ATE400660T1 - Vektoren für genmutagenese und genentdeckung - Google Patents
Vektoren für genmutagenese und genentdeckungInfo
- Publication number
- ATE400660T1 ATE400660T1 AT99914126T AT99914126T ATE400660T1 AT E400660 T1 ATE400660 T1 AT E400660T1 AT 99914126 T AT99914126 T AT 99914126T AT 99914126 T AT99914126 T AT 99914126T AT E400660 T1 ATE400660 T1 AT E400660T1
- Authority
- AT
- Austria
- Prior art keywords
- gene
- vectors
- discovery
- mutagenesis
- novel
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1051—Gene trapping, e.g. exon-, intron-, IRES-, signal sequence-trap cloning, trap vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16041—Use of virus, viral particle or viral elements as a vector
- C12N2740/16043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/60—Vectors containing traps for, e.g. exons, promoters
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
- C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/44—Vectors comprising a special translation-regulating system being a specific part of the splice mechanism, e.g. donor, acceptor
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Virology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Bioinformatics & Computational Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7972998P | 1998-03-27 | 1998-03-27 | |
| US09/057,328 US6080576A (en) | 1998-03-27 | 1998-04-08 | Vectors for gene trapping and gene activation |
| US8172798P | 1998-04-14 | 1998-04-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE400660T1 true ATE400660T1 (de) | 2008-07-15 |
Family
ID=27369230
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99914126T ATE400660T1 (de) | 1998-03-27 | 1999-03-26 | Vektoren für genmutagenese und genentdeckung |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP1066392B1 (de) |
| JP (1) | JP3725782B2 (de) |
| AT (1) | ATE400660T1 (de) |
| AU (1) | AU751520B2 (de) |
| CA (1) | CA2323834C (de) |
| DE (1) | DE69939056D1 (de) |
| DK (1) | DK1066392T3 (de) |
| WO (1) | WO1999050426A1 (de) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7332338B2 (en) | 1996-10-04 | 2008-02-19 | Lexicon Pharmaceuticals, Inc. | Vectors for making genomic modifications |
| US6740503B1 (en) | 1997-09-26 | 2004-05-25 | Athersys, Inc. | Compositions and methods for non-targeted activation of endogenous genes |
| US6897066B1 (en) | 1997-09-26 | 2005-05-24 | Athersys, Inc. | Compositions and methods for non-targeted activation of endogenous genes |
| AU772677B2 (en) * | 1998-03-27 | 2004-05-06 | Lexicon Pharmaceuticals, Inc. | Vectors for gene mutagenesis and gene discovery |
| US6436707B1 (en) | 1998-03-27 | 2002-08-20 | Lexicon Genetics Incorporated | Vectors for gene mutagenesis and gene discovery |
| US6808921B1 (en) | 1998-03-27 | 2004-10-26 | Lexicon Genetics Incorporated | Vectors for gene mutagenesis and gene discovery |
| AU2004203361B2 (en) * | 1998-03-27 | 2007-05-10 | Lexicon Pharmaceuticals, Inc. | Vectors for gene mutagenesis and gene discovery by gene trapping |
| AU5470399A (en) | 1998-08-10 | 2000-03-06 | Lexicon Genetics Incorporated | Construction of normalized cdna libraries from eucaryotic cells |
| EP1584689A1 (de) * | 1998-11-20 | 2005-10-12 | Lexicon Genetics Incorporated | Vektoren für die Gen-Mutagenese und die Entdeckung von Genen |
| WO2000049162A2 (en) * | 1999-02-19 | 2000-08-24 | Athersys, Inc. | Compositions and methods for non-targeted activation of endogenous genes |
| ATE460492T1 (de) | 1999-07-14 | 2010-03-15 | Transgenic Inc | ßGEN-FALLEN-VEKTORß UND VERFAHREN ZUM ßEINFANGENß VON GENEN MITTELS DIESES VEKTORS |
| EP1092768A1 (de) * | 1999-10-16 | 2001-04-18 | ARTEMIS Pharmaceuticals GmbH | Konstrukt zum bedingten einfangen und Disruption von Genen |
| US6897020B2 (en) | 2000-03-20 | 2005-05-24 | Newlink Genetics Inc. | Methods and compositions for elucidating relative protein expression levels in cells |
| CA2403567A1 (en) * | 2000-03-20 | 2001-09-27 | Newlink Genetics | Methods and compositions for elucidating protein expression profiles in cells |
| GB0018876D0 (en) | 2000-08-01 | 2000-09-20 | Applied Research Systems | Method of producing polypeptides |
| US7449179B2 (en) | 2000-11-16 | 2008-11-11 | Cornell Research Foundation, Inc. | Vectors for conditional gene inactivation |
| US20020094536A1 (en) * | 2000-12-28 | 2002-07-18 | Cell Therapeutics, Inc. | Methods for making polynucleotide libraries, polynucleotide arrays, and cell libraries for high-throughput genomics analysis |
| ATE406094T1 (de) * | 2001-03-28 | 2008-09-15 | Dana Farber Cancer Inst Inc | Identifizierung und charakterisierung von genen |
| MXPA04001725A (es) | 2001-08-24 | 2005-04-11 | Advanced Cell Tech Inc | ANáLISIS DE SELECCION PARA IDENTIFICAR AGENTES INDUCTORES DE DIFERENCIACION Y PRODUCCION DE CELULAS DIFERENCIADAS PARA TERAPIA CELULAR. |
| US20040091936A1 (en) | 2002-05-24 | 2004-05-13 | Michael West | Bank of stem cells for producing cells for transplantation having HLA antigens matching those of transplant recipients, and methods for making and using such a stem cell bank |
| US7205148B2 (en) * | 2003-06-11 | 2007-04-17 | Regeneron Pharmaceuticals, Inc. | Genome mutation by intron insertion into an embryonic stem cell genome |
| KR100747381B1 (ko) * | 2006-01-20 | 2007-08-07 | 미쓰비시덴키 가부시키가이샤 | 엘리베이터의 그룹 관리 제어 장치 |
| JP4867012B2 (ja) * | 2007-03-22 | 2012-02-01 | 国立大学法人群馬大学 | レトロウイルス産生用ベクター |
| EP2318527A4 (de) * | 2008-07-30 | 2012-07-04 | Michael Strathmann | Gen-targeting-verfahren |
| CN112824529B (zh) * | 2019-11-21 | 2022-09-09 | 北京大学 | 一种条件性基因敲除或者拯救方法 |
| US20230287458A1 (en) * | 2020-07-14 | 2023-09-14 | Abeona Therapeutics Inc. | Recombinant adeno-associated viral vectors for multipartite gene delivery |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0920508A1 (de) * | 1996-08-23 | 1999-06-09 | Chiron Corporation | Menschliches polyhomeotisch 1 (hph1) wirkt wie ein oncogen |
| US6207371B1 (en) * | 1996-10-04 | 2001-03-27 | Lexicon Genetics Incorporated | Indexed library of cells containing genomic modifications and methods of making and utilizing the same |
-
1999
- 1999-03-26 AU AU32036/99A patent/AU751520B2/en not_active Ceased
- 1999-03-26 WO PCT/US1999/006474 patent/WO1999050426A1/en not_active Ceased
- 1999-03-26 DK DK99914126T patent/DK1066392T3/da active
- 1999-03-26 EP EP99914126A patent/EP1066392B1/de not_active Expired - Lifetime
- 1999-03-26 AT AT99914126T patent/ATE400660T1/de not_active IP Right Cessation
- 1999-03-26 CA CA002323834A patent/CA2323834C/en not_active Expired - Fee Related
- 1999-03-26 DE DE69939056T patent/DE69939056D1/de not_active Expired - Lifetime
- 1999-03-26 JP JP2000541314A patent/JP3725782B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO1999050426A1 (en) | 1999-10-07 |
| EP1066392A1 (de) | 2001-01-10 |
| JP2002509727A (ja) | 2002-04-02 |
| CA2323834C (en) | 2009-01-27 |
| AU3203699A (en) | 1999-10-18 |
| AU751520B2 (en) | 2002-08-15 |
| DK1066392T3 (da) | 2008-08-25 |
| DE69939056D1 (de) | 2008-08-21 |
| EP1066392B1 (de) | 2008-07-09 |
| CA2323834A1 (en) | 1999-10-07 |
| JP3725782B2 (ja) | 2005-12-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |