkyl
- Prior art date
Links
- BQMPGKPTOHKYHS-UHFFFAOYSA-N 1h-pyrrole-2-carbonitrile Chemical compound N#CC1=CC=CN1 BQMPGKPTOHKYHS-UHFFFAOYSA-N 0.000 title abstract 2
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 title 1
- 150000005347 biaryls Chemical class 0.000 title 1
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 125000004103 aminoalkyl group Chemical group 0.000 abstract 3
- JDCAVWLLZCSPTB-UHFFFAOYSA-N 5-(3-acetyl-4-aminophenyl)-1-methylpyrrole-2-carbonitrile Chemical compound C1=C(N)C(C(=O)C)=CC(C=2N(C(C#N)=CC=2)C)=C1 JDCAVWLLZCSPTB-UHFFFAOYSA-N 0.000 abstract 1
- AKWXTECOJTWHIU-UHFFFAOYSA-N 5-[4-amino-3-(2-hydroxypropan-2-yl)phenyl]-1-methylpyrrole-2-carbonitrile Chemical compound CN1C(C#N)=CC=C1C1=CC=C(N)C(C(C)(C)O)=C1 AKWXTECOJTWHIU-UHFFFAOYSA-N 0.000 abstract 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
- 241000689227 Cora <basidiomycete fungus> Species 0.000 abstract 1
- 241000347391 Umbrina cirrosa Species 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- -1 cyclic carbamates Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- IVBWMGBBBAVXRJ-UHFFFAOYSA-N methyl 2-amino-5-(5-cyano-1-methylpyrrol-2-yl)benzoate Chemical compound C1=C(N)C(C(=O)OC)=CC(C=2N(C(C#N)=CC=2)C)=C1 IVBWMGBBBAVXRJ-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 150000003558 thiocarbamic acid derivatives Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US56561604P | 2004-04-27 | 2004-04-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE396189T1 true ATE396189T1 (de) | 2008-06-15 |
Family
ID=35242253
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05740218T ATE396189T1 (de) | 2004-04-27 | 2005-04-25 | Cyanopyrrolhaltige cyclische carbamat- und thiocarbamatbiaryle und verfahren zu deren herstellung |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US7582755B2 (de) |
| EP (1) | EP1756095B1 (de) |
| JP (2) | JP5108506B2 (de) |
| CN (1) | CN1946716B (de) |
| AT (1) | ATE396189T1 (de) |
| AU (1) | AU2005238520B2 (de) |
| BR (1) | BRPI0510278A (de) |
| CA (1) | CA2562160C (de) |
| DE (1) | DE602005007021D1 (de) |
| DK (1) | DK1756095T3 (de) |
| ES (1) | ES2306140T3 (de) |
| MX (1) | MXPA06012402A (de) |
| PL (1) | PL1756095T3 (de) |
| WO (1) | WO2005105739A2 (de) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA73119C2 (en) | 2000-04-19 | 2005-06-15 | American Home Products Corpoir | Derivatives of cyclic thiocarbamates, pharmaceutical composition including noted derivatives of cyclic thiocarbamates and active ingredients of medicines as modulators of progesterone receptors |
| CA2562160C (en) | 2004-04-27 | 2013-05-28 | Wyeth | Cyanopyrrole containing cyclic carbamate and thiocarbamate biaryls and methods for preparing the same |
| SI1896034T1 (sl) | 2005-04-28 | 2010-07-30 | Wyeth Llc | Mikronizirani sestavki tanaprogeta in postopki priprave le-tega |
| EP1877059B8 (de) * | 2005-04-28 | 2010-05-19 | Wyeth a Corporation of the State of Delaware | Mikronisiertes tanaproget und zusammensetzungen damit |
| WO2007030153A2 (en) * | 2005-04-28 | 2007-03-15 | Wyeth | Compositions containing micronized tanaproget |
| PE20070182A1 (es) * | 2005-07-29 | 2007-03-06 | Wyeth Corp | Derivados cianopirrol-fenil amida como moduladores del receptor de progesterona |
| PE20070341A1 (es) * | 2005-07-29 | 2007-04-13 | Wyeth Corp | Derivados de pirrol como moduladores del receptor de progesterona |
| PE20070404A1 (es) * | 2005-07-29 | 2007-05-10 | Wyeth Corp | Compuestos derivados de cianopirrol-sulfonamida como moduladores del receptor de progesterona |
| PE20070220A1 (es) * | 2005-07-29 | 2007-03-19 | Wyeth Corp | Proceso para la sintesis de moduladores del receptor de progesterona |
| US20070213526A1 (en) * | 2006-03-07 | 2007-09-13 | Wyeth | Purification of progesterone receptor modulators |
| US20080319204A1 (en) * | 2007-06-25 | 2008-12-25 | Wyeth | Process for the synthesis of progesterone receptor modulators |
| BRPI0819571A2 (pt) | 2007-12-20 | 2019-09-24 | Teva Womenss Health Inc | "método para contracepção de emergência, pacote farmacêutico para contracepção de emergência e composição farmacêutica" |
| GB0817578D0 (en) * | 2008-09-25 | 2008-11-05 | 3M Innovative Properties Co | Method for treating wheel rims and composition for use therein |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5194628A (en) | 1988-03-18 | 1993-03-16 | Ciba-Geigy Corporation | Process for the preparation of substituted difluorobenzo-1,3-dioxoles |
| JPH09502432A (ja) | 1993-09-10 | 1997-03-11 | チバ−ガイギー アクチエンゲゼルシャフト | フォトクロミック化合物、その製造方法および製造のための中間生成物、ならびにそれらの用法 |
| WO2000050470A2 (en) | 1999-02-22 | 2000-08-31 | Eastman Chemical Company | Catalysts containing n-pyrrolyl substituted nitrogen donors |
| US6545108B1 (en) | 1999-02-22 | 2003-04-08 | Eastman Chemical Company | Catalysts containing N-pyrrolyl substituted nitrogen donors |
| CN1145618C (zh) * | 1999-05-04 | 2004-04-14 | 美国家庭用品有限公司 | 作为黄体酮受体调节剂的环氨基甲酸酯衍生物 |
| EP1175404A1 (de) * | 1999-05-04 | 2002-01-30 | American Home Products Corporation | Chinazolinon und benzoxazin derivate als progesteron rezeptor modulatoren |
| US6509334B1 (en) * | 1999-05-04 | 2003-01-21 | American Home Products Corporation | Cyclocarbamate derivatives as progesterone receptor modulators |
| US6407101B1 (en) | 1999-05-04 | 2002-06-18 | American Home Products Corporation | Cyanopyrroles |
| ATE386729T1 (de) * | 1999-05-04 | 2008-03-15 | Wyeth Corp | Cyclothiocarbamatderivate als progesteron- rezeptormodulatoren |
| US6391907B1 (en) | 1999-05-04 | 2002-05-21 | American Home Products Corporation | Indoline derivatives |
| WO2000066560A1 (en) | 1999-05-04 | 2000-11-09 | American Home Products Corporation | Quinazolinone and benzoxazine derivatives as progesterone receptor modulators |
| US6566372B1 (en) * | 1999-08-27 | 2003-05-20 | Ligand Pharmaceuticals Incorporated | Bicyclic androgen and progesterone receptor modulator compounds and methods |
| US20020065192A1 (en) | 2000-02-18 | 2002-05-30 | Mackenzie Peter Borden | Productivity catalysts and microstructure control |
| UA73119C2 (en) * | 2000-04-19 | 2005-06-15 | American Home Products Corpoir | Derivatives of cyclic thiocarbamates, pharmaceutical composition including noted derivatives of cyclic thiocarbamates and active ingredients of medicines as modulators of progesterone receptors |
| US6350837B1 (en) | 2000-06-09 | 2002-02-26 | Eastman Chemical Company | Copolymerization of norbornene and functional norbornene monomers |
| WO2002036641A2 (en) | 2000-11-06 | 2002-05-10 | Eastman Chemical Company | Improved productivity catalysts and microstructure control |
| WO2002036642A2 (en) | 2000-11-06 | 2002-05-10 | Eastman Chemical Company | Olefin polymerization processes using supported catalysts |
| US6387992B1 (en) | 2000-11-27 | 2002-05-14 | Ciba Specialty Chemicals Corporation | Substituted 5-heteroaryl-2-(2-hydroxyphenyl)-2h-benzotriazole UV absorbers, a process for preparation thereof and compositions stabilized therewith |
| ES2232683T3 (es) | 2000-11-27 | 2005-06-01 | Ciba Specialty Chemicals Holding Inc. | Derivados de 2-(2-hiddroxifenil)-2h-benzotriazoles, sustituidos en posicion 5 por arilo y en posicion 5 por heteroarilo, como absorbentes uv. |
| DE10111262A1 (de) | 2001-03-09 | 2002-09-12 | Studiengesellschaft Kohle Mbh | Verfahren zur Herstellung von Vinyl- Aryl- und Heteroarylessigsäuren und ihrer Devivate |
| JP2005194190A (ja) | 2001-10-05 | 2005-07-21 | Fumie Satou | １９−ノル−ビタミンｄ誘導体の製造法 |
| DE10152989A1 (de) | 2001-10-26 | 2003-05-08 | Bayer Ag | Komplexe N-heterocyslischer Carbene und ihre Verwendung |
| AU2003223930A1 (en) | 2002-06-14 | 2003-12-31 | Novo Nordisk A/S | Pharmaceutical use of boronic acids and esters thereof |
| RU2005101638A (ru) * | 2002-06-25 | 2006-01-20 | Уайт (Us) | Использование циклокарбаматных производных для лечения гормонзависимых состояний |
| US7268149B2 (en) * | 2002-06-25 | 2007-09-11 | Wyeth | Cyclothiocarbamate derivatives as progesterone receptor modulators and methods of treating skin disorders |
| EP1756072A2 (de) | 2004-04-27 | 2007-02-28 | Wyeth | Reinigung von progesteronrezeptor-modulatoren |
| TW200604137A (en) | 2004-04-27 | 2006-02-01 | Wyeth Corp | Coupling process for generating reactive boron-containing derivatives of n-substituted pyrrole-2-carbonitriles to produce biaryls |
| CA2562160C (en) | 2004-04-27 | 2013-05-28 | Wyeth | Cyanopyrrole containing cyclic carbamate and thiocarbamate biaryls and methods for preparing the same |
-
2005
- 2005-04-25 CA CA2562160A patent/CA2562160C/en not_active Expired - Fee Related
- 2005-04-25 JP JP2007510902A patent/JP5108506B2/ja not_active Expired - Fee Related
- 2005-04-25 BR BRPI0510278-2A patent/BRPI0510278A/pt not_active IP Right Cessation
- 2005-04-25 CN CN200580013271XA patent/CN1946716B/zh not_active Expired - Fee Related
- 2005-04-25 DE DE602005007021T patent/DE602005007021D1/de not_active Expired - Lifetime
- 2005-04-25 EP EP05740218A patent/EP1756095B1/de not_active Expired - Lifetime
- 2005-04-25 AT AT05740218T patent/ATE396189T1/de not_active IP Right Cessation
- 2005-04-25 DK DK05740218T patent/DK1756095T3/da active
- 2005-04-25 WO PCT/US2005/014342 patent/WO2005105739A2/en not_active Ceased
- 2005-04-25 MX MXPA06012402A patent/MXPA06012402A/es active IP Right Grant
- 2005-04-25 ES ES05740218T patent/ES2306140T3/es not_active Expired - Lifetime
- 2005-04-25 PL PL05740218T patent/PL1756095T3/pl unknown
- 2005-04-25 AU AU2005238520A patent/AU2005238520B2/en not_active Ceased
- 2005-04-25 US US11/113,795 patent/US7582755B2/en not_active Expired - Fee Related
-
2009
- 2009-07-24 US US12/508,679 patent/US8003784B2/en not_active Expired - Fee Related
-
2011
- 2011-07-11 US US13/179,730 patent/US8129524B2/en not_active Expired - Fee Related
-
2012
- 2012-08-28 JP JP2012187513A patent/JP2013006853A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| JP2007534767A (ja) | 2007-11-29 |
| US8003784B2 (en) | 2011-08-23 |
| AU2005238520B2 (en) | 2011-09-08 |
| AU2005238520A1 (en) | 2005-11-10 |
| MXPA06012402A (es) | 2007-01-17 |
| ES2306140T3 (es) | 2008-11-01 |
| CA2562160C (en) | 2013-05-28 |
| JP2013006853A (ja) | 2013-01-10 |
| JP5108506B2 (ja) | 2012-12-26 |
| DK1756095T3 (da) | 2008-08-11 |
| US8129524B2 (en) | 2012-03-06 |
| WO2005105739A3 (en) | 2006-02-16 |
| WO2005105739A2 (en) | 2005-11-10 |
| PL1756095T3 (pl) | 2008-10-31 |
| US20090306371A1 (en) | 2009-12-10 |
| US7582755B2 (en) | 2009-09-01 |
| EP1756095A2 (de) | 2007-02-28 |
| BRPI0510278A (pt) | 2007-10-30 |
| DE602005007021D1 (de) | 2008-07-03 |
| CN1946716B (zh) | 2011-12-21 |
| US20120016118A1 (en) | 2012-01-19 |
| CA2562160A1 (en) | 2005-11-10 |
| CN1946716A (zh) | 2007-04-11 |
| US20050239779A1 (en) | 2005-10-27 |
| EP1756095B1 (de) | 2008-05-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |