ATE294793T1 - Phenantrhridin-n-oxides mit pde-iv hemmender wirkung - Google Patents

Phenantrhridin-n-oxides mit pde-iv hemmender wirkung

Info

Publication number
ATE294793T1
ATE294793T1 AT00901539T AT00901539T ATE294793T1 AT E294793 T1 ATE294793 T1 AT E294793T1 AT 00901539 T AT00901539 T AT 00901539T AT 00901539 T AT00901539 T AT 00901539T AT E294793 T1 ATE294793 T1 AT E294793T1
Authority
AT
Austria
Prior art keywords
oxides
phenantrhridine
pde
inhibiting effect
compounds
Prior art date
Application number
AT00901539T
Other languages
English (en)
Inventor
Dieter Flockerzi
Hermann Amschler
Armin Hatzelmann
Daniela Bundschuh
Rolf Beume
Hildegard Boss
Hans-Peter Kley
Beate Schmidt
Original Assignee
Altana Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Altana Pharma Ag filed Critical Altana Pharma Ag
Application granted granted Critical
Publication of ATE294793T1 publication Critical patent/ATE294793T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Junction Field-Effect Transistors (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT00901539T 1999-01-15 2000-01-13 Phenantrhridin-n-oxides mit pde-iv hemmender wirkung ATE294793T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99100693 1999-01-15
PCT/EP2000/000192 WO2000042034A1 (en) 1999-01-15 2000-01-13 Phenanthridine-n-oxides with pde-iv inhibiting activity

Publications (1)

Publication Number Publication Date
ATE294793T1 true ATE294793T1 (de) 2005-05-15

Family

ID=8237350

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00901539T ATE294793T1 (de) 1999-01-15 2000-01-13 Phenantrhridin-n-oxides mit pde-iv hemmender wirkung

Country Status (12)

Country Link
US (1) US6534519B1 (de)
EP (1) EP1147103B1 (de)
JP (1) JP2003502278A (de)
AT (1) ATE294793T1 (de)
AU (1) AU2290000A (de)
CA (1) CA2359449A1 (de)
DE (1) DE60019894T2 (de)
DK (1) DK1147103T3 (de)
ES (1) ES2241571T3 (de)
PT (1) PT1147103E (de)
SI (1) SI1147103T1 (de)
WO (1) WO2000042034A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20010578A2 (en) * 1999-01-15 2002-08-31 Byk Gulden Lomberg Chem Fab Phenylphenanthridines with pde-iv inhibiting activity
JP2003519686A (ja) 2000-01-11 2003-06-24 アルタナ ファルマ アクチエンゲゼルシャフト フェナントリジン−ｎ−オキシド
PT1303506E (pt) 2000-07-14 2005-06-30 Altana Pharma Ag 6-heteroarilfenantridinas
JP4587294B2 (ja) * 2002-08-29 2010-11-24 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｐｄｅ４インヒビターとしての２−ヒドロキシ−６−フェニルフェナントリジン
ATE353217T1 (de) 2002-08-29 2007-02-15 Altana Pharma Ag 3-hydroxy-6-phenylphenanthridine als pde-4 inhibitoren
EP1658271A1 (de) * 2003-07-31 2006-05-24 ALTANA Pharma AG Neue 6-phenylphenanthridine
JP2007500685A (ja) * 2003-07-31 2007-01-18 アルタナ　ファルマ　アクチエンゲゼルシャフト 新規の６−フェニルフェナントリジン
US20050187278A1 (en) * 2003-08-28 2005-08-25 Pharmacia Corporation Treatment or prevention of vascular disorders with Cox-2 inhibitors in combination with cyclic AMP-specific phosphodiesterase inhibitors
AU2004269923B2 (en) * 2003-09-05 2010-05-13 Takeda Gmbh Use of PDE4 inhibitors for the treatment of diabetes mellitus
JP4728259B2 (ja) 2004-02-18 2011-07-20 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング 効果的なホスホジエステラーゼ（ｐｄｅ）４インヒビターとしての新規のグアニジニル置換されたヒドロキシ−６−フェニルフェナントリジン
CN104803973A (zh) 2004-03-03 2015-07-29 塔科达有限责任公司 新的羟基-6-杂芳基菲啶及其作为pde4抑制剂的用途
AR049419A1 (es) * 2004-03-03 2006-08-02 Altana Pharma Ag Hidroxi-6-fenilfenantridinas sustituidas con heterociclilo
KR20060130697A (ko) * 2004-03-10 2006-12-19 알타나 파마 아게 신규한 아미도-치환 히드록시-6-페닐페난트리딘 및 ｐｄｅ4억제제로서의 이의 용도
ES2440590T3 (es) * 2005-03-02 2014-01-29 Takeda Gmbh Nuevas sales de derivados de hexahidrofenantridina 6-heterociclil-sustituidos
US8017633B2 (en) 2005-03-08 2011-09-13 Nycomed Gmbh Roflumilast for the treatment of diabetes mellitus
CN101815512B (zh) 2007-10-04 2013-04-24 弗·哈夫曼-拉罗切有限公司 环丙基芳基酰胺衍生物和其用途
WO2013106547A1 (en) 2012-01-10 2013-07-18 President And Fellows Of Harvard College Beta-cell replication promoting compounds and methods of their use

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5455252A (en) * 1993-03-31 1995-10-03 Syntex (U.S.A.) Inc. Optionally substituted 6,8-quinolines
US5475003A (en) * 1994-03-03 1995-12-12 Syntex (U.S.A.) Inc. 8-phenylcyclopentenoquinoline and 8-phenylcyclohexenoquinoline derivatives
CA2143143A1 (en) * 1994-03-08 1995-09-09 Toshihiko Tanaka 3-phenylpyrrolidine derivatives
US5466697A (en) * 1994-07-13 1995-11-14 Syntex (U.S.A.) Inc. 8-phenyl-1,6-naphthyridin-5-ones
EE03523B1 (et) * 1996-01-31 2001-10-15 Byk Gulden Lomberg Chemische Fabrik Gmbh Fenantridiinid, neid sisaldavad ravimid ja nende kasutamine
JP4141501B2 (ja) * 1996-03-26 2008-08-27 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規の６位置換フェナントリジン
US6127378A (en) 1996-03-26 2000-10-03 Byk Gulden Lomberg Chemische Fabrik Gmbh Phenanthridines substituted in the 6 position
GB9622386D0 (en) 1996-10-28 1997-01-08 Sandoz Ltd Organic compounds
EP0937074B1 (de) 1996-11-11 2003-03-12 ALTANA Pharma AG Benzonaphthyridine als bronchialtherapeutika
GB9626643D0 (en) 1996-12-21 1997-02-12 Astra Pharma Prod Compounds
SI0968211T1 (en) 1997-03-07 2004-02-29 Altana Pharma Ag Tetrazole derivatives
CA2291153A1 (en) 1997-06-03 1998-12-10 Byk Gulden Lomberg Chemische Fabrik Gmbh Benzonaphthyridine
SI0998460T1 (en) * 1997-07-25 2004-08-31 Altana Pharma Ag Novel tetrazole derivatives
AU5970199A (en) 1998-08-31 2000-03-21 Byk Gulden Lomberg Chemische Fabrik Gmbh Benzonaphthyridine-n-oxides comprising a pde3 and pde4 inhibiting activity

Also Published As

Publication number Publication date
CA2359449A1 (en) 2000-07-20
DE60019894T2 (de) 2006-01-12
WO2000042034A1 (en) 2000-07-20
SI1147103T1 (en) 2005-10-31
EP1147103A1 (de) 2001-10-24
AU2290000A (en) 2000-08-01
ES2241571T3 (es) 2005-11-01
JP2003502278A (ja) 2003-01-21
PT1147103E (pt) 2005-08-31
DE60019894D1 (de) 2005-06-09
DK1147103T3 (da) 2005-08-29
US6534519B1 (en) 2003-03-18
EP1147103B1 (de) 2005-05-04

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