ATE398134T1 - Neue analoga von nitrobenzylthioinosin - Google Patents

Neue analoga von nitrobenzylthioinosin

Info

Publication number: ATE398134T1
Authority: AT; Austria
Prior art keywords: nitrobenzylthioinosine; new; new analogue; analogue; analogs
Prior art date: 2002-04-10

Application number

AT03724994T

Other languages

English (en)

Inventor

Claudia Puetz

Corinna Sundermann

Bernd Sundermann

Adriaan Ijzerman

Reynier Tromp

Frijtag Drabbe Kuenzel Jac Von

Original Assignee

Gruenenthal Gmbh

Univ Leiden

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-04-10

Filing date

2003-04-10

Publication date

2008-07-15

2003-04-10 Application filed by Gruenenthal Gmbh, Univ Leiden filed Critical Gruenenthal Gmbh

2008-07-15 Application granted granted Critical

2008-07-15 Publication of ATE398134T1 publication Critical patent/ATE398134T1/de

Links

YRDGIFPBFBQFND-MCPWVCTESA-N 9-[(2r,3r,4r,5r)-2-benzyl-3,4-dihydroxy-5-(hydroxymethyl)-3-nitrooxolan-2-yl]-3h-purine-6-thione Chemical class [O-][N+](=O)[C@@]1(O)[C@H](O)[C@@H](CO)O[C@]1(N1C2=NC=NC(S)=C2N=C1)CC1=CC=CC=C1 YRDGIFPBFBQFND-MCPWVCTESA-N 0.000 title abstract 2
DYCJFJRCWPVDHY-LSCFUAHRSA-N NBMPR Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C2=NC=NC(SCC=3C=CC(=CC=3)[N+]([O-])=O)=C2N=C1 DYCJFJRCWPVDHY-LSCFUAHRSA-N 0.000 abstract 2
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/36—Sulfur atom
- C07D473/38—Sulfur atom attached in position 6

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Pain & Pain Management (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Heart & Thoracic Surgery (AREA)
Rheumatology (AREA)
Cardiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT03724994T 2002-04-10 2003-04-10 Neue analoga von nitrobenzylthioinosin ATE398134T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP02076420A EP1352910A1 (de)	2002-04-10	2002-04-10	Neue Analoga von Nitrobenzylthioinosine

Publications (1)

Publication Number	Publication Date
ATE398134T1 true ATE398134T1 (de)	2008-07-15

Family

ID=28051821

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT03724994T ATE398134T1 (de)	2002-04-10	2003-04-10	Neue analoga von nitrobenzylthioinosin

Country Status (8)

Country	Link
US (1)	US7358235B2 (de)
EP (2)	EP1352910A1 (de)
JP (1)	JP2005526106A (de)
AT (1)	ATE398134T1 (de)
AU (1)	AU2003227593A1 (de)
DE (1)	DE60321554D1 (de)
ES (1)	ES2307931T3 (de)
WO (1)	WO2003084975A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE602004009166T2 (de) *	2004-06-29	2008-08-21	Grünenthal GmbH	Neue Analoga von Nitrobenzylthioinosin
WO2009034411A1 (en) *	2007-09-12	2009-03-19	Centre National De La Recherche Scientifique	Perharidines as cdk inhibitors
AU2015206292B2 (en)	2014-01-20	2018-02-15	Cleave Biosciences, Inc.	Fused pyrimidines as inhibitors of p97 complex
EP3411046B1 (de)	2016-02-04	2025-07-16	The Johns Hopkins University	Rapaglutine, neuartige glut-inhibitoren und verwendungen dafür
WO2017136717A1 (en)	2016-02-04	2017-08-10	The Johns Hopkins University	Rapadocins, inhibitors of equilibrative nucleoside transporter 1 and uses thereof
WO2018140734A1 (en)	2017-01-27	2018-08-02	Academia Sinica	Compound with analgesic effect for use in prevention and treatment of pain
ES2686909B1 (es) *	2017-03-22	2019-08-16	Consejo Superior Investigacion	Compuestos inhibidores de cdc-7 y su uso para el tratamiento de patologias neurologicas

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2524284A1 (de) *	1966-12-21	1976-10-28	Boehringer Mannheim Gmbh	Adenosin-derivate und verfahren zu ihrer herstellung
US3948886A (en) *	1972-03-13	1976-04-06	Icn Pharmaceuticals, Inc.	6-Substituted purine 3',5'-cyclic nucleotides
US5968914A (en) *	1987-10-28	1999-10-19	Pro-Neuron, Inc.	Treatment of chemotherapeutic agent and antiviral agent toxicity with acylated pyrimidine nucleosides
JPH03504246A (ja) *	1988-05-16	1991-09-19	アメリカ合衆国	エイズのための化学療法剤組成物
GB8817607D0 (en) *	1988-07-23	1988-09-01	Beecham Group Plc	Novel process
PT95516A (pt) *	1989-10-06	1991-08-14	Wellcome Found	Processo para a preparacao de derivados de 2',3'-didesoxi nucleosidos 6-substituidos
ATE178335T1 (de) *	1992-01-06	1999-04-15	Wellcome Found	Therapeutische nukleoside der 2',3'-dideoxy-3'- fluor -purin reihe
FR2685918B1 (fr) *	1992-01-08	1995-06-23	Union Pharma Scient Appl	Nouveaux derives de l'adenosine, leurs procedes de preparation, compositions pharmaceutiques les contenant.
JPH10512896A (ja) *	1995-11-14	1998-12-08	フアルマシア・エ・アツプジヨン・エツセ・ピー・アー	アリールおよびヘテロアリールプリン化合物
US5780450A (en) *	1995-11-21	1998-07-14	Alcon Laboratories, Inc.	Use of adenosine uptake inhibitors for treating retinal or optic nerve head damage
US5801159A (en) *	1996-02-23	1998-09-01	Galileo Laboratories, Inc.	Method and composition for inhibiting cellular irreversible changes due to stress
WO1999045935A1 (en) *	1998-03-11	1999-09-16	Lipitek International, Inc.	Novel nucleoside analogs and uses in treating disease
DE60118521T2 (de) *	2000-01-07	2006-10-12	Universitaire Instelling Antwerpen	Purin derivate, ihre herstellung und verwendung

2002
- 2002-04-10 EP EP02076420A patent/EP1352910A1/de not_active Withdrawn
2003
- 2003-04-10 DE DE60321554T patent/DE60321554D1/de not_active Expired - Lifetime
- 2003-04-10 EP EP03724994A patent/EP1492803B1/de not_active Expired - Lifetime
- 2003-04-10 ES ES03724994T patent/ES2307931T3/es not_active Expired - Lifetime
- 2003-04-10 JP JP2003582171A patent/JP2005526106A/ja not_active Ceased
- 2003-04-10 AT AT03724994T patent/ATE398134T1/de not_active IP Right Cessation
- 2003-04-10 WO PCT/EP2003/003724 patent/WO2003084975A1/en not_active Ceased
- 2003-04-10 AU AU2003227593A patent/AU2003227593A1/en not_active Abandoned
2004
- 2004-10-06 US US10/958,681 patent/US7358235B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
JP2005526106A (ja)	2005-09-02
US7358235B2 (en)	2008-04-15
ES2307931T3 (es)	2008-12-01
AU2003227593A1 (en)	2003-10-20
EP1352910A1 (de)	2003-10-15
WO2003084975A1 (en)	2003-10-16
US20050096293A1 (en)	2005-05-05
EP1492803B1 (de)	2008-06-11
DE60321554D1 (de)	2008-07-24
EP1492803A1 (de)	2005-01-05

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Legal Events

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2008-11-15

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Publication of translation of european patent specification

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2012-01-15

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Ceased due to non-payment of the annual fee