ATE401894T1 - Verwendung von 15-keto-prostaglandin-e verbindungen als endothelin antagonisten - Google Patents

Verwendung von 15-keto-prostaglandin-e verbindungen als endothelin antagonisten

Info

Publication number: ATE401894T1
Authority: AT; Austria
Prior art keywords: keto; prostaglandin; compounds; endothelin antagonists; endothelin
Prior art date: 1997-11-28

Application number

AT98953058T

Other languages

English (en)

Inventor

Ryuji Ueno

Original Assignee

Sucampo Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-11-28

Filing date

1998-11-16

Publication date

2008-08-15

1998-11-16 Application filed by Sucampo Ag filed Critical Sucampo Ag

2008-08-15 Application granted granted Critical

2008-08-15 Publication of ATE401894T1 publication Critical patent/ATE401894T1/de

Links

VXPBDCBTMSKCKZ-XQHNHVHJSA-N 15-dehydro-prostaglandin E1 Chemical class CCCCCC(=O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(O)=O VXPBDCBTMSKCKZ-XQHNHVHJSA-N 0.000 title abstract 2
102000002045 Endothelin Human genes 0.000 title abstract 2
108050009340 Endothelin Proteins 0.000 title abstract 2
239000005557 antagonist Substances 0.000 title abstract 2
ZUBDGKVDJUIMQQ-UBFCDGJISA-N endothelin-1 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSSC[C@@H](C(N[C@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)CSSC1)C1=CNC=N1 ZUBDGKVDJUIMQQ-UBFCDGJISA-N 0.000 title abstract 2
208000033386 Buerger disease Diseases 0.000 abstract 1
206010020772 Hypertension Diseases 0.000 abstract 1
206010043540 Thromboangiitis obliterans Diseases 0.000 abstract 1
208000006673 asthma Diseases 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
239000002308 endothelin receptor antagonist Substances 0.000 abstract 1
229940094443 oxytocics prostaglandins Drugs 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Epidemiology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Diabetes (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Hematology (AREA)
Obesity (AREA)
Ophthalmology & Optometry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT98953058T 1997-11-28 1998-11-16 Verwendung von 15-keto-prostaglandin-e verbindungen als endothelin antagonisten ATE401894T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP32783297		1997-11-28

Publications (1)

Publication Number	Publication Date
ATE401894T1 true ATE401894T1 (de)	2008-08-15

Family

ID=18203488

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT98953058T ATE401894T1 (de)	1997-11-28	1998-11-16	Verwendung von 15-keto-prostaglandin-e verbindungen als endothelin antagonisten

Country Status (16)

Country	Link
US (1)	US6197821B1 (de)
EP (1)	EP0978284B1 (de)
JP (1)	JP4319256B2 (de)
KR (1)	KR100648868B1 (de)
CN (1)	CN1206997C (de)
AT (1)	ATE401894T1 (de)
AU (1)	AU739343B2 (de)
CA (1)	CA2279267C (de)
DE (1)	DE69839767D1 (de)
DK (1)	DK0978284T3 (de)
ES (1)	ES2310013T3 (de)
NO (1)	NO328460B1 (de)
NZ (1)	NZ336960A (de)
PT (1)	PT978284E (de)
TW (1)	TW592701B (de)
WO (1)	WO1999027934A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2002330747B2 (en)	2001-08-31	2007-07-19	Sucampo Ag	Prostaglandin analogs as chloride channel opener
TWI331920B (en) *	2001-11-14	2010-10-21	Sucampo Ag	Unit dosage form for relieving or treating constipation in human patients
US7732487B2 (en) *	2001-11-19	2010-06-08	Sucampo Ag	Method for treating a disease or condition responsive to opening of C1C-2 channel
AU2003292556B2 (en) *	2002-12-27	2009-09-10	Sucampo Ag	Derivatives of prostaglandins for treating abdominal discomfort
AR043161A1 (es) *	2003-02-14	2005-07-20	Sucampo Pharmaceuticals Inc	Composicion oftalmica para tratar hipertension ocular y glaucoma
AU2006209072B2 (en) *	2005-01-27	2011-02-24	Sucampo Ag	Method and composition for treating central nervous system disorders
US8143316B2 (en) *	2005-03-04	2012-03-27	Sucampo Ag	Method for treating peripheral vascular diseases
CN103804338A (zh) *	2006-02-07	2014-05-21	株式会社·R-技术上野	用于制备前列腺素衍生物的方法
AU2007223469B2 (en) *	2006-02-28	2012-06-07	Sucampo Ag	Method and composition for treating chronic obstructive pulmonary disease
US20100022568A1 (en) *	2006-04-13	2010-01-28	Actelion Pharmaceeuticals Ltd.	Endothelin receptor antagonists for early stage idiopathic pulmonary fibrosis
JP2010519177A (ja) *	2007-02-27	2010-06-03	スキャンポ・アーゲー	ミトコンドリアを保護するための組成物および方法
US20090082442A1 (en) *	2007-09-26	2009-03-26	Protia, Llc	Deuterium-enriched lubiprostone
CN102050808B (zh) *	2009-11-02	2014-03-12	上海天伟生物制药有限公司	一种前列腺素中间体的制备方法
WO2011072383A1 (en) *	2009-12-18	2011-06-23	Apotex Pharmachem Inc.	Processes for the purification of lubiprostone
CN104557845B (zh) *	2015-01-13	2020-12-22	齐鲁制药有限公司	一种鲁比前列酮化合物的制备方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3853951A (en)	1971-07-14	1974-12-10	American Cyanamid Co	Preparation of 9-oxo-13-trans-prostenoic acid esters by alanate addition to cyclopentenone
US4018811A (en)	1972-02-11	1977-04-19	American Cyanamid Company	3-Alkyl-2-(6-carboxyhexyl)cyclopentanones and esters and salts thereof
US3981868A (en)	1973-05-31	1976-09-21	American Cyanamid Company	Derivatives of 9-oxo-13-trans-prostenoic acid amides
CA1323364C (en) *	1987-01-28	1993-10-19	Ryuzo Ueno	Prostaglandins e and anti ulcer agents containing same
US5362751A (en)	1988-05-11	1994-11-08	Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo	Tracheobronchodilator using 16-substituted PGEs
JP2597649B2 (ja) *	1988-05-11	1997-04-09	株式会社上野製薬応用研究所	気管・気管支拡張剤
DE68906193T2 (de) *	1988-05-23	1993-08-05	Ueno Seiyaku Oyo Kenkyujo Kk	Hypersphyxia verursachende zusammensetzung.
JPH0232031A (ja) *	1988-07-22	1990-02-01	Nippon Steel Chem Co Ltd	イソプロピル化ｐ‐ターフェニル類の製造法
CA2027814C (en) *	1989-10-20	1996-07-30	Ryuji Ueno	Treatment of hepatobiliary disease with 15-keto-prostaglandin compounds
CA2030344C (en) *	1989-11-22	2000-04-18	Ryuji Ueno	Treatment of pulmonary dysfunction with 15-keto-prostaglandin compounds
CA2030345C (en) *	1989-11-22	1998-12-08	Ryuji Ueno	Use of 15-keto-prostaglandin compound for improvement of encephalic function
CA2030346C (en) *	1989-11-22	2000-04-11	Ryuji Ueno	Treatment of cardiac dysfunction with 15-keto-prostaglandin compounds
TW224942B (de)	1990-04-04	1994-06-11	Adka Ueno Kk
EP0455448B1 (de) *	1990-05-01	1998-12-09	R-Tech Ueno Ltd.	Behandlung von Pankreaskrankheit mit 15-keto-Prostaglandin E-Derivaten
CA2046069C (en)	1990-07-10	2002-04-09	Ryuji Ueno	Treatment of inflammatory diseases with 15-keto-prostaglandin compounds
ES2093774T3 (es)	1991-03-14	1997-01-01	R Tech Ueno Ltd	Estimulacion de la curacion de heridas con un compuesto 15-cetoprostaglandina.
US6242485B1 (en)	1996-06-10	2001-06-05	R-Tech Ueno	Endothelin antagonist
JPH107574A (ja)	1996-06-17	1998-01-13	R Tec Ueno:Kk	エンドセリン拮抗剤

1998
- 1998-11-16 EP EP98953058A patent/EP0978284B1/de not_active Expired - Lifetime
- 1998-11-16 DK DK98953058T patent/DK0978284T3/da active
- 1998-11-16 JP JP53056099A patent/JP4319256B2/ja not_active Expired - Fee Related
- 1998-11-16 KR KR1019997006752A patent/KR100648868B1/ko not_active Expired - Fee Related
- 1998-11-16 US US09/355,270 patent/US6197821B1/en not_active Expired - Lifetime
- 1998-11-16 DE DE69839767T patent/DE69839767D1/de not_active Expired - Lifetime
- 1998-11-16 CA CA002279267A patent/CA2279267C/en not_active Expired - Fee Related
- 1998-11-16 AU AU10537/99A patent/AU739343B2/en not_active Ceased
- 1998-11-16 ES ES98953058T patent/ES2310013T3/es not_active Expired - Lifetime
- 1998-11-16 NZ NZ336960A patent/NZ336960A/en not_active IP Right Cessation
- 1998-11-16 CN CNB988035863A patent/CN1206997C/zh not_active Expired - Fee Related
- 1998-11-16 AT AT98953058T patent/ATE401894T1/de active
- 1998-11-16 PT PT98953058T patent/PT978284E/pt unknown
- 1998-11-16 WO PCT/JP1998/005143 patent/WO1999027934A1/ja not_active Ceased
- 1998-11-17 TW TW087118975A patent/TW592701B/zh not_active IP Right Cessation
1999
- 1999-07-27 NO NO19993647A patent/NO328460B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
JP4319256B2 (ja)	2009-08-26
PT978284E (pt)	2008-10-07
DK0978284T3 (da)	2008-10-27
NZ336960A (en)	2001-02-23
EP0978284B1 (de)	2008-07-23
TW592701B (en)	2004-06-21
EP0978284A1 (de)	2000-02-09
NO993647L (no)	1999-09-27
DE69839767D1 (de)	2008-09-04
WO1999027934A1 (fr)	1999-06-10
CN1251040A (zh)	2000-04-19
KR20000070508A (ko)	2000-11-25
KR100648868B1 (ko)	2006-11-24
AU739343B2 (en)	2001-10-11
EP0978284A4 (de)	2001-07-18
US6197821B1 (en)	2001-03-06
CN1206997C (zh)	2005-06-22
CA2279267C (en)	2010-01-12
NO328460B1 (no)	2010-02-22
ES2310013T3 (es)	2008-12-16
AU1053799A (en)	1999-06-16
NO993647D0 (no)	1999-07-27
CA2279267A1 (en)	1999-06-10
HK1025521A1 (en)	2000-11-17

Legal Events

Date

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Title

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2009-02-15

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Publication of translation of european patent specification

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DE69839767D1 (de)	2008-09-04	Verwendung von 15-keto-prostaglandin-e verbindungen als endothelin antagonisten
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