ATE401894T1 - Verwendung von 15-keto-prostaglandin-e verbindungen als endothelin antagonisten - Google Patents

Verwendung von 15-keto-prostaglandin-e verbindungen als endothelin antagonisten

Info

Publication number: ATE401894T1
Authority: AT; Austria
Prior art keywords: keto; prostaglandin; compounds; endothelin antagonists; endothelin
Prior art date: 1997-11-28

Application number

AT98953058T

Other languages

English (en)

Inventor

Ryuji Ueno

Original Assignee

Sucampo Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-11-28

Filing date

1998-11-16

Publication date

2008-08-15

1998-11-16 Application filed by Sucampo Ag filed Critical Sucampo Ag

2008-08-15 Application granted granted Critical

2008-08-15 Publication of ATE401894T1 publication Critical patent/ATE401894T1/de

Links

VXPBDCBTMSKCKZ-XQHNHVHJSA-N 15-dehydro-prostaglandin E1 Chemical class CCCCCC(=O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(O)=O VXPBDCBTMSKCKZ-XQHNHVHJSA-N 0.000 title abstract 2
102000002045 Endothelin Human genes 0.000 title abstract 2
108050009340 Endothelin Proteins 0.000 title abstract 2
239000005557 antagonist Substances 0.000 title abstract 2
ZUBDGKVDJUIMQQ-UBFCDGJISA-N endothelin-1 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSSC[C@@H](C(N[C@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)CSSC1)C1=CNC=N1 ZUBDGKVDJUIMQQ-UBFCDGJISA-N 0.000 title abstract 2
208000033386 Buerger disease Diseases 0.000 abstract 1
206010020772 Hypertension Diseases 0.000 abstract 1
206010043540 Thromboangiitis obliterans Diseases 0.000 abstract 1
208000006673 asthma Diseases 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
239000002308 endothelin receptor antagonist Substances 0.000 abstract 1
229940094443 oxytocics prostaglandins Drugs 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Epidemiology (AREA)
Diabetes (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Ophthalmology & Optometry (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Hematology (AREA)
Obesity (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT98953058T 1997-11-28 1998-11-16 Verwendung von 15-keto-prostaglandin-e verbindungen als endothelin antagonisten ATE401894T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP32783297		1997-11-28

Publications (1)

Publication Number	Publication Date
ATE401894T1 true ATE401894T1 (de)	2008-08-15

Family

ID=18203488

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT98953058T ATE401894T1 (de)	1997-11-28	1998-11-16	Verwendung von 15-keto-prostaglandin-e verbindungen als endothelin antagonisten

Country Status (16)

Country	Link
US (1)	US6197821B1 (de)
EP (1)	EP0978284B1 (de)
JP (1)	JP4319256B2 (de)
KR (1)	KR100648868B1 (de)
CN (1)	CN1206997C (de)
AT (1)	ATE401894T1 (de)
AU (1)	AU739343B2 (de)
CA (1)	CA2279267C (de)
DE (1)	DE69839767D1 (de)
DK (1)	DK0978284T3 (de)
ES (1)	ES2310013T3 (de)
NO (1)	NO328460B1 (de)
NZ (1)	NZ336960A (de)
PT (1)	PT978284E (de)
TW (1)	TW592701B (de)
WO (1)	WO1999027934A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1420794B1 (de) *	2001-08-31	2017-12-27	Sucampo AG	Prostaglandin-analoga als chloridkanalöffner
AR037524A1 (es) *	2001-11-14	2004-11-17	Sucampo Ag	Unidad de dosificacion que comprende un analogo de prostaglandina para el tratamiento de la constipacion
TWI263505B (en)	2001-11-19	2006-10-11	Sucampo Ag	Pharmaceutical composition comprising a C1C-2 channel opener
BRPI0317740B8 (pt) *	2002-12-27	2021-05-25	Sucampo Ag	uso do composto 13,14-diidro-15-ceto-16,16-diflúorprostaglandina e1
US20040225014A1 (en) *	2003-02-14	2004-11-11	Sucampo Ag	Method for treating ocular hypertension and glaucoma
DK1841433T3 (da) *	2005-01-27	2012-01-16	Sucampo Ag	Præparat til behandling af lidelser i centralnervesystemet
DE602006018583D1 (de)	2005-03-04	2011-01-13	Sucampo Ag	Verfahren und zusammensetzung zur behandlung von peripheren gefässkrankheiten
EP2735566A1 (de) *	2006-02-07	2014-05-28	R-Tech Ueno, Ltd.	Verfahren zur Herstellung von Prostaglandin-Derivaten
CA2642744C (en) *	2006-02-28	2015-02-24	Sucampo Ag	Method and composition for treating chronic obstructive pulmonary disease
SG174050A1 (en) *	2006-04-13	2011-09-29	Actelion Pharmaceuticals Ltd	Endothelin receptor antagonists for early stage idiopathic pulmonary fibrosis
EP2114411A2 (de) *	2007-02-27	2009-11-11	Sucampo AG	Zusammensetzung und verfahren zum schutz der mitochondrien
US20090082442A1 (en) *	2007-09-26	2009-03-26	Protia, Llc	Deuterium-enriched lubiprostone
CN102050808B (zh) *	2009-11-02	2014-03-12	上海天伟生物制药有限公司	一种前列腺素中间体的制备方法
EP2516412A4 (de) *	2009-12-18	2013-05-29	Apotex Pharmachem Inc	Verfahren zur reinigung von lubiproston
CN104557845B (zh) *	2015-01-13	2020-12-22	齐鲁制药有限公司	一种鲁比前列酮化合物的制备方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3853951A (en)	1971-07-14	1974-12-10	American Cyanamid Co	Preparation of 9-oxo-13-trans-prostenoic acid esters by alanate addition to cyclopentenone
US4018811A (en)	1972-02-11	1977-04-19	American Cyanamid Company	3-Alkyl-2-(6-carboxyhexyl)cyclopentanones and esters and salts thereof
US3981868A (en)	1973-05-31	1976-09-21	American Cyanamid Company	Derivatives of 9-oxo-13-trans-prostenoic acid amides
CA1323364C (en) *	1987-01-28	1993-10-19	Ryuzo Ueno	Prostaglandins e and anti ulcer agents containing same
US5362751A (en)	1988-05-11	1994-11-08	Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo	Tracheobronchodilator using 16-substituted PGEs
JP2597649B2 (ja) *	1988-05-11	1997-04-09	株式会社上野製薬応用研究所	気管・気管支拡張剤
DE68906193T2 (de) *	1988-05-23	1993-08-05	Ueno Seiyaku Oyo Kenkyujo Kk	Hypersphyxia verursachende zusammensetzung.
JPH0232031A (ja) *	1988-07-22	1990-02-01	Nippon Steel Chem Co Ltd	イソプロピル化ｐ‐ターフェニル類の製造法
CA2027814C (en) *	1989-10-20	1996-07-30	Ryuji Ueno	Treatment of hepatobiliary disease with 15-keto-prostaglandin compounds
CA2030345C (en) *	1989-11-22	1998-12-08	Ryuji Ueno	Use of 15-keto-prostaglandin compound for improvement of encephalic function
CA2030346C (en) *	1989-11-22	2000-04-11	Ryuji Ueno	Treatment of cardiac dysfunction with 15-keto-prostaglandin compounds
CA2030344C (en) *	1989-11-22	2000-04-18	Ryuji Ueno	Treatment of pulmonary dysfunction with 15-keto-prostaglandin compounds
TW224942B (de)	1990-04-04	1994-06-11	Adka Ueno Kk
EP0455448B1 (de) *	1990-05-01	1998-12-09	R-Tech Ueno Ltd.	Behandlung von Pankreaskrankheit mit 15-keto-Prostaglandin E-Derivaten
CA2046069C (en) *	1990-07-10	2002-04-09	Ryuji Ueno	Treatment of inflammatory diseases with 15-keto-prostaglandin compounds
EP0503887B1 (de) *	1991-03-14	1996-08-28	R-Tech Ueno Ltd.	Stimulierung von Wundheilung mit 15-Keto-prostaglandinverbindungen
JP3187438B2 (ja)	1996-06-10	2001-07-11	株式会社アールテック・ウエノ	エンドセリン拮抗剤
JPH107574A (ja)	1996-06-17	1998-01-13	R Tec Ueno:Kk	エンドセリン拮抗剤

1998
- 1998-11-16 ES ES98953058T patent/ES2310013T3/es not_active Expired - Lifetime
- 1998-11-16 WO PCT/JP1998/005143 patent/WO1999027934A1/ja not_active Ceased
- 1998-11-16 AT AT98953058T patent/ATE401894T1/de active
- 1998-11-16 DE DE69839767T patent/DE69839767D1/de not_active Expired - Lifetime
- 1998-11-16 KR KR1019997006752A patent/KR100648868B1/ko not_active Expired - Fee Related
- 1998-11-16 EP EP98953058A patent/EP0978284B1/de not_active Expired - Lifetime
- 1998-11-16 NZ NZ336960A patent/NZ336960A/en not_active IP Right Cessation
- 1998-11-16 CA CA002279267A patent/CA2279267C/en not_active Expired - Fee Related
- 1998-11-16 AU AU10537/99A patent/AU739343B2/en not_active Ceased
- 1998-11-16 PT PT98953058T patent/PT978284E/pt unknown
- 1998-11-16 DK DK98953058T patent/DK0978284T3/da active
- 1998-11-16 JP JP53056099A patent/JP4319256B2/ja not_active Expired - Fee Related
- 1998-11-16 US US09/355,270 patent/US6197821B1/en not_active Expired - Lifetime
- 1998-11-16 CN CNB988035863A patent/CN1206997C/zh not_active Expired - Fee Related
- 1998-11-17 TW TW087118975A patent/TW592701B/zh not_active IP Right Cessation
1999
- 1999-07-27 NO NO19993647A patent/NO328460B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
AU739343B2 (en)	2001-10-11
KR100648868B1 (ko)	2006-11-24
CN1251040A (zh)	2000-04-19
EP0978284A4 (de)	2001-07-18
AU1053799A (en)	1999-06-16
NO993647L (no)	1999-09-27
NO328460B1 (no)	2010-02-22
JP4319256B2 (ja)	2009-08-26
PT978284E (pt)	2008-10-07
DK0978284T3 (da)	2008-10-27
TW592701B (en)	2004-06-21
EP0978284B1 (de)	2008-07-23
CA2279267A1 (en)	1999-06-10
NO993647D0 (no)	1999-07-27
ES2310013T3 (es)	2008-12-16
HK1025521A1 (en)	2000-11-17
US6197821B1 (en)	2001-03-06
KR20000070508A (ko)	2000-11-25
CN1206997C (zh)	2005-06-22
EP0978284A1 (de)	2000-02-09
DE69839767D1 (de)	2008-09-04
NZ336960A (en)	2001-02-23
WO1999027934A1 (fr)	1999-06-10
CA2279267C (en)	2010-01-12

Legal Events

Date

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Title

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2009-02-15

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Publication of translation of european patent specification

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Publication	Publication Date	Title
ATE401894T1 (de)	2008-08-15	Verwendung von 15-keto-prostaglandin-e verbindungen als endothelin antagonisten
FI20030162A7 (fi)	2003-02-03	Uusia yhdisteitä
DE69006131D1 (de)	1994-03-03	Substituierte Chinazolinone als Angiotensin II-Antagonisten.
DE69940063D1 (de)	2009-01-22	Biphenylsulfonamide als zweifach aktive rezeptor antagonisten von angiotensin und endothelin
CY1105836T1 (el)	2011-02-02	12, 13-τροποποιημενα παραγωγα εποθιλονης
CO4940465A1 (es)	2000-07-24	Sal mesilato trihidrato de 5-(2-(4-(1,2-benzoisotiazol-3- il)-1-piperazinil)etil)-6-cloro-1,3-dihidro-2h-indol-2-ona
ATE464299T1 (de)	2010-04-15	Neues phenylalaninderivat
DE69734321D1 (de)	2006-02-16	Non-peptidische vasopressin via antagonisten
MX9302618A (es)	1994-05-31	Antagonistas de endotelina de fenil sulfonamidas.
DE69714698D1 (de)	2002-09-19	Endothelin-antagonisten
BR9813228A (pt)	2000-08-29	Formulação de 2-metil-tieno-benzodiazepina
TR199901710T2 (xx)	1999-09-21	IL-8 resept�r antagonistleri.
EA199901100A1 (ru)	2000-08-28	Фармацевтические композиции, содержащие гемисульфат элетриптана и кофеин
IT1293778B1 (it)	1999-03-10	1,4,7,10-tetraazabiciclo(8.2.2.)tetradecan-2 one, sua preparazione e suo uso per la preparazione di tetraazamacrocicli
BR9813214A (pt)	2000-08-29	Antagonista de receptor vitronectina
DE69610316D1 (de)	2000-10-19	Piperazin-derivate und ihre verwendung als 5-ht1a-antagoniste
TR200100885T2 (tr)	2001-08-21	2-Metil-tieno-benzodiazepin formülasyonu
ATE241360T1 (de)	2003-06-15	Blutlipoproteinspiegel regulierendes präparat
EA200000198A1 (ru)	2000-10-30	2-ациламинопропанамины в качестве антагонистов рецепторов тахикининов
TR199901761T2 (xx)	1999-10-21	IL-8 resept�r antagonistleri.
EA200401137A1 (ru)	2005-04-28	Фармацевтическая композиция, содержащая ингибитор pde4 или pde3/4 и антагонист гистаминового рецептора
ATE257706T1 (de)	2004-01-15	Endothelin antagonist und renin-angiotensin system hemmer als kombinationspräparate
ATE238791T1 (de)	2003-05-15	Verwendung von 2-methyl-thiazolidin-2,4- dicarbonsäure als mukolytikum
NO20000518L (no)	2000-03-31	2-acylaminopropanaminer som takykininreseptorantagonister
DK0741743T3 (da)	1999-06-23	Cycliske neurokinin A-antagonister