NO20002429L - Para-hydrogenmerkede midler og bruk av disse ved magnetresonansavbildning - Google Patents

Para-hydrogenmerkede midler og bruk av disse ved magnetresonansavbildning

Info

Publication number
NO20002429L
NO20002429L NO20002429A NO20002429A NO20002429L NO 20002429 L NO20002429 L NO 20002429L NO 20002429 A NO20002429 A NO 20002429A NO 20002429 A NO20002429 A NO 20002429A NO 20002429 L NO20002429 L NO 20002429L
Authority
NO
Norway
Prior art keywords
hydrogen
magnetic resonance
sample
imaging agent
nuclear spin
Prior art date
Application number
NO20002429A
Other languages
English (en)
Other versions
NO320225B1 (no
NO20002429D0 (no
Inventor
Klaes Golman
Oskar Axelsson
Haukur Johanneson
Charlotte Olofsson
Sven Monsson
Stefan Petersson
Original Assignee
Nycomed Imaging As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9723920.6A external-priority patent/GB9723920D0/en
Priority claimed from GBGB9800158.9A external-priority patent/GB9800158D0/en
Application filed by Nycomed Imaging As filed Critical Nycomed Imaging As
Publication of NO20002429D0 publication Critical patent/NO20002429D0/no
Publication of NO20002429L publication Critical patent/NO20002429L/no
Publication of NO320225B1 publication Critical patent/NO320225B1/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1806—Suspensions, emulsions, colloids, dispersions
    • A61K49/1815—Suspensions, emulsions, colloids, dispersions compo-inhalant, e.g. breath tests
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/62—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using double resonance

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Chemical & Material Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Signal Processing (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
NO20002429A 1997-11-12 2000-05-10 Para-hydrogenmerkede midler og bruk av disse ved magnetresonansavbildning NO320225B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9723920.6A GB9723920D0 (en) 1997-11-12 1997-11-12 Method
GBGB9800158.9A GB9800158D0 (en) 1998-01-05 1998-01-05 Method
PCT/GB1998/003399 WO1999024080A1 (en) 1997-11-12 1998-11-12 Para-hydrogen labelled agents and their use in magnetic resonance imaging

Publications (3)

Publication Number Publication Date
NO20002429D0 NO20002429D0 (no) 2000-05-10
NO20002429L true NO20002429L (no) 2000-05-10
NO320225B1 NO320225B1 (no) 2005-11-14

Family

ID=26312589

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20002429A NO320225B1 (no) 1997-11-12 2000-05-10 Para-hydrogenmerkede midler og bruk av disse ved magnetresonansavbildning

Country Status (11)

Country Link
US (2) US6574495B1 (no)
EP (1) EP1047455B1 (no)
JP (1) JP2001522819A (no)
KR (1) KR100600670B1 (no)
CN (1) CN100571787C (no)
AT (1) ATE405297T1 (no)
AU (1) AU1047399A (no)
DE (1) DE69839924D1 (no)
NO (1) NO320225B1 (no)
RU (1) RU2218182C2 (no)
WO (1) WO1999024080A1 (no)

Families Citing this family (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1047399A (en) * 1997-11-12 1999-05-31 Nycomed Imaging As Para-hydrogen labelled agents and their use in magnetic resonance imaging
GB9911679D0 (en) * 1999-05-19 1999-07-21 Nycomed Imaging As Magnetic resonance imaging
GB9911681D0 (en) 1999-05-19 1999-07-21 Nycomed Imaging As Process
GB0009353D0 (en) * 2000-04-14 2000-05-31 Nycomed Imaging As Method
GB0022341D0 (en) * 2000-09-12 2000-10-25 Nycomed Imaging As Method
NO20004561D0 (no) * 2000-09-13 2000-09-13 Nycomed Imaging As Metode for magnetisk resonansavbildning
US7269157B2 (en) * 2001-04-10 2007-09-11 Internap Network Services Corporation System and method to assure network service levels with intelligent routing
GB0122049D0 (en) * 2001-09-12 2001-10-31 Nycomed Imaging As Method
US7133365B2 (en) * 2001-11-02 2006-11-07 Internap Network Services Corporation System and method to provide routing control of information over networks
US7222190B2 (en) * 2001-11-02 2007-05-22 Internap Network Services Corporation System and method to provide routing control of information over data networks
US7668966B2 (en) * 2001-11-02 2010-02-23 Internap Network Services Corporation Data network controller
GB0219954D0 (en) * 2002-08-29 2002-10-02 Amersham Health R & D Ab Method and apparatus for producing contrast agents for magnetic resonance imaging
GB0219952D0 (en) * 2002-08-29 2002-10-02 Amersham Health R & D Ab Method and apparatus for producing contrast agents for magnetic resonance imaging
GB0219953D0 (en) * 2002-08-29 2002-10-02 Amersham Health R & D Ab An arrangement and a method for providing contrast agents
US7623908B2 (en) * 2003-01-24 2009-11-24 The Board Of Trustees Of The University Of Illinois Nonlinear interferometric vibrational imaging
NO20031736D0 (no) * 2003-04-15 2003-04-15 Amersham Health As Forbindelser
JP3993127B2 (ja) * 2003-04-24 2007-10-17 株式会社日立製作所 Nmr装置用超電導プローブコイル
WO2005015253A1 (en) * 2003-07-28 2005-02-17 University Of Southampton Nmr spectroscopy using spin states with long lifetimes
US7432014B2 (en) 2003-11-05 2008-10-07 Sony Corporation Anode and battery
US7610074B2 (en) * 2004-01-08 2009-10-27 The Board Of Trustees Of The University Of Illinois Multi-functional plasmon-resonant contrast agents for optical coherence tomography
US7586618B2 (en) 2005-02-28 2009-09-08 The Board Of Trustees Of The University Of Illinois Distinguishing non-resonant four-wave-mixing noise in coherent stokes and anti-stokes Raman scattering
US7725169B2 (en) * 2005-04-15 2010-05-25 The Board Of Trustees Of The University Of Illinois Contrast enhanced spectroscopic optical coherence tomography
JP2007021008A (ja) * 2005-07-20 2007-02-01 Hitachi Ltd Dnp過分極手段を備えた磁気共鳴イメージング装置
EP1940475A4 (en) 2005-09-28 2010-05-26 Harvard College HYPERPOLARIZED SOLID MATERIALS WITH LONG SPIN RECOVERY TIMES FOR USE AS IMAGING MEANS IN MAGNETIC RESONANCE TOMOGRAPHY
ES2654520T3 (es) * 2005-10-11 2018-02-14 Huntington Medical Research Institutes Agentes de formación de imágenes y métodos de uso de los mismos
EP1968442A4 (en) * 2005-12-10 2009-11-04 Harvard College In situ hyperpolarization of imaging agents
US20090252686A1 (en) * 2006-01-11 2009-10-08 President And Fellows Of Harvard College Ex Vivo Hyperpolarization of Imaging Agents
US7787129B2 (en) 2006-01-31 2010-08-31 The Board Of Trustees Of The University Of Illinois Method and apparatus for measurement of optical properties in tissue
US8703102B2 (en) 2008-04-04 2014-04-22 Millikelvin Technologies Llc Systems and methods for producing hyperpolarized materials and mixtures thereof
KR101321862B1 (ko) 2006-02-21 2013-10-28 밀리켈빈 테크놀로지스 엘엘씨 과분극화 방법, 시스템 및 조성물
US8623327B2 (en) 2006-06-19 2014-01-07 Beth Israel Deaconess Medical Center, Inc. Imaging agents for use in magnetic resonance blood flow/perfusion imaging
EP2117607A4 (en) 2007-01-11 2012-08-08 Huntington Medical Res Inst PICTURES AND METHOD FOR THEIR USE
GB2450316A (en) 2007-06-18 2008-12-24 Univ York Hyperpolarizing nuclei
WO2009046457A2 (en) * 2007-10-05 2009-04-09 Huntington Medical Research Institutes Imaging of genetic material with magnetic resonance
EP2902041A1 (en) * 2007-12-19 2015-08-05 GE Healthcare Limited Composition and method for generating a metabolic profile using 13C-MR detection
US8983580B2 (en) 2008-01-18 2015-03-17 The Board Of Trustees Of The University Of Illinois Low-coherence interferometry and optical coherence tomography for image-guided surgical treatment of solid tumors
US7751057B2 (en) 2008-01-18 2010-07-06 The Board Of Trustees Of The University Of Illinois Magnetomotive optical coherence tomography
US8115934B2 (en) 2008-01-18 2012-02-14 The Board Of Trustees Of The University Of Illinois Device and method for imaging the ear using optical coherence tomography
WO2009124250A1 (en) * 2008-04-03 2009-10-08 The Trustees Of The University Of Pennsylvania Compositions and methods for detecting tricarboxylic acid (tca) metabolic flux
WO2009129265A1 (en) * 2008-04-14 2009-10-22 Huntington Medical Research Institutes Methods and apparatus for pasadena hyperpolarization
WO2009133169A1 (en) 2008-05-02 2009-11-05 General Electric Company Method of determining alanine transaminase (alt) activity by 13c-mr detection using hyperpolarised 13c-pyruvate
DK2349350T3 (en) * 2008-10-03 2017-02-27 Bracco Imaging Spa PROCEDURE FOR PREPARING Aqueous SOLUTIONS OF HYPERPOLARIZED MOLECULES
IT1391330B1 (it) * 2008-10-03 2011-12-05 Bracco Imaging Spa Processo per la preparazione di molecole iperpolarizzate.
US20100092390A1 (en) * 2008-10-09 2010-04-15 President And Fellows Of Harvard College Methods for Making Particles Having Long Spin-Lattice Relaxation Times
DE102008059313A1 (de) 2008-11-27 2010-06-02 Bruker Biospin Gmbh NMR-Messaparatur mit Durchfluss-Probenkopf und druckgasbetriebener Mischkammer, insbesondere zur para-Wasserstoff-induzierten Polarisierung einer flüssigen NMR-Messprobe
US20110274626A1 (en) 2008-12-10 2011-11-10 University Of York Pulse sequencing with hyperpolarisable nuclei
BRPI1013677A2 (pt) 2009-04-02 2016-04-26 Ge Healthcare Ltd método para detectar inflamação ou infecção, e, usos de um 13c-piruvato hiperpolarizado, e de um meio de formação de imagem.
KR20120101339A (ko) 2009-08-31 2012-09-13 밀리켈빈 테크놀로지스 엘엘씨 과분극 물질 및 그 혼합물의 제조용 시스템 및 제조방법
EP2473199A1 (en) 2009-08-31 2012-07-11 Brain Watch Ltd. Isotopically labeled neurochemical agents and uses thereof for diagnosing conditions and disorders
EP2476009A1 (en) 2009-09-10 2012-07-18 GE Healthcare UK Limited 13c-mr detection using hyperpolarised 13c-fructose
EP2316492A1 (en) 2009-10-30 2011-05-04 Bracco Imaging S.p.A Para-hydrogen labelled magnetic resonance imaging contrast agent
WO2011076228A1 (en) * 2009-12-21 2011-06-30 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e. V. Improved nmr measurement based on antiphase signals
EP2555803B1 (en) 2010-04-08 2018-09-12 Bracco Imaging S.p.A Process for preparing hyperpolarized substrates and method for mri
US8970217B1 (en) 2010-04-14 2015-03-03 Hypres, Inc. System and method for noise reduction in magnetic resonance imaging
JP5879333B2 (ja) 2010-05-03 2016-03-08 ジーイー・ヘルスケア・リミテッド Ldh活性を決定するための過分極乳酸塩造影剤
WO2012056447A1 (en) 2010-10-25 2012-05-03 Brain Watch Ltd. Isotopically labeled deoxy-glucose and derivatives thereof, compositions comprising them and uses thereof
US9452409B2 (en) 2011-04-22 2016-09-27 Vanderbilt University Para-hydrogen polarizer
WO2012164563A1 (en) 2011-06-01 2012-12-06 Brain Watch Ltd. Isotopically labeled cdp-choline and uses thereof
EP2766050B1 (en) 2011-10-12 2018-09-05 Bracco Imaging S.p.A Process for the preparation of hyperpolarized derivatives for use in mri analysis
EP2788035B1 (en) 2011-12-05 2016-03-09 Bracco Imaging S.p.A Composition comprising acetic anhydride and a gadolinium complex, and method for the use in hyperpolarisation mri analysis
WO2013167587A1 (en) 2012-05-07 2013-11-14 Albeda Innovation Aps Intra-operative cancer diagnosis based on a hyperpolarized marker
US9566354B2 (en) 2012-10-23 2017-02-14 Vanderbilt University Systems and methods of performing NMR spectroscopy and MRI
US9404984B2 (en) 2012-11-06 2016-08-02 Bruker Uk Limited Method of hyperpolarization applying brute force using particulate acceleration agents
US9551768B2 (en) 2013-03-15 2017-01-24 East Carolina University NMR method for monitoring changes in the core of lipoprotein particles in metabolism and disease
WO2014150909A1 (en) * 2013-03-15 2014-09-25 Cambridge Isotope Laboratories, Inc. Lysine isotopologues, compositions comprising the same and methods of synthesis
US10003536B2 (en) 2013-07-25 2018-06-19 Grigore Raileanu System and method for managing bandwidth usage rates in a packet-switched network
US9642924B2 (en) 2013-08-29 2017-05-09 Duke University Contrast agents based on long-lived nuclear singlet states and related methods
EP2863229A1 (en) 2013-10-15 2015-04-22 Technische Universität München pH-biosensors based on compounds with pH-sensitive enolic groups for magnetic resonance imaging and spectroscopy and their uses
CN105683144B (zh) * 2013-10-28 2019-06-04 伯拉考成像股份公司 用于制备超极化羧化物化合物的方法
EP2891500B1 (en) 2014-01-07 2018-08-01 Cambridge Enterprise Limited Contrast agent for determination of aldehyde dehydrogenase (ALDH) activity
EP3015855A1 (en) 2014-10-27 2016-05-04 Klinikum rechts der Isar der Technischen Universität München Metal biosensors based on compounds with metal-sensitive chemical shifts for magnetic resonance spectroscopy and imaging
US11156684B2 (en) * 2014-10-28 2021-10-26 Duke University Method for creating hyperpolarization at microTesla magnetic fields
US10924408B2 (en) 2014-11-07 2021-02-16 Noction, Inc. System and method for optimizing traffic in packet-switched networks with internet exchanges
US9769070B2 (en) 2015-01-28 2017-09-19 Maxim Basunov System and method of providing a platform for optimizing traffic through a computer network with distributed routing domains interconnected through data center interconnect links
EP3203256A1 (en) * 2016-02-02 2017-08-09 B. Braun Melsungen AG Calibration of mri systems using pre-defined concentrations of 19f isotopes as reference
CA3033346A1 (en) * 2016-08-09 2018-02-15 Beth Israel Deaconess Medical Center, Inc. System and method for microfluidic parahydrogen induced polarization hyperpolarizer for magnetic resonance imaging (mri) and nuclear magnetic resonance (nmr) applications
WO2018158891A1 (ja) * 2017-03-01 2018-09-07 国立大学法人九州大学 生体計測方法
US10775458B2 (en) 2018-03-05 2020-09-15 Texas Tech University System Method and system for non-invasive measurement of metabolic health
WO2021198776A2 (en) * 2020-03-31 2021-10-07 Nvision Imaging Technologies Gmbh Systems and method for generation of hyperpolarized materials
JP7846128B2 (ja) * 2020-12-07 2026-04-14 エヌビジョン イメージング テクノロジーズ ゲゼルシャフト ミット ベシュレンクテル ハフツング パラ水素を使用する超偏極化合物の生成のためのシステム及び方法
WO2023205400A1 (en) * 2022-04-23 2023-10-26 Wayne State University Method and apparatus for magnetic resonance (mr) contrast agents
EP4587413A1 (en) * 2022-09-13 2025-07-23 NVision Imaging Technologies GmbH Systems and methods for generation of hyperpolarized materials

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0662004T3 (da) * 1991-08-09 1998-10-19 Nycomed Innovation Ab Anvendelse af stabile frie radikaler ved magnetiskresonans-billeddannnelse
JPH0753967A (ja) * 1993-08-18 1995-02-28 Catalysts & Chem Ind Co Ltd 重質油の水素化処理方法
US5479925A (en) * 1994-06-23 1996-01-02 General Electric Company Magnetic resonance (MR) angiography in a low-field imaging magnet
JPH0919449A (ja) * 1995-07-06 1997-01-21 Tadashi Matsuoka おむつに対する失禁センサー
US5611340A (en) * 1995-10-02 1997-03-18 General Electric Company Apparatus and methods for magnetic resonance (MR) angiography using hydrogen polarized at low temperatures
JP3897841B2 (ja) * 1995-10-31 2007-03-28 独立行政法人科学技術振興機構 標識アシル−l−カルニチンを用いた疾患診断剤
AU1047399A (en) * 1997-11-12 1999-05-31 Nycomed Imaging As Para-hydrogen labelled agents and their use in magnetic resonance imaging
US6574496B1 (en) * 1999-05-19 2003-06-03 Amersham Health As Magnetic resonance imaging
GB0022341D0 (en) * 2000-09-12 2000-10-25 Nycomed Imaging As Method

Also Published As

Publication number Publication date
NO320225B1 (no) 2005-11-14
NO20002429D0 (no) 2000-05-10
JP2001522819A (ja) 2001-11-20
WO1999024080A1 (en) 1999-05-20
KR100600670B1 (ko) 2006-07-13
ATE405297T1 (de) 2008-09-15
DE69839924D1 (de) 2008-10-02
AU1047399A (en) 1999-05-31
KR20010024606A (ko) 2001-03-26
US6574495B1 (en) 2003-06-03
CN100571787C (zh) 2009-12-23
EP1047455A1 (en) 2000-11-02
EP1047455B1 (en) 2008-08-20
RU2218182C2 (ru) 2003-12-10
CN1306441A (zh) 2001-08-01
US20040024307A1 (en) 2004-02-05

Similar Documents

Publication Publication Date Title
NO20002429D0 (no) Para-hydrogenmerkede midler og bruk av disse ved magnetresonansavbildning
DE69820415D1 (de) Verfahren zur bilderzeugung mit magnetischer resonanz
NZ505151A (en) Method of magnetic resonance investigation of a sample using a hyperpolarised solution of a high T1 agent
Golman et al. Real-time metabolic imaging
Budinger et al. Nuclear magnetic resonance technology for medical studies
Wilke et al. Concepts of myocardial perfusion imaging in magnetic resonance imaging
Schick et al. Localized proton MR spectroscopy of citrate in vitro and of the human prostate in vivo at 1.5 T
Golman et al. Parahydrogen‐induced polarization in imaging: Subsecond 13C angiography
FI86775B (fi) Kaernmagnetisk resonans anvaendande projektionsavbildningssystem foer en blodaoder.
Marco‐Rius et al. Hyperpolarized singlet lifetimes of pyruvate in human blood and in the mouse
ATE337558T1 (de) Verfahren zur bilderzeugung durch magnetische resonanz und zur spektroskopischen analyse und dazugehörendes gerät
CA2417724A1 (en) Method of magnetic resonance investigation of a sample using a nuclear spin polarised mr imaging agent
AU2001264072A1 (en) Method for investigating the fate of a test compound or the stateof a biologicalsystem by means of nmr of hyperpolarised nmr active nuclei
EP0351919A1 (en) Stable free radical-containing contrast media
WO1999032897A3 (en) Nmr apparatus and method for non-invasive in vivo testing of a patient's body fluid glucose levels
RU2000115296A (ru) Агенты, меченные параводородом, и их применение для магнитной резонансной визуализации
Jannin et al. Kinetics of yttrium− ligand complexation monitored using hyperpolarized 89Y as a model for gadolinium in contrast agents
EP0302742A3 (en) Methods of obtaining images representing the distribution of paramagnetic molecules in solution
Li et al. Quantitative evaluation of pulmonary gas‐exchange function using hyperpolarized 129Xe CEST MRS and MRI
Ris et al. Assessment of human islet labeling with clinical grade iron nanoparticles prior to transplantation for graft monitoring by MRI
PL337286A1 (en) Projection mammography apparatus
Kushlan et al. Proton-detected NMR relaxation of methylene carbons via stereoselective and random fractional deuteration
JPH03505692A (ja) スピン共鳴スペクトルの記録方法
EP1058122A3 (en) Ex vivo nuclear polarisation of a magnetic resonance imaging contrast agent by means of ortho-deuterium enriched hydrogen gas
JPH11113882A (ja) 拡散スペクトルmri

Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees