ATE401407T1 - Verfahren zur herstellung von cytosin- nukleosidverbindungen - Google Patents

Verfahren zur herstellung von cytosin- nukleosidverbindungen

Info

Publication number: ATE401407T1
Authority: AT; Austria
Prior art keywords: cytosine; producing; cytosine nucleoside; nucleoside compounds; product
Prior art date: 2001-05-01

Application number

AT02253075T

Other languages

English (en)

Inventor

Tadashi Araki

Ichirou Ikeda

Kaori Matoishi

Reiko Abe

Toshihiro Oikawa

Yasuko Matsuba

Hiroki Ishibashi

Kiyoteru Nagahara

Yasushi Fukuiri

Original Assignee

Mitsui Chemicals Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-05-01

Filing date

2002-05-01

Publication date

2008-08-15

2002-05-01 Application filed by Mitsui Chemicals Inc filed Critical Mitsui Chemicals Inc

2008-08-15 Application granted granted Critical

2008-08-15 Publication of ATE401407T1 publication Critical patent/ATE401407T1/de

Links

OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Natural products NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 title abstract 7
229940104302 cytosine Drugs 0.000 title abstract 5
-1 CYTOSINE NUCLEOSIDE COMPOUNDS Chemical class 0.000 title abstract 3
238000004519 manufacturing process Methods 0.000 title abstract 3
239000002777 nucleoside Substances 0.000 title abstract 3
OQRXBXNATIHDQO-UHFFFAOYSA-N 6-chloropyridine-3,4-diamine Chemical compound NC1=CN=C(Cl)C=C1N OQRXBXNATIHDQO-UHFFFAOYSA-N 0.000 abstract 1
241000894006 Bacteria Species 0.000 abstract 1
102000004190 Enzymes Human genes 0.000 abstract 1
108090000790 Enzymes Proteins 0.000 abstract 1
229910019142 PO4 Inorganic materials 0.000 abstract 1
102100036286 Purine nucleoside phosphorylase Human genes 0.000 abstract 1
239000006227 byproduct Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
108010009099 nucleoside phosphorylase Proteins 0.000 abstract 1
239000010452 phosphate Substances 0.000 abstract 1
239000000047 product Substances 0.000 abstract 1
239000000758 substrate Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/38—Nucleosides
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1077—Pentosyltransferases (2.4.2)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/38—Nucleosides
- C12P19/385—Pyrimidine nucleosides

Landscapes

Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Genetics & Genomics (AREA)
Wood Science & Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Biotechnology (AREA)
Molecular Biology (AREA)
General Engineering & Computer Science (AREA)
Microbiology (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Biomedical Technology (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Physics & Mathematics (AREA)
Biophysics (AREA)
Plant Pathology (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Enzymes And Modification Thereof (AREA)
Saccharide Compounds (AREA)

AT02253075T 2001-05-01 2002-05-01 Verfahren zur herstellung von cytosin- nukleosidverbindungen ATE401407T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP2001134352		2001-05-01

Publications (1)

Publication Number	Publication Date
ATE401407T1 true ATE401407T1 (de)	2008-08-15

Family

ID=34131298

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02253075T ATE401407T1 (de)	2001-05-01	2002-05-01	Verfahren zur herstellung von cytosin- nukleosidverbindungen

Country Status (8)

Country	Link
US (2)	US6858721B2 (de)
EP (1)	EP1254959B1 (de)
KR (1)	KR100476294B1 (de)
CN (1)	CN100546997C (de)
AT (1)	ATE401407T1 (de)
BR (1)	BR0203343A (de)
CA (1)	CA2380804A1 (de)
DE (1)	DE60227595D1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE60136209D1 (de) *	2000-11-06	2008-11-27	Mitsui Chemicals Inc	Verfahren zur herstellung einer nukleosidverbindung
CN103509837B (zh) *	2012-06-28	2016-03-09	张金荣	一种酶法复合化学法制备卡培他滨中间体2’，3’-二-o-乙酰基-5’-脱氧-5-氟胞苷的方法
CN103451255B (zh) *	2013-03-28	2016-03-16	南京工业大学	次黄嘌呤核苷酸的生产方法
EP2883959A1 (de)	2013-12-13	2015-06-17	Plasmia Biotech, S.L.	Enzymatische Herstellung von Cytosin-Nukleosidanaloga
US20160312261A1 (en) *	2015-04-24	2016-10-27	Plasmia Biotech, S.L.	Enzymatic production of cytosinic nucleoside analogues
CN105087515B (zh) *	2015-09-10	2018-12-04	江南大学	一种嘌呤核苷磷酸化酶的制备方法及应用
KR101877120B1 (ko) *	2016-07-08	2018-07-11	에스티팜 주식회사	생물전환공정을 이용한 2'-데옥시시티딘의 제조방법
CN108265095B (zh) *	2017-12-13	2020-11-24	东莞理工学院	一种15n稳定性同位素标记5-甲基脱氧胞苷的制备方法
CN114107413B (zh) *	2021-11-03	2023-10-20	江苏香地化学有限公司	一种酶催化胞嘧啶生产胞苷的方法及应用
CN117106680B (zh) *	2022-05-17	2024-02-23	苏州华赛生物工程技术有限公司	一种生产胞嘧啶的重组微生物及方法
CN115011653B (zh) *	2022-07-12	2024-07-30	苏州华赛生物工程技术有限公司	一种生产2′-脱氧胞苷的重组微生物及方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5856779A (ja)	1981-09-24	1983-04-04	高野　政晴	五節リンクロボツト
JPS61135597A (ja) *	1984-12-06	1986-06-23	Takeda Chem Ind Ltd	シチジンおよびデオキシシチジンの製造法
JPH0763385B2 (ja)	1987-07-17	1995-07-12	味の素株式会社	チミジンの製造方法
JPH0789948B2 (ja)	1987-08-28	1995-10-04	味の素株式会社	２▲’▼−デオキシシチジンの製造方法
AU631607B2 (en) *	1989-02-28	1992-12-03	Yamasa Shoyu Kabushiki Kaisha	Production of nucleoside
US5075225A (en) *	1989-04-06	1991-12-24	The Texas A&M University System	Process for the enzymatic synthesis of nucleosides
JPH03127986A (ja)	1989-10-12	1991-05-31	Takara Shuzo Co Ltd	新規ヌクレオシドホスホリラーゼ
US5204466A (en) *	1990-02-01	1993-04-20	Emory University	Method and compositions for the synthesis of bch-189 and related compounds
JP3864357B2 (ja)	1997-08-04	2006-12-27	有機合成薬品工業株式会社	プリンヌクレオシド化合物の製造方法
JP3928676B2 (ja)	1997-11-14	2007-06-13	味の素株式会社	２’−デオキシアデノシン、２’−デオキシグアノシンの製造法
KR20020006046A (ko) *	1999-05-13	2002-01-18	사토 아키오	뉴클레오사이드화합물의 제조방법
DE60042209D1 (de)	1999-08-20	2009-06-25	Pasteur Institut	Enzymatische synthese von deoxyribonucleotiden

2002
- 2002-04-30 CA CA002380804A patent/CA2380804A1/en not_active Abandoned
- 2002-04-30 US US10/134,624 patent/US6858721B2/en not_active Expired - Lifetime
- 2002-05-01 KR KR10-2002-0023995A patent/KR100476294B1/ko not_active Expired - Lifetime
- 2002-05-01 DE DE60227595T patent/DE60227595D1/de not_active Expired - Lifetime
- 2002-05-01 EP EP02253075A patent/EP1254959B1/de not_active Expired - Lifetime
- 2002-05-01 AT AT02253075T patent/ATE401407T1/de not_active IP Right Cessation
- 2002-05-02 BR BR0203343-7A patent/BR0203343A/pt not_active IP Right Cessation
- 2002-05-08 CN CNB021193029A patent/CN100546997C/zh not_active Expired - Lifetime
2004
- 2004-10-19 US US10/967,239 patent/US7629457B2/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
KR20020085798A (ko)	2002-11-16
EP1254959A2 (de)	2002-11-06
US20050233420A1 (en)	2005-10-20
US7629457B2 (en)	2009-12-08
CN100546997C (zh)	2009-10-07
BR0203343A (pt)	2003-06-10
EP1254959B1 (de)	2008-07-16
EP1254959A3 (de)	2003-07-09
US6858721B2 (en)	2005-02-22
CN1392153A (zh)	2003-01-22
KR100476294B1 (ko)	2005-03-16
DE60227595D1 (de)	2008-08-28
US20030207405A1 (en)	2003-11-06
CA2380804A1 (en)	2002-11-01

Similar Documents

Publication	Publication Date	Title
ATE426021T1 (de)	2009-04-15	Verfahren zur herstellung von biopterinen
DE50008164D1 (de)	2004-11-11	Galactomannan-oligosaccharide und verfahren zu deren herstellung sowie deren verwendung
ATE419374T1 (de)	2009-01-15	Verfahren zur herstellung von hochreiner maltose
ATE493502T1 (de)	2011-01-15	Glucosamin und verfahren zur herstellung von glucosamin aus mikrobieller biomasse
ATE549402T1 (de)	2012-03-15	Alpha-isomaltosylglukosaccharidsynthase, verfahren zu deren herstellung und verwendung
ATE401407T1 (de)	2008-08-15	Verfahren zur herstellung von cytosin- nukleosidverbindungen
AU2003294564A1 (en)	2004-06-23	A selective synthesis of organophosphites
AU5630999A (en)	2000-04-10	Endofucanases and method using same for preparing fuco-oligosaccharides from fucanes, bacterium producing endofucanases and uses of fuco-oligosaccharides for plant protection
AU2003258187A1 (en)	2004-02-25	Enzymatic processes for the production of 4-substituted 3-hydroxybutyric acid derivatives
WO2003008533A3 (en)	2004-01-08	Method for virus propagation
ATE427359T1 (de)	2009-04-15	5'-inosinsaure herstellender mikroorganismus und verfahren zur herstellung von 5'- inosinsaure unter verwendung desselben
DE69911430D1 (de)	2003-10-23	Verfahren zur herstellung von 1-(1h)-benzoquinolizin-3-on derivaten
MY139322A (en)	2009-09-30	Method for producing 2-azetidinone derivative
DE60127946D1 (de)	2007-05-31	Ein stereoselektives verfahren zur herstellung von nukleosidanalogen
DE60307403D1 (de)	2006-09-21	Bakterien und Verfahren zur Herstellung von Riboflavin durch Fermentation
ATE469235T1 (de)	2010-06-15	Verfahren zur herstellung von isomaltose und isomaltit sowie verwendung davon
ATE417919T1 (de)	2009-01-15	Mikrobiologisches verfahren zur herstellung von amiden
DE60214283D1 (de)	2006-10-12	Fructosyl-Transferase produzierender Mikroorganismus und Verfahren zur Herstellung von Fructooligosacchariden und Neofructooligosacchariden unter dessen Verwendung
ATE223496T1 (de)	2002-09-15	Verfahren zur enzymatischen herstellung von betalaktamantibiotika mit produktrückgewinnung bei ph 1 in gegenwart von immobilisiertes penicillinamidase
TR200002755T2 (tr)	2002-05-21	Aracı hazırlamak için süreç.
ATE326545T1 (de)	2006-06-15	Verfahren zur herstellung von d- oder l-menthol
AU2002336564A1 (en)	2003-04-01	Method of enzyme production by microorganisms
BR0317351A (pt)	2005-11-16	Ativador orgânico, processo para a produção, composição de limpeza e método de limpeza do mesmo
YU67203A (sh)	2006-08-17	Derivati caloporosida, postupak za njihovu proizvodnju i njihova primena
ATE219142T1 (de)	2002-06-15	Verfahren zur herstellung von trans-4-hydroxy-l- prolin

Legal Events

Date	Code	Title	Description
2009-01-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties