ATE397616T1 - Verwendung von arylthioimine in der herstellung von erythromycinderivate - Google Patents
Verwendung von arylthioimine in der herstellung von erythromycinderivateInfo
- Publication number
- ATE397616T1 ATE397616T1 AT01992462T AT01992462T ATE397616T1 AT E397616 T1 ATE397616 T1 AT E397616T1 AT 01992462 T AT01992462 T AT 01992462T AT 01992462 T AT01992462 T AT 01992462T AT E397616 T1 ATE397616 T1 AT E397616T1
- Authority
- AT
- Austria
- Prior art keywords
- erythromycin
- ketone
- arylthioimine
- production
- erythromycin derivatives
- Prior art date
Links
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical class O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 title abstract 5
- 238000000034 method Methods 0.000 abstract 4
- 150000002576 ketones Chemical class 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 239000000543 intermediate Substances 0.000 abstract 2
- 150000002923 oximes Chemical class 0.000 abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000003386 deoximation reaction Methods 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/747,724 US6455680B1 (en) | 2000-12-21 | 2000-12-21 | Methods utilizing aryl thioimines in synthesis of erythromycin derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE397616T1 true ATE397616T1 (de) | 2008-06-15 |
Family
ID=25006347
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01992462T ATE397616T1 (de) | 2000-12-21 | 2001-12-19 | Verwendung von arylthioimine in der herstellung von erythromycinderivate |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US6455680B1 (de) |
| EP (1) | EP1345954B1 (de) |
| JP (1) | JP2004520315A (de) |
| KR (1) | KR100804439B1 (de) |
| CN (1) | CN1252080C (de) |
| AT (1) | ATE397616T1 (de) |
| AU (2) | AU3294602A (de) |
| CA (1) | CA2430734C (de) |
| DE (1) | DE60134339D1 (de) |
| ES (1) | ES2306739T3 (de) |
| IL (1) | IL155669A0 (de) |
| MX (1) | MXPA03005675A (de) |
| TW (1) | TWI232866B (de) |
| WO (1) | WO2002050093A2 (de) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6417366B2 (en) * | 1999-06-24 | 2002-07-09 | Abbott Laboratories | Preparation of quinoline-substituted carbonate and carbamate derivatives |
| US9486467B2 (en) | 2006-06-12 | 2016-11-08 | Ramot At Tel-Aviv University Ltd. | Method of treating colorectal cancer that expresses a mutated APC gene by administering erythromycin or tylosin |
| WO2010079057A1 (en) * | 2008-12-18 | 2010-07-15 | Shell Internationale Research Maatschappij B.V. | Multi stage process for producing hydrocarbons from syngas |
| JP2016503051A (ja) | 2012-12-24 | 2016-02-01 | ラモット・アット・テル−アヴィヴ・ユニヴァーシティ・リミテッド | ナンセンス変異に起因する遺伝性疾患を治療する作用剤、及びこれを同定する方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4331803A (en) | 1980-06-04 | 1982-05-25 | Taisho Pharmaceutical Co., Ltd. | Novel erythromycin compounds |
| JPS5896097A (ja) * | 1981-12-01 | 1983-06-07 | Taisho Pharmaceut Co Ltd | エリスロマイシンｂ誘導体 |
| JP2751385B2 (ja) | 1988-05-19 | 1998-05-18 | 大正製薬株式会社 | エリスロマイシンａオキシム及びその塩の製造方法 |
| US5872229A (en) | 1995-11-21 | 1999-02-16 | Abbott Laboratories | Process for 6-O-alkylation of erythromycin derivatives |
| JP2000509712A (ja) | 1996-05-07 | 2000-08-02 | アボツト・ラボラトリーズ | ６―ｏ―置換エリスロマイシン及びその製造方法 |
| UA51730C2 (uk) | 1996-09-04 | 2002-12-16 | Ебботт Лабораторіз | 6-o-заміщені кетоліди з антибактеріальною активністю, спосіб їх одержання (варіанти), фармацевтична композиція та спосіб регулювання бактеріальної інфекції у ссавців |
| US6124269A (en) | 1997-10-29 | 2000-09-26 | Abbott Laboratories | 2-Halo-6-O-substituted ketolide derivatives |
| US5852180A (en) * | 1997-11-17 | 1998-12-22 | Abbott Laboratories | Chemical synthesis of 6-O-alkyl erythromycin A |
| IL135792A0 (en) | 1997-12-01 | 2001-05-20 | Abbott Lab | 6-o-alkyl derivatives of erythronolide b |
| US5932710A (en) | 1997-12-01 | 1999-08-03 | Abbott Laboratories | Process for preparing 6-O-alkyl-9-oxime erythromycin B |
| US6040440A (en) | 1998-03-06 | 2000-03-21 | Abbott Laboratories | Hypophosphite deoxygenation reactions in the synthesis of erythromycin derivatives |
-
2000
- 2000-12-21 US US09/747,724 patent/US6455680B1/en not_active Expired - Lifetime
-
2001
- 2001-12-14 TW TW090131053A patent/TWI232866B/zh not_active IP Right Cessation
- 2001-12-19 CN CNB01821004XA patent/CN1252080C/zh not_active Expired - Fee Related
- 2001-12-19 AT AT01992462T patent/ATE397616T1/de not_active IP Right Cessation
- 2001-12-19 AU AU3294602A patent/AU3294602A/xx active Pending
- 2001-12-19 MX MXPA03005675A patent/MXPA03005675A/es active IP Right Grant
- 2001-12-19 AU AU2002232946A patent/AU2002232946B2/en not_active Ceased
- 2001-12-19 DE DE60134339T patent/DE60134339D1/de not_active Expired - Fee Related
- 2001-12-19 CA CA002430734A patent/CA2430734C/en not_active Expired - Fee Related
- 2001-12-19 EP EP01992462A patent/EP1345954B1/de not_active Expired - Lifetime
- 2001-12-19 ES ES01992462T patent/ES2306739T3/es not_active Expired - Lifetime
- 2001-12-19 IL IL15566901A patent/IL155669A0/xx unknown
- 2001-12-19 WO PCT/US2001/051124 patent/WO2002050093A2/en not_active Ceased
- 2001-12-19 KR KR1020037008275A patent/KR100804439B1/ko not_active Expired - Fee Related
- 2001-12-19 JP JP2002551986A patent/JP2004520315A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| TWI232866B (en) | 2005-05-21 |
| AU2002232946B2 (en) | 2007-02-08 |
| EP1345954A2 (de) | 2003-09-24 |
| US6455680B1 (en) | 2002-09-24 |
| KR20040014440A (ko) | 2004-02-14 |
| ES2306739T3 (es) | 2008-11-16 |
| IL155669A0 (en) | 2003-11-23 |
| AU3294602A (en) | 2002-07-01 |
| CN1505634A (zh) | 2004-06-16 |
| MXPA03005675A (es) | 2004-04-21 |
| DE60134339D1 (de) | 2008-07-17 |
| CA2430734A1 (en) | 2002-06-27 |
| JP2004520315A (ja) | 2004-07-08 |
| EP1345954B1 (de) | 2008-06-04 |
| US20020115835A1 (en) | 2002-08-22 |
| CA2430734C (en) | 2009-04-28 |
| WO2002050093A3 (en) | 2003-03-06 |
| WO2002050093A2 (en) | 2002-06-27 |
| CN1252080C (zh) | 2006-04-19 |
| KR100804439B1 (ko) | 2008-02-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |