ATE406171T1 - Aplidine zur behandlung von multiplem myelom - Google Patents

Aplidine zur behandlung von multiplem myelom

Info

Publication number: ATE406171T1
Authority: AT; Austria
Prior art keywords: aplidine; multiple myeloma; treatment; medicament; manufacture
Prior art date: 2003-03-12

Application number

AT04720081T

Other languages

English (en)

Inventor

Joseph R Bertino

Daniel Medina

Glynn Thomas Faircloth

Constantine S Mitsiades

Kenneth Anderson

Nicholas Mitsiades

Original Assignee

Dana Farber Cancer Inst Inc

Pharma Mar Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-03-12

Filing date

2004-03-12

Publication date

2008-09-15

2004-03-12 Application filed by Dana Farber Cancer Inst Inc, Pharma Mar Sa filed Critical Dana Farber Cancer Inst Inc

2008-09-15 Application granted granted Critical

2008-09-15 Publication of ATE406171T1 publication Critical patent/ATE406171T1/de

Links

UUSZLLQJYRSZIS-LXNNNBEUSA-N plitidepsin Chemical compound CN([C@H](CC(C)C)C(=O)N[C@@H]1C(=O)N[C@@H]([C@H](CC(=O)O[C@H](C(=O)[C@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N2CCC[C@H]2C(=O)N(C)[C@@H](CC=2C=CC(OC)=CC=2)C(=O)O[C@@H]1C)C(C)C)O)[C@@H](C)CC)C(=O)[C@@H]1CCCN1C(=O)C(C)=O UUSZLLQJYRSZIS-LXNNNBEUSA-N 0.000 title abstract 3
208000034578 Multiple myelomas Diseases 0.000 title abstract 2
206010035226 Plasma cell myeloma Diseases 0.000 title abstract 2
229950008499 plitidepsin Drugs 0.000 title abstract 2
108010049948 plitidepsin Proteins 0.000 title abstract 2
239000003814 drug Substances 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/15—Depsipeptides; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Epidemiology (AREA)
Gastroenterology & Hepatology (AREA)
Immunology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Production Of Liquid Hydrocarbon Mixture For Refining Petroleum (AREA)
Steroid Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

AT04720081T 2003-03-12 2004-03-12 Aplidine zur behandlung von multiplem myelom ATE406171T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US45412503P	2003-03-12	2003-03-12
US52029303P	2003-11-14	2003-11-14

Publications (1)

Publication Number	Publication Date
ATE406171T1 true ATE406171T1 (de)	2008-09-15

Family

ID=32994545

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT04720081T ATE406171T1 (de)	2003-03-12	2004-03-12	Aplidine zur behandlung von multiplem myelom

Country Status (20)

Country	Link
US (1)	US7381703B2 (de)
EP (1)	EP1603584B1 (de)
JP (1)	JP4584245B2 (de)
KR (1)	KR101160320B1 (de)
AT (1)	ATE406171T1 (de)
AU (1)	AU2004218883B2 (de)
CA (1)	CA2519789C (de)
CY (1)	CY1108599T1 (de)
DE (1)	DE602004016126D1 (de)
DK (1)	DK1603584T3 (de)
ES (1)	ES2312979T3 (de)
IL (1)	IL170136A (de)
MX (1)	MXPA05009742A (de)
NO (1)	NO334264B1 (de)
NZ (1)	NZ541611A (de)
PL (1)	PL1603584T3 (de)
PT (1)	PT1603584E (de)
RU (1)	RU2335294C2 (de)
SI (1)	SI1603584T1 (de)
WO (1)	WO2004080477A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1229922B1 (de) *	1999-11-15	2007-06-06	Pharma Mar, S.A.	Behandlung von krebserkrankungen durch aplidin
WO2004080421A2 (en)	2003-03-12	2004-09-23	Pharma Mar, S.A.	Improved antitumoral treatments
US20090226465A1 (en) *	2005-10-31	2009-09-10	Jackson David Y	Macrocyclic depsipeptide antibody-drug conjugates and methods
MX2008010999A (es) *	2006-02-28	2008-09-08	Pharma Mar Sa	Tratamientos anti-tumor mejorados.
WO2008080956A1 (en) *	2006-12-29	2008-07-10	Pharma Mar, S.A.	Prognostic molecular markers for the cancer therapy with aplidine
WO2009002553A1 (en) *	2007-06-25	2008-12-31	Prolexys Pharmaceuticals, Inc.	Methods of treating multiple myeloma and resistant cancers
EP2205263A1 (de) *	2007-10-19	2010-07-14	Pharma Mar, S.A.	Verbesserte antitumorbehandlungen
CN101965191A (zh) *	2008-03-07	2011-02-02	法马马有限公司	改善的抗癌治疗
CN102065865B (zh) *	2008-05-16	2013-03-20	马尔药品公司	多发性骨髓瘤治疗
TWI807411B (zh)	2017-04-27	2023-07-01	西班牙商瑪製藥股份有限公司	抗腫瘤化合物

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DE3161556D1 (en)	1980-09-12	1984-01-05	Univ Illinois	Novel antibiotics, derivatives thereof, processes for their extraction, and compositions containing them
US4950649A (en) *	1980-09-12	1990-08-21	University Of Illinois	Didemnins and nordidemnins
IT1153974B (it) *	1982-09-23	1987-01-21	Erba Farmitalia	Composizioni farmacologiche a base di cisplatino e metodo per il loro ottenimento
US4948791A (en)	1989-04-10	1990-08-14	The Board Of Trustees Of The University Of Illinois	Novel Cytotoxic cyclic depsipeptides from the tunicate trididemnum solidum
GB8922026D0 (en)	1989-09-29	1989-11-15	Pharma Mar Sa	Novel anti-viral and cytotoxic agent
DE4120327A1 (de)	1991-06-20	1992-12-24	Basf Ag	Neue peptide, ihre herstellung und verwendung
US5462726A (en) *	1993-12-17	1995-10-31	Bristol-Myers Squibb Company	Method of inhibiting side effects of solvents containing ricinoleic acid or castor oil or derivatives thereof employing a thromboxane A2 receptor antagonist and pharmaceutical compositions containing such solvents
AU681231B2 (en) *	1993-12-29	1997-08-21	Intarcia Therapeutics, Inc.	Methods and compositions for the treatment of a host with a cellular proliferative disease
ATE208633T1 (de) *	1994-09-16	2001-11-15	Merck Patent Gmbh	Immunokonjugate
US5861439A (en) *	1994-11-14	1999-01-19	Alza Corporation	Method for enhanced electrotransport agent delivery
ES2102322B1 (es)	1995-07-13	1998-03-01	Pharma Mar Sa	Procedimiento de preparacion de didemnina a.
ES2151277T3 (es) *	1996-05-22	2000-12-16	Protarga Inc	Composiciones que comprenden conjugados de acido cis-docosahexaenoico y taxotere.
US6156724A (en) *	1996-06-07	2000-12-05	Rinehart; Kenneth L.	Uses of didemnins as immunomodulating agents
GB2331983B (en)	1996-07-03	2000-03-08	Mckechnie Uk Ltd	Containers
WO1998017302A1 (en)	1996-10-24	1998-04-30	The Board Of Trustees Of The University Of Illinois	Total synthesis of the amino hip analogue of didemnin a
JP2001503746A (ja)	1996-10-24	2001-03-21	ザ・ボード・オブ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・イリノイ	ジデムニン類似体の半合成法
US6034058A (en) *	1997-04-15	2000-03-07	Rinehart; Kenneth L.	Semi-synthetic alanyl dilemnin analogs
AU740598B2 (en) *	1997-05-07	2001-11-08	William J. Crumb	Aplidine as an L-type calcium channel enhancer
GB9803448D0 (en) *	1998-02-18	1998-04-15	Pharma Mar Sa	Pharmaceutical formulation
WO2000006134A2 (en) *	1998-07-30	2000-02-10	Sigma-Tau Industrie Farmaceutiche Riunite S.P.A.	Use of l-carnitine and its alkanoyl derivatives in the preparation of medicaments with anticancer activity
US20010021380A1 (en) *	1999-04-19	2001-09-13	Pluenneke John D.	Soluble tumor necrosis factor receptor treatment of medical disorders
CA2373643A1 (en)	1999-05-25	2000-11-30	Point Therapeutics, Inc.	Anti-tumor comprising boroproline compounds
US6890904B1 (en) *	1999-05-25	2005-05-10	Point Therapeutics, Inc.	Anti-tumor agents
EP1229922B1 (de)	1999-11-15	2007-06-06	Pharma Mar, S.A.	Behandlung von krebserkrankungen durch aplidin
DK1276491T3 (da)	2000-04-07	2007-02-05	Univ Pennsylvania	Tamandarin- og didemnin-analoger og fremgangsmåder til fremstilling og anvendelse af dem
US6509315B1 (en) *	2000-04-07	2003-01-21	The Trustees Of The University Of Pennsylvania	Didemnin analogs and fragments and methods of making and using them
UA76718C2 (uk)	2000-06-30	2006-09-15	Фарма Мар, С.А.	Протипухлинні похідні аплідину
CA2423462A1 (en) *	2000-10-05	2002-04-11	Immunex Corporation	Nectin polypeptides, polynucleotides, methods of making and use thereof
AU9402401A (en)	2000-10-12	2002-04-22	Pharma Mar Sa	Treatment of cancers
WO2002032374A2 (en) *	2000-10-18	2002-04-25	Immunex Corporation	Methods for treating il-18 mediated disorders
WO2002053138A2 (en) *	2001-01-02	2002-07-11	Elisabeth Shanahan-Prendergast	Treatment for inhibiting neoplastic lesions using incensole and/or furanogermacrens
DE60229414D1 (de)	2001-10-19	2008-11-27	Pharma Mar Sa	Verwendung von aplidine in der behandlung von pankreaskrebs
WO2004080421A2 (en)	2003-03-12	2004-09-23	Pharma Mar, S.A.	Improved antitumoral treatments

2004
- 2004-03-12 NZ NZ541611A patent/NZ541611A/en not_active IP Right Cessation
- 2004-03-12 DK DK04720081T patent/DK1603584T3/da active
- 2004-03-12 AT AT04720081T patent/ATE406171T1/de active
- 2004-03-12 JP JP2006505957A patent/JP4584245B2/ja not_active Expired - Lifetime
- 2004-03-12 DE DE602004016126T patent/DE602004016126D1/de not_active Expired - Lifetime
- 2004-03-12 PT PT04720081T patent/PT1603584E/pt unknown
- 2004-03-12 AU AU2004218883A patent/AU2004218883B2/en not_active Expired
- 2004-03-12 RU RU2005131578/15A patent/RU2335294C2/ru active
- 2004-03-12 PL PL04720081T patent/PL1603584T3/pl unknown
- 2004-03-12 EP EP04720081A patent/EP1603584B1/de not_active Expired - Lifetime
- 2004-03-12 SI SI200430878T patent/SI1603584T1/sl unknown
- 2004-03-12 KR KR1020057016966A patent/KR101160320B1/ko not_active Expired - Lifetime
- 2004-03-12 MX MXPA05009742A patent/MXPA05009742A/es active IP Right Grant
- 2004-03-12 CA CA2519789A patent/CA2519789C/en not_active Expired - Lifetime
- 2004-03-12 US US10/548,710 patent/US7381703B2/en not_active Expired - Lifetime
- 2004-03-12 WO PCT/GB2004/001062 patent/WO2004080477A1/en not_active Ceased
- 2004-03-12 ES ES04720081T patent/ES2312979T3/es not_active Expired - Lifetime
2005
- 2005-08-07 IL IL170136A patent/IL170136A/en active IP Right Grant
- 2005-10-11 NO NO20054668A patent/NO334264B1/no unknown
2008
- 2008-11-26 CY CY20081101367T patent/CY1108599T1/el unknown

Also Published As

Publication number	Publication date
PT1603584E (pt)	2008-11-21
DK1603584T3 (da)	2009-01-05
KR20060006779A (ko)	2006-01-19
CA2519789C (en)	2012-07-03
SI1603584T1 (sl)	2009-02-28
PL1603584T3 (pl)	2009-02-27
RU2005131578A (ru)	2006-01-27
MXPA05009742A (es)	2006-05-25
AU2004218883A1 (en)	2004-09-23
WO2004080477A1 (en)	2004-09-23
JP2006519828A (ja)	2006-08-31
JP4584245B2 (ja)	2010-11-17
IL170136A (en)	2014-04-30
WO2004080477A8 (en)	2004-11-11
CA2519789A1 (en)	2004-09-23
ES2312979T3 (es)	2009-03-01
NZ541611A (en)	2008-04-30
DE602004016126D1 (de)	2008-10-09
KR101160320B1 (ko)	2012-06-26
AU2004218883B2 (en)	2009-10-01
US7381703B2 (en)	2008-06-03
EP1603584A1 (de)	2005-12-14
NO20054668L (no)	2005-10-11
US20060172926A1 (en)	2006-08-03
CY1108599T1 (el)	2014-04-09
US20070149445A9 (en)	2007-06-28
EP1603584B1 (de)	2008-08-27
RU2335294C2 (ru)	2008-10-10
NO334264B1 (no)	2014-01-20

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2009-04-15

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