ATE399323T1 - Verfahren zur bestimmung von amyloidogenen proteinen - Google Patents

Verfahren zur bestimmung von amyloidogenen proteinen

Info

Publication number: ATE399323T1
Authority: AT; Austria
Prior art keywords: aggregation; assay; determining; amyloid; peptide
Prior art date: 1999-12-29

Application number

AT00980905T

Other languages

English (en)

Inventor

Girija Krishnamurthy

Original Assignee

Wyeth Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-12-29

Filing date

2000-12-01

Publication date

2008-07-15

2000-12-01 Application filed by Wyeth Corp filed Critical Wyeth Corp

2008-07-15 Application granted granted Critical

2008-07-15 Publication of ATE399323T1 publication Critical patent/ATE399323T1/de

Links

238000000034 method Methods 0.000 title abstract 3
102000009091 Amyloidogenic Proteins Human genes 0.000 title 1
108010048112 Amyloidogenic Proteins Proteins 0.000 title 1
230000002776 aggregation Effects 0.000 abstract 4
238000004220 aggregation Methods 0.000 abstract 4
238000003556 assay Methods 0.000 abstract 3
108090000765 processed proteins & peptides Proteins 0.000 abstract 3
239000003112 inhibitor Substances 0.000 abstract 2
238000004847 absorption spectroscopy Methods 0.000 abstract 1
DZHSAHHDTRWUTF-SIQRNXPUSA-N amyloid-beta polypeptide 42 Chemical compound C([C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(O)=O)[C@@H](C)CC)C(C)C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(C)C)C1=CC=CC=C1 DZHSAHHDTRWUTF-SIQRNXPUSA-N 0.000 abstract 1
238000002983 circular dichroism Methods 0.000 abstract 1
IQFVPQOLBLOTPF-HKXUKFGYSA-L congo red Chemical compound [Na+].[Na+].C1=CC=CC2=C(N)C(/N=N/C3=CC=C(C=C3)C3=CC=C(C=C3)/N=N/C3=C(C4=CC=CC=C4C(=C3)S([O-])(=O)=O)N)=CC(S([O-])(=O)=O)=C21 IQFVPQOLBLOTPF-HKXUKFGYSA-L 0.000 abstract 1
230000035557 fibrillogenesis Effects 0.000 abstract 1
238000001506 fluorescence spectroscopy Methods 0.000 abstract 1
238000010874 in vitro model Methods 0.000 abstract 1
210000002569 neuron Anatomy 0.000 abstract 1
239000000523 sample Substances 0.000 abstract 1
230000001988 toxicity Effects 0.000 abstract 1
231100000419 toxicity Toxicity 0.000 abstract 1

Classifications

- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4709—Amyloid plaque core protein
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
- G01N2800/2821—Alzheimer

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Chemical & Material Sciences (AREA)
Immunology (AREA)
Molecular Biology (AREA)
Urology & Nephrology (AREA)
Hematology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Analytical Chemistry (AREA)
Food Science & Technology (AREA)
Pathology (AREA)
General Physics & Mathematics (AREA)
Biochemistry (AREA)
Physics & Mathematics (AREA)
Microbiology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biotechnology (AREA)
Cell Biology (AREA)
Bioinformatics & Cheminformatics (AREA)
Organic Chemistry (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Investigating Or Analysing Biological Materials (AREA)
Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
Investigating Or Analysing Materials By Optical Means (AREA)

AT00980905T 1999-12-29 2000-12-01 Verfahren zur bestimmung von amyloidogenen proteinen ATE399323T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US09/474,970 US6399314B1 (en)	1999-12-29	1999-12-29	Methods of detection of amyloidogenic proteins

Publications (1)

Publication Number	Publication Date
ATE399323T1 true ATE399323T1 (de)	2008-07-15

Family

ID=23885720

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT00980905T ATE399323T1 (de)	1999-12-29	2000-12-01	Verfahren zur bestimmung von amyloidogenen proteinen

Country Status (21)

Country	Link
US (1)	US6399314B1 (de)
EP (1)	EP1242822B1 (de)
JP (1)	JP2003519383A (de)
KR (1)	KR20020070470A (de)
CN (1)	CN1211661C (de)
AT (1)	ATE399323T1 (de)
AU (1)	AU774377B2 (de)
BR (1)	BR0016883A (de)
CA (1)	CA2395789C (de)
DE (1)	DE60039310D1 (de)
DK (1)	DK1242822T3 (de)
EA (1)	EA005582B1 (de)
ES (1)	ES2309003T3 (de)
HK (1)	HK1046550B (de)
IL (2)	IL150080A0 (de)
MX (1)	MXPA02006362A (de)
NO (1)	NO20023163L (de)
NZ (1)	NZ519612A (de)
PL (1)	PL356813A1 (de)
PT (1)	PT1242822E (de)
WO (1)	WO2001050134A2 (de)

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US6787523B1 (en)	1997-12-02	2004-09-07	Neuralab Limited	Prevention and treatment of amyloidogenic disease
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US6913745B1 (en)	1997-12-02	2005-07-05	Neuralab Limited	Passive immunization of Alzheimer's disease
US7179892B2 (en) *	2000-12-06	2007-02-20	Neuralab Limited	Humanized antibodies that recognize beta amyloid peptide
TWI239847B (en) *	1997-12-02	2005-09-21	Elan Pharm Inc	N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease
US7588766B1 (en)	2000-05-26	2009-09-15	Elan Pharma International Limited	Treatment of amyloidogenic disease
US6761888B1 (en) *	2000-05-26	2004-07-13	Neuralab Limited	Passive immunization treatment of Alzheimer's disease
US7964192B1 (en) *	1997-12-02	2011-06-21	Janssen Alzheimer Immunotherapy	Prevention and treatment of amyloidgenic disease
US20080050367A1 (en)	1998-04-07	2008-02-28	Guriq Basi	Humanized antibodies that recognize beta amyloid peptide
US20030147882A1 (en) *	1998-05-21	2003-08-07	Alan Solomon	Methods for amyloid removal using anti-amyloid antibodies
DE19923811C1 (de) *	1999-05-20	2000-12-07	Robert Koch Inst	Verfahren zur Diagnose TSE-induzierter Veränderungen in Geweben mittels Infrarotspektroskopie
US6787637B1 (en)	1999-05-28	2004-09-07	Neuralab Limited	N-Terminal amyloid-β antibodies
US6689753B1 (en) *	1999-11-05	2004-02-10	Axonyx, Inc.	β sheet breaker peptide analogs that inhibit β pleated sheet formation in amyloid β-peptide
JP4853936B2 (ja)	2000-08-21	2012-01-11	ザジェネラルホスピタルコーポレイション	神経変性状態の診断方法
PE20020574A1 (es) *	2000-12-06	2002-07-02	Wyeth Corp	Anticuerpos humanizados que reconocen el peptido amiloideo beta
US7700751B2 (en)	2000-12-06	2010-04-20	Janssen Alzheimer Immunotherapy	Humanized antibodies that recognize β-amyloid peptide
WO2003018068A1 (en) *	2001-04-27	2003-03-06	The General Hospital Corporation	Ocular diagnosis of alzheimer's disease
US20050026165A1 (en) *	2001-05-31	2005-02-03	Cindy Orser	Detection of conformationally altered proteins and prions
AU2002320045B2 (en) *	2001-05-31	2008-05-08	Adlyfe, Inc.	Misfolded protein sensor method
WO2003059387A2 (en) *	2001-12-21	2003-07-24	Ilex Oncology, Inc.	Combination comprising anti-cd52 antibodies and other therapeutic agents for treatment for multiple sclerosis
MY139983A (en) *	2002-03-12	2009-11-30	Janssen Alzheimer Immunotherap	Humanized antibodies that recognize beta amyloid peptide
EP1380290A1 (de) *	2002-07-09	2004-01-14	Universitair Medisch Centrum Utrecht	Cross-Beta-Strukturweg und seine therapeutische Relevanz
US20070003552A1 (en) *	2002-07-09	2007-01-04	Gebbink Martijn F B	Cross-beta structure comprising amyloid binding proteins and methods for detection of the cross-beta structure, for modulating cross-beta structures fibril formation and for modulating cross-beta structure-mediated toxicity and method for interfering with blood coagulation
TWI306458B (en)	2003-05-30	2009-02-21	Elan Pharma Int Ltd	Humanized antibodies that recognize beta amyloid peptide
US20050048539A1 (en) *	2003-06-13	2005-03-03	The General Hospital Corporation	Methods to monitor molecule conformation and molecule/molecule proximity
SE0401219D0 (sv) *	2004-05-10	2004-05-10	Biochromix Ab	Metoder för detektera konformationsförändringar eller aggregering hos proteiner med hjälp av konjugerade polyelektrolyter
US20060057671A1 (en) *	2004-09-10	2006-03-16	Orser Cindy S	Immobilized probes and methods of detecting conformationally altered prion proteins
JP2008523815A (ja)	2004-12-15	2008-07-10	エランファーマインターナショナルリミテッド	認知の改善における使用のためのヒト化アミロイドβ抗体
US7625560B2 (en) *	2004-12-15	2009-12-01	Janssen Alzheimer Immunotherapy	Humanized antibodies that recognize beta amyloid peptide
EP1838349A1 (de) *	2004-12-15	2007-10-03	Neuralab, Ltd.	Amyloid-beta-antikörper zur verbesserung der kognition
JP4568840B2 (ja) *	2004-12-28	2010-10-27	国立大学法人金沢大学	アルツハイマー病の検査方法
WO2006069697A1 (en) *	2004-12-30	2006-07-06	F. Hoffmann-La Roche Ag	Colorimetrically assessing peptide characteristics
ATE528649T1 (de) *	2005-02-15	2011-10-15	Adlyfe Inc	Verfahren zum nachweis falsch gefalteter proteine und prionen
US20090202980A1 (en) *	2005-03-21	2009-08-13	Crossbeta Biosciences B.V.	Cross-Beta Structure Comprising Amyloid Binding Proteins and Methods for Detection of the Cross-Beta Structure, for Modulating Cross-Beta Structures Fibril Formation and for Modulating Cross-Beta Structure-Mediated Toxicity and Method for Interfering With Blood Coagulation
US8114832B2 (en) *	2005-07-13	2012-02-14	Crossbeta Biosciences B.V.	Method for detecting and/or removing a protein comprising a cross-beta structure from a pharmaceutical composition
EP1906995A2 (de) *	2005-07-13	2008-04-09	Crossbeta Biosciences B.V.	Adjuvation durch kreuzstruktur
US20070015133A1 (en) *	2005-07-13	2007-01-18	Umc Utrecht Holding B.V.	Method for detecting and/or removing protein and/or peptide comprising a cross-beta structure from an aqueous solution comprising a protein
AU2006267176A1 (en) *	2005-07-13	2007-01-18	Crossbeta Biosciences B.V.	Cross-beta structure binding compounds
US8784810B2 (en)	2006-04-18	2014-07-22	Janssen Alzheimer Immunotherapy	Treatment of amyloidogenic diseases
US8673579B2 (en) *	2006-07-28	2014-03-18	Adlyfe, Inc.	Peptide probes for diagnostics and therapeutics
US8003097B2 (en)	2007-04-18	2011-08-23	Janssen Alzheimer Immunotherapy	Treatment of cerebral amyloid angiopathy
ES2498040T3 (es)	2007-07-27	2014-09-24	Janssen Alzheimer Immunotherapy	Tratamiento de enfermedades amiloidogénicas con anticuerpos anti-beta humanizados
JO3076B1 (ar)	2007-10-17	2017-03-15	Janssen Alzheimer Immunotherap	نظم العلاج المناعي المعتمد على حالة apoe
EP2058000A1 (de) *	2007-11-08	2009-05-13	Crossbeta Biosciences B.V.	Zur Aktivierung von T-Zellen fähige immunogene Zusammensetzung
EP2058001A1 (de) *	2007-11-08	2009-05-13	Crossbeta Biosciences B.V.	Steigerung der Immunogenizität von Antigenen
US20100021390A1 (en) *	2008-03-17	2010-01-28	The Research Foundation Of State University Of New York	Fluorescent Analogs Of The Islet Amyloid Polypeptide
US9067981B1 (en)	2008-10-30	2015-06-30	Janssen Sciences Ireland Uc	Hybrid amyloid-beta antibodies
RU2509155C1 (ru) *	2012-10-25	2014-03-10	Федеральное государственное бюджетное учреждение науки Институт биохимии им. А.Н. Баха Российской академии наук	Способ детекции белков в амилоидном состоянии и набор для детекции белков в амилоидном состоянии
GB201303507D0 (en) *	2013-02-27	2013-04-10	Hollfelder Florian	Assays
US9588129B2 (en) *	2013-03-15	2017-03-07	Amira Medical Technologies Inc.	Methods for analyzing blood to detect diseases associated with abnormal protein aggregation
CN104803993B (zh) *	2015-03-01	2017-11-03	四川大学	一种具有Aβ亲和力的荧光化合物及其用途
CN105651752B (zh) *	2016-02-26	2019-04-12	国家纳米科学中心	淀粉样蛋白的检测方法
CN105717182B (zh) *	2016-03-10	2018-05-11	中南大学	一种用于同步检测淀粉样多肽单体和聚集体的生物传感器及其构建方法和应用
US11536731B2 (en)	2017-01-23	2022-12-27	Rensselaer Polytechnic Institute	Systems and methods for binding amyloid fibrils using fluorescent protein
CN108489941B (zh) *	2018-01-31	2021-07-27	吉林大学	溴酚蓝在作为检测牛胰岛素淀粉样纤维探针和作为牛胰岛素淀粉样纤维抑制剂方面的应用
CN112912732A (zh) *	2018-08-03	2021-06-04	香港大学	用于淀粉样蛋白原纤维、淀粉样蛋白斑块、rna和核仁的检测和成像的组合物和方法
CA3120066A1 (en)	2018-11-14	2020-05-22	University Of Kentucky Research Foundation	Diagnosis of diabetes by detecting aggregated amylin in erythrocytes
CN111504957B (zh) *	2019-01-31	2021-12-03	吉林大学	一种维多利亚蓝b及其衍生物在制备异构化蛋白的探针或抑制剂中的应用
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1999
- 1999-12-29 US US09/474,970 patent/US6399314B1/en not_active Expired - Fee Related
2000
- 2000-12-01 HK HK02108122.2A patent/HK1046550B/en not_active IP Right Cessation
- 2000-12-01 EP EP00980905A patent/EP1242822B1/de not_active Expired - Lifetime
- 2000-12-01 BR BR0016883-1A patent/BR0016883A/pt not_active Application Discontinuation
- 2000-12-01 MX MXPA02006362A patent/MXPA02006362A/es active IP Right Grant
- 2000-12-01 ES ES00980905T patent/ES2309003T3/es not_active Expired - Lifetime
- 2000-12-01 PT PT00980905T patent/PT1242822E/pt unknown
- 2000-12-01 JP JP2001550033A patent/JP2003519383A/ja active Pending
- 2000-12-01 IL IL15008000A patent/IL150080A0/xx active IP Right Grant
- 2000-12-01 DE DE60039310T patent/DE60039310D1/de not_active Expired - Lifetime
- 2000-12-01 AU AU18103/01A patent/AU774377B2/en not_active Ceased
- 2000-12-01 KR KR1020027008505A patent/KR20020070470A/ko not_active Ceased
- 2000-12-01 PL PL00356813A patent/PL356813A1/xx not_active Application Discontinuation
- 2000-12-01 CN CNB008178658A patent/CN1211661C/zh not_active Expired - Fee Related
- 2000-12-01 WO PCT/US2000/032693 patent/WO2001050134A2/en not_active Ceased
- 2000-12-01 EA EA200200722A patent/EA005582B1/ru not_active IP Right Cessation
- 2000-12-01 NZ NZ519612A patent/NZ519612A/en unknown
- 2000-12-01 CA CA2395789A patent/CA2395789C/en not_active Expired - Fee Related
- 2000-12-01 AT AT00980905T patent/ATE399323T1/de not_active IP Right Cessation
- 2000-12-01 DK DK00980905T patent/DK1242822T3/da active
2002
- 2002-06-06 IL IL150080A patent/IL150080A/en not_active IP Right Cessation
- 2002-06-28 NO NO20023163A patent/NO20023163L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
NZ519612A (en)	2004-04-30
HK1046550B (en)	2008-12-19
IL150080A (en)	2009-02-11
CN1211661C (zh)	2005-07-20
JP2003519383A (ja)	2003-06-17
NO20023163L (no)	2002-08-27
CA2395789C (en)	2010-03-30
HK1046550A1 (en)	2003-01-17
WO2001050134A2 (en)	2001-07-12
BR0016883A (pt)	2002-10-01
AU1810301A (en)	2001-07-16
MXPA02006362A (es)	2002-11-29
WO2001050134A3 (en)	2002-06-27
DK1242822T3 (da)	2008-09-29
AU774377B2 (en)	2004-06-24
EP1242822B1 (de)	2008-06-25
DE60039310D1 (de)	2008-08-07
EA200200722A1 (ru)	2002-12-26
EP1242822A2 (de)	2002-09-25
US6399314B1 (en)	2002-06-04
PL356813A1 (en)	2004-07-12
IL150080A0 (en)	2002-12-01
CN1415074A (zh)	2003-04-30
EA005582B1 (ru)	2005-04-28
CA2395789A1 (en)	2001-07-12
ES2309003T3 (es)	2008-12-16
KR20020070470A (ko)	2002-09-09
NO20023163D0 (no)	2002-06-28
PT1242822E (pt)	2008-09-29

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Publication	Publication Date	Title
DE60039310D1 (de)	2008-08-07	Verfahren zur bestimmung von amyloidogenen proteinen
DK0679251T3 (da)	1999-01-25	Fremgangsmåde og apparat til vurdering af biopolymerers fitness
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