ATE406366T1 - Gehinderte himbacinanaloga als thrombinrezeptorantagonisten - Google Patents

Gehinderte himbacinanaloga als thrombinrezeptorantagonisten

Info

Publication number: ATE406366T1
Authority: AT; Austria
Prior art keywords: hindernated; receptor antagonists; thrombin receptor; himbacine analogs; himbacine
Prior art date: 2004-05-28

Application number

AT05755642T

Other languages

English (en)

Inventor

Mariappan Chelliah

Samuel Chackalamannil

Yan Xia

Martin Clasby

William Greenlee

Yuguang Wang

Enrico Veltri

Wenxue Wu

Michael Graziano

Teddy Kosoglou

Madhu Chintala

Original Assignee

Schering Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-05-28

Filing date

2005-05-25

Publication date

2008-09-15

2005-05-25 Application filed by Schering Corp filed Critical Schering Corp

2008-09-15 Application granted granted Critical

2008-09-15 Publication of ATE406366T1 publication Critical patent/ATE406366T1/de

Links

FMPNFDSPHNUFOS-LPJDIUFZSA-N himbacine Chemical class C(/[C@@H]1[C@H]2CCCC[C@@H]2C[C@@H]2C(=O)O[C@H]([C@H]12)C)=C\[C@H]1CCC[C@H](C)N1C FMPNFDSPHNUFOS-LPJDIUFZSA-N 0.000 title 1
239000003856 thrombin receptor antagonist Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
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- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Biomedical Technology (AREA)
Cardiology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Heart & Thoracic Surgery (AREA)
Pulmonology (AREA)
Diabetes (AREA)
Ophthalmology & Optometry (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Dermatology (AREA)
Hematology (AREA)
Endocrinology (AREA)
Urology & Nephrology (AREA)
Orthopedic Medicine & Surgery (AREA)
Pain & Pain Management (AREA)
Psychology (AREA)
Hospice & Palliative Care (AREA)
Reproductive Health (AREA)
Gynecology & Obstetrics (AREA)
Psychiatry (AREA)
Immunology (AREA)
Gastroenterology & Hepatology (AREA)
Vascular Medicine (AREA)
Emergency Medicine (AREA)

AT05755642T 2004-05-28 2005-05-25 Gehinderte himbacinanaloga als thrombinrezeptorantagonisten ATE406366T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US57511504P	2004-05-28	2004-05-28

Publications (1)

Publication Number	Publication Date
ATE406366T1 true ATE406366T1 (de)	2008-09-15

Family

ID=35058111

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT05755642T ATE406366T1 (de)	2004-05-28	2005-05-25	Gehinderte himbacinanaloga als thrombinrezeptorantagonisten

Country Status (13)

Country	Link
US (1)	US7442712B2 (de)
EP (1)	EP1751144B1 (de)
JP (1)	JP4558788B2 (de)
CN (1)	CN1984905B (de)
AR (1)	AR049429A1 (de)
AT (1)	ATE406366T1 (de)
CA (1)	CA2567981C (de)
DE (1)	DE602005009355D1 (de)
ES (1)	ES2311996T3 (de)
MX (1)	MXPA06013903A (de)
MY (1)	MY143987A (de)
TW (1)	TWI357326B (de)
WO (1)	WO2005118576A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7488742B2 (en) *	2000-06-15	2009-02-10	Schering Corporation	Thrombin receptor antagonists
ATE530516T1 (de)	2005-01-14	2011-11-15	Schering Corp	Exo- und diastereoselektive synthese von himbacin-analoga
TW200812619A (en) *	2006-04-06	2008-03-16	Schering Corp	TRA combination therapies
CA2655720A1 (en) *	2006-06-29	2008-01-10	Schering Corporation	Substituted bicyclic and tricyclic thrombin receptor antagonists
AR061727A1 (es) *	2006-06-30	2008-09-17	Schering Corp	Sintesis de dietil [[ 5- ( 3-fluorofenil) -piridin -2il] metil] fosfonato
US8227412B2 (en) *	2007-03-29	2012-07-24	Tsopanoglou Nikos E	Bioactive parstatin peptides and methods of use
WO2008128038A2 (en) *	2007-04-13	2008-10-23	The Scripps Research Institute	Methods and compositions for treating cardiac dysfunctions
PL2558462T3 (pl)	2010-04-16	2015-03-31	Sanofi Sa	Pirydylo-winylo-pirazolo-chinoliny jako inhibitory PAR1
ES2532902T3 (es)	2010-04-16	2015-04-01	Sanofi	Piridil-vinil-pirroles tricíclicos como inhibidores de PAR1
KR101303348B1 (ko)	2010-06-25	2013-09-03	한국화학연구원	트롬빈 수용체 길항제인 ［6＋5］접합 바이사이클, 그의 제조방법 및 그를 포함하는 약제학적 조성물
US9340530B2 (en)	2012-03-06	2016-05-17	Merck Sharp & Dohme Corp.	Preparation and use of bicyclic himbacine derivatives as PAR-1 receptor antagonists
WO2015026693A1 (en)	2013-08-22	2015-02-26	Merck Sharp & Dohme Corp.	7a-amide substituted-6,6-difluoro bicyclic himbacine derivatives
WO2015026686A1 (en)	2013-08-22	2015-02-26	Merck Sharp & Dohme Corp.	3'-pyridyl substituted- 6,6-difluoro bicyclic himbacine derivatives
WO2015026685A1 (en)	2013-08-22	2015-02-26	Merck Sharp & Dohme Corp.	7a-heterocycle substituted- 6, 6-difluoro bicyclic himbacine derivatives
ITUB20160876A1 (it)	2016-02-19	2017-08-19	Dambrosio Enzo Maria	Combinazione di un agente antiallergico con un antagonista muscarinico e/o un agonista dopaminergico per l'uso in prevenzione/ arresto di miopia assiale nell’uomo
CN116640058B (zh) *	2023-04-08	2026-01-27	郑州大学	一种有机炔酸酯的合成方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL106197A (en)	1992-07-30	1999-11-30	Cor Therapeutics Inc	Agagonists for the rhombin receptors and pharmaceutical preparations containing them
KR100393492B1 (ko) *	1997-11-25	2003-08-02	쉐링 코포레이션	트롬빈 수용체 길항제
US6063847A (en) *	1997-11-25	2000-05-16	Schering Corporation	Thrombin receptor antagonists
US7488742B2 (en)	2000-06-15	2009-02-10	Schering Corporation	Thrombin receptor antagonists
US7304078B2 (en)	2002-04-16	2007-12-04	Schering Corporation	Thrombin receptor antagonists
ES2291323T3 (es) *	2000-06-15	2008-03-01	Schering Corporation	Antagonistas de receptores de trombina.
BR0213967A (pt)	2001-10-18	2005-08-30	Schering Corp	Análogos de himbacina como antagonistas do receptor de trombina

2005
- 2005-05-25 MX MXPA06013903A patent/MXPA06013903A/es active IP Right Grant
- 2005-05-25 AT AT05755642T patent/ATE406366T1/de not_active IP Right Cessation
- 2005-05-25 DE DE602005009355T patent/DE602005009355D1/de not_active Expired - Lifetime
- 2005-05-25 JP JP2007515301A patent/JP4558788B2/ja not_active Expired - Fee Related
- 2005-05-25 CA CA2567981A patent/CA2567981C/en not_active Expired - Fee Related
- 2005-05-25 MY MYPI20052380A patent/MY143987A/en unknown
- 2005-05-25 ES ES05755642T patent/ES2311996T3/es not_active Expired - Lifetime
- 2005-05-25 CN CN2005800232506A patent/CN1984905B/zh not_active Expired - Fee Related
- 2005-05-25 US US11/137,283 patent/US7442712B2/en not_active Expired - Lifetime
- 2005-05-25 WO PCT/US2005/018372 patent/WO2005118576A1/en not_active Ceased
- 2005-05-25 EP EP05755642A patent/EP1751144B1/de not_active Expired - Lifetime
- 2005-05-26 TW TW094117273A patent/TWI357326B/zh not_active IP Right Cessation
- 2005-05-26 AR ARP050102170A patent/AR049429A1/es not_active Application Discontinuation

Also Published As

Publication number	Publication date
JP4558788B2 (ja)	2010-10-06
AR049429A1 (es)	2006-08-02
US7442712B2 (en)	2008-10-28
WO2005118576A1 (en)	2005-12-15
MY143987A (en)	2011-07-29
TWI357326B (en)	2012-02-01
US20050267155A1 (en)	2005-12-01
MXPA06013903A (es)	2007-01-26
HK1100667A1 (en)	2007-09-28
CA2567981A1 (en)	2005-12-15
EP1751144A1 (de)	2007-02-14
DE602005009355D1 (de)	2008-10-09
CN1984905B (zh)	2011-06-22
CA2567981C (en)	2010-08-31
CN1984905A (zh)	2007-06-20
TW200602024A (en)	2006-01-16
ES2311996T3 (es)	2009-02-16
JP2008500360A (ja)	2008-01-10
EP1751144B1 (de)	2008-08-27

Legal Events

Date	Code	Title	Description
2009-02-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE525378T1 (de)	2011-10-15	Himbacinanaloga als thrombinrezeptorantagonisten
LTPA2017005I1 (lt)	2017-03-27	Nauji junginiai, kaip opioido receptoriaus moduliatoriai
ATE395335T1 (de)	2008-05-15	Als muscarinrezeptorantagonisten geeignete biphenylverbindungen
DK1638969T3 (da)	2009-01-26	CGRP-receptorantagonister
DK2089382T3 (da)	2013-02-04	Substituerede diazepan-forbindelser som orexin-receptor-antagonister
DK1740177T3 (da)	2012-10-29	Antagonister til muskarinfølsomme acetylcholinreceptorer
NL1028624A1 (nl)	2005-10-03	Alfa-aryl- of -heteroarylmethyl-bèta-piperidinopropaan-zuurverbindingen als ORL1-receptorantagonisten.
EP1765805A4 (de)	2009-08-26	Cgrp-rezeptorantagonisten
ATE413874T1 (de)	2008-11-15	Neue thiophen-derivate als sphingosin-1-phosphat- 1-rezeptorantagonisten
NO20054951D0 (no)	2005-10-25	Prostaglandinanaloger som EP4-reseptorantagonister
ATE523195T1 (de)	2011-09-15	Neue thiophen-derivate als sphingosin-1-phosphat- 1-rezeptorantagonisten
ZA200708067B (en)	2008-11-26	Spirocyclic thrombin receptor antagonists
ATE452886T1 (de)	2010-01-15	Chemokinrezeptorantagonisten
ATE509928T1 (de)	2011-06-15	8-azabicycloä3.2.1üoktan-verbindungen als mu- opioid-rezeptorantagonisten
ATE406366T1 (de)	2008-09-15	Gehinderte himbacinanaloga als thrombinrezeptorantagonisten
DE602005004011D1 (de)	2008-02-07	Hydroisoindolin-tachykininrezeptorantagonisten
ATE555111T1 (de)	2012-05-15	Chinuclidinol-derivate als muscarinrezeptor- antagonisten
ATE477243T1 (de)	2010-08-15	2-aminochinoline als 5-ht(5a)- rezeptorantagonisten
DK1973886T3 (da)	2013-03-18	Prokineticin-1-receptor-antagonister
ATE439358T1 (de)	2009-08-15	3-heterocyclyl-azetidin-verbindungen als nk1/nk2 rezeptoren antagonisten
EP1799672A4 (de)	2011-01-19	Cgrp-rezeptorantagonisten
ATE429428T1 (de)	2009-05-15	Indanderivate als antagonisten des mch-rezeptors
DK1758886T3 (da)	2015-04-27	Piperazindioner som oxytocinreceptor-antagonister
EP1951042A4 (de)	2010-11-03	Trizyklische spirolactam-cgrp-rezeptorantagonisten
ATE462688T1 (de)	2010-04-15	Diarylsulfone als 5-ht2a-antagonisten