ATE406171T1 - Aplidine zur behandlung von multiplem myelom - Google Patents

Aplidine zur behandlung von multiplem myelom

Info

Publication number: ATE406171T1
Authority: AT; Austria
Prior art keywords: aplidine; multiple myeloma; treatment; medicament; manufacture
Prior art date: 2003-03-12

Application number

AT04720081T

Other languages

English (en)

Inventor

Joseph R Bertino

Daniel Medina

Glynn Thomas Faircloth

Constantine S Mitsiades

Kenneth Anderson

Nicholas Mitsiades

Original Assignee

Dana Farber Cancer Inst Inc

Pharma Mar Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-03-12

Filing date

2004-03-12

Publication date

2008-09-15

2004-03-12 Application filed by Dana Farber Cancer Inst Inc, Pharma Mar Sa filed Critical Dana Farber Cancer Inst Inc

2008-09-15 Application granted granted Critical

2008-09-15 Publication of ATE406171T1 publication Critical patent/ATE406171T1/de

Links

UUSZLLQJYRSZIS-LXNNNBEUSA-N plitidepsin Chemical compound CN([C@H](CC(C)C)C(=O)N[C@@H]1C(=O)N[C@@H]([C@H](CC(=O)O[C@H](C(=O)[C@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N2CCC[C@H]2C(=O)N(C)[C@@H](CC=2C=CC(OC)=CC=2)C(=O)O[C@@H]1C)C(C)C)O)[C@@H](C)CC)C(=O)[C@@H]1CCCN1C(=O)C(C)=O UUSZLLQJYRSZIS-LXNNNBEUSA-N 0.000 title abstract 3
208000034578 Multiple myelomas Diseases 0.000 title abstract 2
206010035226 Plasma cell myeloma Diseases 0.000 title abstract 2
229950008499 plitidepsin Drugs 0.000 title abstract 2
108010049948 plitidepsin Proteins 0.000 title abstract 2
239000003814 drug Substances 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/15—Depsipeptides; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Epidemiology (AREA)
Gastroenterology & Hepatology (AREA)
Immunology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Production Of Liquid Hydrocarbon Mixture For Refining Petroleum (AREA)
Steroid Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

AT04720081T 2003-03-12 2004-03-12 Aplidine zur behandlung von multiplem myelom ATE406171T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US45412503P	2003-03-12	2003-03-12
US52029303P	2003-11-14	2003-11-14

Publications (1)

Publication Number	Publication Date
ATE406171T1 true ATE406171T1 (de)	2008-09-15

Family

ID=32994545

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT04720081T ATE406171T1 (de)	2003-03-12	2004-03-12	Aplidine zur behandlung von multiplem myelom

Country Status (20)

Country	Link
US (1)	US7381703B2 (de)
EP (1)	EP1603584B1 (de)
JP (1)	JP4584245B2 (de)
KR (1)	KR101160320B1 (de)
AT (1)	ATE406171T1 (de)
AU (1)	AU2004218883B2 (de)
CA (1)	CA2519789C (de)
CY (1)	CY1108599T1 (de)
DE (1)	DE602004016126D1 (de)
DK (1)	DK1603584T3 (de)
ES (1)	ES2312979T3 (de)
IL (1)	IL170136A (de)
MX (1)	MXPA05009742A (de)
NO (1)	NO334264B1 (de)
NZ (1)	NZ541611A (de)
PL (1)	PL1603584T3 (de)
PT (1)	PT1603584E (de)
RU (1)	RU2335294C2 (de)
SI (1)	SI1603584T1 (de)
WO (1)	WO2004080477A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
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IL149488A0 (en) *	1999-11-15	2002-11-10	Pharma Mar Sa	Pharmaceutical compositions containing aplidine
KR20060002778A (ko)	2003-03-12	2006-01-09	파르마 마르, 에스.에이.	개선된 항종양 치료
US20090226465A1 (en) *	2005-10-31	2009-09-10	Jackson David Y	Macrocyclic depsipeptide antibody-drug conjugates and methods
HUE028055T2 (en) *	2006-02-28	2016-11-28	Pharma Mar Sa	Improved treatment of myeloma multiplex
WO2008080956A1 (en) *	2006-12-29	2008-07-10	Pharma Mar, S.A.	Prognostic molecular markers for the cancer therapy with aplidine
WO2009002553A1 (en) *	2007-06-25	2008-12-31	Prolexys Pharmaceuticals, Inc.	Methods of treating multiple myeloma and resistant cancers
AU2008313627A1 (en) *	2007-10-19	2009-04-23	Pharma Mar, S.A.	Improved antitumoral treatments
CN101965191A (zh) *	2008-03-07	2011-02-02	法马马有限公司	改善的抗癌治疗
AU2009248039B2 (en) *	2008-05-16	2014-07-31	Pharma Mar, S.A.	Multiple myeloma treatments
LT3615544T (lt)	2017-04-27	2023-05-10	Pharma Mar S.A.	Priešnavikiniai junginiai

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GB8922026D0 (en) *	1989-09-29	1989-11-15	Pharma Mar Sa	Novel anti-viral and cytotoxic agent
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DE69431071T2 (de) *	1993-12-29	2003-03-20	Matrix Pharma	Zusammensetzung für lokale freigabe von zytostatika
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US20010021380A1 (en) *	1999-04-19	2001-09-13	Pluenneke John D.	Soluble tumor necrosis factor receptor treatment of medical disorders
HK1046846A1 (zh)	1999-05-25	2003-01-30	Point Therapeutics, Inc.	包含boroproline的抗肿瘤复合物
US6890904B1 (en) *	1999-05-25	2005-05-10	Point Therapeutics, Inc.	Anti-tumor agents
IL149488A0 (en) *	1999-11-15	2002-11-10	Pharma Mar Sa	Pharmaceutical compositions containing aplidine
ES2272462T3 (es)	2000-04-07	2007-05-01	The Trustees Of The University Of Pennsylvania	Analogos de tamadarina y didemnina y procedimiento de fabricacion y uso.
US6509315B1 (en) *	2000-04-07	2003-01-21	The Trustees Of The University Of Pennsylvania	Didemnin analogs and fragments and methods of making and using them
UA76718C2 (uk)	2000-06-30	2006-09-15	Фарма Мар, С.А.	Протипухлинні похідні аплідину
AU1305302A (en) *	2000-10-05	2002-04-15	Immunex Corp	Nectin polypeptides, polynucleotides, methods of making and use thereof
WO2002030441A2 (en) *	2000-10-12	2002-04-18	Pharma Mar, S.A.	Treatment of cancers by aplidine in conjunction with a myoprotector
WO2002032374A2 (en) *	2000-10-18	2002-04-25	Immunex Corporation	Methods for treating il-18 mediated disorders
EP1351678A2 (de) *	2001-01-02	2003-10-15	Elizabeth Shanahan-Prendergast	Behandlung von neoplastischen erkrankungen mit incensol und/oder furanogermacren
EP1435991B1 (de)	2001-10-19	2008-10-15	Pharma Mar, S.A.	Verwendung von aplidine in der behandlung von pankreaskrebs
KR20060002778A (ko)	2003-03-12	2006-01-09	파르마 마르, 에스.에이.	개선된 항종양 치료

2004
- 2004-03-12 JP JP2006505957A patent/JP4584245B2/ja not_active Expired - Lifetime
- 2004-03-12 ES ES04720081T patent/ES2312979T3/es not_active Expired - Lifetime
- 2004-03-12 AU AU2004218883A patent/AU2004218883B2/en not_active Expired
- 2004-03-12 DK DK04720081T patent/DK1603584T3/da active
- 2004-03-12 MX MXPA05009742A patent/MXPA05009742A/es active IP Right Grant
- 2004-03-12 US US10/548,710 patent/US7381703B2/en not_active Expired - Lifetime
- 2004-03-12 PL PL04720081T patent/PL1603584T3/pl unknown
- 2004-03-12 RU RU2005131578/15A patent/RU2335294C2/ru active
- 2004-03-12 KR KR1020057016966A patent/KR101160320B1/ko not_active Expired - Lifetime
- 2004-03-12 SI SI200430878T patent/SI1603584T1/sl unknown
- 2004-03-12 EP EP04720081A patent/EP1603584B1/de not_active Expired - Lifetime
- 2004-03-12 PT PT04720081T patent/PT1603584E/pt unknown
- 2004-03-12 DE DE602004016126T patent/DE602004016126D1/de not_active Expired - Lifetime
- 2004-03-12 AT AT04720081T patent/ATE406171T1/de active
- 2004-03-12 NZ NZ541611A patent/NZ541611A/en not_active IP Right Cessation
- 2004-03-12 CA CA2519789A patent/CA2519789C/en not_active Expired - Lifetime
- 2004-03-12 WO PCT/GB2004/001062 patent/WO2004080477A1/en not_active Ceased
2005
- 2005-08-07 IL IL170136A patent/IL170136A/en active IP Right Grant
- 2005-10-11 NO NO20054668A patent/NO334264B1/no unknown
2008
- 2008-11-26 CY CY20081101367T patent/CY1108599T1/el unknown

Also Published As

Publication number	Publication date
KR20060006779A (ko)	2006-01-19
AU2004218883A1 (en)	2004-09-23
SI1603584T1 (sl)	2009-02-28
JP4584245B2 (ja)	2010-11-17
RU2335294C2 (ru)	2008-10-10
ES2312979T3 (es)	2009-03-01
EP1603584A1 (de)	2005-12-14
CA2519789A1 (en)	2004-09-23
WO2004080477A8 (en)	2004-11-11
IL170136A (en)	2014-04-30
JP2006519828A (ja)	2006-08-31
US20060172926A1 (en)	2006-08-03
DK1603584T3 (da)	2009-01-05
WO2004080477A1 (en)	2004-09-23
CA2519789C (en)	2012-07-03
PT1603584E (pt)	2008-11-21
NZ541611A (en)	2008-04-30
KR101160320B1 (ko)	2012-06-26
US7381703B2 (en)	2008-06-03
NO334264B1 (no)	2014-01-20
CY1108599T1 (el)	2014-04-09
RU2005131578A (ru)	2006-01-27
AU2004218883B2 (en)	2009-10-01
US20070149445A9 (en)	2007-06-28
PL1603584T3 (pl)	2009-02-27
NO20054668L (no)	2005-10-11
DE602004016126D1 (de)	2008-10-09
MXPA05009742A (es)	2006-05-25
EP1603584B1 (de)	2008-08-27

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2009-04-15

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