ATE39930T1 - Oligopeptide pro-arzneimittel. - Google Patents

Oligopeptide pro-arzneimittel.

Info

Publication number
ATE39930T1
ATE39930T1 AT83302736T AT83302736T ATE39930T1 AT E39930 T1 ATE39930 T1 AT E39930T1 AT 83302736 T AT83302736 T AT 83302736T AT 83302736 T AT83302736 T AT 83302736T AT E39930 T1 ATE39930 T1 AT E39930T1
Authority
AT
Austria
Prior art keywords
oligopeptides
pro
drug
nucleophilic
prodrugs
Prior art date
Application number
AT83302736T
Other languages
English (en)
Inventor
Charles Gilvarg
William Dennis Kingsbury
Original Assignee
Smithkline Beckman Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beckman Corp filed Critical Smithkline Beckman Corp
Application granted granted Critical
Publication of ATE39930T1 publication Critical patent/ATE39930T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT83302736T 1982-05-18 1983-05-16 Oligopeptide pro-arzneimittel. ATE39930T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37953782A 1982-05-18 1982-05-18
EP83302736A EP0094815B1 (de) 1982-05-18 1983-05-16 Oligopeptide Pro-Arzneimittel

Publications (1)

Publication Number Publication Date
ATE39930T1 true ATE39930T1 (de) 1989-01-15

Family

ID=23497666

Family Applications (1)

Application Number Title Priority Date Filing Date
AT83302736T ATE39930T1 (de) 1982-05-18 1983-05-16 Oligopeptide pro-arzneimittel.

Country Status (12)

Country Link
EP (1) EP0094815B1 (de)
JP (1) JPS58219151A (de)
AT (1) ATE39930T1 (de)
AU (2) AU563196B2 (de)
CA (1) CA1247088A (de)
DE (1) DE3378914D1 (de)
DK (1) DK207583A (de)
ES (1) ES8407010A1 (de)
GR (1) GR81343B (de)
IE (1) IE54927B1 (de)
PT (1) PT76677B (de)
ZA (1) ZA832844B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4479898A (en) * 1982-05-18 1984-10-30 Smithkline Beckman Corporation Oligopeptide prodrugs
US5036054A (en) * 1988-02-11 1991-07-30 Warner-Lambert Company Renin inhibitors containing alpha-heteroatom amino acids
US5126451A (en) * 1988-02-11 1992-06-30 Warner-Lambert Company Renin inhibitors containing α-heteroatom amino acids
JP2578044B2 (ja) * 1992-03-14 1997-02-05 呉羽化学工業株式会社 フェニルアラニン−グリシン誘導体、その製造方法、及びその誘導体を含有する抗腫瘍剤
FR2736055B1 (fr) * 1995-06-29 1997-09-12 Laphal Sa Lab Nouveaux thiophenoxy peptides, leur procede de preparation et les compositions pharmaceutiques en renfermant
IT1292438B1 (it) * 1997-06-30 1999-02-08 Zambon Spa Derivati peptidomimetici inibitori suicidi della proliferazione del hiv

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH338197A (fr) * 1954-08-18 1959-05-15 Uclaf Societe Anonyme Procédé d'obtention de peptides
CH616912A5 (en) * 1974-06-17 1980-04-30 Sandoz Ag Process for the preparation of dipeptide derivatives.
PH14064A (en) * 1977-05-06 1981-01-26 Pfizer Phenylgycine derivatives,pharmaceutical compositions and method of use
DE2917001A1 (de) * 1978-04-28 1979-11-08 Toyo Jozo Kk Neue disulfidverbindungen
US4258193A (en) * 1978-07-13 1981-03-24 Toyo Jozo Kabushiki Kaisha Disulfide derivatives having S--S exchange reactivity
IL58849A (en) * 1978-12-11 1983-03-31 Merck & Co Inc Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them
US4284624A (en) * 1980-05-02 1981-08-18 E. R. Squibb & Sons, Inc. Mixed disulfides
DE3164437D1 (en) * 1980-08-25 1984-08-02 Kabivitrum Ab Peptide substrates for determination of protease activity
JPS5754151A (en) * 1980-09-18 1982-03-31 Takeda Chem Ind Ltd Physiologically active substance b-52653 and its preparation
CY1406A (en) * 1980-12-18 1988-04-22 Schering Corp Substituted dipeptides, processes for their preparation and pharmaceutical compositions containing them and their use in the inhibition of enkephalinase
JPS57123155A (en) * 1981-01-26 1982-07-31 Takeda Chem Ind Ltd Preparation of pyrrolidine derivative and its intermediate
DE3127930A1 (de) * 1981-07-15 1983-01-27 A. Nattermann & Cie GmbH, 5000 Köln Neue optisch aktive dipeptide, verfahren zur herstellung und diese enthaltende pharmazeutische praeparate
DE3173632D1 (en) * 1981-09-11 1986-03-13 Amersham Int Plc Derivatives of iodothyronine compounds and their use in an assay for the free iodothyronine compounds
JPS58105948A (ja) * 1981-12-16 1983-06-24 Fujirebio Inc ジペプチド誘導体
US4427582A (en) * 1982-06-08 1984-01-24 Smithkline Beckman Corporation Antimicrobial disulfide prodrugs

Also Published As

Publication number Publication date
AU563196B2 (en) 1987-07-02
AU586743B2 (en) 1989-07-20
AU1388383A (en) 1983-11-24
PT76677A (en) 1983-06-01
GR81343B (de) 1984-12-11
DK207583A (da) 1983-11-19
JPS58219151A (ja) 1983-12-20
PT76677B (en) 1986-01-14
AU7175987A (en) 1987-08-13
DK207583D0 (da) 1983-05-10
IE831144L (en) 1983-11-18
DE3378914D1 (en) 1989-02-16
IE54927B1 (en) 1990-03-28
EP0094815A2 (de) 1983-11-23
EP0094815B1 (de) 1989-01-11
EP0094815A3 (en) 1986-03-12
ES522476A0 (es) 1984-08-16
ES8407010A1 (es) 1984-08-16
ZA832844B (en) 1984-03-28
CA1247088A (en) 1988-12-20

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee