ATE406369T1 - Indol-derivate, die durch einen thiazol ring substituiert sind und deren verwendung als ppar modulatoren - Google Patents

Indol-derivate, die durch einen thiazol ring substituiert sind und deren verwendung als ppar modulatoren

Info

Publication number
ATE406369T1
ATE406369T1 AT04740332T AT04740332T ATE406369T1 AT E406369 T1 ATE406369 T1 AT E406369T1 AT 04740332 T AT04740332 T AT 04740332T AT 04740332 T AT04740332 T AT 04740332T AT E406369 T1 ATE406369 T1 AT E406369T1
Authority
AT
Austria
Prior art keywords
sup
thiazole ring
indole derivatives
derivatives substituted
ppar modulators
Prior art date
Application number
AT04740332T
Other languages
English (en)
Inventor
Jean Ackermann
Johannes Aebi
Alfred Binggeli
Uwe Grether
Georges Hirth
Bernd Kuhn
Hans-Peter Maerki
Markus Meyer
Peter Mohr
Matthew Wright
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE406369T1 publication Critical patent/ATE406369T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Neurology (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Reproductive Health (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT04740332T 2003-07-02 2004-06-25 Indol-derivate, die durch einen thiazol ring substituiert sind und deren verwendung als ppar modulatoren ATE406369T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03014476 2003-07-02
EP04100157 2004-01-20

Publications (1)

Publication Number Publication Date
ATE406369T1 true ATE406369T1 (de) 2008-09-15

Family

ID=33553804

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04740332T ATE406369T1 (de) 2003-07-02 2004-06-25 Indol-derivate, die durch einen thiazol ring substituiert sind und deren verwendung als ppar modulatoren

Country Status (14)

Country Link
US (1) US7235572B2 (de)
EP (1) EP1644368B1 (de)
JP (1) JP4627298B2 (de)
KR (1) KR100796093B1 (de)
CN (1) CN1816550B (de)
AT (1) ATE406369T1 (de)
AU (1) AU2004255580B2 (de)
BR (1) BRPI0412236A (de)
CA (1) CA2530452C (de)
DE (1) DE602004016162D1 (de)
ES (1) ES2313022T3 (de)
MX (1) MXPA06000235A (de)
RU (1) RU2344135C2 (de)
WO (1) WO2005005423A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050203151A1 (en) * 2003-12-19 2005-09-15 Kalypsys, Inc. Novel compounds, compositions and uses thereof for treatment of metabolic disorders and related conditions
KR100989093B1 (ko) 2008-01-18 2010-10-25 한화제약주식회사 생강나무 가지의 추출물을 포함하는 심혈관계 질환의 예방 및 치료용 조성물
US9227969B2 (en) 2013-08-14 2016-01-05 Novartis Ag Compounds and compositions as inhibitors of MEK

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1280753C (en) 1985-07-02 1991-02-26 Philip Michael Carabateas Process for preparing heterocyclic substituted- phenoxyalkyl isoxazoles and-furans
AU679626B2 (en) * 1994-03-08 1997-07-03 Wyeth Thiazolidinedione derivatives as anti-hyperglycemic agents
GB9604242D0 (en) 1996-02-28 1996-05-01 Glaxo Wellcome Inc Chemical compounds
US6531609B2 (en) 2000-04-14 2003-03-11 Hoffmann-La Roche Inc. Process for the preparation of thiazolidinedione derivatives
GB0024362D0 (en) 2000-10-05 2000-11-22 Glaxo Group Ltd Medicaments
JP2004529855A (ja) * 2000-10-10 2004-09-30 スミスクライン ビーチャム コーポレーション 置換インドール類、そのような置換インドール類を含む医薬組成物及びＰＰＡＲ−γ結合剤としてのそれらの使用
GB0031107D0 (en) 2000-12-20 2001-01-31 Glaxo Group Ltd Chemical compounds
DE60226441D1 (de) * 2001-06-18 2008-06-19 Ono Pharmaceutical Co Tetrahydrochinolinderivatverbindung und die verbindung als wirkstoff enthaltendes arzneimittel
KR20040044515A (ko) * 2001-08-29 2004-05-28 워너-램버트 캄파니 엘엘씨 경구용 항당뇨병제
US6867224B2 (en) * 2002-03-07 2005-03-15 Warner-Lambert Company Compounds that modulate PPAR activity and methods of preparation
AU2003300131A1 (en) * 2003-01-06 2004-11-04 Eli Lilly And Company Indole derivatives as ppar modulators
RU2367659C2 (ru) * 2003-11-05 2009-09-20 Ф.Хоффманн-Ля Рош Аг Гетероарильные производные в качестве активаторов рецепторов, активируемых пролифераторами пероксисом (ppar)

Also Published As

Publication number Publication date
BRPI0412236A (pt) 2006-09-12
US20050004187A1 (en) 2005-01-06
KR100796093B1 (ko) 2008-01-21
EP1644368A1 (de) 2006-04-12
EP1644368B1 (de) 2008-08-27
CA2530452A1 (en) 2005-01-20
RU2344135C2 (ru) 2009-01-20
WO2005005423A1 (en) 2005-01-20
ES2313022T3 (es) 2009-03-01
JP4627298B2 (ja) 2011-02-09
CN1816550B (zh) 2010-04-28
US7235572B2 (en) 2007-06-26
KR20060027830A (ko) 2006-03-28
RU2006102866A (ru) 2007-08-20
JP2009501693A (ja) 2009-01-22
CA2530452C (en) 2011-07-26
AU2004255580B2 (en) 2009-10-08
CN1816550A (zh) 2006-08-09
AU2004255580A1 (en) 2005-01-20
DE602004016162D1 (de) 2008-10-09
MXPA06000235A (es) 2006-04-11

Similar Documents

Publication Publication Date Title
EA201190139A1 (ru) Производные тиенопиримидиндиона в качестве модуляторов trpa1
SE0303180D0 (sv) Novel compounds
EA201190143A1 (ru) Сочлененные производные пиримидиндионов в качестве модуляторов trpa1
SE0302232D0 (sv) Novel Compounds
EA201390947A1 (ru) Соединения 2-амино-4-арилтиазола в качестве антагонистов trpa1
MY138906A (en) Phenyl derivatives as ppar agonists
HRP20041042A2 (hr) Novi supstituirani derivati sulfamata kao antikonvulzivi
EA200500304A1 (ru) Производные 3-(сульфонамидоэтил)индола, предназначенные для использования в качестве миметиков глюкокортикоидов при лечении воспалительных, аллергических и пролиферативных заболеваний
NO20090979L (no) (3-amino-1,2,3,4-tetrahydro-9H-karbazol-9-yl)-eddiksyrederivater
NO20055370L (no) Alfa-substituert karboksylsyre som PPAR modulatorer
NO20055688L (no) Organiske forbindelser
NO20085323L (no) Smeltede, tricykliske sulfonamidinhibitorer av gammasekretase
EA201070804A1 (ru) (аза)индольное производное, замещенное по положению 5, содержащая его фармацевтическая композиция, промежуточные соединения и способ их получения
TW200502221A (en) Novel lactams and uses thereof
MA30916B1 (fr) Nouveaux derives de benzamide en tant qu'antagonistes de bradykinine
WO2010010435A3 (en) Fused oxazole and thiazole derivatives as trpms modulators
ATE380816T1 (de) Substituierte imidazopyrimidine zur prävention und behandlung von krebs
DE60020246D1 (de) Substituierte benzylthiazolidin-2,4-dion derivate
ATE493404T1 (de) Azabicyclo-(3,1,0)-hexan-derivate als modulatoren von dopamin-d3-rezeptoren
TW200716547A (en) Piperidin-4-yl-amide derivatives
WO2007025897A3 (en) Benzooxazole, oxazolopyridine, benzothiazole and thiazolopyridine derivatives
AR056574A1 (es) Derivados de pirazol, composiciones que contienen dichos compuestos y procedimientos de uso
ATE472526T1 (de) Neue verbindungen und deren verwendung als ppar- modulatoren
ATE454383T1 (de) Neue verbindungen, deren verwendung und herstellung
ATE469882T1 (de) Neue verbindungen, die sich f r die behandlung von durch ppar vermittelten krankheiten eignen

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1644368

Country of ref document: EP