ATE407934T1 - Azadecalinverbindungen mit kondensiertem ring als glucocorticoidrezeptormodulatoren - Google Patents

Azadecalinverbindungen mit kondensiertem ring als glucocorticoidrezeptormodulatoren

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Publication number
ATE407934T1
ATE407934T1 AT05725295T AT05725295T ATE407934T1 AT E407934 T1 ATE407934 T1 AT E407934T1 AT 05725295 T AT05725295 T AT 05725295T AT 05725295 T AT05725295 T AT 05725295T AT E407934 T1 ATE407934 T1 AT E407934T1
Authority
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Austria
Prior art keywords
receptor modulators
azadecaline
glucocorticoid receptor
condensed ring
ring compounds
Prior art date
Application number
AT05725295T
Other languages
English (en)
Inventor
Robin Clark
Nicholas Ray
Paul Blaney
Christopher A Hurley
Karen Williams
Original Assignee
Corcept Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Corcept Therapeutics Inc filed Critical Corcept Therapeutics Inc
Application granted granted Critical
Publication of ATE407934T1 publication Critical patent/ATE407934T1/de

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
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    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
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    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
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    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/42—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of mineralocorticosteroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/46—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of glucocorticosteroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
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  • Physical Education & Sports Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
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AT05725295T 2004-03-09 2005-03-09 Azadecalinverbindungen mit kondensiertem ring als glucocorticoidrezeptormodulatoren ATE407934T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US55183604P 2004-03-09 2004-03-09

Publications (1)

Publication Number Publication Date
ATE407934T1 true ATE407934T1 (de) 2008-09-15

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Application Number Title Priority Date Filing Date
AT05725295T ATE407934T1 (de) 2004-03-09 2005-03-09 Azadecalinverbindungen mit kondensiertem ring als glucocorticoidrezeptormodulatoren

Country Status (17)

Country Link
US (4) US7928237B2 (de)
EP (1) EP1735308B1 (de)
JP (1) JP4931794B2 (de)
KR (1) KR101185281B1 (de)
CN (1) CN101027301B (de)
AT (1) ATE407934T1 (de)
AU (1) AU2005222421B2 (de)
CA (1) CA2558899C (de)
CY (1) CY1108621T1 (de)
DE (1) DE602005009687D1 (de)
DK (1) DK1735308T3 (de)
ES (1) ES2313317T3 (de)
IL (1) IL177982A (de)
NZ (1) NZ550362A (de)
PT (1) PT1735308E (de)
WO (1) WO2005087769A1 (de)
ZA (1) ZA200608306B (de)

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AU2005222421B2 (en) 2010-09-23
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CY1108621T1 (el) 2014-04-09
KR101185281B1 (ko) 2012-09-21
HK1104813A1 (en) 2008-01-25
EP1735308A1 (de) 2006-12-27
US20070281928A1 (en) 2007-12-06
US20120225856A1 (en) 2012-09-06
US20140179671A1 (en) 2014-06-26
ZA200608306B (en) 2009-02-25
CN101027301B (zh) 2011-06-29
NZ550362A (en) 2010-06-25
AU2005222421A1 (en) 2005-09-22
EP1735308B1 (de) 2008-09-10
DK1735308T3 (da) 2009-01-19
KR20070029684A (ko) 2007-03-14
US8557839B2 (en) 2013-10-15
JP4931794B2 (ja) 2012-05-16
US7928237B2 (en) 2011-04-19
IL177982A0 (en) 2006-12-31
IL177982A (en) 2012-09-24
CA2558899A1 (en) 2005-09-22
PT1735308E (pt) 2008-12-02
WO2005087769A1 (en) 2005-09-22
CN101027301A (zh) 2007-08-29
CA2558899C (en) 2013-02-05
ES2313317T3 (es) 2009-03-01

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