ATE396273T1 - G-protein chimären - Google Patents

G-protein chimären

Info

Publication number
ATE396273T1
ATE396273T1 AT04078332T AT04078332T ATE396273T1 AT E396273 T1 ATE396273 T1 AT E396273T1 AT 04078332 T AT04078332 T AT 04078332T AT 04078332 T AT04078332 T AT 04078332T AT E396273 T1 ATE396273 T1 AT E396273T1
Authority
AT
Austria
Prior art keywords
amino acids
chimeric
compound
observing
alpha
Prior art date
Application number
AT04078332T
Other languages
English (en)
Inventor
Andrew J Brown
Simon J Dowell
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Application granted granted Critical
Publication of ATE396273T1 publication Critical patent/ATE396273T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4722—G-proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
AT04078332T 1997-09-13 1998-09-11 G-protein chimären ATE396273T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9719496.3A GB9719496D0 (en) 1997-09-13 1997-09-13 G protien chimeras

Publications (1)

Publication Number Publication Date
ATE396273T1 true ATE396273T1 (de) 2008-06-15

Family

ID=10819017

Family Applications (2)

Application Number Title Priority Date Filing Date
AT04078332T ATE396273T1 (de) 1997-09-13 1998-09-11 G-protein chimären
AT98942898T ATE291627T1 (de) 1997-09-13 1998-09-11 Chimäre des g-proteins

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT98942898T ATE291627T1 (de) 1997-09-13 1998-09-11 Chimäre des g-proteins

Country Status (9)

Country Link
US (1) US6509447B1 (de)
EP (2) EP1012311B1 (de)
JP (2) JP4587563B2 (de)
AT (2) ATE396273T1 (de)
AU (1) AU9086398A (de)
DE (2) DE69839536D1 (de)
ES (1) ES2308104T3 (de)
GB (1) GB9719496D0 (de)
WO (1) WO1999014344A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7067277B1 (en) 1999-12-23 2006-06-27 H. Lundbeck A/S Chimeric G proteins and uses thereof
CA2482915A1 (en) * 2002-04-16 2003-10-23 Kyowa Hakko Kogyo Co., Ltd. Endocrine cell lines and method of using the same
DE10233516A1 (de) 2002-07-23 2004-02-12 Aventis Pharma Deutschland Gmbh Verfahren zur Identifizierung von Substanzen
JP5774264B2 (ja) 2005-04-27 2015-09-09 アリーナ ファーマシューティカルズ， インコーポレイテッド 肥満および糖尿病、ならびにそれらに関連する病態の処置のため、ならびに血中ｇｌｐ−１レベルを増大させることによって緩和される病態の処置のための、併用療法
CA2613235A1 (en) 2005-06-30 2007-01-11 Prosidion Limited Gpcr agonists
EP1971862B1 (de) 2006-04-11 2010-11-10 Arena Pharmaceuticals, Inc. Verfahren zur verwendung des gpr119-rezeptors zur identifizierung von verbindungen zur erhöhung der knochenmasse bei einer person
CL2008000017A1 (es) 2007-01-04 2008-08-01 Prosidion Ltd Compuestos derivados de heterociclos de nitrogeno y oxigeno, agonistas de gpcr; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento de la obesidad, diabetes, sindrome metabolico, hiperlipidemia, toleranci
AR064735A1 (es) 2007-01-04 2009-04-22 Prosidion Ltd Agonistas de gpcr y composicion farmaceutica en base al compuesto
US20100048632A1 (en) 2007-01-04 2010-02-25 Matthew Colin Thor Fyfe Piperidine GPCR Agonists
JP2010539152A (ja) 2007-09-10 2010-12-16 プロシディオン・リミテッド 代謝障害の治療のための化合物
GB0720389D0 (en) 2007-10-18 2008-11-12 Prosidion Ltd G-Protein Coupled Receptor Agonists
GB0720390D0 (en) 2007-10-18 2007-11-28 Prosidion Ltd G-Protein coupled receptor agonists
EP2108960A1 (de) 2008-04-07 2009-10-14 Arena Pharmaceuticals, Inc. Verfahren zur Verwendung eines A G Protein-gekoppelten Rezeptors zur Identifikation von Peptid YY (PYY) Sekretagoga und nützliche Verbindungen zur Behandlung von durch (PYY) Sekretagoga modulierten Zuständen und nützliche Verbindungen zur Behandlung von Zuständen durch PYY
GB0904285D0 (en) 2009-03-12 2009-04-22 Prosidion Ltd Compounds for the treatment of metabolic disorders
GB0904284D0 (en) 2009-03-12 2009-04-22 Prosidion Ltd Compounds for the treatment of metabolic disorders
GB0904287D0 (en) 2009-03-12 2009-04-22 Prosidion Ltd Compounds for the treatment of metabolic disorders
US9809862B2 (en) * 2014-08-11 2017-11-07 Georgia Tech Research Corporation G-protein coupled receptor (GPCR)-based biosensors and uses thereof
EP4021931A4 (de) * 2019-08-26 2023-10-04 The Brigham and Women's Hospital, Inc. Zusammensetzungen und verwendungen von manipulierten therapeutischen mikroben und assoziierten rezeptoren

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5691188A (en) * 1994-02-14 1997-11-25 American Cyanamid Company Transformed yeast cells expressing heterologous G-protein coupled receptor
WO1998016557A1 (en) 1996-10-11 1998-04-23 The General Hospital Corporation Assays for g-protein-linked receptors

Also Published As

Publication number Publication date
WO1999014344A1 (en) 1999-03-25
JP4587563B2 (ja) 2010-11-24
DE69839536D1 (de) 2008-07-03
JP2010279369A (ja) 2010-12-16
JP2001516587A (ja) 2001-10-02
JP5108062B2 (ja) 2012-12-26
ES2308104T3 (es) 2008-12-01
GB9719496D0 (en) 1997-11-19
EP1012311B1 (de) 2005-03-23
EP1012311A1 (de) 2000-06-28
ATE291627T1 (de) 2005-04-15
US6509447B1 (en) 2003-01-21
EP1533379A1 (de) 2005-05-25
DE69829485D1 (de) 2005-04-28
DE69829485T2 (de) 2006-05-04
AU9086398A (en) 1999-04-05
EP1533379B1 (de) 2008-05-21

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