ATE399185T1 - Maleinsäureamid polymerderivate und ihre biokonjugate - Google Patents
Maleinsäureamid polymerderivate und ihre biokonjugateInfo
- Publication number
- ATE399185T1 ATE399185T1 AT03800397T AT03800397T ATE399185T1 AT E399185 T1 ATE399185 T1 AT E399185T1 AT 03800397 T AT03800397 T AT 03800397T AT 03800397 T AT03800397 T AT 03800397T AT E399185 T1 ATE399185 T1 AT E399185T1
- Authority
- AT
- Austria
- Prior art keywords
- bioconjugates
- maleic acid
- acid amide
- polymer derivatives
- amide polymer
- Prior art date
Links
- 229920000642 polymer Polymers 0.000 title abstract 2
- FSQQTNAZHBEJLS-UPHRSURJSA-N maleamic acid Chemical compound NC(=O)\C=C/C(O)=O FSQQTNAZHBEJLS-UPHRSURJSA-N 0.000 title 1
- 235000018102 proteins Nutrition 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- KZNICNPSHKQLFF-UHFFFAOYSA-N succinimide Chemical group O=C1CCC(=O)N1 KZNICNPSHKQLFF-UHFFFAOYSA-N 0.000 abstract 2
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 1
- 239000004472 Lysine Substances 0.000 abstract 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 abstract 1
- 235000018417 cysteine Nutrition 0.000 abstract 1
- 229920003169 water-soluble polymer Polymers 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
- C08G65/333—Polymers modified by chemical after-treatment with organic compounds containing nitrogen
- C08G65/33331—Polymers modified by chemical after-treatment with organic compounds containing nitrogen containing imide group
- C08G65/33337—Polymers modified by chemical after-treatment with organic compounds containing nitrogen containing imide group cyclic
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
- C08G65/333—Polymers modified by chemical after-treatment with organic compounds containing nitrogen
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2203/00—Applications
- C08L2203/02—Applications for biomedical use
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Polymers & Plastics (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Child & Adolescent Psychology (AREA)
- Obesity (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Communicable Diseases (AREA)
- Medicinal Preparation (AREA)
- Polyamides (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Polyethers (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43725102P | 2002-12-31 | 2002-12-31 | |
| US46834003P | 2003-05-05 | 2003-05-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE399185T1 true ATE399185T1 (de) | 2008-07-15 |
Family
ID=32717886
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03800397T ATE399185T1 (de) | 2002-12-31 | 2003-12-31 | Maleinsäureamid polymerderivate und ihre biokonjugate |
Country Status (11)
| Country | Link |
|---|---|
| US (4) | US7329721B2 (de) |
| EP (1) | EP1578841B2 (de) |
| JP (1) | JP4490369B2 (de) |
| KR (1) | KR101031206B1 (de) |
| AT (1) | ATE399185T1 (de) |
| AU (1) | AU2003300139B2 (de) |
| CA (1) | CA2509260C (de) |
| DE (1) | DE60321825D1 (de) |
| ES (1) | ES2308032T5 (de) |
| MX (1) | MXPA05007163A (de) |
| WO (1) | WO2004060966A2 (de) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004060966A2 (en) | 2002-12-31 | 2004-07-22 | Nektar Therapeutics Al, Corporation | Maleamic acid polymer derivatives and their bioconjugates |
| DE60329627D1 (de) * | 2002-12-31 | 2009-11-19 | Nektar Therapeutics Al Corp | Hydrolysestabile maleimidendgruppen-enthaltende polymere |
| US7432331B2 (en) | 2002-12-31 | 2008-10-07 | Nektar Therapeutics Al, Corporation | Hydrolytically stable maleimide-terminated polymers |
| CA2509939C (en) * | 2003-01-06 | 2013-05-21 | Nektar Therapeutics Al, Corporation | Thiol-selective water-soluble polymer derivatives |
| US7947261B2 (en) | 2003-05-23 | 2011-05-24 | Nektar Therapeutics | Conjugates formed from polymer derivatives having particular atom arrangements |
| PT1656410E (pt) | 2003-07-22 | 2010-06-11 | Nektar Therapeutics | Processo para preparação de polímeros funcionalizados a partir de álcoois poliméricos |
| WO2005016260A2 (en) * | 2003-08-08 | 2005-02-24 | The Regents Of The University Of California | Prodrugs for the oral and parenteral delivery of amine-containing drugs, amino acids, and peptides |
| US20050147581A1 (en) * | 2003-11-19 | 2005-07-07 | The Board Of Trustees Of The University Of Illinois | Macromolecular drug complexes having improved stability and therapeutic use of the same |
| US7790835B2 (en) * | 2003-12-03 | 2010-09-07 | Nektar Therapeutics | Method of preparing maleimide functionalized polymers |
| JP4805911B2 (ja) | 2004-03-15 | 2011-11-02 | ネクター セラピューティクス | Ｈｉｖ侵入阻害剤のポリマー系組成物及び複合体 |
| WO2006005058A2 (en) * | 2004-06-30 | 2006-01-12 | Nektar Therapeutics Al, Corporation | Polymer-factor ix moiety conjugates |
| US7632921B2 (en) | 2004-11-12 | 2009-12-15 | Bayer Healthcare Llc | Site-directed modification of FVIII |
| DE602005025805D1 (de) * | 2004-12-21 | 2011-02-17 | Nektar Therapeutics San Carlos | Stabilisierte polymer-thiol-reagenzien |
| MX2007007590A (es) | 2004-12-22 | 2007-12-10 | Ambrx Inc | Composiciones que contienen, metodos que involucran y usos de aminoacidos no naturales y polipeptidos. |
| EP2412744B1 (de) | 2005-07-18 | 2014-01-22 | Nektar Therapeutics | Verfahren zur Herstellung von verzweigten funktionalisierten Polymeren mithilfe von verzweigten Polyol-Kernen |
| AU2006269845B2 (en) * | 2005-07-19 | 2012-03-22 | Nektar Therapeutics | Method for preparing polymer maleimides |
| WO2007048019A2 (en) * | 2005-10-20 | 2007-04-26 | The Penn State Research Foundation | Delivery system for diagnostic and therapeutic agents |
| JP5096363B2 (ja) | 2005-12-16 | 2012-12-12 | ネクター セラピューティックス | Ｇｌｐ−１のポリマ複合体 |
| US7743730B2 (en) * | 2005-12-21 | 2010-06-29 | Lam Research Corporation | Apparatus for an optimized plasma chamber grounded electrode assembly |
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| PT2101821E (pt) * | 2006-12-15 | 2014-10-03 | Baxter Int | Fator conjugado viia-ácido (poli)siálico com prolongamento do tempo de meia vida in vivo |
| US20110183906A1 (en) * | 2008-04-24 | 2011-07-28 | Celtic Pharma Peg Ltd. | Factor ix conjugates with extended half-lives |
| KR20130133104A (ko) * | 2008-08-07 | 2013-12-05 | 입센 파마 에스.에이.에스 | 포도당 의존적인 인슐린 분비 자극성 폴리펩타이드 유사체 |
| CA2733005C (en) * | 2008-08-07 | 2016-09-27 | Ipsen Pharma S.A.S. | Truncated analogues of glucose-dependent insulinotropic polypeptide |
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| SG178141A1 (en) * | 2009-07-27 | 2012-03-29 | Baxter Int | Blood coagulation protein conjugates |
| CN104530182A (zh) | 2009-07-27 | 2015-04-22 | 利普森技术有限公司 | 非凝血蛋白的糖基多唾液酸化 |
| SG178051A1 (en) | 2009-07-27 | 2012-03-29 | Lipoxen Technologies Ltd | Glycopolysialylation of non-blood coagulation proteins |
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| US8642737B2 (en) | 2010-07-26 | 2014-02-04 | Baxter International Inc. | Nucleophilic catalysts for oxime linkage |
| EA201290804A1 (ru) | 2010-02-21 | 2013-03-29 | БАЙЕР ХелсКер ЛЛСи | Способ активации и сопряжения биомолекул |
| EP3372617B1 (de) | 2010-04-02 | 2024-07-24 | Amunix Pharmaceuticals, Inc. | Bindungsfusionsproteine, bindungsfusionsproteinarzneimittelkonjugate, xten-arzneimittelkonjugate sowie verfahren zur herstellung und verwendung davon |
| AU2011277983C1 (en) * | 2010-07-16 | 2016-09-29 | Ablynx Nv | Modified single domain antigen binding molecules and uses thereof |
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| EP3228325A1 (de) | 2011-06-10 | 2017-10-11 | Mersana Therapeutics, Inc. | Protein-polymer-wirkstoffkonjugate |
| US8815226B2 (en) | 2011-06-10 | 2014-08-26 | Mersana Therapeutics, Inc. | Protein-polymer-drug conjugates |
| US9044515B2 (en) * | 2011-09-06 | 2015-06-02 | University Of Delaware | Chemical conjugates for targeted degradation under reducing conditions |
| EP2931316B1 (de) | 2012-12-12 | 2019-02-20 | Mersana Therapeutics, Inc. | Hydroxylpolymer-heilmittelproteinkonjugate |
| CA2926586C (en) | 2013-10-11 | 2020-04-07 | Mersana Therapeutics, Inc. | Polymeric scaffold based on phf for targeted drug delivery |
| KR102572149B1 (ko) | 2013-10-11 | 2023-08-30 | 아사나 바이오사이언시스 엘엘씨 | 단백질-폴리머-약물 접합체 |
| CN104862233B (zh) * | 2014-02-25 | 2018-06-05 | 上海多米瑞生物技术有限公司 | 一株产黄青霉及其应用 |
| KR20240010534A (ko) | 2016-08-09 | 2024-01-23 | 씨젠 인크. | 개선된 물리화학적 특성을 갖는 자기 안정화 링커를 구비한 약물 접합체 |
| CN106750334B (zh) * | 2016-12-08 | 2020-10-16 | 云南师范大学 | 两亲性蝌蚪形嵌段共聚物及其制备方法 |
| CN113382775A (zh) * | 2019-01-28 | 2021-09-10 | 东丽株式会社 | 肝细胞生长因子或其活性片段的聚乙二醇修饰物 |
| JP2024500921A (ja) * | 2020-12-23 | 2024-01-10 | ジーンクアンタム ヘルスケア （スーチョウ） シーオー．， エルティーディー． | 開環チオスクシンイミド基、オリゴペプチドフラグメント及びキラル部分を含む新規異性化合物 |
| CN115028923B (zh) * | 2021-03-08 | 2024-02-13 | 嘉瑞塑胶科技有限公司 | 防细菌聚合物复合材料 |
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| WO2004060966A2 (en) | 2002-12-31 | 2004-07-22 | Nektar Therapeutics Al, Corporation | Maleamic acid polymer derivatives and their bioconjugates |
-
2003
- 2003-12-31 WO PCT/US2003/041705 patent/WO2004060966A2/en not_active Ceased
- 2003-12-31 US US10/750,996 patent/US7329721B2/en not_active Expired - Lifetime
- 2003-12-31 AT AT03800397T patent/ATE399185T1/de not_active IP Right Cessation
- 2003-12-31 CA CA2509260A patent/CA2509260C/en not_active Expired - Lifetime
- 2003-12-31 EP EP03800397.6A patent/EP1578841B2/de not_active Expired - Lifetime
- 2003-12-31 JP JP2005508648A patent/JP4490369B2/ja not_active Expired - Lifetime
- 2003-12-31 MX MXPA05007163A patent/MXPA05007163A/es active IP Right Grant
- 2003-12-31 DE DE60321825T patent/DE60321825D1/de not_active Expired - Lifetime
- 2003-12-31 KR KR1020057012473A patent/KR101031206B1/ko not_active Expired - Lifetime
- 2003-12-31 ES ES03800397.6T patent/ES2308032T5/es not_active Expired - Lifetime
- 2003-12-31 AU AU2003300139A patent/AU2003300139B2/en not_active Expired
-
2007
- 2007-09-27 US US11/904,990 patent/US7659361B2/en not_active Expired - Lifetime
-
2009
- 2009-12-18 US US12/642,413 patent/US7994272B2/en not_active Expired - Lifetime
-
2011
- 2011-06-29 US US13/172,043 patent/US8304511B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO2004060966A3 (en) | 2004-09-16 |
| US20080146771A1 (en) | 2008-06-19 |
| US7329721B2 (en) | 2008-02-12 |
| JP2006522167A (ja) | 2006-09-28 |
| US7994272B2 (en) | 2011-08-09 |
| CA2509260A1 (en) | 2004-07-22 |
| US20110262379A1 (en) | 2011-10-27 |
| MXPA05007163A (es) | 2005-09-21 |
| CA2509260C (en) | 2012-10-02 |
| ES2308032T5 (es) | 2017-04-24 |
| ES2308032T3 (es) | 2008-12-01 |
| KR101031206B1 (ko) | 2011-04-27 |
| AU2003300139A1 (en) | 2004-07-29 |
| US20040167287A1 (en) | 2004-08-26 |
| US20100113329A1 (en) | 2010-05-06 |
| US8304511B2 (en) | 2012-11-06 |
| JP4490369B2 (ja) | 2010-06-23 |
| WO2004060966A2 (en) | 2004-07-22 |
| KR20050096116A (ko) | 2005-10-05 |
| AU2003300139B2 (en) | 2008-08-28 |
| US7659361B2 (en) | 2010-02-09 |
| EP1578841B1 (de) | 2008-06-25 |
| EP1578841A2 (de) | 2005-09-28 |
| DE60321825D1 (de) | 2008-08-07 |
| EP1578841B2 (de) | 2016-10-12 |
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| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |