ATE291627T1 - Chimäre des g-proteins - Google Patents

Chimäre des g-proteins

Info

Publication number
ATE291627T1
ATE291627T1 AT98942898T AT98942898T ATE291627T1 AT E291627 T1 ATE291627 T1 AT E291627T1 AT 98942898 T AT98942898 T AT 98942898T AT 98942898 T AT98942898 T AT 98942898T AT E291627 T1 ATE291627 T1 AT E291627T1
Authority
AT
Austria
Prior art keywords
amino acids
protein
chimeric
compound
observing
Prior art date
Application number
AT98942898T
Other languages
English (en)
Inventor
Andrew James Brown
Simon Jeremy Dowell
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Application granted granted Critical
Publication of ATE291627T1 publication Critical patent/ATE291627T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4722—G-proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
AT98942898T 1997-09-13 1998-09-11 Chimäre des g-proteins ATE291627T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9719496.3A GB9719496D0 (en) 1997-09-13 1997-09-13 G protien chimeras
PCT/GB1998/002759 WO1999014344A1 (en) 1997-09-13 1998-09-11 G protein chimeras

Publications (1)

Publication Number Publication Date
ATE291627T1 true ATE291627T1 (de) 2005-04-15

Family

ID=10819017

Family Applications (2)

Application Number Title Priority Date Filing Date
AT98942898T ATE291627T1 (de) 1997-09-13 1998-09-11 Chimäre des g-proteins
AT04078332T ATE396273T1 (de) 1997-09-13 1998-09-11 G-protein chimären

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT04078332T ATE396273T1 (de) 1997-09-13 1998-09-11 G-protein chimären

Country Status (9)

Country Link
US (1) US6509447B1 (de)
EP (2) EP1012311B1 (de)
JP (2) JP4587563B2 (de)
AT (2) ATE291627T1 (de)
AU (1) AU9086398A (de)
DE (2) DE69839536D1 (de)
ES (1) ES2308104T3 (de)
GB (1) GB9719496D0 (de)
WO (1) WO1999014344A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7067277B1 (en) 1999-12-23 2006-06-27 H. Lundbeck A/S Chimeric G proteins and uses thereof
AU2003235193A1 (en) * 2002-04-16 2003-10-27 Kyowa Hakko Kogyo Co., Ltd. Endocrine cell lines and method of using the same
DE10233516A1 (de) * 2002-07-23 2004-02-12 Aventis Pharma Deutschland Gmbh Verfahren zur Identifizierung von Substanzen
AU2006285393A1 (en) 2005-04-27 2007-03-08 Arena Pharmaceuticals, Inc. Combination therapy for the treatment of obesity and diabetes and conditions related thereto and for the treatment of conditions ameliorated by increasing a blood GLP-1 level
NZ564759A (en) 2005-06-30 2011-08-26 Prosidion Ltd GPCR agonists
ES2354390T3 (es) 2006-04-11 2011-03-14 Arena Pharmaceuticals, Inc. Procedimientos de uso del receptor gpr119 para identificar compuestos útiles para aumentar la masa ósea en un individuo.
CL2008000018A1 (es) 2007-01-04 2008-08-01 Prosidion Ltd Compuestos derivados de heterociclos de nitrogeno y oxigeno, agonistas de gpcr; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento de la obesidad, diabetes, sindrome metabolico, hiperlipidemia, toleranci
AR064736A1 (es) 2007-01-04 2009-04-22 Prosidion Ltd Agonistas de gpcr
BRPI0806498A2 (pt) 2007-01-04 2014-04-22 Prosidion Ltd Agonistas gpcr piperidina
WO2009034388A1 (en) 2007-09-10 2009-03-19 Prosidion Limited Compounds for the treatment of metabolic disorders
GB0720389D0 (en) 2007-10-18 2008-11-12 Prosidion Ltd G-Protein Coupled Receptor Agonists
GB0720390D0 (en) 2007-10-18 2007-11-28 Prosidion Ltd G-Protein coupled receptor agonists
EP2146210A1 (de) 2008-04-07 2010-01-20 Arena Pharmaceuticals, Inc. Verfahren zur Verwendung eines AG-Protein-gekoppelten Rezeptors zur Identifikation von Peptid-YY (PPY)-Sekretagogen sowie Verbindungen zur Behandlung durch PYY modulierter Leiden
GB0904284D0 (en) 2009-03-12 2009-04-22 Prosidion Ltd Compounds for the treatment of metabolic disorders
GB0904285D0 (en) 2009-03-12 2009-04-22 Prosidion Ltd Compounds for the treatment of metabolic disorders
GB0904287D0 (en) 2009-03-12 2009-04-22 Prosidion Ltd Compounds for the treatment of metabolic disorders
US9809862B2 (en) * 2014-08-11 2017-11-07 Georgia Tech Research Corporation G-protein coupled receptor (GPCR)-based biosensors and uses thereof
EP4021931A4 (de) * 2019-08-26 2023-10-04 The Brigham and Women's Hospital, Inc. Zusammensetzungen und verwendungen von manipulierten therapeutischen mikroben und assoziierten rezeptoren

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5691188A (en) * 1994-02-14 1997-11-25 American Cyanamid Company Transformed yeast cells expressing heterologous G-protein coupled receptor
WO1998016557A1 (en) * 1996-10-11 1998-04-23 The General Hospital Corporation Assays for g-protein-linked receptors

Also Published As

Publication number Publication date
AU9086398A (en) 1999-04-05
JP2001516587A (ja) 2001-10-02
GB9719496D0 (en) 1997-11-19
DE69829485T2 (de) 2006-05-04
JP2010279369A (ja) 2010-12-16
EP1533379A1 (de) 2005-05-25
ATE396273T1 (de) 2008-06-15
DE69829485D1 (de) 2005-04-28
WO1999014344A1 (en) 1999-03-25
DE69839536D1 (de) 2008-07-03
EP1012311A1 (de) 2000-06-28
EP1533379B1 (de) 2008-05-21
EP1012311B1 (de) 2005-03-23
ES2308104T3 (es) 2008-12-01
JP4587563B2 (ja) 2010-11-24
US6509447B1 (en) 2003-01-21
JP5108062B2 (ja) 2012-12-26

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