ATE490788T1 - Antivirale phosphonate analoge - Google Patents

Antivirale phosphonate analoge

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Publication number
ATE490788T1
ATE490788T1 AT04750807T AT04750807T ATE490788T1 AT E490788 T1 ATE490788 T1 AT E490788T1 AT 04750807 T AT04750807 T AT 04750807T AT 04750807 T AT04750807 T AT 04750807T AT E490788 T1 ATE490788 T1 AT E490788T1
Authority
AT
Austria
Prior art keywords
compounds
phosphonate analogue
antiviral phosphonate
antiviral
analogue
Prior art date
Application number
AT04750807T
Other languages
English (en)
Inventor
Constantine Boojamra
Carina Cannizzaro
James Chen
Xiaowu Chen
Aesop Cho
Lee Chong
Maria Fardis
Haolun Jin
Ralph Hirschmann
Alan Huang
Choung Kim
Thorsten Kirschberg
Christopher Lee
William Lee
Richard Mackman
David Markevitch
Vidya Prasad
Hyung-Jung Pyun
Adrian Ray
Rosemarie Sherlock
Sundaramoorthi Swaminathan
Will Watkins
Jennifer Zhang
David Oare
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Application granted granted Critical
Publication of ATE490788T1 publication Critical patent/ATE490788T1/de

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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A—HUMAN NECESSITIES
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    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
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