ATE528649T1 - Verfahren zum nachweis falsch gefalteter proteine und prionen - Google Patents

Verfahren zum nachweis falsch gefalteter proteine und prionen

Info

Publication number
ATE528649T1
ATE528649T1 AT06720716T AT06720716T ATE528649T1 AT E528649 T1 ATE528649 T1 AT E528649T1 AT 06720716 T AT06720716 T AT 06720716T AT 06720716 T AT06720716 T AT 06720716T AT E528649 T1 ATE528649 T1 AT E528649T1
Authority
AT
Austria
Prior art keywords
prions
misfolded proteins
complexes
detecting
proteins
Prior art date
Application number
AT06720716T
Other languages
English (en)
Inventor
Cindy Orser
Tao Pan
Jasmeet Sethi
Original Assignee
Adlyfe Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adlyfe Inc filed Critical Adlyfe Inc
Application granted granted Critical
Publication of ATE528649T1 publication Critical patent/ATE528649T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G01N33/54333—Modification of conditions of immunological binding reaction, e.g. use of more than one type of particle, use of chemical agents to improve binding, choice of incubation time or application of magnetic field during binding reaction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2828—Prion diseases

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
AT06720716T 2005-02-15 2006-02-14 Verfahren zum nachweis falsch gefalteter proteine und prionen ATE528649T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65273305P 2005-02-15 2005-02-15
PCT/US2006/005095 WO2006088823A2 (en) 2005-02-15 2006-02-14 Method for detecting misfolded proteins and prions

Publications (1)

Publication Number Publication Date
ATE528649T1 true ATE528649T1 (de) 2011-10-15

Family

ID=36916969

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06720716T ATE528649T1 (de) 2005-02-15 2006-02-14 Verfahren zum nachweis falsch gefalteter proteine und prionen

Country Status (10)

Country Link
US (1) US8372593B2 (de)
EP (1) EP1853915B1 (de)
JP (1) JP5048522B2 (de)
CN (1) CN101156068B (de)
AT (1) ATE528649T1 (de)
AU (1) AU2006214463B2 (de)
BR (1) BRPI0607350A2 (de)
CA (1) CA2597912C (de)
MX (1) MX2007009819A (de)
WO (1) WO2006088823A2 (de)

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US20050026165A1 (en) * 2001-05-31 2005-02-03 Cindy Orser Detection of conformationally altered proteins and prions
EP1395833B1 (de) 2001-05-31 2013-02-27 Adlyfe, Inc. Verfahren zum erkennen von inkorrekt gefalteten proteinen
EP1931695B1 (de) 2005-09-09 2013-04-10 Novartis AG Prionspezifische Peptoidreagentien
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CA2675039A1 (en) * 2007-01-12 2008-07-17 Alicon Ag Method for removing prion protein
CN102014967A (zh) * 2008-03-21 2011-04-13 阿德利夫股份有限公司 芘携带肽穿过血脑屏障的用途
CN107677828A (zh) * 2008-10-31 2018-02-09 耶鲁大学 子痫前期检测和治疗的方法和组合物
CN102365295A (zh) * 2009-01-30 2012-02-29 阿德利夫股份有限公司 构象动力肽
WO2011149917A1 (en) 2010-05-25 2011-12-01 Adlyfe, Inc. STABILIZED AMYLOID- β OLIGOMERS AND USES THEREOF
CA2834056A1 (en) 2011-04-27 2012-11-01 Adlyfe, Inc. Ocular detection of amyloid proteins
CN102901825A (zh) * 2011-07-29 2013-01-30 中国科学院生物物理研究所 丙二醛修饰蛋白质作为错误折叠蛋白质荧光探剂的应用
DE102012104504B4 (de) * 2012-05-24 2021-10-07 Bundesrepublik Deutschland, vertreten durch das Bundesministerium für Wirtschaft und Technologie, dieses vertreten durch den Präsidenten der BAM, Bundesanstalt für Materialforschung und -prüfung Polypeptidmarker
JP6178586B2 (ja) * 2013-02-20 2017-08-09 サヴィッド・セラピューティックス株式会社 ビオチン改変体、ストレプトアビジン変異体およびそれらの利用
CN105092854A (zh) * 2014-05-07 2015-11-25 湖州数问生物技术有限公司 体外诊断装置和试剂盒
EP3191599B1 (de) * 2014-09-11 2023-08-02 Board Of Regents Of the University Of Texas System Detektion von fehlgefalteten proteinen
CN118731363A (zh) * 2020-11-21 2024-10-01 浙江数问生物技术有限公司 用于检测生物样本中的错误折叠蛋白质的装置和方法

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WO2001014412A1 (en) 1999-08-23 2001-03-01 The Regents Of The University Of California Compounds useful to mimic peptide beta-strands
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US20050026165A1 (en) * 2001-05-31 2005-02-03 Cindy Orser Detection of conformationally altered proteins and prions
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US20040072236A1 (en) * 2002-09-27 2004-04-15 Neil Cashman PrPSc -interacting molecules and uses thereof
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US7510848B2 (en) 2003-04-04 2009-03-31 North Carolina State University Prion protein binding materials and methods of use
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US20070054322A1 (en) 2003-07-31 2007-03-08 Hadasit Medical Research Services & Development Lt Methods and kits for the detection of prion diseases
US20060035242A1 (en) 2004-08-13 2006-02-16 Michelitsch Melissa D Prion-specific peptide reagents
NZ580256A (en) 2003-08-13 2011-07-29 Novartis Vaccines & Diagnostic Prion-specific peptide reagents comprising the sequence KKRPKPGG
JP3910569B2 (ja) 2003-08-19 2007-04-25 独立行政法人科学技術振興機構 アミロイドβ蛋白質のアミロイド線維化を増幅するための試薬
US20060057671A1 (en) * 2004-09-10 2006-03-16 Orser Cindy S Immobilized probes and methods of detecting conformationally altered prion proteins
JP5097206B2 (ja) 2006-07-28 2012-12-12 エイディーライフ インコーポレイティッド 診断および治療のためのペプチドプローブ

Also Published As

Publication number Publication date
AU2006214463B2 (en) 2012-08-30
US8372593B2 (en) 2013-02-12
MX2007009819A (es) 2007-11-07
CN101156068A (zh) 2008-04-02
WO2006088823A2 (en) 2006-08-24
EP1853915A2 (de) 2007-11-14
JP5048522B2 (ja) 2012-10-17
AU2006214463A1 (en) 2006-08-24
WO2006088823A3 (en) 2007-03-29
HK1110936A1 (en) 2008-07-25
JP2008530565A (ja) 2008-08-07
US20110081660A1 (en) 2011-04-07
CA2597912A1 (en) 2006-08-24
EP1853915A4 (de) 2008-09-03
EP1853915B1 (de) 2011-10-12
CN101156068B (zh) 2015-03-18
BRPI0607350A2 (pt) 2009-09-01
CA2597912C (en) 2013-06-04

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