ATE401054T1 - Flüssige depotformulierungen - Google Patents

Flüssige depotformulierungen

Info

Publication number
ATE401054T1
ATE401054T1 AT05749850T AT05749850T ATE401054T1 AT E401054 T1 ATE401054 T1 AT E401054T1 AT 05749850 T AT05749850 T AT 05749850T AT 05749850 T AT05749850 T AT 05749850T AT E401054 T1 ATE401054 T1 AT E401054T1
Authority
AT
Austria
Prior art keywords
preformulation
low viscosity
parenteral
administration
liquid crystalline
Prior art date
Application number
AT05749850T
Other languages
English (en)
Inventor
Krister Thuresson
Fredrik Tiberg
Markus Johansson
Ian Harwigsson
Fredrik Joabsson
Markus Johnsson
Original Assignee
Camurus Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0412530A external-priority patent/GB0412530D0/en
Priority claimed from GB0500807A external-priority patent/GB0500807D0/en
Priority claimed from GB0507811A external-priority patent/GB0507811D0/en
Application filed by Camurus Ab filed Critical Camurus Ab
Application granted granted Critical
Publication of ATE401054T1 publication Critical patent/ATE401054T1/de

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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1274—Non-vesicle bilayer structures, e.g. liquid crystals, tubules, cubic phases or cochleates; Sponge phases
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    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q3/00—Manicure or pedicure preparations
    • A61Q3/02—Nail coatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/10—General cosmetic use
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59—Mixtures
    • A61K2800/592—Mixtures of compounds complementing their respective functions

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Families Citing this family (116)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007501213A (ja) * 2003-08-04 2007-01-25 カムルス エービー 両親媒性粒子に活性因子を装填する方法
ATE401054T1 (de) 2004-06-04 2008-08-15 Camurus Ab Flüssige depotformulierungen
US20110177169A1 (en) * 2004-07-13 2011-07-21 David Anderson Ophthalmic formulations of reversed liquid crystalline phase materials and methods of using
CN101890167B (zh) * 2004-10-01 2017-03-01 拉姆斯科股份有限公司 可方便植入的缓释药物组合物
SI1845942T1 (sl) 2005-01-14 2014-06-30 Camurus Ab Gnrh analogne formulacije
US8871712B2 (en) 2005-01-14 2014-10-28 Camurus Ab Somatostatin analogue formulations
EP1848403B8 (de) * 2005-01-14 2010-05-19 Camurus Ab Topische bioadhäsive formulierungen
US9649382B2 (en) 2005-01-14 2017-05-16 Camurus Ab Topical bioadhesive formulations
KR101245022B1 (ko) * 2005-01-21 2013-03-19 카무러스 에이비 약제학적 지질 조성물
DK1888031T3 (da) 2005-06-06 2013-02-18 Camurus Ab GLP-1-analogformuleringer
US8852638B2 (en) 2005-09-30 2014-10-07 Durect Corporation Sustained release small molecule drug formulation
US8911751B2 (en) 2005-10-11 2014-12-16 Yissum Research Development Company Of The Hebrew University Of Jerusalem Compositions for nasal delivery
DE202006018609U1 (de) 2006-08-29 2007-05-16 Euro-Celtique S.A. Verwendung von Opioidformulierungen in nadellosen Vorrichtungen zur Medikamentenverabreichung
CZ2006697A3 (cs) * 2006-11-07 2008-05-21 Zentiva, A. S. Kompozice depotních olanzapinových injekcních systému
US8530463B2 (en) 2007-05-07 2013-09-10 Hale Biopharma Ventures Llc Multimodal particulate formulations
JP2010531807A (ja) 2007-05-25 2010-09-30 トルマー セラピューティクス， インコーポレイテッド リスペリドン化合物の徐放送達製剤
GB0711656D0 (en) * 2007-06-15 2007-07-25 Camurus Ab Formulations
AU2015227534B2 (en) * 2007-06-15 2017-02-23 Camurus Ab Peptide slow-release formulations
GB0716385D0 (en) 2007-08-22 2007-10-03 Camurus Ab Formulations
US8946208B2 (en) 2007-08-31 2015-02-03 Archimedes Development Limited Non-aqueous pharmaceutical composition
WO2009046444A2 (en) * 2007-10-05 2009-04-09 Mdrna, Inc. Formulation for intranasal administration of diazepam
EP2052716B1 (de) 2007-10-24 2014-12-31 Camurus AB Formulierungen mit gesteuerter Freisetzung
EP2209908B1 (de) * 2007-11-01 2014-09-03 University Of Rochester Rekombinanter faktor viii mit erhöhter stabilität
WO2009070829A1 (en) * 2007-12-05 2009-06-11 Krius Pty Ltd Non-aqueous oil-based fentanyl compositions for transmucosal administration
ES2586032T3 (es) * 2008-03-28 2016-10-11 Hale Biopharma Ventures, Llc Administración de composiciones de benzodiazepinas
CA2730340C (en) 2008-07-14 2017-02-07 Polypid Ltd. Sustained-release drug carrier composition
GB0815435D0 (en) 2008-08-22 2008-10-01 Camurus Ab Formulations
US8741930B2 (en) * 2008-10-24 2014-06-03 Bridge Pharma, Inc. Treating xerophthalmia with norketotifen
WO2010059894A1 (en) * 2008-11-21 2010-05-27 Bridge Pharma, Inc. Ocular formulations of norketotifen
WO2010135731A1 (en) * 2009-05-22 2010-11-25 Kaufman Herbert E Preparations and methods for ameliorating or reducing presbyopia
US8299079B2 (en) 2009-05-22 2012-10-30 Kaufman Herbert E Preparations and methods for ameliorating or reducing presbyopia
CN105126179B (zh) * 2009-07-14 2018-09-25 波利皮得有限公司 持续释放药物载体组合物
WO2011011675A1 (en) * 2009-07-23 2011-01-27 Zelos Therapeutics, Inc. Pharmaceutically acceptable formulations/compositions for peptidyl drugs
US20130236448A1 (en) * 2009-08-04 2013-09-12 F. Hoffmann-La Roche Ag (Roche Glycart Ag) Concentrated polypeptide formulations with reduced viscosity
JP5860409B2 (ja) 2010-01-19 2016-02-16 ポリピッド リミテッド 徐放性核酸マトリックス組成物
US9272044B2 (en) 2010-06-08 2016-03-01 Indivior Uk Limited Injectable flowable composition buprenorphine
GB2513060B (en) 2010-06-08 2015-01-07 Rb Pharmaceuticals Ltd Microparticle buprenorphine suspension
SG187770A1 (en) 2010-08-12 2013-03-28 Univ Nanyang Tech A liposomal formulation for ocular drug delivery
JP5877843B2 (ja) * 2010-10-22 2016-03-08 ドクター レディズ ラボラトリーズ， インコーポレイテッド 創傷を処置するための保存に安定した粘性リン脂質デポーの使用
US20140088199A1 (en) * 2011-04-05 2014-03-27 Optosolve Llp Ophthalmic treatments
WO2012142273A1 (en) 2011-04-12 2012-10-18 Revogenex Inc. Intravenous administration of tramadol
US9592243B2 (en) 2011-04-25 2017-03-14 Warsaw Orthopedic, Inc. Medical devices and methods comprising an anabolic agent for treatment of an injury
US9511077B2 (en) 2011-04-25 2016-12-06 Warsaw Orthopedic, Inc. Medical devices and methods comprising an anabolic agent for wound healing
PE20141484A1 (es) 2011-05-25 2014-10-31 Camurus Ab Formulaciones peptidicas de liberacion controlada
WO2012160212A1 (en) 2011-05-25 2012-11-29 Camurus Ab Peptide controlled-release formulations
CN103796656A (zh) 2011-06-14 2014-05-14 哈尔生物药投资有限责任公司 苯二氮卓的投与
KR101494594B1 (ko) 2011-08-30 2015-02-23 주식회사 종근당 약리학적 활성물질의 서방성 지질 초기제제 및 이를 포함하는 약제학적 조성물
BR112014013693B1 (pt) * 2011-12-05 2023-01-31 Camurus Ab Pré-formulação, e, uso de uma pré-formulação
TW201336526A (zh) * 2012-01-31 2013-09-16 參天製藥股份有限公司 非水性液體組成物
MX2014011855A (es) 2012-04-17 2016-09-09 Purdue Pharma Lp Sistemas y metodos para tratar una respuesta farmacodinamica adversa inducida por opioides.
CA2871821C (en) 2012-05-10 2021-01-12 Painreform Ltd. Depot formulations of a local anesthetic and methods for preparation thereof
ES2834318T3 (es) 2012-05-25 2021-06-17 Camurus Ab Formulaciones de agonistas de receptores de la somatostatina
PL4512390T1 (pl) * 2012-06-01 2025-09-01 Ferring B.V. Wytwarzanie degareliksu
EP3045162B1 (de) 2012-07-26 2021-07-07 Camurus AB Opioid-formulierungen
SG11201500554XA (en) 2012-07-26 2015-02-27 Camurus Ab Opioid formulations
FR2994390B1 (fr) 2012-08-10 2014-08-15 Adocia Procede d'abaissement de la viscosite de solutions de proteines a concentration elevee
TWI523863B (zh) 2012-11-01 2016-03-01 艾普森藥品公司 體抑素－多巴胺嵌合體類似物
CN104768565B (zh) 2012-11-01 2017-04-26 益普生制药股份有限公司 促生长素抑制素类似物及其二聚体
KR101586789B1 (ko) * 2012-12-28 2016-01-19 주식회사 종근당 양이온성 약리학적 활성물질의 서방성 지질 초기제제 및 이를 포함하는 약제학적 조성물
KR101586790B1 (ko) * 2012-12-28 2016-01-19 주식회사 종근당 음이온성 약리학적 활성물질의 서방성 지질 초기제제 및 이를 포함하는 약제학적 조성물
KR101586791B1 (ko) * 2012-12-28 2016-01-19 주식회사 종근당 ＧｎＲＨ 유도체의 서방성 지질 초기제제 및 이를 포함하는 약제학적 조성물
KR101601035B1 (ko) 2013-02-28 2016-03-08 주식회사 종근당 키토산 및 액상결정 형성 물질을 포함하는 유전자 전달용 조성물
US9956195B2 (en) 2014-01-07 2018-05-01 Nanyang Technological University Stable liposomal formulations for ocular drug delivery
US11547446B2 (en) 2014-01-13 2023-01-10 Trice Medical, Inc. Fully integrated, disposable tissue visualization device
US10545388B2 (en) 2014-01-31 2020-01-28 Hewlett-Packard Development Company, L.P. Display device
GB201404139D0 (en) * 2014-03-10 2014-04-23 Rb Pharmaceuticals Ltd Sustained release buprenorphine solution formulations
CN106456704A (zh) 2014-04-16 2017-02-22 Veyx-药物有限公司 兽药组合物和其应用
KR101809908B1 (ko) * 2014-07-21 2018-01-25 주식회사 종근당 5-알파환원효소억제제를 포함하는 조성물
GB201419091D0 (en) 2014-10-27 2014-12-10 Camurus Ab Formulations
AU2015341490C1 (en) 2014-11-07 2021-03-11 Indivior Uk Limited Buprenorphine dosing regimens
CA2971642A1 (en) * 2014-12-23 2016-06-30 Camurus Ab Controlled-release formulations
GB201516554D0 (en) * 2015-09-18 2015-11-04 Camurus Ab Controlled-release formulations
EP3352735B1 (de) 2015-09-21 2023-08-30 Teva Pharmaceuticals International GmbH Olanzapinformulierungen mit verzögerter freisetzung
US9980900B2 (en) 2015-12-22 2018-05-29 Revogenex Ireland Ltd Intravenous administration of tramadol
US9693949B1 (en) 2015-12-22 2017-07-04 Revogenex Ireland Ltd Intravenous administration of tramadol
US10022321B2 (en) 2016-06-30 2018-07-17 Revogenex Ireland Ltd. Intravenous administration of tramadol
PL3512518T3 (pl) 2016-09-13 2023-03-27 Alar Pharmaceuticals Inc. Preparaty buprenorfiny o przedłużonym uwalnianiu
WO2018050864A1 (en) * 2016-09-15 2018-03-22 Camurus Ab Prostacyclin analogue formulations
AU2017336199B2 (en) * 2016-09-27 2020-08-20 Camurus Ab Mixtures and formulations comprising an alkyl ammonium EDTA salt
AU2018238136A1 (en) 2017-03-20 2019-11-07 Teva Pharmaceuticals International Gmbh Sustained release olanzapine formulations
EP3612166A4 (de) 2017-04-20 2020-11-04 Zeenar Enterprises Pty Ltd Flüssigkristalline darreichungsform zur verabreichung eines statins
AU2018255718A1 (en) 2017-04-20 2019-12-05 Zeenar Enterprises Pty Ltd Fast disintegrating tablet
EP3638240A2 (de) 2017-06-16 2020-04-22 Indivior UK Limited Verfahren zur behandlung einer opioidkonsumstörung
US10646484B2 (en) 2017-06-16 2020-05-12 Indivior Uk Limited Methods to treat opioid use disorder
CN107308024A (zh) * 2017-06-23 2017-11-03 上海利康消毒高科技有限公司 鼠尾草精油口腔护理凝胶及制备方法
EP3421485A1 (de) 2017-06-30 2019-01-02 Université de Strasbourg Peptide zur behandlung und prävention von hyperglykämie
EP3437651A1 (de) 2017-08-03 2019-02-06 Université de Strasbourg Peptide zur behandlung und vorbeugung von nichtalkoholischer fettlebererkrankung
EP3710041A4 (de) * 2017-11-15 2021-08-18 Rhythm Pharmaceuticals, Inc. Peptidformulierungen mit verzögerter freisetzung
CN111432829B (zh) 2017-12-14 2023-07-14 斯特拉斯堡大学 用于治疗和预防非酒精性脂肪肝病和纤维化的肽
CN112236142A (zh) * 2018-01-22 2021-01-15 逸达生物科技股份有限公司 用于缓释递送丁丙诺啡的药物组合物
CN108295045B (zh) * 2018-03-16 2020-02-11 武汉百纳礼康生物制药有限公司 一种液晶凝胶微囊及其制备方法
WO2019182745A1 (en) 2018-03-19 2019-09-26 Bryn Pharma, LLC Epinephrine spray formulations
WO2019204729A1 (en) * 2018-04-19 2019-10-24 Worcester Polytechnic Institute Compositions and methods for skin treatments
CA3097926A1 (en) * 2018-05-01 2019-11-07 Chibi, Inc. Eye drop formulation and method for sustained delivery of medicament to the retina
EP3787611A4 (de) 2018-05-01 2022-03-09 Chibi, Inc. Flüssiges depot zur nichtinvasiven verzögerten verabreichung von wirkstoffen an das auge
EP3790881A4 (de) 2018-05-11 2022-03-09 Alar Pharmaceuticals Inc. Langwirkende injizierbare formulierungen und kristalline formen von buprenorphinderivaten
US11103619B2 (en) * 2018-08-30 2021-08-31 Efstathios-Andreas AGATHOS Anticalcification treatment for impantable biological tissues using calcitonin
AU2019357036B2 (en) 2018-10-11 2024-11-14 Indivior Uk Limited Buprenorphine to treat respiratory depression
CN109498547B (zh) * 2018-12-20 2022-04-12 武汉科福新药有限责任公司 一种平阳霉素局部注射制剂及其制备方法
DK3897697T5 (da) 2018-12-21 2024-08-05 Univ Strasbourg Peptider til behandling og forebyggelse af diabetes og forbundne lidelser
KR102186704B1 (ko) 2019-02-18 2020-12-04 (주)아이엠디팜 서방성 지질 전구 제제 및 이를 포함하는 지질 용액 형태의 서방성 주사용 약학 조성물
BR112021018439A2 (pt) 2019-03-18 2021-11-23 Sunstar Americas Inc Composição para higiene bucal
CN111904928A (zh) * 2019-05-07 2020-11-10 江苏恒瑞医药股份有限公司 一种包含布托啡诺的可注射的药物组合物及其制备方法
JP7752051B2 (ja) * 2019-05-24 2025-10-09 デクラ ベテリナリー プロダクツ リミテッド ライアビリティー カンパニー 長時間作用型注射用製剤およびその使用
MX2021014450A (es) 2019-05-29 2022-01-06 Camurus Ab Composiciones de liberacion controlada de lipidos.
WO2020240018A1 (en) 2019-05-29 2020-12-03 Camurus Ab Administration device & regime
WO2021043771A1 (en) 2019-09-02 2021-03-11 Camurus Ab Formulations and treatment methods
WO2021072027A1 (en) * 2019-10-08 2021-04-15 Hallux Inc. Onychomycosis treatment compositions and methods
JP2021059680A (ja) 2019-10-08 2021-04-15 花王株式会社 液晶組成物
CN113797167B (zh) * 2020-06-16 2024-05-10 苏州恩华生物医药科技有限公司 一种塞纳布啡的储库制剂
AU2021299156C1 (en) 2020-06-30 2025-02-06 Chong Kun Dang Pharmaceutical Corp. Injectable composition comprising GnRH analogue
EP4277661A1 (de) 2021-01-18 2023-11-22 Anton Frenkel Pharmazeutische darreichungsform
JP7670390B2 (ja) 2021-04-08 2025-04-30 ティオンラボ・セラピューティクス 徐放性脂質前駆製剤
CN118284414A (zh) 2021-07-06 2024-07-02 M·哈斯莱顿 血清素再摄取抑制剂戒断综合征的治疗
CN117999079A (zh) * 2021-08-20 2024-05-07 苏州恩华生物医药科技有限公司 一种包含塞纳布啡的药物组合物
KR20250110749A (ko) 2024-01-12 2025-07-21 주식회사 티온랩테라퓨틱스 소르비탄 포화지방산을 포함하는 서방성 지질 전구 제제 및 이의 제조방법

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4610868A (en) * 1984-03-20 1986-09-09 The Liposome Company, Inc. Lipid matrix carriers for use in drug delivery systems
US4938763B1 (en) * 1988-10-03 1995-07-04 Atrix Lab Inc Biodegradable in-situ forming implants and method of producing the same
MY107937A (en) * 1990-02-13 1996-06-29 Takeda Chemical Industries Ltd Prolonged release microcapsules.
WO1994009898A1 (de) * 1992-10-26 1994-05-11 Schwarz Pharma Ag Verfahren zur herstellung von mikrokapseln
DK0729351T3 (da) * 1993-11-16 2000-10-16 Skyepharma Inc Vesikler med reguleret afgivelse af aktivstoffer
ES2135723T3 (es) * 1994-03-30 1999-11-01 Gs Dev Ab Uso de esteres de acidos grasos como sustancias bioadhesivas.
DK0754032T3 (da) * 1994-04-08 2002-04-02 Atrix Lab Inc Flydende frigivelsessammensætninger
SE518578C2 (sv) 1994-06-15 2002-10-29 Gs Dev Ab Lipidbaserad komposition
DE19536244A1 (de) * 1994-09-30 1996-04-04 Juergen Dr Regenold Pharmazeutische Zusammensetzung zur lokalen Applikation
FR2726762B1 (fr) * 1994-11-10 1997-01-17 Oreal Composition cosmetique ou dermatologique sous forme d'une dispersion d'une phase huileuse dans une phase aqueuse stabilisee a l'aide de particules de gel cubique et son procede d'obtention
US5931809A (en) * 1995-07-14 1999-08-03 Depotech Corporation Epidural administration of therapeutic compounds with sustained rate of release
JPH11513393A (ja) * 1995-10-12 1999-11-16 ジーエス ディベロップメント エービー 皮膚又は粘膜表面へのもしくは介する活性物質の投与用医薬組成物
EP0839525B1 (de) * 1996-10-31 2004-08-04 Takeda Chemical Industries, Ltd. Zubereitung mit verzögerter Freisetzung
SE511313C2 (sv) * 1997-01-13 1999-09-06 Gs Dev Ab Komposition med reglerad frisättning innefattande fettsyraester av diacylglycerol
US7160898B2 (en) * 2001-12-14 2007-01-09 Board Of Trustees Of The University Of Illinois Pharmacological treatment for sleep apnea
BE1011899A6 (fr) * 1998-04-30 2000-02-01 Ucb Sa Compositions pharmaceutiques gelifiables utilisables.
TWI241915B (en) * 1998-05-11 2005-10-21 Ciba Sc Holding Ag A method of preparing a pharmaceutical end formulation using a nanodispersion
SE9802528D0 (sv) * 1998-07-13 1998-07-13 Gs Dev Ab Bone tissue restoring composition
US6143314A (en) * 1998-10-28 2000-11-07 Atrix Laboratories, Inc. Controlled release liquid delivery compositions with low initial drug burst
JP3952617B2 (ja) * 1998-12-11 2007-08-01 株式会社日立製作所 内燃機関の排ガス浄化装置，排ガス浄化方法及び排ガス浄化触媒
US6716449B2 (en) * 2000-02-08 2004-04-06 Euro-Celtique S.A. Controlled-release compositions containing opioid agonist and antagonist
JP4659943B2 (ja) * 2000-02-25 2011-03-30 帝三製薬株式会社 塩酸ブプレノルフィン含有貼付剤
US6455066B1 (en) * 2000-03-10 2002-09-24 Epicept Corporation Intradermal-penetration agents for topical local anesthetic administration
US6495164B1 (en) * 2000-05-25 2002-12-17 Alkermes Controlled Therapeutics, Inc. I Preparation of injectable suspensions having improved injectability
US6936187B2 (en) * 2001-02-21 2005-08-30 Matthew Lawrence Lynch Functionalized cubic liquid crystalline phase materials and methods for their preparation and use
US6656385B2 (en) * 2001-02-21 2003-12-02 The Procter & Gamble Company Functionalized cubic liquid crystalline phase materials and methods for their preparation and use
WO2002087543A1 (en) * 2001-05-01 2002-11-07 Biozone Laboratories, Inc. Sustained release formulations for nifedipine, dextromethorphan, and danazol
US20030044458A1 (en) * 2001-08-06 2003-03-06 Curtis Wright Oral dosage form comprising a therapeutic agent and an adverse-effect agent
US20040022820A1 (en) * 2001-11-28 2004-02-05 David Anderson Reversed liquid crystalline phases with non-paraffin hydrophobes
AU2003240493B2 (en) * 2002-05-31 2008-06-12 L. Molteni & C. Dei Fratelli Alitti Societa' Di Esercizio S.P.A. Implantable polymeric device for sustained release of buprenorphine
US20030232340A1 (en) * 2002-06-13 2003-12-18 David Anderson Nanoporous particle with a retained target
CA2521420A1 (en) * 2003-04-08 2004-10-28 Progenics Pharmaceuticals, Inc. Combination therapy for constipation comprising a laxative and a peripheral opioid antagonist
EP1682091B1 (de) * 2003-11-07 2017-03-29 Camurus Ab Zusammensetzungen von lipiden und kationischen peptiden
ATE401054T1 (de) * 2004-06-04 2008-08-15 Camurus Ab Flüssige depotformulierungen
SI1845942T1 (sl) * 2005-01-14 2014-06-30 Camurus Ab Gnrh analogne formulacije
DK1888031T3 (da) * 2005-06-06 2013-02-18 Camurus Ab GLP-1-analogformuleringer
PE20141484A1 (es) * 2011-05-25 2014-10-31 Camurus Ab Formulaciones peptidicas de liberacion controlada
BR112014013693B1 (pt) * 2011-12-05 2023-01-31 Camurus Ab Pré-formulação, e, uso de uma pré-formulação
ES2834318T3 (es) * 2012-05-25 2021-06-17 Camurus Ab Formulaciones de agonistas de receptores de la somatostatina
AU2017336199B2 (en) * 2016-09-27 2020-08-20 Camurus Ab Mixtures and formulations comprising an alkyl ammonium EDTA salt
EP4181942A4 (de) * 2020-07-28 2024-10-02 Susavion Biosciences, Inc. Verfahren zur behandlung von neutrophil-gesteuerten entzündlichen erkrankungen

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US20250281407A1 (en) 2025-09-11
ES2309766T3 (es) 2008-12-16
JP2008501676A (ja) 2008-01-24
AU2005249274A1 (en) 2005-12-15
US20230027339A1 (en) 2023-01-26
CN102008728A (zh) 2011-04-13
EP1768650A1 (de) 2007-04-04
US20150064118A1 (en) 2015-03-05
AU2010202794B2 (en) 2011-10-27
US8236292B2 (en) 2012-08-07
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US20140193347A1 (en) 2014-07-10
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US20120269772A1 (en) 2012-10-25
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RU2390331C2 (ru) 2010-05-27
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