ATE291616T1 - Neue carbonyl-reduktase, gen davon und verfahren der anwendung derselben - Google Patents

Neue carbonyl-reduktase, gen davon und verfahren der anwendung derselben

Info

Publication number: ATE291616T1
Authority: AT; Austria
Prior art keywords: polypeptide; chloro; butyl; amino acid; gene
Prior art date: 1999-12-03

Application number

AT00977938T

Other languages

English (en)

Inventor

Noriyuki Kizaki

Yukio Yamada

Yoshihiko Yasohara

Junzo Hasegawa

Original Assignee

Kaneka Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-12-03

Filing date

2000-11-24

Publication date

2005-04-15

2000-11-24 Application filed by Kaneka Corp filed Critical Kaneka Corp

2005-04-15 Application granted granted Critical

2005-04-15 Publication of ATE291616T1 publication Critical patent/ATE291616T1/de

Links

238000000034 method Methods 0.000 title abstract 2
108090000623 proteins and genes Proteins 0.000 title abstract 2
102000005751 Alcohol Oxidoreductases Human genes 0.000 title 1
108010031132 Alcohol Oxidoreductases Proteins 0.000 title 1
229920001184 polypeptide Polymers 0.000 abstract 5
108090000765 processed proteins & peptides Proteins 0.000 abstract 5
102000004196 processed proteins & peptides Human genes 0.000 abstract 5
125000003275 alpha amino acid group Chemical group 0.000 abstract 3
FIKPWJZUGTVXCO-SFYZADRCSA-N tert-butyl (3r,5s)-6-chloro-3,5-dihydroxyhexanoate Chemical compound CC(C)(C)OC(=O)C[C@H](O)C[C@H](O)CCl FIKPWJZUGTVXCO-SFYZADRCSA-N 0.000 abstract 2
108090000790 Enzymes Proteins 0.000 abstract 1
102000004190 Enzymes Human genes 0.000 abstract 1
238000007792 addition Methods 0.000 abstract 1
238000012217 deletion Methods 0.000 abstract 1
230000037430 deletion Effects 0.000 abstract 1
238000003780 insertion Methods 0.000 abstract 1
230000037431 insertion Effects 0.000 abstract 1
238000006467 substitution reaction Methods 0.000 abstract 1
WLRFCPQXWBDLRG-QMMMGPOBSA-N tert-butyl (5s)-6-chloro-5-hydroxy-3-oxohexanoate Chemical compound CC(C)(C)OC(=O)CC(=O)C[C@H](O)CCl WLRFCPQXWBDLRG-QMMMGPOBSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
- C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
- C07K14/40—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts from Candida
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/002—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by oxidation/reduction reactions
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/62—Carboxylic acid esters

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Zoology (AREA)
Engineering & Computer Science (AREA)
Wood Science & Technology (AREA)
Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Microbiology (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Analytical Chemistry (AREA)
Molecular Biology (AREA)
Medicinal Chemistry (AREA)
Biomedical Technology (AREA)
Mycology (AREA)
Gastroenterology & Hepatology (AREA)
Biophysics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Enzymes And Modification Thereof (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Saccharide Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

AT00977938T 1999-12-03 2000-11-24 Neue carbonyl-reduktase, gen davon und verfahren der anwendung derselben ATE291616T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP34554199		1999-12-03
PCT/JP2000/008321 WO2001040450A1 (en)	1999-12-03	2000-11-24	Novel carbonyl reductase, gene thereof and method of using the same

Publications (1)

Publication Number	Publication Date
ATE291616T1 true ATE291616T1 (de)	2005-04-15

Family

ID=18377296

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT00977938T ATE291616T1 (de)	1999-12-03	2000-11-24	Neue carbonyl-reduktase, gen davon und verfahren der anwendung derselben

Country Status (15)

Country	Link
US (1)	US6645746B1 (de)
EP (1)	EP1152054B1 (de)
JP (1)	JP4510351B2 (de)
KR (1)	KR100512080B1 (de)
AT (1)	ATE291616T1 (de)
AU (1)	AU1551701A (de)
CA (1)	CA2360376C (de)
CZ (1)	CZ20012792A3 (de)
DE (1)	DE60018909T2 (de)
ES (1)	ES2240205T3 (de)
HU (1)	HUP0105331A3 (de)
MX (1)	MXPA01007858A (de)
NO (1)	NO20013801L (de)
SI (1)	SI20642A (de)
WO (1)	WO2001040450A1 (de)

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AT504542B1 (de) *	2006-12-07	2008-09-15	Iep Gmbh	Verfahren zur enantioselektiven enzymatischen reduktion von secodionderivaten
EP2115130B1 (de)	2007-02-08	2011-08-03	Codexis, Inc.	Ketoreduktasen und anwendungen davon
JP2010536385A (ja)	2007-08-24	2010-12-02	コデクシス，インコーポレイテッド	（ｒ）−３−ヒドロキシチオランの立体選択的生成のための改善されたケトレダクターゼポリペプチド
EP2198018B1 (de)	2007-09-13	2013-11-20	Codexis, Inc.	Ketoreduktase-polypeptide zur reduktion von acetophenonen
TWI601825B (zh) *	2007-09-27	2017-10-11	Ｉｅｐ有限公司	對映異構選擇性酶催化還原中間產物之方法
EP2203557B1 (de) *	2007-09-28	2012-02-29	Codexis, Inc.	Ketoreduktase-polypeptide und verwendungen davon
HUE027683T2 (en)	2007-10-01	2016-10-28	Codexis Inc	Ketoreductase polypeptides for the production of azetidinone
EP2329013B1 (de)	2008-08-27	2015-10-28	Codexis, Inc.	Ketoreduktasepolypeptide zur herstellung von einem 3-aryl-3-hydroxypropanamin aus einem 3-aryl-3-ketopropanamin
WO2010025287A2 (en)	2008-08-27	2010-03-04	Codexis, Inc.	Ketoreductase polypeptides for the production of 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine
US8288131B2 (en) *	2008-08-27	2012-10-16	Codexis, Inc.	Ketoreductase polypeptides and uses thereof
US8273554B2 (en)	2008-08-29	2012-09-25	Codexis, Inc.	Ketoreductase polypeptides for the stereoselective production of (4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one
WO2010080635A2 (en) *	2008-12-18	2010-07-15	Codexis, Inc.	Recombinant halohydrin dehalogenase polypeptides
EP2226386A1 (de)	2009-03-05	2010-09-08	IEP GmbH	Verfahren zur stereoselektiven enzymatischen Reduktion von Ketoverbindungen
SG177331A1 (en)	2009-06-22	2012-02-28	Codexis Inc	Ketoreductase-mediated stereoselective route to alpha chloroalcohols
PL2445890T3 (pl) *	2009-06-22	2016-02-29	Sk Biopharmaceuticals Co Ltd	Sposób wytwarzania estru (R)-1-arylo-2-tetrazoliloetylowego kwasu karbaminowego
ES2575560T3 (es)	2009-08-19	2016-06-29	Codexis, Inc.	Polipéptidos cetorreductasa para preparar fenilefrina
US8404461B2 (en)	2009-10-15	2013-03-26	SK Biopharmaceutical Co. Ltd.	Method for preparation of carbamic acid (R)-1-aryl-2-tetrazolyl-ethyl ester
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HUE026367T2 (en)	2010-05-04	2016-06-28	Codexis Inc	Biocatalysts for ezetimibe synthesis
EP2639216B1 (de)	2010-11-09	2018-07-11	Kaneka Corporation	Halogenierte indenone und verfahren zur herstellung optisch aktiver indanone oder optisch aktiver indanole unter verwendung dieser
CN102676596A (zh) *	2011-03-16	2012-09-19	苏州国镝医药科技有限公司	生物酶手性合成立普妥中间体ats-7
IN2014CN04470A (de)	2011-11-18	2015-09-04	Codexis Inc
TW201343623A (zh)	2012-02-07	2013-11-01	Annikki Gmbh	使氧化還原輔因子經酶催化再生之方法
WO2013117251A1 (de)	2012-02-07	2013-08-15	Annikki Gmbh	Verfahren zur enzymatischen regenerierung von redoxkofaktoren
SI2812440T1 (sl)	2012-02-07	2020-03-31	Annikki Gmbh	Postopek za izdelavo derivatov furana iz glukoze
DE102012017026A1 (de)	2012-08-28	2014-03-06	Forschungszentrum Jülich GmbH	Sensor für NADP(H) und Entwicklung von Alkoholdehydrogenasen
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CN105087684A (zh) *	2015-09-16	2015-11-25	连云港宏业化工有限公司	一种（3r，5s）-6-氯-3,5-二羟基己酸叔丁酯的制备方法
CN106011092A (zh) *	2016-06-20	2016-10-12	苏州汉酶生物技术有限公司	一种工程化酮还原酶多肽及其用于制备孟鲁斯特中间体的方法
CN106011095B (zh) *	2016-07-27	2021-02-26	苏州汉酶生物技术有限公司	工程化酮还原酶多肽及使用其制备依替米贝中间体的方法
CN110831618B (zh)	2017-04-27	2023-08-25	科德克希思公司	酮还原酶多肽及多核苷酸
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CN108441523A (zh) *	2018-03-22	2018-08-24	南京工业大学	（3r,5s）-6-氯-3,5,-二羟基己酸叔丁酯的制备方法
CN110387359B (zh) *	2018-04-17	2021-04-20	湖州颐盛生物科技有限公司	羰基还原酶突变体及其应用
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2000
- 2000-11-24 JP JP2001542518A patent/JP4510351B2/ja not_active Expired - Fee Related
- 2000-11-24 AT AT00977938T patent/ATE291616T1/de active
- 2000-11-24 AU AU15517/01A patent/AU1551701A/en not_active Abandoned
- 2000-11-24 MX MXPA01007858A patent/MXPA01007858A/es active IP Right Grant
- 2000-11-24 KR KR10-2001-7009856A patent/KR100512080B1/ko not_active Expired - Fee Related
- 2000-11-24 SI SI200020017A patent/SI20642A/sl not_active IP Right Cessation
- 2000-11-24 WO PCT/JP2000/008321 patent/WO2001040450A1/ja not_active Ceased
- 2000-11-24 EP EP00977938A patent/EP1152054B1/de not_active Expired - Lifetime
- 2000-11-24 CA CA002360376A patent/CA2360376C/en not_active Expired - Fee Related
- 2000-11-24 US US09/890,821 patent/US6645746B1/en not_active Expired - Lifetime
- 2000-11-24 DE DE60018909T patent/DE60018909T2/de not_active Expired - Lifetime
- 2000-11-24 ES ES00977938T patent/ES2240205T3/es not_active Expired - Lifetime
- 2000-11-24 CZ CZ20012792A patent/CZ20012792A3/cs unknown
- 2000-11-24 HU HU0105331A patent/HUP0105331A3/hu unknown
2001
- 2001-08-02 NO NO20013801A patent/NO20013801L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
HUP0105331A3 (en)	2005-10-28
NO20013801D0 (no)	2001-08-02
CA2360376A1 (en)	2001-06-07
US6645746B1 (en)	2003-11-11
CA2360376C (en)	2005-04-26
SI20642A (sl)	2002-02-28
JP4510351B2 (ja)	2010-07-21
KR100512080B1 (ko)	2005-09-02
HUP0105331A2 (hu)	2002-05-29
KR20020008116A (ko)	2002-01-29
MXPA01007858A (es)	2003-07-14
AU1551701A (en)	2001-06-12
DE60018909T2 (de)	2006-03-30
ES2240205T3 (es)	2005-10-16
EP1152054B1 (de)	2005-03-23
EP1152054A1 (de)	2001-11-07
EP1152054A4 (de)	2002-11-20
WO2001040450A1 (en)	2001-06-07
CZ20012792A3 (cs)	2002-03-13
DE60018909D1 (de)	2005-04-28
NO20013801L (no)	2001-10-03

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2005-12-15

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