ATE398134T1 - Neue analoga von nitrobenzylthioinosin - Google Patents

Neue analoga von nitrobenzylthioinosin

Info

Publication number: ATE398134T1
Authority: AT; Austria
Prior art keywords: nitrobenzylthioinosine; new; new analogue; analogue; analogs
Prior art date: 2002-04-10

Application number

AT03724994T

Other languages

English (en)

Inventor

Claudia Puetz

Corinna Sundermann

Bernd Sundermann

Adriaan Ijzerman

Reynier Tromp

Frijtag Drabbe Kuenzel Jac Von

Original Assignee

Gruenenthal Gmbh

Univ Leiden

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-04-10

Filing date

2003-04-10

Publication date

2008-07-15

2003-04-10 Application filed by Gruenenthal Gmbh, Univ Leiden filed Critical Gruenenthal Gmbh

2008-07-15 Application granted granted Critical

2008-07-15 Publication of ATE398134T1 publication Critical patent/ATE398134T1/de

Links

YRDGIFPBFBQFND-MCPWVCTESA-N 9-[(2r,3r,4r,5r)-2-benzyl-3,4-dihydroxy-5-(hydroxymethyl)-3-nitrooxolan-2-yl]-3h-purine-6-thione Chemical class [O-][N+](=O)[C@@]1(O)[C@H](O)[C@@H](CO)O[C@]1(N1C2=NC=NC(S)=C2N=C1)CC1=CC=CC=C1 YRDGIFPBFBQFND-MCPWVCTESA-N 0.000 title abstract 2
DYCJFJRCWPVDHY-LSCFUAHRSA-N NBMPR Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C2=NC=NC(SCC=3C=CC(=CC=3)[N+]([O-])=O)=C2N=C1 DYCJFJRCWPVDHY-LSCFUAHRSA-N 0.000 abstract 2
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/36—Sulfur atom
- C07D473/38—Sulfur atom attached in position 6

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Pain & Pain Management (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biotechnology (AREA)
Heart & Thoracic Surgery (AREA)
Rheumatology (AREA)
Cardiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT03724994T 2002-04-10 2003-04-10 Neue analoga von nitrobenzylthioinosin ATE398134T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP02076420A EP1352910A1 (de)	2002-04-10	2002-04-10	Neue Analoga von Nitrobenzylthioinosine

Publications (1)

Publication Number	Publication Date
ATE398134T1 true ATE398134T1 (de)	2008-07-15

Family

ID=28051821

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT03724994T ATE398134T1 (de)	2002-04-10	2003-04-10	Neue analoga von nitrobenzylthioinosin

Country Status (8)

Country	Link
US (1)	US7358235B2 (de)
EP (2)	EP1352910A1 (de)
JP (1)	JP2005526106A (de)
AT (1)	ATE398134T1 (de)
AU (1)	AU2003227593A1 (de)
DE (1)	DE60321554D1 (de)
ES (1)	ES2307931T3 (de)
WO (1)	WO2003084975A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE374202T1 (de) *	2004-06-29	2007-10-15	Gruenenthal Gmbh	Neue analoga von nitrobenzylthioinosin
WO2009034411A1 (en) *	2007-09-12	2009-03-19	Centre National De La Recherche Scientifique	Perharidines as cdk inhibitors
JP6387111B2 (ja)	2014-01-20	2018-09-05	クリーブバイオサイエンシズインコーポレイテッド	ｐ９７複合体の阻害剤としての縮合ピリミジン
US11708391B2 (en)	2016-02-04	2023-07-25	The Johns Hopkins University	Rapaglutins, novel inhibitors of GLUT and use thereof
MX380313B (es)	2016-02-04	2025-03-12	Univ Johns Hopkins	Rapadocinas, inhibidores de transportador 1 de nucleósido equilibrador y usos de los mismos.
US11753432B2 (en)	2017-01-27	2023-09-12	Academia Sinica	Compound with analgesic effect for use in prevention and treatment of pain
ES2686909B1 (es) *	2017-03-22	2019-08-16	Consejo Superior Investigacion	Compuestos inhibidores de cdc-7 y su uso para el tratamiento de patologias neurologicas

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2524284A1 (de) *	1966-12-21	1976-10-28	Boehringer Mannheim Gmbh	Adenosin-derivate und verfahren zu ihrer herstellung
US3948886A (en) *	1972-03-13	1976-04-06	Icn Pharmaceuticals, Inc.	6-Substituted purine 3',5'-cyclic nucleotides
US5968914A (en) *	1987-10-28	1999-10-19	Pro-Neuron, Inc.	Treatment of chemotherapeutic agent and antiviral agent toxicity with acylated pyrimidine nucleosides
AU623910B2 (en) *	1988-05-16	1992-05-28	United States of America, as represented by the Secretary, U.S. Department of Commerce, The	Chemotherapeutic composition for aids
GB8817607D0 (en) *	1988-07-23	1988-09-01	Beecham Group Plc	Novel process
PT95516A (pt) *	1989-10-06	1991-08-14	Wellcome Found	Processo para a preparacao de derivados de 2',3'-didesoxi nucleosidos 6-substituidos
DE69324244T2 (de) *	1992-01-06	1999-09-30	The Wellcome Foundation Ltd., Greenford	Therapeutische nukleoside der 2',3'-dideoxy-3'-fluor -purin reihe
FR2685918B1 (fr) *	1992-01-08	1995-06-23	Union Pharma Scient Appl	Nouveaux derives de l'adenosine, leurs procedes de preparation, compositions pharmaceutiques les contenant.
BR9607089A (pt) *	1995-11-14	1997-11-11	Pharmacia & Upjohn Spa	Compostos de pirimidina condensada biciclica composição farmacéutica utilização e produtos que contém os mesmos e processo para a preparação desses compostos
US5780450A (en) *	1995-11-21	1998-07-14	Alcon Laboratories, Inc.	Use of adenosine uptake inhibitors for treating retinal or optic nerve head damage
US5801159A (en) *	1996-02-23	1998-09-01	Galileo Laboratories, Inc.	Method and composition for inhibiting cellular irreversible changes due to stress
EP1069903A1 (de) *	1998-03-11	2001-01-24	Lipitek International, Inc.	Neue nucleosidanaloge und deren verwendung in der krankheitsbehandlung
IL150594A0 (en) *	2000-01-07	2003-02-12	Ustav Ex Botan Adademie Ved Ce	Purine derivatives, process for their preparation and use

2002
- 2002-04-10 EP EP02076420A patent/EP1352910A1/de not_active Withdrawn
2003
- 2003-04-10 DE DE60321554T patent/DE60321554D1/de not_active Expired - Lifetime
- 2003-04-10 WO PCT/EP2003/003724 patent/WO2003084975A1/en not_active Ceased
- 2003-04-10 AT AT03724994T patent/ATE398134T1/de not_active IP Right Cessation
- 2003-04-10 AU AU2003227593A patent/AU2003227593A1/en not_active Abandoned
- 2003-04-10 ES ES03724994T patent/ES2307931T3/es not_active Expired - Lifetime
- 2003-04-10 EP EP03724994A patent/EP1492803B1/de not_active Expired - Lifetime
- 2003-04-10 JP JP2003582171A patent/JP2005526106A/ja not_active Ceased
2004
- 2004-10-06 US US10/958,681 patent/US7358235B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP1352910A1 (de)	2003-10-15
ES2307931T3 (es)	2008-12-01
JP2005526106A (ja)	2005-09-02
US7358235B2 (en)	2008-04-15
US20050096293A1 (en)	2005-05-05
AU2003227593A1 (en)	2003-10-20
EP1492803A1 (de)	2005-01-05
DE60321554D1 (de)	2008-07-24
EP1492803B1 (de)	2008-06-11
WO2003084975A1 (en)	2003-10-16

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Legal Events

Date

Code

Title

Description

2008-11-15

UEP

Publication of translation of european patent specification

Ref document number: 1492803

Country of ref document: EP

2012-01-15

REN

Ceased due to non-payment of the annual fee