NO20055370L - Alfa-substituert karboksylsyre som PPAR modulatorer - Google Patents

Alfa-substituert karboksylsyre som PPAR modulatorer

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Publication number
NO20055370L
NO20055370L NO20055370A NO20055370A NO20055370L NO 20055370 L NO20055370 L NO 20055370L NO 20055370 A NO20055370 A NO 20055370A NO 20055370 A NO20055370 A NO 20055370A NO 20055370 L NO20055370 L NO 20055370L
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NO
Norway
Prior art keywords
formula
substituted carboxylic
alpha
carboxylic acid
ppar modulators
Prior art date
Application number
NO20055370A
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English (en)
Other versions
NO20055370D0 (no
Inventor
Simon Bailey
Paul Stuart Humphries
Donald James Skalitzky
Wei-Guo Su
Luke Raymond Zehnder
Original Assignee
Pfizer
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Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of NO20055370D0 publication Critical patent/NO20055370D0/no
Publication of NO20055370L publication Critical patent/NO20055370L/no

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/65—One oxygen atom attached in position 3 or 5
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    • C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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Abstract

a-substituerte karboksylsyrer med formel (I): hvori R og R^ er som definert i beskrivelsen og R^ er A) formel (II): B) formel II); C) formel (IV) og D) formel (V), hvori Y, Art, Are, AP, R^ R\ R\ BJ, R^ R'^ R'°, R", R'', R", ring A og p er som definert i beskrivelsen; farmasøytiske sammensetninger som inneholder eflektive mengder av nevnte forbindelser eller deres salter er anvendehge for behandling av PPAR, særlig PPAR-a/y-relaterte forstyrrelser, slike som diabetes, dyslipidemi, fedme og inflammasj onsforsty rrelser.
NO20055370A 2003-04-15 2005-11-14 Alfa-substituert karboksylsyre som PPAR modulatorer NO20055370L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46321303P 2003-04-15 2003-04-15
PCT/IB2004/001159 WO2004092145A1 (en) 2003-04-15 2004-04-01 Alpha substituted carboxylic acid as ppar modulators

Publications (2)

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NO20055370D0 NO20055370D0 (no) 2005-11-14
NO20055370L true NO20055370L (no) 2006-01-12

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NO20055370A NO20055370L (no) 2003-04-15 2005-11-14 Alfa-substituert karboksylsyre som PPAR modulatorer

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EP (1) EP1615899A1 (no)
JP (1) JP2006523671A (no)
KR (1) KR20060009846A (no)
CN (1) CN1805943A (no)
AP (1) AP2005003418A0 (no)
AR (1) AR044514A1 (no)
AU (1) AU2004230316A1 (no)
BR (1) BRPI0409429A (no)
CA (1) CA2521915A1 (no)
CL (1) CL2004000800A1 (no)
EA (1) EA200501462A1 (no)
EC (1) ECSP056105A (no)
IS (1) IS8033A (no)
MA (1) MA27764A1 (no)
MX (1) MXPA05010967A (no)
NL (1) NL1025946C2 (no)
NO (1) NO20055370L (no)
OA (1) OA13157A (no)
PA (1) PA8600201A1 (no)
PE (1) PE20050415A1 (no)
TN (1) TNSN05262A1 (no)
TW (1) TW200510353A (no)
UY (1) UY28266A1 (no)
WO (1) WO2004092145A1 (no)
ZA (1) ZA200508362B (no)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2005247473A1 (en) * 2004-05-25 2005-12-08 Metabolex, Inc. Substituted triazoles as modulators of PPAR and methods of their preparation
NZ563866A (en) 2005-05-09 2011-03-31 Achillion Pharmaceuticals Inc Thiazole compounds and methods of use
US8962825B2 (en) 2006-10-30 2015-02-24 Glaxosmithkline Intellectual Property Development Limited Hydroxamates as inhibitors of histone deacetylase
AU2008221673B2 (en) * 2007-03-08 2013-03-28 Albireo Ab 2 -substituted- 3 -phenylpropionic acid derivatives and their use in the treatment of inflammatory bowel disease
US8183263B2 (en) 2007-05-22 2012-05-22 Achillion Pharmaceuticals, Inc. Heteroaryl substituted thiazoles
US8106209B2 (en) 2008-06-06 2012-01-31 Achillion Pharmaceuticals, Inc. Substituted aminothiazole prodrugs of compounds with anti-HCV activity
WO2010009166A1 (en) 2008-07-14 2010-01-21 Gilead Colorado, Inc. Oxindolyl inhibitor compounds
NZ602832A (en) 2008-07-14 2014-04-30 Gilead Sciences Inc Fused heterocyclic hdac inhibitor compounds
JP5640005B2 (ja) 2008-07-14 2014-12-10 ギリアード サイエンシーズ， インコーポレイテッド Ｈｄａｃおよび／またはｃｄｋ阻害剤としてのイミダゾシルピリジン化合物
JP2011529504A (ja) 2008-07-28 2011-12-08 ギリアード サイエンシーズ， インコーポレイテッド シクロアルキリデンヒストン脱アセチル化酵素阻害剤化合物およびヘテロシクロアルキリデンヒストン脱アセチル化酵素阻害剤化合物
KR20120031170A (ko) 2009-06-08 2012-03-30 길리애드 사이언시즈, 인코포레이티드 알카노일아미노 벤즈아미드 아닐린 ｈｄａｃ 저해제 화합물
WO2010144378A2 (en) 2009-06-08 2010-12-16 Gilead Colorado, Inc. Cycloalkylcarbamate benzamide aniline hdac inhibitor compounds
DE102010055499A1 (de) * 2010-12-22 2011-06-16 W.C. Heraeus Gmbh Prozess zur Herstellung von Bendamustinalkylester, Bendarmustin sowie Derivaten davon
RU2014121984A (ru) 2011-10-31 2015-12-10 Ксенон Фармасьютикалз Инк. Бензолсульфонамидные соединения и их применение в качестве терапевтических средств
JP6014155B2 (ja) 2011-10-31 2016-10-25 ゼノン・ファーマシューティカルズ・インコーポレイテッドＸｅｎｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃ． ビアリールエーテルスルホンアミドおよび治療剤としてのそれらの使用
FR2982858B1 (fr) * 2011-11-18 2013-11-29 Rhodia Operations Procede de fabrication de composes comprenant des fonctions nitriles
FR2984322B1 (fr) * 2011-12-16 2013-12-20 Rhodia Operations Procede de fabrication de composes comprenant des fonctions nitriles
CN104718188B (zh) 2012-05-22 2018-08-21 基因泰克公司 N-取代的苯甲酰胺类及其在治疗疼痛中的用途
KR101663436B1 (ko) 2012-07-06 2016-10-06 제넨테크, 인크. N-치환된 벤즈아미드 및 이의 사용 방법
RU2015143906A (ru) 2013-03-14 2017-04-18 Дженентек, Инк. Замещенные триазолопиридины и способы их применения
BR112015023397A2 (pt) 2013-03-15 2017-07-18 Genentech Inc benzoxazois substituídos e métodos de uso dos mesmos
WO2015078374A1 (en) 2013-11-27 2015-06-04 Genentech, Inc. Substituted benzamides and methods of use thereof
JP2017525677A (ja) 2014-07-07 2017-09-07 ジェネンテック， インコーポレイテッド 治療用化合物及びその使用方法
HK1252567A1 (zh) 2015-05-22 2019-05-31 基因泰克公司 被取代的苯甲酰胺和其使用方法
JP2018526371A (ja) 2015-08-27 2018-09-13 ジェネンテック， インコーポレイテッド 治療化合物及びその使用方法
CA2999769A1 (en) 2015-09-28 2017-04-06 Genentech, Inc. Therapeutic compounds and methods of use thereof
EP3380466A1 (en) 2015-11-25 2018-10-03 Genentech, Inc. Substituted benzamides useful as sodium channel blockers
EP3436432B1 (en) 2016-03-30 2021-01-27 Genentech, Inc. Substituted benzamides and methods of use thereof
PE20190980A1 (es) 2016-10-17 2019-07-09 Genentech Inc Compuestos terapeuticos y metodos para utilizarlos
JP2020511511A (ja) 2017-03-24 2020-04-16 ジェネンテック， インコーポレイテッド ナトリウムチャネル阻害剤としての４−ピペリジン−ｎ−（ピリミジン−４−イル）クロマン−７−スルホンアミド誘導体
AR114263A1 (es) 2018-02-26 2020-08-12 Genentech Inc Compuestos terapéuticos y métodos para utilizarlos
US10947251B2 (en) 2018-03-30 2021-03-16 Genentech, Inc. Therapeutic compounds and methods of use thereof
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AP2005003418A0 (en) 2005-12-31
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AR044514A1 (es) 2005-09-14
BRPI0409429A (pt) 2006-04-18
OA13157A (en) 2006-12-13
NL1025946C2 (nl) 2005-02-01
AU2004230316A1 (en) 2004-10-28
CL2004000800A1 (es) 2005-03-04
CA2521915A1 (en) 2004-10-28
WO2004092145A8 (en) 2005-05-12
IS8033A (is) 2005-09-15
NO20055370D0 (no) 2005-11-14
MXPA05010967A (es) 2005-11-28
EP1615899A1 (en) 2006-01-18
PA8600201A1 (es) 2005-02-04
NL1025946A1 (nl) 2004-10-18
WO2004092145A1 (en) 2004-10-28
TW200510353A (en) 2005-03-16
PE20050415A1 (es) 2005-06-13
CN1805943A (zh) 2006-07-19
ECSP056105A (es) 2006-03-01
JP2006523671A (ja) 2006-10-19
KR20060009846A (ko) 2006-02-01
EA200501462A1 (ru) 2006-04-28
ZA200508362B (en) 2006-11-29

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