ATE399208T1 - Neue carbonylreduktase, deren gen und verfahren zu dessen verwendung - Google Patents
Neue carbonylreduktase, deren gen und verfahren zu dessen verwendungInfo
- Publication number
- ATE399208T1 ATE399208T1 AT01956776T AT01956776T ATE399208T1 AT E399208 T1 ATE399208 T1 AT E399208T1 AT 01956776 T AT01956776 T AT 01956776T AT 01956776 T AT01956776 T AT 01956776T AT E399208 T1 ATE399208 T1 AT E399208T1
- Authority
- AT
- Austria
- Prior art keywords
- benzyl
- polypeptide
- pyrrolidinol
- amino acid
- acid sequence
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 102000005751 Alcohol Oxidoreductases Human genes 0.000 title 1
- 108010031132 Alcohol Oxidoreductases Proteins 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 abstract 4
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 4
- YQMXOIAIYXXXEE-NSHDSACASA-N (3s)-1-benzylpyrrolidin-3-ol Chemical compound C1[C@@H](O)CCN1CC1=CC=CC=C1 YQMXOIAIYXXXEE-NSHDSACASA-N 0.000 abstract 3
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 3
- DHGMDHQNUNRMIN-UHFFFAOYSA-N 1-benzylpyrrolidin-3-one Chemical compound C1C(=O)CCN1CC1=CC=CC=C1 DHGMDHQNUNRMIN-UHFFFAOYSA-N 0.000 abstract 2
- 238000004458 analytical method Methods 0.000 abstract 2
- JPVYNHNXODAKFH-UHFFFAOYSA-N Cu2+ Chemical compound [Cu+2] JPVYNHNXODAKFH-UHFFFAOYSA-N 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- ACFIXJIJDZMPPO-NNYOXOHSSA-N NADPH Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](OP(O)(O)=O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 ACFIXJIJDZMPPO-NNYOXOHSSA-N 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 239000005515 coenzyme Substances 0.000 abstract 1
- 229910001431 copper ion Inorganic materials 0.000 abstract 1
- 238000012217 deletion Methods 0.000 abstract 1
- 230000037430 deletion Effects 0.000 abstract 1
- 238000002523 gelfiltration Methods 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 238000003780 insertion Methods 0.000 abstract 1
- 230000037431 insertion Effects 0.000 abstract 1
- 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 abstract 1
- 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 abstract 1
- 238000006467 substitution reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/10—Nitrogen as only ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/002—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by oxidation/reduction reactions
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2000232756 | 2000-08-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE399208T1 true ATE399208T1 (de) | 2008-07-15 |
Family
ID=18725384
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01956776T ATE399208T1 (de) | 2000-08-01 | 2001-08-01 | Neue carbonylreduktase, deren gen und verfahren zu dessen verwendung |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7033808B2 (de) |
| EP (1) | EP1306438B1 (de) |
| JP (1) | JP4880859B2 (de) |
| KR (1) | KR20020056894A (de) |
| AT (1) | ATE399208T1 (de) |
| AU (1) | AU2001278683A1 (de) |
| CA (1) | CA2384625A1 (de) |
| DE (1) | DE60134557D1 (de) |
| ES (1) | ES2309082T3 (de) |
| WO (1) | WO2002010399A1 (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004052829A1 (ja) * | 2002-12-06 | 2004-06-24 | Kaneka Corporation | 光学活性３−ヒドロキシプロピオン酸エステル誘導体の製造法 |
| JP4884996B2 (ja) * | 2006-10-03 | 2012-02-29 | 国立大学法人 奈良先端科学技術大学院大学 | 新規な（ｓ）−ｎ−ベンジル−３−ピロリジノール脱水素酵素、その製造方法、及びこれを利用したアルコールの製造方法 |
| WO2009041415A1 (ja) * | 2007-09-26 | 2009-04-02 | Kaneka Corporation | 新規グルコース脱水素酵素 |
| WO2009084603A1 (ja) * | 2007-12-27 | 2009-07-09 | Otsuka Pharmaceutical Co., Ltd. | エクオール合成に関与する酵素 |
| US10000557B2 (en) * | 2012-12-19 | 2018-06-19 | Dnae Group Holdings Limited | Methods for raising antibodies |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4096331A (en) * | 1976-12-28 | 1978-06-20 | A. H. Robins Company, Incorporated | 1-Substituted-3-aminoethoxypyrrolidines |
| FI83517C (fi) | 1985-01-24 | 1991-07-25 | Yamanouchi Pharma Co Ltd | Foerfarande foer framstaellning av hoegervridande optisk isomer av (+-)-2,6-dimetyl-4-(m-nitrofenyl)-1,4 -dihydropyridin-3,5-dikarboxylsyra-3-(1-bensylpyrrolidin-3-yl) ester -5-metylester (ym-09730) av a-diastereomer. |
| JPH06141876A (ja) | 1992-11-10 | 1994-05-24 | Kyowa Hakko Kogyo Co Ltd | 光学活性なｎ−ベンジル−３−ピロリジノールの製造法 |
| JPH10150998A (ja) * | 1996-11-26 | 1998-06-09 | Kanegafuchi Chem Ind Co Ltd | Ｎ−ベンジル−３−ピロリジノールの製造方法 |
| JP3703928B2 (ja) | 1996-11-26 | 2005-10-05 | 株式会社カネカ | 光学活性ｎ−ベンジル−３−ピロリジノールの製造方法 |
-
2001
- 2001-08-01 CA CA002384625A patent/CA2384625A1/en not_active Abandoned
- 2001-08-01 AT AT01956776T patent/ATE399208T1/de active
- 2001-08-01 DE DE60134557T patent/DE60134557D1/de not_active Expired - Lifetime
- 2001-08-01 ES ES01956776T patent/ES2309082T3/es not_active Expired - Lifetime
- 2001-08-01 EP EP01956776A patent/EP1306438B1/de not_active Expired - Lifetime
- 2001-08-01 KR KR1020027004227A patent/KR20020056894A/ko not_active Withdrawn
- 2001-08-01 AU AU2001278683A patent/AU2001278683A1/en not_active Abandoned
- 2001-08-01 JP JP2002516315A patent/JP4880859B2/ja not_active Expired - Fee Related
- 2001-08-01 US US10/088,920 patent/US7033808B2/en not_active Expired - Fee Related
- 2001-08-01 WO PCT/JP2001/006619 patent/WO2002010399A1/ja not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| JP4880859B2 (ja) | 2012-02-22 |
| EP1306438B1 (de) | 2008-06-25 |
| CA2384625A1 (en) | 2002-02-07 |
| EP1306438A1 (de) | 2003-05-02 |
| ES2309082T3 (es) | 2008-12-16 |
| AU2001278683A1 (en) | 2002-02-13 |
| EP1306438A4 (de) | 2005-03-02 |
| DE60134557D1 (de) | 2008-08-07 |
| KR20020056894A (ko) | 2002-07-10 |
| WO2002010399A1 (en) | 2002-02-07 |
| US20030186412A1 (en) | 2003-10-02 |
| US7033808B2 (en) | 2006-04-25 |
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| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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