ATE406171T1 - Aplidine zur behandlung von multiplem myelom - Google Patents

Aplidine zur behandlung von multiplem myelom

Info

Publication number: ATE406171T1
Authority: AT; Austria
Prior art keywords: aplidine; multiple myeloma; treatment; medicament; manufacture
Prior art date: 2003-03-12

Application number

AT04720081T

Other languages

English (en)

Inventor

Joseph R Bertino

Daniel Medina

Glynn Thomas Faircloth

Constantine S Mitsiades

Kenneth Anderson

Nicholas Mitsiades

Original Assignee

Dana Farber Cancer Inst Inc

Pharma Mar Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-03-12

Filing date

2004-03-12

Publication date

2008-09-15

2004-03-12 Application filed by Dana Farber Cancer Inst Inc, Pharma Mar Sa filed Critical Dana Farber Cancer Inst Inc

2008-09-15 Application granted granted Critical

2008-09-15 Publication of ATE406171T1 publication Critical patent/ATE406171T1/de

Links

UUSZLLQJYRSZIS-LXNNNBEUSA-N plitidepsin Chemical compound CN([C@H](CC(C)C)C(=O)N[C@@H]1C(=O)N[C@@H]([C@H](CC(=O)O[C@H](C(=O)[C@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N2CCC[C@H]2C(=O)N(C)[C@@H](CC=2C=CC(OC)=CC=2)C(=O)O[C@@H]1C)C(C)C)O)[C@@H](C)CC)C(=O)[C@@H]1CCCN1C(=O)C(C)=O UUSZLLQJYRSZIS-LXNNNBEUSA-N 0.000 title abstract 3
208000034578 Multiple myelomas Diseases 0.000 title abstract 2
206010035226 Plasma cell myeloma Diseases 0.000 title abstract 2
229950008499 plitidepsin Drugs 0.000 title abstract 2
108010049948 plitidepsin Proteins 0.000 title abstract 2
239000003814 drug Substances 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/15—Depsipeptides; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Epidemiology (AREA)
Gastroenterology & Hepatology (AREA)
Immunology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Production Of Liquid Hydrocarbon Mixture For Refining Petroleum (AREA)
Steroid Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

AT04720081T 2003-03-12 2004-03-12 Aplidine zur behandlung von multiplem myelom ATE406171T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US45412503P	2003-03-12	2003-03-12
US52029303P	2003-11-14	2003-11-14

Publications (1)

Publication Number	Publication Date
ATE406171T1 true ATE406171T1 (de)	2008-09-15

Family

ID=32994545

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT04720081T ATE406171T1 (de)	2003-03-12	2004-03-12	Aplidine zur behandlung von multiplem myelom

Country Status (20)

Country	Link
US (1)	US7381703B2 (de)
EP (1)	EP1603584B1 (de)
JP (1)	JP4584245B2 (de)
KR (1)	KR101160320B1 (de)
AT (1)	ATE406171T1 (de)
AU (1)	AU2004218883B2 (de)
CA (1)	CA2519789C (de)
CY (1)	CY1108599T1 (de)
DE (1)	DE602004016126D1 (de)
DK (1)	DK1603584T3 (de)
ES (1)	ES2312979T3 (de)
IL (1)	IL170136A (de)
MX (1)	MXPA05009742A (de)
NO (1)	NO334264B1 (de)
NZ (1)	NZ541611A (de)
PL (1)	PL1603584T3 (de)
PT (1)	PT1603584E (de)
RU (1)	RU2335294C2 (de)
SI (1)	SI1603584T1 (de)
WO (1)	WO2004080477A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CZ302498B6 (cs) *	1999-11-15	2011-06-15	Pharma Mar, S. A.	Farmaceutický prípravek obsahující aplidin pro lécení rakovinových onemocnení
EP1620117A4 (de)	2003-03-12	2009-07-29	Pharma Mar Sa	Verbesserte antitumorale behandlungen
EP1942944A2 (de) *	2005-10-31	2008-07-16	Genentech, Inc.	Makrozyklische depsipeptid-antikörper-wirkstoff-konjugate und entsprechende verfahren
WO2007101235A2 (en) *	2006-02-28	2007-09-07	Pharma Mar, S.A.	Improved antitumoral treatments
WO2008080956A1 (en) *	2006-12-29	2008-07-10	Pharma Mar, S.A.	Prognostic molecular markers for the cancer therapy with aplidine
WO2009002553A1 (en) *	2007-06-25	2008-12-31	Prolexys Pharmaceuticals, Inc.	Methods of treating multiple myeloma and resistant cancers
AU2008313627A1 (en) *	2007-10-19	2009-04-23	Pharma Mar, S.A.	Improved antitumoral treatments
CA2717409A1 (en) *	2008-03-07	2009-09-11	Pharma Mar, S.A.	Improved anticancer treatments
NZ589270A (en) *	2008-05-16	2011-12-22	Pharma Mar Sa	Multiple myeloma treatments
KR102491180B1 (ko)	2017-04-27	2023-01-20	파르마 마르 에스.에이.	항종양 화합물

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US4950649A (en) *	1980-09-12	1990-08-21	University Of Illinois	Didemnins and nordidemnins
IT1153974B (it) *	1982-09-23	1987-01-21	Erba Farmitalia	Composizioni farmacologiche a base di cisplatino e metodo per il loro ottenimento
US4948791A (en)	1989-04-10	1990-08-14	The Board Of Trustees Of The University Of Illinois	Novel Cytotoxic cyclic depsipeptides from the tunicate trididemnum solidum
GB8922026D0 (en) *	1989-09-29	1989-11-15	Pharma Mar Sa	Novel anti-viral and cytotoxic agent
DE4120327A1 (de)	1991-06-20	1992-12-24	Basf Ag	Neue peptide, ihre herstellung und verwendung
US5462726A (en) *	1993-12-17	1995-10-31	Bristol-Myers Squibb Company	Method of inhibiting side effects of solvents containing ricinoleic acid or castor oil or derivatives thereof employing a thromboxane A2 receptor antagonist and pharmaceutical compositions containing such solvents
JPH09507233A (ja) *	1993-12-29	1997-07-22	マトリクスファーマスーティカル，インコーポレイティド	細胞増殖性疾患に罹る宿主の治療方法及び治療のための組成物
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ES2102322B1 (es)	1995-07-13	1998-03-01	Pharma Mar Sa	Procedimiento de preparacion de didemnina a.
ES2151277T3 (es) *	1996-05-22	2000-12-16	Protarga Inc	Composiciones que comprenden conjugados de acido cis-docosahexaenoico y taxotere.
US6156724A (en) *	1996-06-07	2000-12-05	Rinehart; Kenneth L.	Uses of didemnins as immunomodulating agents
EP0918693B1 (de)	1996-07-03	2001-11-07	C G Paxton Limited	Behälter
DE69735583T2 (de)	1996-10-24	2007-04-05	The Board Of Trustees Of The University Of Illinois, Urbana	Semisynthetisches verfahren zur herstellung von didemninanalogen
US6380156B1 (en)	1996-10-24	2002-04-30	The Board Of Trustees Of The University Of Illnois	Total synthesis of the amino hip analogue of didemnin A
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GB9803448D0 (en) *	1998-02-18	1998-04-15	Pharma Mar Sa	Pharmaceutical formulation
CA2338638C (en) *	1998-07-30	2009-03-17	Sigma-Tau Industrie Farmaceutiche Riunite S.P.A.	Use of l-carnitine and its alkanoyl derivatives in the preparation of medicaments with anticancer activity
US20010021380A1 (en) *	1999-04-19	2001-09-13	Pluenneke John D.	Soluble tumor necrosis factor receptor treatment of medical disorders
US6890904B1 (en) *	1999-05-25	2005-05-10	Point Therapeutics, Inc.	Anti-tumor agents
AU781897B2 (en)	1999-05-25	2005-06-23	Point Therapeutics, Inc.	Anti-tumor comprising boroproline compounds
CZ302498B6 (cs)	1999-11-15	2011-06-15	Pharma Mar, S. A.	Farmaceutický prípravek obsahující aplidin pro lécení rakovinových onemocnení
US6509315B1 (en) *	2000-04-07	2003-01-21	The Trustees Of The University Of Pennsylvania	Didemnin analogs and fragments and methods of making and using them
CA2405779A1 (en)	2000-04-07	2001-10-18	The Trustees Of The University Of Pennsylvania	Tamandarin and didemnin analogs and methods of making and using them
UA76718C2 (uk) *	2000-06-30	2006-09-15	Фарма Мар, С.А.	Протипухлинні похідні аплідину
AU1305302A (en) *	2000-10-05	2002-04-15	Immunex Corp	Nectin polypeptides, polynucleotides, methods of making and use thereof
MXPA03003230A (es)	2000-10-12	2004-12-03	Pharma Mar Sa	Tratamiento de canceres.
WO2002032374A2 (en) *	2000-10-18	2002-04-25	Immunex Corporation	Methods for treating il-18 mediated disorders
WO2002053138A2 (en) *	2001-01-02	2002-07-11	Elisabeth Shanahan-Prendergast	Treatment for inhibiting neoplastic lesions using incensole and/or furanogermacrens
DE60229414D1 (de)	2001-10-19	2008-11-27	Pharma Mar Sa	Verwendung von aplidine in der behandlung von pankreaskrebs
EP1620117A4 (de)	2003-03-12	2009-07-29	Pharma Mar Sa	Verbesserte antitumorale behandlungen

2004
- 2004-03-12 AU AU2004218883A patent/AU2004218883B2/en not_active Expired
- 2004-03-12 CA CA2519789A patent/CA2519789C/en not_active Expired - Lifetime
- 2004-03-12 KR KR1020057016966A patent/KR101160320B1/ko not_active Expired - Lifetime
- 2004-03-12 PL PL04720081T patent/PL1603584T3/pl unknown
- 2004-03-12 JP JP2006505957A patent/JP4584245B2/ja not_active Expired - Lifetime
- 2004-03-12 AT AT04720081T patent/ATE406171T1/de active
- 2004-03-12 SI SI200430878T patent/SI1603584T1/sl unknown
- 2004-03-12 MX MXPA05009742A patent/MXPA05009742A/es active IP Right Grant
- 2004-03-12 PT PT04720081T patent/PT1603584E/pt unknown
- 2004-03-12 US US10/548,710 patent/US7381703B2/en not_active Expired - Lifetime
- 2004-03-12 DK DK04720081T patent/DK1603584T3/da active
- 2004-03-12 DE DE602004016126T patent/DE602004016126D1/de not_active Expired - Lifetime
- 2004-03-12 ES ES04720081T patent/ES2312979T3/es not_active Expired - Lifetime
- 2004-03-12 RU RU2005131578/15A patent/RU2335294C2/ru active
- 2004-03-12 WO PCT/GB2004/001062 patent/WO2004080477A1/en not_active Ceased
- 2004-03-12 EP EP04720081A patent/EP1603584B1/de not_active Expired - Lifetime
- 2004-03-12 NZ NZ541611A patent/NZ541611A/en not_active IP Right Cessation
2005
- 2005-08-07 IL IL170136A patent/IL170136A/en active IP Right Grant
- 2005-10-11 NO NO20054668A patent/NO334264B1/no unknown
2008
- 2008-11-26 CY CY20081101367T patent/CY1108599T1/el unknown

Also Published As

Publication number	Publication date
SI1603584T1 (sl)	2009-02-28
CA2519789C (en)	2012-07-03
CY1108599T1 (el)	2014-04-09
JP2006519828A (ja)	2006-08-31
EP1603584A1 (de)	2005-12-14
EP1603584B1 (de)	2008-08-27
MXPA05009742A (es)	2006-05-25
DE602004016126D1 (de)	2008-10-09
AU2004218883A1 (en)	2004-09-23
NO334264B1 (no)	2014-01-20
NZ541611A (en)	2008-04-30
RU2005131578A (ru)	2006-01-27
WO2004080477A8 (en)	2004-11-11
PT1603584E (pt)	2008-11-21
RU2335294C2 (ru)	2008-10-10
KR101160320B1 (ko)	2012-06-26
KR20060006779A (ko)	2006-01-19
US20070149445A9 (en)	2007-06-28
US20060172926A1 (en)	2006-08-03
NO20054668L (no)	2005-10-11
WO2004080477A1 (en)	2004-09-23
ES2312979T3 (es)	2009-03-01
PL1603584T3 (pl)	2009-02-27
JP4584245B2 (ja)	2010-11-17
IL170136A (en)	2014-04-30
DK1603584T3 (da)	2009-01-05
US7381703B2 (en)	2008-06-03
AU2004218883B2 (en)	2009-10-01
CA2519789A1 (en)	2004-09-23

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2009-04-15

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