ATE406094T1 - Identifizierung und charakterisierung von genen - Google Patents

Identifizierung und charakterisierung von genen

Info

Publication number
ATE406094T1
ATE406094T1 AT02757850T AT02757850T ATE406094T1 AT E406094 T1 ATE406094 T1 AT E406094T1 AT 02757850 T AT02757850 T AT 02757850T AT 02757850 T AT02757850 T AT 02757850T AT E406094 T1 ATE406094 T1 AT E406094T1
Authority
AT
Austria
Prior art keywords
characterization
genes
identification
methods
phenotypes
Prior art date
Application number
AT02757850T
Other languages
English (en)
Inventor
Ronald Depinho
Lynda Chin
Original Assignee
Dana Farber Cancer Inst Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dana Farber Cancer Inst Inc filed Critical Dana Farber Cancer Inst Inc
Application granted granted Critical
Publication of ATE406094T1 publication Critical patent/ATE406094T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0276—Knock-out vertebrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/20—Animal model comprising regulated expression system
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0331—Animal model for proliferative diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0393—Animal model comprising a reporter system for screening tests
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/027—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a retrovirus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Environmental Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Plant Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT02757850T 2001-03-28 2002-03-28 Identifizierung und charakterisierung von genen ATE406094T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US27950601P 2001-03-28 2001-03-28

Publications (1)

Publication Number Publication Date
ATE406094T1 true ATE406094T1 (de) 2008-09-15

Family

ID=23069287

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02757850T ATE406094T1 (de) 2001-03-28 2002-03-28 Identifizierung und charakterisierung von genen

Country Status (11)

Country Link
US (1) US7371515B2 (de)
EP (1) EP1450602B1 (de)
JP (2) JP4170766B2 (de)
AT (1) ATE406094T1 (de)
CA (1) CA2442349C (de)
DE (1) DE60228609D1 (de)
DK (1) DK1450602T3 (de)
ES (1) ES2312607T3 (de)
IL (2) IL158147A0 (de)
NZ (1) NZ529101A (de)
WO (1) WO2002079419A2 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004077942A2 (en) * 2003-02-28 2004-09-16 Genpath Pharmaceuticals, Incorporated Inducible prostate cancer model
WO2004089073A2 (en) * 2003-04-03 2004-10-21 Genpath Pharmaceuticals, Incorporated Inducible breast cancer model
CA2523517C (en) 2003-04-25 2013-07-30 Dana-Farber Cancer Institute, Inc. Bcl2l12 polypeptide activators and inhibitors
JP4733644B2 (ja) * 2003-11-26 2011-07-27 ダナ−ファーバー キャンサー インスティテュート インク． 膵臓腺癌の動物モデルおよびその使用
US9345788B2 (en) 2004-12-07 2016-05-24 Aveo Pharmaceuticals, Inc. Reconstituted human breast tumor model
EP1855522A2 (de) * 2005-01-06 2007-11-21 Aveo Pharmaceuticals, Inc. Zielvalidierungs-testverfahren
US20060222590A1 (en) * 2005-04-05 2006-10-05 Murray Robinson Directed complementation
JP2007306885A (ja) * 2006-05-22 2007-11-29 Mitsubishi Chemicals Corp 新規非ヒト動物
JP2010529834A (ja) * 2007-05-21 2010-09-02 デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド 癌遺伝子の発見のための組成物および方法
US8731956B2 (en) * 2008-03-21 2014-05-20 Signature Genomic Laboratories Web-based genetics analysis
US8954337B2 (en) * 2008-11-10 2015-02-10 Signature Genomic Interactive genome browser
JP6538707B2 (ja) * 2014-03-07 2019-07-03 ユニバーシティ ヘルス ネットワーク 免疫応答を調節するための方法及び組成物
AU2016330612A1 (en) * 2015-09-29 2018-04-26 Celularity Inc. Cell potency assay
US10424397B2 (en) * 2015-12-18 2019-09-24 International Business Machines Corporation Classification and identification of disease genes using biased feature correction

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5919997A (en) 1993-11-18 1999-07-06 Cold Spring Habor Labortary Transgenic mice having modified cell-cycle regulation
US5965440A (en) * 1995-12-07 1999-10-12 The General Hospital Corporation Controlled gene product delivery from a regulatable retroviral vector
DK1066392T3 (da) * 1998-03-27 2008-08-25 Lexicon Pharmaceuticals Inc Vektorer til genmutagenese og gen-discovery
EP1200575A4 (de) * 1999-07-29 2008-03-05 Dana Farber Cancer Inst Inc Induzierbares krebsmodell zur untersuchung der molekularen grundlage von in vivo interaktionen zwischen wirt und tumor

Also Published As

Publication number Publication date
EP1450602A2 (de) 2004-09-01
CA2442349A1 (en) 2002-10-10
DE60228609D1 (de) 2008-10-09
JP2008263987A (ja) 2008-11-06
ES2312607T3 (es) 2009-03-01
WO2002079419A2 (en) 2002-10-10
EP1450602B1 (de) 2008-08-27
EP1450602A4 (de) 2005-03-16
JP4170766B2 (ja) 2008-10-22
JP2004535786A (ja) 2004-12-02
WO2002079419A3 (en) 2004-06-17
DK1450602T3 (da) 2008-11-24
IL158147A (en) 2008-07-08
CA2442349C (en) 2011-10-25
US7371515B2 (en) 2008-05-13
IL158147A0 (en) 2004-03-28
NZ529101A (en) 2008-04-30
US20030003478A1 (en) 2003-01-02

Similar Documents

Publication Publication Date Title
ATE406094T1 (de) Identifizierung und charakterisierung von genen
WO2004063362A3 (en) Cell cycle progression proteins
NO20071127L (no) Triazoloftalaziner
DK1210411T3 (da) Sammensætninger og fremgangsmåder til forbedret celledyrkning
EP0804548A4 (de) Ptc gene und ihre verwendung
EP1644514A4 (de) Temperaturstabile amylase-polypeptide, für diese polypeptide codierende nukleinsäuren und verwendungen davon
DE60330841D1 (de) Überexpression von extremozymgenen in pseudomonas und nahe verwandte bakterien
DE60235005D1 (de) Nachweis der instabilität von mikrosatelliten und
DK1379671T3 (da) Fremgangsmåder til dyrkning af circovirus
ATE295888T1 (de) Genfallen-konstrukt zur identifizierung und isolierung von genen
WO2004099422A3 (en) Adenovirus particles with enhanced infectivity of dendritic cells and particles with decreased infectivity of hepatocytes
DE60033918D1 (de) Polysubstituted 6-phenylphenanthridines mit pde-iv hemmender wirkung
DE60017141D1 (de) Replikationskompetente anti-tumor vektoren
ATE294793T1 (de) Phenantrhridin-n-oxides mit pde-iv hemmender wirkung
ATE315029T1 (de) 6-arylphenanthridine mit pde-iv hemmender wirkung
TR200003695T2 (tr) Anjiyostatin bağlayıcı protein.
DE60039306D1 (de) Nonapeptidische ny-eso-1 derivate und deren verwendung
AU302605S (en) Aquarium
NO20040174L (no) Fremgangsmate for donorspesifikk krysstilpasning
EP1639109A4 (de) Dna-vektoren
ATE508130T1 (de) 3-oxa-10-aza-phenanthrene als pde4- oder pde3/4- inhibitoren
WO2004096991A3 (en) Bcl2l12 polypeptide activators and inhibitors
DE69936234D1 (de) Verfahren und Zusammenstzung zur Hemmung des Wachtums von neoplastischen Zellen
WO2003016839A3 (en) Modified railroad worm red luciferase coding sequences
ATE402258T1 (de) Gene differentiell experimiert in brudtkrebs

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties