ATE402951T1 - Verfahren zur reduktiven alkylierung von glykopeptiden - Google Patents

Verfahren zur reduktiven alkylierung von glykopeptiden

Info

Publication number
ATE402951T1
ATE402951T1 AT01930978T AT01930978T ATE402951T1 AT E402951 T1 ATE402951 T1 AT E402951T1 AT 01930978 T AT01930978 T AT 01930978T AT 01930978 T AT01930978 T AT 01930978T AT E402951 T1 ATE402951 T1 AT E402951T1
Authority
AT
Austria
Prior art keywords
reductive alkylation
glycopeptides
saccharide
amines
provides
Prior art date
Application number
AT01930978T
Other languages
English (en)
Inventor
Martin Linsell
Original Assignee
Theravance Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Theravance Inc filed Critical Theravance Inc
Application granted granted Critical
Publication of ATE402951T1 publication Critical patent/ATE402951T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
    • C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Dermatology (AREA)
  • Nanotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AT01930978T 2000-05-02 2001-05-01 Verfahren zur reduktiven alkylierung von glykopeptiden ATE402951T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20117800P 2000-05-02 2000-05-02
US21314800P 2000-06-22 2000-06-22

Publications (1)

Publication Number Publication Date
ATE402951T1 true ATE402951T1 (de) 2008-08-15

Family

ID=26896472

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01930978T ATE402951T1 (de) 2000-05-02 2001-05-01 Verfahren zur reduktiven alkylierung von glykopeptiden

Country Status (13)

Country Link
US (1) US6831150B2 (de)
EP (1) EP1276759B1 (de)
JP (2) JP4713810B2 (de)
KR (1) KR100856479B1 (de)
CN (1) CN100532392C (de)
AT (1) ATE402951T1 (de)
AU (1) AU2001257464A1 (de)
CA (1) CA2407994C (de)
DE (1) DE60135102D1 (de)
ES (1) ES2311014T3 (de)
NO (1) NO330134B1 (de)
SI (1) SI1276759T1 (de)
WO (1) WO2001083521A2 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI275594B (en) 2001-08-24 2007-03-11 Theravance Inc Process for preparing vancomycin phosphonate derivatives
TWI312785B (en) 2001-08-24 2009-08-01 Theravance Inc Process for preparing vancomycin derivatives
EP2753637A1 (de) 2011-09-09 2014-07-16 Sandoz AG Verfahren zur synthese von telavancin, seine pharmazeutisch akzeptablen salze sowie ein n-geschütztes iminderivat von telavancin
WO2013034675A1 (en) 2011-09-09 2013-03-14 Sandoz Ag Process for the synthesis of telavancin and its pharmaceutically acceptable salts as well as n-protected derivatives thereof
CN103897040B (zh) * 2012-12-27 2018-05-22 浙江医药股份有限公司新昌制药厂 新型糖肽类化合物或其药用盐及其制备方法、以及药物组合物和用途
JP6617097B2 (ja) 2013-03-15 2019-12-04 メリンタ サブシディアリー コーポレーション 抗生物質を用いて過体重および肥満の患者における感染を治療するための組成物
CN106188243B (zh) * 2015-05-05 2020-06-26 博瑞生物医药（苏州）股份有限公司 一种奥利万星的制备方法
US10729708B2 (en) * 2016-05-09 2020-08-04 Xellia Pharmaceuticals Aps Stabilized glycopeptide antibiotic formulations
CN108409837B (zh) 2018-03-06 2021-09-24 上海来益生物药物研究开发中心有限责任公司 一组具有抗耐药性细菌活性的糖肽类化合物、其制备方法和应用

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL78597A0 (en) 1985-04-25 1986-08-31 Lilly Co Eli Novel glycopeptide derivatives
US4698327A (en) * 1985-04-25 1987-10-06 Eli Lilly And Company Novel glycopeptide derivatives
US4644533A (en) * 1985-05-06 1987-02-17 American Telephone & Telegraph Company Packet switch trunk circuit queueing arrangement
US4643987A (en) * 1985-08-14 1987-02-17 Eli Lilly And Company Modified glycopeptides
NZ236393A (en) * 1989-12-13 1992-05-26 Lilly Co Eli N-alkylated glycopeptide derivatives prepared from antibiotics a82846 series and pa-42867-a; pharmaceutical compositions
US5750509A (en) * 1991-07-29 1998-05-12 Gruppo Lepetit S.P.A. Amide derivatives of antibiotic A 40926
US5840684A (en) * 1994-01-28 1998-11-24 Eli Lilly And Company Glycopeptide antibiotic derivatives
NZ270387A (en) * 1994-01-28 1996-11-26 Lilly Co Eli Glycopeptide antibiotic, its production and compositions thereof
US5919756A (en) 1996-06-28 1999-07-06 Eli Lilly And Company Amides
US5952466A (en) * 1997-11-12 1999-09-14 Eli Lilly And Company Reductive alkylation of glycopeptide antibiotics
US5939382A (en) 1996-11-21 1999-08-17 Eli Lilly And Company Reducing agent for reductive alkylation of glycopeptide antibiotics
ID18900A (id) * 1996-11-21 1998-05-20 Lilly Co Eli Alkilasi menurun dari gliko peptida anti biotik
US5916873A (en) 1997-04-17 1999-06-29 Eli Lilly And Company Teicoplanin derivatives
WO1999042476A1 (en) 1998-02-20 1999-08-26 Advanced Medicine, Inc. Novel antibacterial agents
DK1140993T3 (da) 1998-12-23 2003-10-06 Theravance Inc Glycopeptidderivater og farmaceutiske præparater indeholdende dem
AU4054900A (en) 1999-04-02 2000-10-23 Advanced Medicine East, Inc. Desleucyl glycopeptide antibiotics and methods of making same
WO2001098327A2 (en) * 2000-06-22 2001-12-27 Theravance, Inc. Glycopeptide carboxy-saccharide derivatives

Also Published As

Publication number Publication date
ES2311014T3 (es) 2009-02-01
CA2407994C (en) 2010-02-02
NO330134B1 (no) 2011-02-21
EP1276759A2 (de) 2003-01-22
WO2001083521A3 (en) 2002-09-19
NO20025264L (no) 2002-12-18
JP2008222718A (ja) 2008-09-25
CN100532392C (zh) 2009-08-26
DE60135102D1 (de) 2008-09-11
SI1276759T1 (sl) 2008-12-31
NO20025264D0 (no) 2002-11-01
CN1432023A (zh) 2003-07-23
US6831150B2 (en) 2004-12-14
JP2003531917A (ja) 2003-10-28
KR20020093110A (ko) 2002-12-12
CA2407994A1 (en) 2001-11-08
US20020010131A1 (en) 2002-01-24
EP1276759B1 (de) 2008-07-30
WO2001083521A2 (en) 2001-11-08
JP4713810B2 (ja) 2011-06-29
KR100856479B1 (ko) 2008-09-04
AU2001257464A1 (en) 2001-11-12

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Legal Events

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