ATE39935T1 - Copolymer und verfahren zu seiner herstellung. - Google Patents

Copolymer und verfahren zu seiner herstellung.

Info

Publication number
ATE39935T1
ATE39935T1 AT85304733T AT85304733T ATE39935T1 AT E39935 T1 ATE39935 T1 AT E39935T1 AT 85304733 T AT85304733 T AT 85304733T AT 85304733 T AT85304733 T AT 85304733T AT E39935 T1 ATE39935 T1 AT E39935T1
Authority
AT
Austria
Prior art keywords
copolymer
production
weight
dispersity
average molecular
Prior art date
Application number
AT85304733T
Other languages
English (en)
Inventor
Motoaki Tanaka
Yasuaki Ogawa
Tsutomu Miyagawa
Toshio Watanabe
Original Assignee
Wako Pure Chem Ind Ltd
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=15266918&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE39935(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from JP59140356A external-priority patent/JPH0678425B2/ja
Application filed by Wako Pure Chem Ind Ltd, Takeda Chemical Industries Ltd filed Critical Wako Pure Chem Ind Ltd
Application granted granted Critical
Publication of ATE39935T1 publication Critical patent/ATE39935T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
    • C08G63/06—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxycarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
AT85304733T 1984-07-06 1985-07-03 Copolymer und verfahren zu seiner herstellung. ATE39935T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP59140356A JPH0678425B2 (ja) 1984-07-06 1984-07-06 重合体の新規製造法
EP85304733A EP0171907B2 (de) 1984-07-06 1985-07-03 Verwendung eines Copolymeres in einem Depotpräparat

Publications (1)

Publication Number Publication Date
ATE39935T1 true ATE39935T1 (de) 1989-01-15

Family

ID=15266918

Family Applications (2)

Application Number Title Priority Date Filing Date
AT85304733T ATE39935T1 (de) 1984-07-06 1985-07-03 Copolymer und verfahren zu seiner herstellung.
AT85304734T ATE39936T1 (de) 1984-07-06 1985-07-03 Verfahren zur herstellung eines polymers oder copolymers aus milchsaeure und/oder glycolsaeure.

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT85304734T ATE39936T1 (de) 1984-07-06 1985-07-03 Verfahren zur herstellung eines polymers oder copolymers aus milchsaeure und/oder glycolsaeure.

Country Status (8)

Country Link
US (2) US4683288A (de)
EP (2) EP0171907B2 (de)
AT (2) ATE39935T1 (de)
BG (1) BG61520B2 (de)
CA (2) CA1256638A (de)
DE (2) DE3567470D1 (de)
HK (1) HK19592A (de)
SG (1) SG108191G (de)

Families Citing this family (144)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4880635B1 (en) * 1984-08-08 1996-07-02 Liposome Company Dehydrated liposomes
GB8609537D0 (en) * 1986-04-18 1986-05-21 Ici Plc Polyesters
DE3720806C2 (de) * 1986-07-03 1997-08-21 Clariant Finance Bvi Ltd Verwendung eines Stabilisators in Peroxydbleichverfahren
US4758435A (en) * 1986-08-11 1988-07-19 American Cyanamid Company Estradiol implant composition and method for preparation
DE3641692A1 (de) * 1986-12-06 1988-06-09 Boehringer Ingelheim Kg Katalysatorfreie resorbierbare homopolymere und copolymere
DE3710175A1 (de) * 1987-02-12 1988-08-25 Hoechst Ag Mehrteilige implantierbare arzneizubereitung mit langzeitwirkung
DE68928938T2 (de) * 1988-08-08 1999-09-30 Biopak Technology Ltd., Golden Verfahren zur Weichmachung von Lactidpolymerisaten
US5180765A (en) * 1988-08-08 1993-01-19 Biopak Technology, Ltd. Biodegradable packaging thermoplastics from lactides
US6323307B1 (en) 1988-08-08 2001-11-27 Cargill Dow Polymers, Llc Degradation control of environmentally degradable disposable materials
AU634723B2 (en) * 1988-08-08 1993-03-04 Biopak Technology, Ltd. Degradable thermoplastic from lactides
US5424346A (en) * 1988-08-08 1995-06-13 Ecopol, Llc Biodegradable replacement of crystal polystyrene
US5250584A (en) * 1988-08-31 1993-10-05 G-C Dental Industrial Corp. Periodontium-regenerative materials
JP2714454B2 (ja) * 1988-11-07 1998-02-16 三井東圧化学株式会社 生体吸収性ポリエステルの製造方法
US4990336A (en) * 1989-02-08 1991-02-05 Biosearch, Inc. Sustained release dosage form
FR2654337B1 (fr) * 1989-11-15 1994-08-05 Roussel Uclaf Nouvelles microspheres injectables biodegradables procede de preparation et suspensions injectables les renfermant.
US5126147A (en) * 1990-02-08 1992-06-30 Biosearch, Inc. Sustained release dosage form
DE4005415C2 (de) * 1990-02-21 1996-04-11 Boehringer Ingelheim Kg Verfahren zum Herstellen von Polyestern auf der Basis von Hydroxycarbonsäuren
US5288496A (en) * 1990-05-15 1994-02-22 Stolle Research & Development Corporation Growth promoters for animals
US5733566A (en) * 1990-05-15 1998-03-31 Alkermes Controlled Therapeutics Inc. Ii Controlled release of antiparasitic agents in animals
US6353030B1 (en) * 1990-08-01 2002-03-05 Novartis Ag Relating to organic compounds
MY108621A (en) * 1990-08-01 1996-10-31 Novartis Ag Polylactide preparation and purification
ZA918168B (en) 1990-10-16 1993-04-14 Takeda Chemical Industries Ltd Prolonged release preparation and polymers thereof.
IT1249045B (it) * 1991-02-21 1995-02-11 Himont Inc Processo per la sintesi allo stato solido di polimeri dell'acido lattico e prodotti cosi ottenuti
US5247058A (en) * 1992-01-24 1993-09-21 Cargill, Incorporated Continuous process for manufacture of lactide polymers with controlled optical purity
US6326458B1 (en) 1992-01-24 2001-12-04 Cargill, Inc. Continuous process for the manufacture of lactide and lactide polymers
US5258488A (en) * 1992-01-24 1993-11-02 Cargill, Incorporated Continuous process for manufacture of lactide polymers with controlled optical purity
US6005067A (en) * 1992-01-24 1999-12-21 Cargill Incorporated Continuous process for manufacture of lactide polymers with controlled optical purity
US5247059A (en) * 1992-01-24 1993-09-21 Cargill, Incorporated Continuous process for the manufacture of a purified lactide from esters of lactic acid
US5142023A (en) * 1992-01-24 1992-08-25 Cargill, Incorporated Continuous process for manufacture of lactide polymers with controlled optical purity
US5294469A (en) * 1992-06-17 1994-03-15 Mitsui Toatsu Chemicals, Incorporated Industrial woven fabric and composite sheet comprising same
US5758053A (en) * 1992-07-22 1998-05-26 Hitachi, Ltd. Fault handling and recovery for system having plural processors
US6005068A (en) 1992-10-02 1999-12-21 Cargill Incorporated Melt-stable amorphous lactide polymer film and process for manufacture thereof
US5338822A (en) * 1992-10-02 1994-08-16 Cargill, Incorporated Melt-stable lactide polymer composition and process for manufacture thereof
DE69330046T2 (de) * 1992-10-02 2001-11-15 Cargill, Inc. Schmelzstabiles lactidpolymergewebe und verfahren zu seiner herstellung
NZ256978A (en) * 1992-10-02 1996-05-28 Cargill Inc Paper product coated with a poly(lactide) composition comprising no more than 5 wt % lactide monomer, the poly(lactide) having a number average mw of 10,000 to 200,000
US5643595A (en) * 1992-11-24 1997-07-01 Alkermes Controlled Therapeutics Inc. Ii Growth promoters for animals
TW333456B (en) * 1992-12-07 1998-06-11 Takeda Pharm Ind Co Ltd A pharmaceutical composition of sustained-release preparation the invention relates to a pharmaceutical composition of sustained-release preparation which comprises a physiologically active peptide.
US6090925A (en) 1993-03-09 2000-07-18 Epic Therapeutics, Inc. Macromolecular microparticles and methods of production and use
CN1074923C (zh) * 1993-11-19 2001-11-21 詹森药业有限公司 微囊密封的3-哌啶基取代的1,2-苯并异唑类和1,2-苯并异噻唑类
WO1997008220A1 (fr) * 1995-08-29 1997-03-06 Kyowa Hakko Kogyo Co., Ltd. Processus de production d'acide polyhydroxy carboxylique
SE505146C2 (sv) * 1995-10-19 1997-06-30 Biogram Ab Partiklar för fördröjd frisättning
WO1997031049A1 (fr) * 1996-02-23 1997-08-28 Kyowa Hakko Kogyo Co., Ltd. Procede d'elaboration d'acide polyhydroxycarboxylique
US20070185032A1 (en) * 1996-12-11 2007-08-09 Praecis Pharmaceuticals, Inc. Pharmaceutical formulations for sustained drug delivery
US5968895A (en) 1996-12-11 1999-10-19 Praecis Pharmaceuticals, Inc. Pharmaceutical formulations for sustained drug delivery
US6126919A (en) 1997-02-07 2000-10-03 3M Innovative Properties Company Biocompatible compounds for pharmaceutical drug delivery systems
US6113947A (en) * 1997-06-13 2000-09-05 Genentech, Inc. Controlled release microencapsulated NGF formulation
US6663899B2 (en) 1997-06-13 2003-12-16 Genentech, Inc. Controlled release microencapsulated NGF formulation
US6733767B2 (en) * 1998-03-19 2004-05-11 Merck & Co., Inc. Liquid polymeric compositions for controlled release of bioactive substances
US6217844B1 (en) 1998-04-27 2001-04-17 Praecis Pharmaceuticals, Inc. Methods for detecting lesions in dense breast tissue using LHRH antagonists
ATE293652T1 (de) 1999-12-10 2005-05-15 Equipolymers Gmbh Katalysatorsysteme für polykondensationsreaktionen
US7256241B2 (en) 2000-01-21 2007-08-14 Cyclics Corporation Methods for polymerizing macrocyclic polyester oligomers using catalyst promoters
US6960626B2 (en) * 2000-01-21 2005-11-01 Cyclics Corporation Intimate physical mixtures containing macrocyclic polyester oligomer and filler
CN1269870C (zh) * 2000-08-07 2006-08-16 和光纯药工业株式会社 乳酸聚合物及其制备方法
US6362308B1 (en) 2000-08-10 2002-03-26 Alkermes Controlled Therapeutics Inc. Ii Acid end group poly(d,l-lactide-co-glycolide) copolymers high glycolide content
AU2001290515B2 (en) * 2000-08-16 2007-02-01 Covidien Lp High consistency absorbable polymeric resin
US7750109B2 (en) 2000-09-01 2010-07-06 Cyclics Corporation Use of a residual oligomer recyclate in the production of macrocyclic polyester oligomer
US7767781B2 (en) 2000-09-01 2010-08-03 Cyclics Corporation Preparation of low-acid polyalkylene terephthalate and preparation of macrocyclic polyester oligomer therefrom
WO2002018476A2 (en) 2000-09-01 2002-03-07 Cyclics Corporation Methods for converting linear polyesters to macrocyclic oligoester compositions and macrocyclic oligoesters
WO2003000156A1 (en) 2001-06-22 2003-01-03 Southern Biosystems, Inc. Zero-order prolonged release coaxial implants
US7304123B2 (en) 2001-06-27 2007-12-04 Cyclics Corporation Processes for shaping macrocyclic oligoesters
JP2005515965A (ja) 2001-06-27 2005-06-02 サイクリクス コーポレイション 大環状オリゴエステルの単離、処方、および成形
TWI225416B (en) 2001-06-29 2004-12-21 Takeda Chemical Industries Ltd Sustained-release composition and process for producing the same
TWI332407B (en) 2001-06-29 2010-11-01 Takeda Chemical Industries Ltd Controlled release composition and method of producting the same
US6787632B2 (en) 2001-10-09 2004-09-07 Cyclics Corporation Organo-titanate catalysts for preparing pure macrocyclic oligoesters
JP2003192773A (ja) * 2001-12-26 2003-07-09 Mitsui Chemicals Inc 生体吸収性ポリヒドロキシカルボン酸及びその製造法
US6849600B2 (en) * 2002-03-25 2005-02-01 The Regents Of The University Of California, Berkeley Corticotropin-releasing hormone analogs
KR100684682B1 (ko) * 2002-09-24 2007-02-22 아사히 가세이 케미칼즈 가부시키가이샤 글리콜산 공중합체 및 그의 제조 방법
EP1440992A1 (de) * 2003-01-21 2004-07-28 Société de Conseils de Recherches et d'Applications Scientifiques ( S.C.R.A.S.) Katalysatorzusammensetzung für die (Co)polymerisation von Lactid und Glycolid
US20060193825A1 (en) * 2003-04-29 2006-08-31 Praecis Phamaceuticals, Inc. Pharmaceutical formulations for sustained drug delivery
US20050112087A1 (en) * 2003-04-29 2005-05-26 Musso Gary F. Pharmaceutical formulations for sustained drug delivery
ES2600554T3 (es) 2003-07-18 2017-02-09 Oakwood Laboratories L.L.C. Prevención de la reducción del peso molecular del polímero, de la formación de impurezas y de la gelificación en composiciones poliméricas
US20060210614A1 (en) * 2003-12-26 2006-09-21 Nastech Pharmaceutical Company Inc. Method of treatment of a metabolic disease using intranasal administration of exendin peptide
US20060074025A1 (en) * 2003-12-26 2006-04-06 Nastech Pharmaceutical Company Inc. Therapeutic formulations for transmucosal administration that increase glucagon-like peptide-1 bioavailability
US20050143303A1 (en) * 2003-12-26 2005-06-30 Nastech Pharmaceutical Company Inc. Intranasal administration of glucose-regulating peptides
US20080318837A1 (en) * 2003-12-26 2008-12-25 Nastech Pharmaceutical Company Inc. Pharmaceutical Formation For Increased Epithelial Permeability of Glucose-Regulating Peptide
WO2005105908A1 (ja) * 2004-04-28 2005-11-10 Keio University 主鎖にエステル結合を有するポリマーの解重合方法及び解重合生成物から主鎖にエステル結合を有するポリマーを製造する方法
CA2567331C (en) * 2004-05-21 2012-08-14 Microtherapeutics, Inc. Metallic coils enlaced with biological or biodegradable or synthetic polymers or fibers for embolization of a body cavity
US20070254314A1 (en) * 2004-09-16 2007-11-01 Geier Mark R Methods of treating autism and autism spectrum disorders
US8845676B2 (en) * 2004-09-22 2014-09-30 Micro Therapeutics Micro-spiral implantation device
ATE382337T1 (de) * 2005-04-28 2008-01-15 Nipro Corp Bioabsorbierbare pharmazeutische zusammensetzung enthaltend einen plga-copolymer
DE102005019782A1 (de) * 2005-04-28 2006-11-09 Dendron Gmbh Vorrichtung zur Implantation von Okklusionswendeln mit innenliegendem Sicherungsmittel
US8362086B2 (en) 2005-08-19 2013-01-29 Merial Limited Long acting injectable formulations
US20070106271A1 (en) * 2005-11-09 2007-05-10 Searete Llc, A Limited Liability Corporation Remote control of substance delivery system
US20080318861A1 (en) * 2005-12-08 2008-12-25 Nastech Pharmaceutical Company Inc. Mucosal Delivery of Stabilized Formulations of Exendin
DK2444807T3 (da) 2006-11-01 2014-08-11 Ventana Med Syst Inc Mono- og dinitropyrazolhaptenkonjugater
MX2009006653A (es) 2006-12-18 2009-07-02 Takeda Pharmaceutical Composicion de liberacion prolongada y metodo para producirla.
JP5249249B2 (ja) 2007-03-13 2013-07-31 コヴィディエン リミテッド パートナーシップ コイルと耐伸張性部材とが含まれているインプラント
BRPI0916761A2 (pt) 2008-07-17 2018-02-14 Ap Pharma formulações analgésicas injetáveis de ação prolongada para animais
WO2010047674A1 (en) 2008-10-20 2010-04-29 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Low molecular weight thyroid stimulating hormone receptor (tshr) agonists
WO2010048302A1 (en) 2008-10-21 2010-04-29 Oregon Health & Science University Naphthamides as anticancer agents
CN101445595B (zh) * 2008-12-26 2011-01-19 上海新上化高分子材料有限公司 聚乙丙交酯及其制备方法和应用
WO2011094426A1 (en) 2010-01-29 2011-08-04 The United State Of America, As Represented By The Secretary, Department Of Health & Human Services Caspase inhibitors
JP5965387B2 (ja) 2010-04-08 2016-08-03 アメリカ合衆国 Ｔｓｈ受容体用のインバースアゴニストおよびニュートラルアンタゴニスト
WO2012125486A1 (en) 2011-03-11 2012-09-20 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Combination chemotherapy for treating cancer
EP2685985B1 (de) 2011-03-17 2016-08-31 The U.S.A. As Represented By The Secretary, Department Of Health And Human Services Verfahren zur behandlung von leukämie und erkrankungen durch cbf- und runx1-proteine
CN102329269B (zh) * 2011-06-30 2013-07-17 南京大学 仿生氯化肌酐胍催化缩聚法合成高分子量聚乳酸
CN102295765B (zh) * 2011-06-30 2012-11-28 南京大学 生物质肌酐催化共缩聚法合成聚乳酸-乙醇酸
WO2013039792A1 (en) 2011-09-12 2013-03-21 The United States Of America As Represented By The Secretary, Department Of Health And Human Services Immunogens based on an hiv-1 gp120 v1v2 epitope
WO2013049535A2 (en) 2011-09-30 2013-04-04 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Influenza vaccine
US9249103B2 (en) 2012-01-13 2016-02-02 Oregon Health & Science University Compounds, compositions and associated methods comprising 3-aryl quinolines
WO2013184202A1 (en) 2012-06-08 2013-12-12 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Fbxo3 inhibitors
CN104884057B (zh) 2012-11-13 2019-08-20 美国政府(由卫生和人类服务部的部长所代表) 大麻素受体介导的化合物
US9775895B2 (en) 2012-12-12 2017-10-03 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services HIV therapeutics and methods of making and using same
EP2970398B1 (de) 2013-03-13 2024-05-08 The United States of America, as Represented by The Secretary, Department of Health and Human Services Rsv-f-prefusionsproteine und deren verwendung
CN105611927A (zh) 2013-05-16 2016-05-25 美国政府(由卫生和人类服务部的部长所代表) 用于抑制耐药性hiv-1整合酶耐药株的化合物
CA2924527C (en) 2013-09-20 2022-07-12 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Compounds for treating prostate cancer
US10398772B2 (en) 2014-01-08 2019-09-03 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Ras pathways as markers of protection against HIV and methods to improve vaccine efficacy
JP6762930B2 (ja) 2014-05-09 2020-09-30 ザ ユナイテッド ステイツ オブ アメリカ， アズ リプレゼンテッド バイ ザ セクレタリー， デパートメント オブ ヘルス アンド ヒューマン サービシーズ カンナビノイド受容体メディエータとしてのピラゾール誘導体およびそれらの使用
US10266549B2 (en) 2014-08-25 2019-04-23 Salk Institute For Biological Studies ULK1 inhibitors and methods using same
WO2016037154A1 (en) 2014-09-04 2016-03-10 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Recombinant hiv-1 envelope proteins and their use
WO2016064716A1 (en) 2014-10-20 2016-04-28 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Combination therapy of tshr antagonist and igfr inhibitor
WO2016103238A1 (en) 2014-12-24 2016-06-30 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Recombinant metapneumovirus f proteins and their use
EP3597186B1 (de) 2015-01-05 2021-12-08 The U.S.A. as represented by the Secretary, Department of Health and Human Services Myc-g-quadruplex-stabilisierende kleine moleküle und deren verwendung
PE20180021A1 (es) 2015-02-20 2018-01-09 Univ Oregon Health & Science Derivados de sobetiroma
WO2016196646A1 (en) 2015-06-04 2016-12-08 The United States Of America, As Represented By The Secretary, Departmet Of Health & Human Services Cannabinoid receptor mediating compounds
JP7062442B2 (ja) 2015-06-11 2022-05-06 ユニバーシティ・オブ・ピッツバーグ－オブ・ザ・コモンウェルス・システム・オブ・ハイヤー・エデュケイション ｐ６２－ＺＺ化学抑制剤
WO2017044803A1 (en) 2015-09-09 2017-03-16 The United States Of America, As Represented By The Secretary Department Of Health And Human Service Expression vector delivery system and use thereof for inducing an immune response
WO2017151802A1 (en) 2016-03-04 2017-09-08 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Cannabinoid receptor mediating compounds
WO2017165822A1 (en) 2016-03-24 2017-09-28 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Small molecule inhibitor of the nuclear translocation of androgen receptor for the treatment of castration-resistant prostate cancer
DK3457851T3 (da) 2016-05-18 2021-09-20 Univ Oregon Health & Science Derivater af sobetirom
EP3471828A1 (de) 2016-06-16 2019-04-24 Acies Bio d.o.o. Zusammensetzungen und verfahren zur behandlung von krankheiten, die durch eine unzureichende pantothenatkinaseaktivität gekennzeichnet sind
US11084850B2 (en) 2016-12-16 2021-08-10 The Pirbright Institute Recombinant prefusion RSV F proteins and uses thereof
CA3053388C (en) 2017-02-22 2024-02-13 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Compounds and methods for inhibiting emt pathways to treat cancer, organ fibrosis and metabolic disorders
IL272809B2 (en) 2017-08-31 2025-05-01 Evonik Corp Improved resorbable polymer purification process
AU2018358238B2 (en) 2017-11-01 2022-08-18 The Scripps Research Institute Novel scaffolded HIV-1 vaccine immunogens
WO2019118803A1 (en) 2017-12-14 2019-06-20 The United States Of America, As Represented By The Secretary,Department Of Health And Human Services Chemical entities for lytic activation of kshv and therapeutic targeting of viral enzymes/proteins
BR112020018832A2 (pt) 2018-03-29 2021-02-09 Elex Biotech, Inc. compostos para o tratamento de arritimias cardíacas e insuficiência cardíaca
EP3856754A1 (de) 2018-09-25 2021-08-04 The United States of America, as represented by the Secretary, Department of Health and Human Services 2'-halogenierte-4'-thio-2'-deoxy-5-azacytidin-analoga und deren verwendung
AU2019397067A1 (en) 2018-12-12 2021-07-22 Autobahn Therapeutics, Inc. Novel thyromimetics
WO2020180624A1 (en) 2019-03-01 2020-09-10 Autobahn Therapeutics, Inc. Novel thyromimetics
WO2020185695A1 (en) 2019-03-11 2020-09-17 Oregon State University Analogues and derivatives of cephalotaxine and methods for making and using the compounds
US12466781B2 (en) 2019-11-29 2025-11-11 Autobahn Therapeutics, Inc. Thyromimetics
KR20220153582A (ko) 2020-02-14 2022-11-18 솔크 인스티튜트 포 바이올로지칼 스터디즈 마크로시클릭 ulk1/2 억제제
WO2021257851A1 (en) 2020-06-17 2021-12-23 Autobahn Therapeutics, Inc. Thyromimetics
US12590072B2 (en) 2020-06-17 2026-03-31 Autobahn Therapeutics, Inc. Thyromimetics
US20240287054A1 (en) 2021-06-09 2024-08-29 The U.S.A., As Represented By The Secretary, Department Of Health And Human Services Compounds that bind non-canonical g-quadruplex structures and methods of making and using the same
WO2023059867A1 (en) 2021-10-08 2023-04-13 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Compounds for treating or preventing alzheimer's disease
US12325688B2 (en) 2022-01-25 2025-06-10 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Gingerenone A prodrugs as sensotherapeutics and methods of use
WO2023177568A1 (en) 2022-03-14 2023-09-21 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Cannabinoid receptor modulating compounds
WO2024151855A1 (en) 2023-01-13 2024-07-18 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Bicyclic carbamoyl pyridone-based integrase strand transfer inhibitors
WO2025196270A1 (en) 2024-03-22 2025-09-25 Limmatech Biologics Ag Outer membrane vesicle vaccines for the prevention of n. gonorrhoeae and methods of making and using thereof
WO2025213007A1 (en) 2024-04-04 2025-10-09 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services S-hydroxychloroquine, optionally with tauroursodeoxycholic acid and/or 3,3'-diindolylmethane, for treating and/or preventing neurological disorders
WO2026085231A1 (en) 2024-10-16 2026-04-23 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Integrase strand transfer inhibitors
CN119979043A (zh) * 2025-04-15 2025-05-13 南京斯瑞奇医疗用品有限公司 一种双层复合的高透气性低敏胶带及其制备方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1995970A (en) * 1931-04-04 1935-03-26 Du Pont Polymeric lactide resin
US2362511A (en) * 1939-11-21 1944-11-14 Du Pont Modified glycolide resins
US2438208A (en) * 1943-07-10 1948-03-23 Us Agriculture Continuous process of converting lactic acid to polylactic acid
US2683136A (en) * 1950-10-25 1954-07-06 Du Pont Copolymers of hydroxyacetic acid with other alcohol acids
US2703316A (en) * 1951-06-05 1955-03-01 Du Pont Polymers of high melting lactide
US2758987A (en) * 1952-06-05 1956-08-14 Du Pont Optically active homopolymers containing but one antipodal species of an alpha-monohydroxy monocarboxylic acid
US3531561A (en) * 1965-04-20 1970-09-29 Ethicon Inc Suture preparation
US3498957A (en) * 1965-09-14 1970-03-03 Ethicon Inc Polymerization of cyclic carboxylic esters in the presense of a nonpolymerizable ester plasticizer
US3468853A (en) * 1966-06-15 1969-09-23 American Cyanamid Co Process of polymerizing a glycolide
BE758156R (fr) * 1970-05-13 1971-04-28 Ethicon Inc Element de suture absorbable et sa
US3839297A (en) * 1971-11-22 1974-10-01 Ethicon Inc Use of stannous octoate catalyst in the manufacture of l(-)lactide-glycolide copolymer sutures
US4137921A (en) * 1977-06-24 1979-02-06 Ethicon, Inc. Addition copolymers of lactide and glycolide and method of preparation
US4273920A (en) * 1979-09-12 1981-06-16 Eli Lilly And Company Polymerization process and product
IE52535B1 (en) * 1981-02-16 1987-12-09 Ici Plc Continuous release pharmaceutical compositions

Also Published As

Publication number Publication date
EP0171907B1 (de) 1989-01-11
DE3567471D1 (en) 1989-02-16
DE3567470D1 (en) 1989-02-16
CA1236641A (en) 1988-05-10
CA1256638A (en) 1989-06-27
US4683288A (en) 1987-07-28
US4677191A (en) 1987-06-30
ATE39936T1 (de) 1989-01-15
HK19592A (en) 1992-03-20
EP0172636A1 (de) 1986-02-26
EP0172636B2 (de) 1992-11-11
BG61520B2 (bg) 1997-10-31
EP0171907B2 (de) 1994-08-10
EP0172636B1 (de) 1989-01-11
EP0171907A1 (de) 1986-02-19
SG108191G (en) 1992-06-12

Similar Documents

Publication Publication Date Title
ATE39935T1 (de) Copolymer und verfahren zu seiner herstellung.
BE1002656A5 (fr) Matieres regeneratrices du perioste dentaire.
US4379138A (en) Biodegradable polymers of lactones
DE59305882D1 (de) Mitogenfreie substanz, deren herstellung sowie verwendung
ATE250663T1 (de) Kulturmedium und verfahren zur herstellung von hyaluronsäure mit hohem molekulargewicht
ES485450A1 (es) Procedimiento de preparacion de agentes de tratamiento de fibras queratinicas
TW333548B (en) Melt-stable lactide polymer composition and process for manufacture thereof
JPH0613602B2 (ja) ｄ▲ｌ▼−乳酸−グリコール酸共重合物の製造方法
PT87455B (pt) Processo para a preparacao de aplicadores biodegradaveis para tampoes higienicos e aplicadores biodegradaveis produzidos por esse processo
JPS5645920A (en) Copolymer by polymerization of glycolic acid and lactic acid
DE3886906D1 (de) Herstellung von wässerigen Fluor-Polymerzusammensetzungen.
EP0399827A3 (de) Modifizierte Polyester-Zusammensetzung, Verfahren zu deren Herstellung und deren Verwendung
SE9100610D0 (sv) Bioresorbable material for medical use
ATE145830T1 (de) Weicher elastischer und bioabsorbierbarer film aus milchsäurepolymer, insbesondere verwendbar zur herstellung von medizinischen verbänden
HUT66370A (en) Polymers containing diester units and process for producing thereof
NO179505C (no) Fremgangsmåte for fremstilling av en syntetisk ekstracellulær matriks
ATE79888T1 (de) Hydroxylgruppenhaltige copolymerisate auf der basis von vinylester-, vinylaromat- und hydroxylalkylester-monomeren, verfahren zu ihrer herstellung sowie ihre verwendung in beschichtungsmitteln.
DE69703616D1 (de) Zeitweilig nassfeste polymere aus oxidiertem umsetzungsprodukt von polyhydroxypolymer und 1,2 disubstituiertem carbonsäure-alkene
DE3855968D1 (de) Welan-Gummi von niedriger Viskosität, Verfahren zu seiner Herstellung und seiner Verwendung in Zementzusammensetzungen.
DE59101881D1 (de) Verfahren zur herstellung von polyacrylsäuren.
DE60034568D1 (de) Zusammensetzungen mit verzögerter freigabe, verfahren zu deren herstellung und verwendung
KR910009241A (ko) 치근막 질환 치료용 서방성 조성물
ATE274013T1 (de) Verfahren zur polymerisation von lactid
DE3766751D1 (de) Dispersionspolymere, verfahren zu ihrer herstellung und ihre verwendung.
ATE29386T1 (de) Verwendung eines sulfonierten homo- oder copolymeren des styrols zur herstellung eines antikonzeptionsmittels.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
UEP Publication of translation of european patent specification
EELA Cancelled due to lapse of time