ATE40688T1 - Acridincarboxamid-verbindungen. - Google Patents

Acridincarboxamid-verbindungen.

Info

Publication number: ATE40688T1
Authority: AT; Austria
Prior art keywords: hydroxyl; optionally substituted; lower alkyl; alkyl optionally; acridincarboxamide
Prior art date: 1982-06-25

Application number

AT83303610T

Other languages

English (en)

Inventor

Graham John Atwell

Bruce Charles Baguley

William Alexander Denny

Gordon William Rewcastle

Original Assignee

New Zealand Dev Finance

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-06-25

Filing date

1983-06-22

Publication date

1989-02-15

1983-06-22 Application filed by New Zealand Dev Finance filed Critical New Zealand Dev Finance

1989-02-15 Application granted granted Critical

1989-02-15 Publication of ATE40688T1 publication Critical patent/ATE40688T1/de

Links

AORNIVFSXFONEC-UHFFFAOYSA-N acridine-1-carboxamide Chemical class C1=CC=C2C=C3C(C(=O)N)=CC=CC3=NC2=C1 AORNIVFSXFONEC-UHFFFAOYSA-N 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
101100294106 Caenorhabditis elegans nhr-3 gene Proteins 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
230000000844 anti-bacterial effect Effects 0.000 abstract 1
230000000259 anti-tumor effect Effects 0.000 abstract 1
125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
125000003170 phenylsulfonyl group Chemical group C1(=CC=CC=C1)S(=O)(=O)* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
- C07D219/06—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
- C07D219/08—Nitrogen atoms
- C07D219/10—Nitrogen atoms attached in position 9

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Materials For Photolithography (AREA)
Electroplating And Plating Baths Therefor (AREA)

AT83303610T 1982-06-25 1983-06-22 Acridincarboxamid-verbindungen. ATE40688T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
NZ201084A NZ201084A (en)	1982-06-25	1982-06-25	4-carboxamidoacridine derivatives and pharmaceutical compositions containing such
EP83303610A EP0098098B1 (de)	1982-06-25	1983-06-22	Acridincarboxamid-Verbindungen

Publications (1)

Publication Number	Publication Date
ATE40688T1 true ATE40688T1 (de)	1989-02-15

Family

ID=19920017

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT83303610T ATE40688T1 (de)	1982-06-25	1983-06-22	Acridincarboxamid-verbindungen.

Country Status (6)

Country	Link
US (1)	US4590277A (de)
EP (1)	EP0098098B1 (de)
JP (1)	JPS597171A (de)
AT (1)	ATE40688T1 (de)
DE (2)	DE98098T1 (de)
NZ (1)	NZ201084A (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ212525A (en) *	1985-06-24	1989-02-24	Dfc New Zealand Ltd Formerly D	Nitrogen-containing heterocyclic compounds, and pharmaceutical compositions containing such
SG45403A1 (en) *	1991-01-11	1998-01-16	Glaxo Lab Sa	Acridine derivatives
GB9100637D0 (en) *	1991-01-11	1991-02-27	Glaxo Lab Sa	Chemical compounds
US5296602A (en) *	1991-03-18	1994-03-22	Sloan-Kettering Institute For Cancer Research	Multisubstituted 1-hydroxy-9-acridones with anticancer activity
WO1993003729A1 (en) *	1991-08-12	1993-03-04	Research Corporation Technologies, Inc.	N-substituted phenoxazines for treating multidrug resistant cancer cells
EP0642343B1 (de) *	1992-05-28	2000-08-30	Xenova Limited	Acridin carboxamide zur behandlung von krebs
US5696131A (en) *	1993-01-22	1997-12-09	Xenova Limited	Treatment of cancers
RU2036198C1 (ru) *	1993-04-01	1995-05-27	Товарищество с ограниченной ответственностью "Полисан"	N-МЕТИЛ-N-( α,D -ГЛЮКОПИРАНОЗИЛ) АММОНИЯ-2-(АКРИДОН-9-ОН-10-ИЛ)АЦЕТАТ(ЦИКЛОФЕРОН), ОБЛАДАЮЩИЙ ИНТЕРФЕРОНОГЕННОЙ, ПРОТИВОВИРУСНОЙ, В ТОМ ЧИСЛЕ АНТИВИЧ, АНТИПАРАЗИТАРНОЙ, АНТИПРОМОТОРНОЙ И РАДИОПРОТЕКТИВНОЙ АКТИВНОСТЬЮ
GB2288333A (en) *	1994-03-17	1995-10-18	Radopath Ltd	Benzoic acid containing chloro and or nitro groups for cancer or viral therapy
EP1225169A1 (de) *	1995-08-18	2002-07-24	Auckland Uniservices Limited	Durch Strahlung aktivierte Cytotoxin-Therapie
GB2333293B (en) *	1996-10-18	2000-07-12	Xenova Ltd	Process for the preparation of N-[2-(dimethylamino)ethyl]acridine-4-carboxamide used as anti cancer compounds
GB9621795D0 (en) *	1996-10-18	1996-12-11	Xenova Ltd	Pharmaceutical compounds
AU4955200A (en)	1999-05-17	2000-12-05	Cancer Research Ventures Limited	A method of improving bioavailability of orally administered drugs, a method of screening for enhancers of such bioavailability and novel pharmaceutical compositions for oral delivery of drugs
AUPS234402A0 (en) *	2002-05-15	2002-06-13	Auckland Uniservices Limited	Anti-tumour polycyclic carboxamides
JP4718328B2 (ja) *	2003-12-31	2011-07-06	カウンシルオブサイエンティフィクアンドインダストリアルリサーチ	Ｃ８連結したピロロ［２，１−ｃ］［１，４］ベンゾジアゼピン−アクリドン／アクリジン・ハイブリッド
US7056913B2 (en)	2004-03-30	2006-06-06	Council Of Scientific And Industrial Research	C8—linked pyrrolo[2,1-c][1,4]benzodiazepine-acridone/acridine hybrids
WO2005118580A2 (en) *	2004-05-12	2005-12-15	The Government Of The United States Of America As Represented By The Secretary, Department Of Health	Tricyclic compounds as inhibitors of the hypoxic signaling pathway
CN109265396A (zh) *	2018-09-12	2019-01-25	李玮	多环酰胺化合物的合成新方法与抗癌活性
CN118852160A (zh) *	2024-09-24	2024-10-29	世华合创生物技术开发(山东)有限公司	一种三环酰胺化合物、制备方法及应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3686180A (en) *	1970-11-04	1972-08-22	Smith Kline French Lab	Substituted 9-lower alkylacridine-4-carboxylic acids
JPS5651457A (en) *	1979-09-14	1981-05-09	Dev Finance	Antitumoral compound and its manufacture
DE3164407D1 (en) *	1980-04-28	1984-08-02	New Zealand Dev Finance	Compound having antitumour properties
NZ198115A (en) *	1981-08-21	1985-05-31	New Zealand Dev Finance	9-anilinoacridines;pharmaceutical compositions

1982
- 1982-06-25 NZ NZ201084A patent/NZ201084A/en unknown
1983
- 1983-06-21 US US06/506,335 patent/US4590277A/en not_active Expired - Lifetime
- 1983-06-22 JP JP58112595A patent/JPS597171A/ja active Pending
- 1983-06-22 DE DE198383303610T patent/DE98098T1/de active Pending
- 1983-06-22 AT AT83303610T patent/ATE40688T1/de active
- 1983-06-22 EP EP83303610A patent/EP0098098B1/de not_active Expired
- 1983-06-22 DE DE8383303610T patent/DE3379168D1/de not_active Expired

Also Published As

Publication number	Publication date
JPS597171A (ja)	1984-01-14
EP0098098B1 (de)	1989-02-08
US4590277A (en)	1986-05-20
DE98098T1 (de)	1985-02-14
NZ201084A (en)	1985-10-11
EP0098098A2 (de)	1984-01-11
EP0098098A3 (en)	1985-05-02
DE3379168D1 (de)	1989-03-16

Publication	Publication Date	Title
DE3379168D1 (de)	1989-03-16	Acridinecarboxamide compounds
ES8205764A1 (es)	1982-06-16	Un procedimiento para la preparacion de ureas e isoureas, utiles como herbicidas y como reguladores del crecimiento delas plantas.
DE3476200D1 (en)	1989-02-23	N-(2-nitrophenyl)-2-aminopyrimidine derivatives, their preparation and use
MXPA04001240A (es)	2004-06-03	Analogos antitumorales.
PT80683B (de)	1987-05-08	Verfahren zur herstellung von neue n-(2-nitrophenyl)-2-amino-pyrimidin-derivate
ES8402575A1 (es)	1984-03-01	"procedimiento para la preparacion de n-(2-piridiloxifenil)-n-benzoilureas substituidas".
EP0094790A3 (de)	1984-07-18	Herbizide O-Alkoxybenzensulfonamide
FI923033A0 (fi)	1992-06-30	N-fenyltioureaderivat och farmaceutisk anvaendning av dem.
GB1006320A (en)	1965-09-29	2-substituted-3-pyrazolidones
ES8706638A1 (es)	1987-07-01	Un procedimiento para la preparacion de nuevos compuestos de sulfonilurea
NZ212525A (en)	1989-02-24	Nitrogen-containing heterocyclic compounds, and pharmaceutical compositions containing such
ATE27452T1 (de)	1987-06-15	Substituierte o-phenylendiaminderivate.
SE7709520L (sv)	1978-02-26	Substituerade bensoylureidodifenyletrar till anvendning som insekticider och sett att framstella foreningarna
GB1078155A (en)	1967-08-02	Production of cross-linked polyurethane resins
ATE14876T1 (de)	1985-08-15	Diisocyanate.
GB1418247A (en)	1975-12-17	Sulphonyloxy-phenylureas process for their preparation and their use as herbicides
GB950715A (en)	1964-02-26	New tetrahydro-quinolines and tetrahydro-isoquinolines
GB1095232A (en)	1967-12-13	Process for the production of azo compounds
SE7710904L (sv)	1978-04-03	N,n-dimetyl-o-pyrazolyl-karbaminsyraestrar till anvendning som insekticider och sett att framstella foreningarna
ES373909A1 (es)	1972-08-16	Procedimiento para la preparacion de quinazolinas.
GB1508250A (en)	1978-04-19	Thiocarbamate derivatives their production and their use in herbicidal germicidal and acaricidal compositions
PT72124B (de)	1981-09-29	Internes trennmittel fur hitzehartbare aminoplastharze
ES375323A1 (es)	1972-04-16	Procedimiento para la obtencion de derivados de la urea de efecto antiparasitario.
GB980277A (en)	1965-01-13	Improvements in or relating to preparation of cyclic amines
GB959993A (en)	1964-06-03	Camphor derivatives