BRPI0510278A - método para produzir compostos, produto, e, composto - Google Patents

método para produzir compostos, produto, e, composto

Info

Publication number
BRPI0510278A
BRPI0510278A BRPI0510278-2A BRPI0510278A BRPI0510278A BR PI0510278 A BRPI0510278 A BR PI0510278A BR PI0510278 A BRPI0510278 A BR PI0510278A BR PI0510278 A BRPI0510278 A BR PI0510278A
Authority
BR
Brazil
Prior art keywords
optionally substituted
methyl
alkyl
aminoalkyl
alkoxy
Prior art date
Application number
BRPI0510278-2A
Other languages
English (en)
Inventor
Bogdan Kazimierz Wilk
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of BRPI0510278A publication Critical patent/BRPI0510278A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

MéTODO PARA PRODUZIR COMPOSTOS, PRODUTO, E, COMPOSTO Métodos para preparar carbamatos e tiocarbamatos cíclicos contendo porções de cianopirrol e da fórmula são fornecidos: Fórmula (I) Z são os mesmos ou diferentes e são H, alquila C~1~ a C~ 6~ opcionalmente substituído, ou COR¬ A¬; R¬ A¬ é H, alquila C~ 1~ a C~ 6~ opcionalmente substituído, alcóxi C~ 1~ a C~ 6~ opecionalmente substituído, ou aminoalquila C~ 1~ a opcionalmente substituído; Q são os mesmos ou diferentes e são H, OH, NH~ 2~, CN, halogênio, alquila C~ 1~ a C~ 6~ opcionalmente substituído, alquenila C~ 1~ a C~ 6~ opcionalmente substituído, alquenila C~ 1~ a C~ 6~ opcionalmente substituído, alcóxi C~ 1~ a C~ 6~ opcionalmente substituído, aminoalquila C~ 1~ a C~ 6~ opcionalmente substituído, ou COR¬ B¬; e RB é H, alquila C~ 1~ a C~ 6~ opcionalmente substituído, alcóxi C~ 1~ a C~ 6~ opcionalmente substituído, ou aminoalquila C~ 1~ a C~ 6~ opcionalmente substituído. Os compostos incluindo éster metílico do ácido 2-amino-5-(5-ciano-l -metil-1H-pirrol-2-il)benzóico, 5- ¢4-amino-3 -(1 -hidróxi- 1 -metil-etil)-fenil!- 1 -metil- 1 H-pirrol-2-carbonitrila, e 2-arnino-5-(5-ciano- 1 -metil-1H-pirrol-2-il)-fenil-etanona, ou sais destes farmacêuticamente aceitáveis, e os usos destes também são fornecidos.
BRPI0510278-2A 2004-04-27 2005-04-25 método para produzir compostos, produto, e, composto BRPI0510278A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US56561604P 2004-04-27 2004-04-27
PCT/US2005/014342 WO2005105739A2 (en) 2004-04-27 2005-04-25 Cyanopyrrole containing cyclic carbamate and thiocarbamate biaryls and methods for preparing the same

Publications (1)

Publication Number Publication Date
BRPI0510278A true BRPI0510278A (pt) 2007-10-30

Family

ID=35242253

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0510278-2A BRPI0510278A (pt) 2004-04-27 2005-04-25 método para produzir compostos, produto, e, composto

Country Status (14)

Country Link
US (3) US7582755B2 (pt)
EP (1) EP1756095B1 (pt)
JP (2) JP5108506B2 (pt)
CN (1) CN1946716B (pt)
AT (1) ATE396189T1 (pt)
AU (1) AU2005238520B2 (pt)
BR (1) BRPI0510278A (pt)
CA (1) CA2562160C (pt)
DE (1) DE602005007021D1 (pt)
DK (1) DK1756095T3 (pt)
ES (1) ES2306140T3 (pt)
MX (1) MXPA06012402A (pt)
PL (1) PL1756095T3 (pt)
WO (1) WO2005105739A2 (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA73119C2 (en) 2000-04-19 2005-06-15 American Home Products Corpoir Derivatives of cyclic thiocarbamates, pharmaceutical composition including noted derivatives of cyclic thiocarbamates and active ingredients of medicines as modulators of progesterone receptors
CA2562160C (en) 2004-04-27 2013-05-28 Wyeth Cyanopyrrole containing cyclic carbamate and thiocarbamate biaryls and methods for preparing the same
SI1896034T1 (sl) 2005-04-28 2010-07-30 Wyeth Llc Mikronizirani sestavki tanaprogeta in postopki priprave le-tega
EP1877059B8 (en) * 2005-04-28 2010-05-19 Wyeth a Corporation of the State of Delaware Micronized tanaproget and compostions containing same
WO2007030153A2 (en) * 2005-04-28 2007-03-15 Wyeth Compositions containing micronized tanaproget
PE20070182A1 (es) * 2005-07-29 2007-03-06 Wyeth Corp Derivados cianopirrol-fenil amida como moduladores del receptor de progesterona
PE20070341A1 (es) * 2005-07-29 2007-04-13 Wyeth Corp Derivados de pirrol como moduladores del receptor de progesterona
PE20070404A1 (es) * 2005-07-29 2007-05-10 Wyeth Corp Compuestos derivados de cianopirrol-sulfonamida como moduladores del receptor de progesterona
PE20070220A1 (es) * 2005-07-29 2007-03-19 Wyeth Corp Proceso para la sintesis de moduladores del receptor de progesterona
US20070213526A1 (en) * 2006-03-07 2007-09-13 Wyeth Purification of progesterone receptor modulators
US20080319204A1 (en) * 2007-06-25 2008-12-25 Wyeth Process for the synthesis of progesterone receptor modulators
BRPI0819571A2 (pt) 2007-12-20 2019-09-24 Teva Womenss Health Inc "método para contracepção de emergência, pacote farmacêutico para contracepção de emergência e composição farmacêutica"
GB0817578D0 (en) * 2008-09-25 2008-11-05 3M Innovative Properties Co Method for treating wheel rims and composition for use therein

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5194628A (en) 1988-03-18 1993-03-16 Ciba-Geigy Corporation Process for the preparation of substituted difluorobenzo-1,3-dioxoles
JPH09502432A (ja) 1993-09-10 1997-03-11 チバ−ガイギー アクチエンゲゼルシャフト フォトクロミック化合物、その製造方法および製造のための中間生成物、ならびにそれらの用法
WO2000050470A2 (en) 1999-02-22 2000-08-31 Eastman Chemical Company Catalysts containing n-pyrrolyl substituted nitrogen donors
US6545108B1 (en) 1999-02-22 2003-04-08 Eastman Chemical Company Catalysts containing N-pyrrolyl substituted nitrogen donors
CN1145618C (zh) * 1999-05-04 2004-04-14 美国家庭用品有限公司 作为黄体酮受体调节剂的环氨基甲酸酯衍生物
EP1175404A1 (en) * 1999-05-04 2002-01-30 American Home Products Corporation Quinazolinone and benzoxazine derivatives as progesterone receptor modulators
US6509334B1 (en) * 1999-05-04 2003-01-21 American Home Products Corporation Cyclocarbamate derivatives as progesterone receptor modulators
US6407101B1 (en) 1999-05-04 2002-06-18 American Home Products Corporation Cyanopyrroles
ATE386729T1 (de) * 1999-05-04 2008-03-15 Wyeth Corp Cyclothiocarbamatderivate als progesteron- rezeptormodulatoren
US6391907B1 (en) 1999-05-04 2002-05-21 American Home Products Corporation Indoline derivatives
WO2000066560A1 (en) 1999-05-04 2000-11-09 American Home Products Corporation Quinazolinone and benzoxazine derivatives as progesterone receptor modulators
US6566372B1 (en) * 1999-08-27 2003-05-20 Ligand Pharmaceuticals Incorporated Bicyclic androgen and progesterone receptor modulator compounds and methods
US20020065192A1 (en) 2000-02-18 2002-05-30 Mackenzie Peter Borden Productivity catalysts and microstructure control
UA73119C2 (en) * 2000-04-19 2005-06-15 American Home Products Corpoir Derivatives of cyclic thiocarbamates, pharmaceutical composition including noted derivatives of cyclic thiocarbamates and active ingredients of medicines as modulators of progesterone receptors
US6350837B1 (en) 2000-06-09 2002-02-26 Eastman Chemical Company Copolymerization of norbornene and functional norbornene monomers
WO2002036641A2 (en) 2000-11-06 2002-05-10 Eastman Chemical Company Improved productivity catalysts and microstructure control
WO2002036642A2 (en) 2000-11-06 2002-05-10 Eastman Chemical Company Olefin polymerization processes using supported catalysts
US6387992B1 (en) 2000-11-27 2002-05-14 Ciba Specialty Chemicals Corporation Substituted 5-heteroaryl-2-(2-hydroxyphenyl)-2h-benzotriazole UV absorbers, a process for preparation thereof and compositions stabilized therewith
ES2232683T3 (es) 2000-11-27 2005-06-01 Ciba Specialty Chemicals Holding Inc. Derivados de 2-(2-hiddroxifenil)-2h-benzotriazoles, sustituidos en posicion 5 por arilo y en posicion 5 por heteroarilo, como absorbentes uv.
DE10111262A1 (de) 2001-03-09 2002-09-12 Studiengesellschaft Kohle Mbh Verfahren zur Herstellung von Vinyl- Aryl- und Heteroarylessigsäuren und ihrer Devivate
JP2005194190A (ja) 2001-10-05 2005-07-21 Fumie Satou １９−ノル−ビタミンｄ誘導体の製造法
DE10152989A1 (de) 2001-10-26 2003-05-08 Bayer Ag Komplexe N-heterocyslischer Carbene und ihre Verwendung
AU2003223930A1 (en) 2002-06-14 2003-12-31 Novo Nordisk A/S Pharmaceutical use of boronic acids and esters thereof
RU2005101638A (ru) * 2002-06-25 2006-01-20 Уайт (Us) Использование циклокарбаматных производных для лечения гормонзависимых состояний
US7268149B2 (en) * 2002-06-25 2007-09-11 Wyeth Cyclothiocarbamate derivatives as progesterone receptor modulators and methods of treating skin disorders
EP1756072A2 (en) 2004-04-27 2007-02-28 Wyeth Purification of progesterone receptor modulators
TW200604137A (en) 2004-04-27 2006-02-01 Wyeth Corp Coupling process for generating reactive boron-containing derivatives of n-substituted pyrrole-2-carbonitriles to produce biaryls
CA2562160C (en) 2004-04-27 2013-05-28 Wyeth Cyanopyrrole containing cyclic carbamate and thiocarbamate biaryls and methods for preparing the same

Also Published As

Publication number Publication date
JP2007534767A (ja) 2007-11-29
US8003784B2 (en) 2011-08-23
AU2005238520B2 (en) 2011-09-08
AU2005238520A1 (en) 2005-11-10
MXPA06012402A (es) 2007-01-17
ES2306140T3 (es) 2008-11-01
CA2562160C (en) 2013-05-28
JP2013006853A (ja) 2013-01-10
JP5108506B2 (ja) 2012-12-26
DK1756095T3 (da) 2008-08-11
US8129524B2 (en) 2012-03-06
ATE396189T1 (de) 2008-06-15
WO2005105739A3 (en) 2006-02-16
WO2005105739A2 (en) 2005-11-10
PL1756095T3 (pl) 2008-10-31
US20090306371A1 (en) 2009-12-10
US7582755B2 (en) 2009-09-01
EP1756095A2 (en) 2007-02-28
DE602005007021D1 (de) 2008-07-03
CN1946716B (zh) 2011-12-21
US20120016118A1 (en) 2012-01-19
CA2562160A1 (en) 2005-11-10
CN1946716A (zh) 2007-04-11
US20050239779A1 (en) 2005-10-27
EP1756095B1 (en) 2008-05-21

Similar Documents

Publication Publication Date Title
EA201591774A1 (ru) Замещенные ароматические соединения для лечения легочного фиброза, фиброза печени, фиброза кожи и фиброза сердца
BRPI0510278A (pt) método para produzir compostos, produto, e, composto
EA201001669A1 (ru) Замещенные пиримидин-5-карбоксамиды 281
MX337588B (es) Metodo para preparar derivados de 5-haloalquil-4,5-dihidroisoxasol .
EA201170922A1 (ru) Производные сульфонамида
NZ596579A (en) Bace inhibitors
EA201391158A8 (ru) Диаминиевые соли фенотиазина и их применение
EA200601852A1 (ru) Тетрагидрохинолиновые производные и способ их получения
EA201700230A1 (ru) Определенные аминопиридины, композиции на их основе и способы их применения
MX2009003739A (es) Derivados de hidrobenzamida como inhibidores de hsp90.
MX2010002938A (es) Derivados de (3-hidroxi-4-amino-butan-2-il)-3-(2-tiazol-2-il-pirro lidin-1-carbonil)benzamida y compuestos relacionados como inhibidores de beta-secretasa para tratar enfermedad de alzheimer.
NZ592543A (en) 4-[2-(2-fluorophenoxymethyl)phenyl]piperidine compounds
ATE512961T1 (de) Amorphes nebivolol hydrochlorid und seine herstellung
MX2008010884A (es) Acidos 4-fenil-tiazol-5-carboxilicos y amidas de acidos 4-fenil-tiazol-5-carboxilicos como inhibidores de la plk1.
JP2012512863A5 (pt)
NZ591498A (en) Novel phenylamino isonicotinamide compounds
CO5670350A2 (es) Proceso para preparar derivados de acido 5-(1,3-oxazol- 2-il) benzoico
EA201270099A1 (ru) Транс-4-[[(5s)-5-[[[3,5-бис(трифторметил)фенил]метил](2-метил-2h-тетразол-5-ил)амино]-2,3,4,5-тетрагидро-7,9-диметил-1h-1-бензазепин-1-ил]метил]циклогексанкарбоновая кислота
NO20071319L (no) Fremgangsmate for fremstilling av isotiazolderivater.
WO2012131656A3 (en) Compounds for use as therapeutic agents affecting p53 expression and/or activity
NZ600266A (en) Compound, certain novel forms thereof, pharmaceutical compositions thereof and methods for preparation and use
CY1113722T1 (el) Μεθοδος για την παρασκευη toy cinacalcet
JP2012520899A5 (pt)
NO20074622L (no) Metabolitter for NK-1 antagonister for brekninger
DK1204658T3 (da) Benzofurylpiperazin-serotoninagonister

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: PAGAR RESTAURACAO.

B25D Requested change of name of applicant approved

Owner name: WYETH LLC. (US)

B08H Application fees: decision cancelled [chapter 8.8 patent gazette]

Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 2260 DE 29/04/2014.

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]