ATE405297T1 - Para-hydrogen markierte mittel und deren verwendung zur bilderzeugung durch nicht-proton magnetische resonanz - Google Patents

Para-hydrogen markierte mittel und deren verwendung zur bilderzeugung durch nicht-proton magnetische resonanz

Info

Publication number
ATE405297T1
ATE405297T1 AT98952931T AT98952931T ATE405297T1 AT E405297 T1 ATE405297 T1 AT E405297T1 AT 98952931 T AT98952931 T AT 98952931T AT 98952931 T AT98952931 T AT 98952931T AT E405297 T1 ATE405297 T1 AT E405297T1
Authority
AT
Austria
Prior art keywords
magnetic resonance
sample
imaging agent
hydrogen
nuclear spin
Prior art date
Application number
AT98952931T
Other languages
English (en)
Inventor
Klaes Golman
Oskar Axelsson
Haukur Johanneson
Charlotte Olofsson
Sven Mansson
Stefan Petersson
Original Assignee
Ge Healthcare As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9723920.6A external-priority patent/GB9723920D0/en
Priority claimed from GBGB9800158.9A external-priority patent/GB9800158D0/en
Application filed by Ge Healthcare As filed Critical Ge Healthcare As
Application granted granted Critical
Publication of ATE405297T1 publication Critical patent/ATE405297T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1806—Suspensions, emulsions, colloids, dispersions
    • A61K49/1815—Suspensions, emulsions, colloids, dispersions compo-inhalant, e.g. breath tests
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/62—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using double resonance

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • General Physics & Mathematics (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Signal Processing (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT98952931T 1997-11-12 1998-11-12 Para-hydrogen markierte mittel und deren verwendung zur bilderzeugung durch nicht-proton magnetische resonanz ATE405297T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9723920.6A GB9723920D0 (en) 1997-11-12 1997-11-12 Method
GBGB9800158.9A GB9800158D0 (en) 1998-01-05 1998-01-05 Method

Publications (1)

Publication Number Publication Date
ATE405297T1 true ATE405297T1 (de) 2008-09-15

Family

ID=26312589

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98952931T ATE405297T1 (de) 1997-11-12 1998-11-12 Para-hydrogen markierte mittel und deren verwendung zur bilderzeugung durch nicht-proton magnetische resonanz

Country Status (11)

Country Link
US (2) US6574495B1 (de)
EP (1) EP1047455B1 (de)
JP (1) JP2001522819A (de)
KR (1) KR100600670B1 (de)
CN (1) CN100571787C (de)
AT (1) ATE405297T1 (de)
AU (1) AU1047399A (de)
DE (1) DE69839924D1 (de)
NO (1) NO320225B1 (de)
RU (1) RU2218182C2 (de)
WO (1) WO1999024080A1 (de)

Families Citing this family (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100600670B1 (ko) * 1997-11-12 2006-07-13 지이 헬스케어 에이에스 파라수소 표지된 작용물질 및 자기공명영상에서의 그의 용도
GB9911679D0 (en) * 1999-05-19 1999-07-21 Nycomed Imaging As Magnetic resonance imaging
GB9911681D0 (en) * 1999-05-19 1999-07-21 Nycomed Imaging As Process
GB0009353D0 (en) * 2000-04-14 2000-05-31 Nycomed Imaging As Method
GB0022341D0 (en) * 2000-09-12 2000-10-25 Nycomed Imaging As Method
NO20004561D0 (no) * 2000-09-13 2000-09-13 Nycomed Imaging As Metode for magnetisk resonansavbildning
US7269157B2 (en) * 2001-04-10 2007-09-11 Internap Network Services Corporation System and method to assure network service levels with intelligent routing
GB0122049D0 (en) * 2001-09-12 2001-10-31 Nycomed Imaging As Method
US7222190B2 (en) * 2001-11-02 2007-05-22 Internap Network Services Corporation System and method to provide routing control of information over data networks
US7133365B2 (en) * 2001-11-02 2006-11-07 Internap Network Services Corporation System and method to provide routing control of information over networks
US7668966B2 (en) * 2001-11-02 2010-02-23 Internap Network Services Corporation Data network controller
GB0219954D0 (en) * 2002-08-29 2002-10-02 Amersham Health R & D Ab Method and apparatus for producing contrast agents for magnetic resonance imaging
GB0219953D0 (en) * 2002-08-29 2002-10-02 Amersham Health R & D Ab An arrangement and a method for providing contrast agents
GB0219952D0 (en) * 2002-08-29 2002-10-02 Amersham Health R & D Ab Method and apparatus for producing contrast agents for magnetic resonance imaging
US7623908B2 (en) * 2003-01-24 2009-11-24 The Board Of Trustees Of The University Of Illinois Nonlinear interferometric vibrational imaging
NO20031736D0 (no) * 2003-04-15 2003-04-15 Amersham Health As Forbindelser
JP3993127B2 (ja) * 2003-04-24 2007-10-17 株式会社日立製作所 Ｎｍｒ装置用超電導プローブコイル
EP1706754A1 (de) * 2003-07-28 2006-10-04 University Of Southampton Nmr-spektroskopie mit langlebigen spinzuständen
US7432014B2 (en) 2003-11-05 2008-10-07 Sony Corporation Anode and battery
US7610074B2 (en) * 2004-01-08 2009-10-27 The Board Of Trustees Of The University Of Illinois Multi-functional plasmon-resonant contrast agents for optical coherence tomography
US7586618B2 (en) 2005-02-28 2009-09-08 The Board Of Trustees Of The University Of Illinois Distinguishing non-resonant four-wave-mixing noise in coherent stokes and anti-stokes Raman scattering
US7725169B2 (en) * 2005-04-15 2010-05-25 The Board Of Trustees Of The University Of Illinois Contrast enhanced spectroscopic optical coherence tomography
JP2007021008A (ja) * 2005-07-20 2007-02-01 Hitachi Ltd Ｄｎｐ過分極手段を備えた磁気共鳴イメージング装置
WO2007038626A2 (en) 2005-09-28 2007-04-05 President And Fellows Of Harvard College Hyperpolarized solid materials with long spin relaxation times for use as imaging agents in magnetic resonance imaging
WO2007044867A2 (en) * 2005-10-11 2007-04-19 Huntington Medical Research Institutes Imaging agents and methods of use thereof
WO2007070466A2 (en) * 2005-12-10 2007-06-21 The President And Fellows Of Harvard College In situ hyperpolarization of imaging agents
EP1984757A4 (de) * 2006-01-11 2009-11-04 Harvard College Ex-vivo-hyperpolarisation von abbildungsmitteln
US7787129B2 (en) 2006-01-31 2010-08-31 The Board Of Trustees Of The University Of Illinois Method and apparatus for measurement of optical properties in tissue
US8703102B2 (en) 2008-04-04 2014-04-22 Millikelvin Technologies Llc Systems and methods for producing hyperpolarized materials and mixtures thereof
EP1986702A4 (de) 2006-02-21 2012-12-12 Avrum Belzer Hyperpolarisationsverfahren, systeme und zusammensetzungen
US8623327B2 (en) 2006-06-19 2014-01-07 Beth Israel Deaconess Medical Center, Inc. Imaging agents for use in magnetic resonance blood flow/perfusion imaging
WO2008086534A1 (en) 2007-01-11 2008-07-17 Huntington Medical Research Institutes Imaging agents and methods of use thereof
GB2450316A (en) 2007-06-18 2008-12-24 Univ York Hyperpolarizing nuclei
US20100233089A1 (en) * 2007-10-05 2010-09-16 Huntington Medical Research Institutes Imaging of genetic material with magnetic resonance
EP2072061A1 (de) 2007-12-19 2009-06-24 GE Healthcare Limited Zusammensetzung und Verfahren zur Erzeugung eines metabolischen Profils bei Verwendung von 13C-MR
US7751057B2 (en) 2008-01-18 2010-07-06 The Board Of Trustees Of The University Of Illinois Magnetomotive optical coherence tomography
US8983580B2 (en) 2008-01-18 2015-03-17 The Board Of Trustees Of The University Of Illinois Low-coherence interferometry and optical coherence tomography for image-guided surgical treatment of solid tumors
US8115934B2 (en) 2008-01-18 2012-02-14 The Board Of Trustees Of The University Of Illinois Device and method for imaging the ear using optical coherence tomography
WO2009124250A1 (en) * 2008-04-03 2009-10-08 The Trustees Of The University Of Pennsylvania Compositions and methods for detecting tricarboxylic acid (tca) metabolic flux
WO2009129265A1 (en) * 2008-04-14 2009-10-22 Huntington Medical Research Institutes Methods and apparatus for pasadena hyperpolarization
US20110038802A1 (en) 2008-05-02 2011-02-17 Zhong-Min Hu Method of determining alanine transaminase (alt) activity by 13c-mr detection using hyperpolarised 13c-pyruvate
US8961933B2 (en) * 2008-10-03 2015-02-24 Bracco Imaging S.P.A. Process for the preparation of aqueous solutions of hyperpolarized molecules
IT1391330B1 (it) * 2008-10-03 2011-12-05 Bracco Imaging Spa Processo per la preparazione di molecole iperpolarizzate.
US20100092390A1 (en) * 2008-10-09 2010-04-15 President And Fellows Of Harvard College Methods for Making Particles Having Long Spin-Lattice Relaxation Times
DE102008059313A1 (de) * 2008-11-27 2010-06-02 Bruker Biospin Gmbh NMR-Messaparatur mit Durchfluss-Probenkopf und druckgasbetriebener Mischkammer, insbesondere zur para-Wasserstoff-induzierten Polarisierung einer flüssigen NMR-Messprobe
EP2374016B1 (de) 2008-12-10 2017-05-10 University of York Impulssequenzierung mit hyperpolarisierbaren kernen
AU2010230330B2 (en) 2009-04-02 2015-06-25 Ge Healthcare Limited Use of a magnetic resonance imaging medium comprising hyperpolarized 13C pyruvate for the detection of inflammation or infection
CA2772190A1 (en) 2009-08-31 2011-03-03 Millikelvin Technologies Llc Systems and methods for producing hyperpolarized materials and mixtures thereof
EP2473199A1 (de) 2009-08-31 2012-07-11 Brain Watch Ltd. Isotopenmarkierte neurochemische stoffe und ihre verwendung zur diagnostizierung von erkrankungen und störungen
US8968703B2 (en) 2009-09-10 2015-03-03 Ge Healthcare Limited 13C-MR detection using hyperpolarised 13C-fructose
EP2316492A1 (de) 2009-10-30 2011-05-04 Bracco Imaging S.p.A Para-Wasserstoff markierte Kontrastmittel für Kernspintomographie
US20120274324A1 (en) * 2009-12-21 2012-11-01 Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften, E.V. Improved nmr measurement based on antiphase signals
JP5758982B2 (ja) * 2010-04-08 2015-08-05 ブラッコ・イメージング・ソシエタ・ペル・アチオニＢｒａｃｃｏ Ｉｍａｇｉｎｇ Ｓ．Ｐ．Ａ． 過分極基質の製造方法およびｍｒｉのための方法
US8970217B1 (en) 2010-04-14 2015-03-03 Hypres, Inc. System and method for noise reduction in magnetic resonance imaging
JP5879333B2 (ja) 2010-05-03 2016-03-08 ジーイー・ヘルスケア・リミテッド Ｌｄｈ活性を決定するための過分極乳酸塩造影剤
WO2012056447A1 (en) 2010-10-25 2012-05-03 Brain Watch Ltd. Isotopically labeled deoxy-glucose and derivatives thereof, compositions comprising them and uses thereof
WO2012145733A1 (en) * 2011-04-22 2012-10-26 Vanderbilt University Para-hydrogen polarizer
US20140099262A1 (en) 2011-06-01 2014-04-10 Brain Watch Ltd. Isotopically labeled cdp-choline and uses thereof
WO2013053839A1 (en) 2011-10-12 2013-04-18 Bracco Imaging Spa Process for the preparation of hyperpolarized derivatives for use in mri analysis
US9693828B2 (en) 2011-12-05 2017-07-04 Bracco Imaging S.P.A. Composition comprising acetic anhydride and a gadolinium complex, and method for the use in hyperpolarisation in MRI analysis
WO2013167587A1 (en) 2012-05-07 2013-11-14 Albeda Innovation Aps Intra-operative cancer diagnosis based on a hyperpolarized marker
US9566354B2 (en) 2012-10-23 2017-02-14 Vanderbilt University Systems and methods of performing NMR spectroscopy and MRI
US9404984B2 (en) 2012-11-06 2016-08-02 Bruker Uk Limited Method of hyperpolarization applying brute force using particulate acceleration agents
US9551768B2 (en) 2013-03-15 2017-01-24 East Carolina University NMR method for monitoring changes in the core of lipoprotein particles in metabolism and disease
WO2014150909A1 (en) * 2013-03-15 2014-09-25 Cambridge Isotope Laboratories, Inc. Lysine isotopologues, compositions comprising the same and methods of synthesis
US10003536B2 (en) 2013-07-25 2018-06-19 Grigore Raileanu System and method for managing bandwidth usage rates in a packet-switched network
US9642924B2 (en) 2013-08-29 2017-05-09 Duke University Contrast agents based on long-lived nuclear singlet states and related methods
EP2863229A1 (de) 2013-10-15 2015-04-22 Technische Universität München pH-Biosensoren auf Basis von Verbindungen mit pH-sensiblen Enolgruppen zur Magnetresonanzbildgebung und Spektroskopie und deren Verwendungen
WO2015063020A1 (en) 2013-10-28 2015-05-07 Bracco Imaging Spa Process for the preparation of hyperpolarized carboxylate compounds
EP2891500B1 (de) 2014-01-07 2018-08-01 Cambridge Enterprise Limited Kontrastmittel zur Bestimmung von Aldehyd-Dehydrogenase-(ALDH)-Aktivität
EP3015855A1 (de) 2014-10-27 2016-05-04 Klinikum rechts der Isar der Technischen Universität München Metall-Biosensoren auf Basis von Verbindungen mit metallempfindlichen chemischen Verschiebungen für magnetische Resonanzspektroskopie und Magnetresonanzbildgebung
US11156684B2 (en) * 2014-10-28 2021-10-26 Duke University Method for creating hyperpolarization at microTesla magnetic fields
US10924408B2 (en) 2014-11-07 2021-02-16 Noction, Inc. System and method for optimizing traffic in packet-switched networks with internet exchanges
US9769070B2 (en) 2015-01-28 2017-09-19 Maxim Basunov System and method of providing a platform for optimizing traffic through a computer network with distributed routing domains interconnected through data center interconnect links
EP3203256A1 (de) * 2016-02-02 2017-08-09 B. Braun Melsungen AG Kalibrierung von mrt-systemen mit vorbestimmten konzentrationen von 19f-isotopen als referenz
CA3033346A1 (en) * 2016-08-09 2018-02-15 Beth Israel Deaconess Medical Center, Inc. System and method for microfluidic parahydrogen induced polarization hyperpolarizer for magnetic resonance imaging (mri) and nuclear magnetic resonance (nmr) applications
US10918744B2 (en) * 2017-03-01 2021-02-16 Educational foundation Kyushu Bunka Gakuen Biometric method
US10775458B2 (en) 2018-03-05 2020-09-15 Texas Tech University System Method and system for non-invasive measurement of metabolic health
WO2021198776A2 (en) * 2020-03-31 2021-10-07 Nvision Imaging Technologies Gmbh Systems and method for generation of hyperpolarized materials
JP7846128B2 (ja) * 2020-12-07 2026-04-14 エヌビジョン イメージング テクノロジーズ ゲゼルシャフト ミット ベシュレンクテル ハフツング パラ水素を使用する超偏極化合物の生成のためのシステム及び方法
US20250283959A1 (en) * 2022-04-23 2025-09-11 Wayne State University Method and apparatus for magnetic resonance (mr) contrast agents
EP4587413A1 (de) * 2022-09-13 2025-07-23 NVision Imaging Technologies GmbH Systeme und verfahren zur erzeugung von hyperpolarisierten materialien

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU668691B2 (en) * 1991-08-09 1996-05-16 Nycomed Innovation Ab Use of persistent free-radicals in magnetic resonance imaging
JPH0753967A (ja) * 1993-08-18 1995-02-28 Catalysts & Chem Ind Co Ltd 重質油の水素化処理方法
US5479925A (en) * 1994-06-23 1996-01-02 General Electric Company Magnetic resonance (MR) angiography in a low-field imaging magnet
JPH0919449A (ja) * 1995-07-06 1997-01-21 Tadashi Matsuoka おむつに対する失禁センサー
US5611340A (en) * 1995-10-02 1997-03-18 General Electric Company Apparatus and methods for magnetic resonance (MR) angiography using hydrogen polarized at low temperatures
JP3897841B2 (ja) * 1995-10-31 2007-03-28 独立行政法人科学技術振興機構 標識アシル−ｌ−カルニチンを用いた疾患診断剤
KR100600670B1 (ko) * 1997-11-12 2006-07-13 지이 헬스케어 에이에스 파라수소 표지된 작용물질 및 자기공명영상에서의 그의 용도
US6574496B1 (en) * 1999-05-19 2003-06-03 Amersham Health As Magnetic resonance imaging
GB0022341D0 (en) * 2000-09-12 2000-10-25 Nycomed Imaging As Method

Also Published As

Publication number Publication date
RU2218182C2 (ru) 2003-12-10
EP1047455A1 (de) 2000-11-02
AU1047399A (en) 1999-05-31
CN100571787C (zh) 2009-12-23
US6574495B1 (en) 2003-06-03
NO20002429D0 (no) 2000-05-10
US20040024307A1 (en) 2004-02-05
DE69839924D1 (de) 2008-10-02
NO320225B1 (no) 2005-11-14
WO1999024080A1 (en) 1999-05-20
CN1306441A (zh) 2001-08-01
JP2001522819A (ja) 2001-11-20
NO20002429L (no) 2000-05-10
KR20010024606A (ko) 2001-03-26
KR100600670B1 (ko) 2006-07-13
EP1047455B1 (de) 2008-08-20

Similar Documents

Publication Publication Date Title
ATE405297T1 (de) Para-hydrogen markierte mittel und deren verwendung zur bilderzeugung durch nicht-proton magnetische resonanz
Edden et al. Macromolecule‐suppressed GABA‐edited magnetic resonance spectroscopy at 3T
Savine et al. Motivated cognitive control: reward incentives modulate preparatory neural activity during task-switching
Labadie et al. Relaxographic imaging
Wardlaw et al. Studies of acute ischemic stroke with proton magnetic resonance spectroscopy: relation between time from onset, neurological deficit, metabolite abnormalities in the infarct, blood flow, and clinical outcome
ATE256293T1 (de) Verfahren zur bilderzeugung mit magnetischer resonanz
Grant et al. NMR spectroscopy of single neurons
NZ505151A (en) Method of magnetic resonance investigation of a sample using a hyperpolarised solution of a high T1 agent
Cai et al. Sensitivity enhancement of multidimensional NMR experiments by paramagnetic relaxation effects
Marco‐Rius et al. Hyperpolarized singlet lifetimes of pyruvate in human blood and in the mouse
Schick et al. Localized proton MR spectroscopy of citrate in vitro and of the human prostate in vivo at 1.5 T
Elmer et al. Interhemispheric transcallosal connectivity between the left and right planum temporale predicts musicianship, performance in temporal speech processing, and functional specialization
Friedrich et al. Magnetic particle mapping using magnetoelectric sensors as an imaging modality
Weiss et al. Language input in late infancy scaffolds emergent literacy skills and predicts reading related white matter development
DE60142788D1 (de) Verfahren zur untersuchung einer probe mittels magnetischer resonanz unter verwendung eines kernspinpolarisierten kontrastmittels
Cleveland et al. Continuously infusing hyperpolarized 129Xe into flowing aqueous solutions using hydrophobic gas exchange membranes
US7295006B2 (en) Method for measuring nuclear magnetic resonance longitudinal axis relaxation time of blood and apparatus using the same
Trampel et al. Continuous arterial spin labeling using a local magnetic field gradient coil
ATE301839T1 (de) Verfahren zur erzeugung von bildern und spektren der extracellulären ph unter verwendung der magnetischen resonanz mithilfe von 1h und 19f enthaltenden extrinsischen indikatorren
Garrido et al. New applications of NMR in drug discovery and development
Haller et al. Mapping continuous neuronal activation without an ON–OFF paradigm: initial results of BOLD ceiling fMRI
Kushlan et al. Proton-detected NMR relaxation of methylene carbons via stereoselective and random fractional deuteration
EP1058122A3 (de) Ex vivo Polarisation der Kerne eines Kontrastmittels für die bildgebende magnetische Resonanz mittels mit ortho-Deuterium angereichertem Wasserstoffgas
JPH03173529A (ja) 物体組織の検査システム
JPS5962038A (ja) 磁気共鳴イメージング装置

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties