ATE407963T1 - Biologisch abbaubare amin-enthaltende polyorthoester und blockcopolymere daraus - Google Patents
Biologisch abbaubare amin-enthaltende polyorthoester und blockcopolymere darausInfo
- Publication number
- ATE407963T1 ATE407963T1 AT02789694T AT02789694T ATE407963T1 AT E407963 T1 ATE407963 T1 AT E407963T1 AT 02789694 T AT02789694 T AT 02789694T AT 02789694 T AT02789694 T AT 02789694T AT E407963 T1 ATE407963 T1 AT E407963T1
- Authority
- AT
- Austria
- Prior art keywords
- block copolymers
- polyorthoesters
- biodegradable amine
- hydrophobic
- biodegradable
- Prior art date
Links
- 229920001400 block copolymer Polymers 0.000 title abstract 3
- 229920001710 Polyorthoester Polymers 0.000 title abstract 2
- 230000002209 hydrophobic effect Effects 0.000 abstract 2
- 239000013543 active substance Substances 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 238000005538 encapsulation Methods 0.000 abstract 1
- 239000002198 insoluble material Substances 0.000 abstract 1
- 239000000693 micelle Substances 0.000 abstract 1
- -1 poly(ortho esters) Polymers 0.000 abstract 1
- 230000007928 solubilization Effects 0.000 abstract 1
- 238000005063 solubilization Methods 0.000 abstract 1
- 238000013268 sustained release Methods 0.000 abstract 1
- 239000012730 sustained-release form Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
- C08G63/12—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from polycarboxylic acids and polyhydroxy compounds
- C08G63/40—Polyesters derived from ester-forming derivatives of polycarboxylic acids or of polyhydroxy compounds, other than from esters thereof
- C08G63/42—Cyclic ethers; Cyclic carbonates; Cyclic sulfites; Cyclic orthoesters
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/66—Polyesters containing oxygen in the form of ether groups
- C08G63/668—Polyesters containing oxygen in the form of ether groups derived from polycarboxylic acids and polyhydroxy compounds
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/002—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from unsaturated compounds
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/34—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from hydroxy compounds or their metallic derivatives
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G2650/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G2650/28—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule characterised by the polymer type
- C08G2650/38—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule characterised by the polymer type containing oxygen in addition to the ether group
- C08G2650/42—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule characterised by the polymer type containing oxygen in addition to the ether group containing orthoester groups
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Materials For Medical Uses (AREA)
- Polyethers (AREA)
- Polyesters Or Polycarbonates (AREA)
- Biological Depolymerization Polymers (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/991,537 US6524606B1 (en) | 2001-11-16 | 2001-11-16 | Bioerodible polyorthoesters containing amine groups |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE407963T1 true ATE407963T1 (de) | 2008-09-15 |
Family
ID=25537313
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02789694T ATE407963T1 (de) | 2001-11-16 | 2002-11-15 | Biologisch abbaubare amin-enthaltende polyorthoester und blockcopolymere daraus |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US6524606B1 (de) |
| EP (1) | EP1448666B1 (de) |
| JP (1) | JP2005509709A (de) |
| KR (1) | KR20040066818A (de) |
| AT (1) | ATE407963T1 (de) |
| AU (1) | AU2002352743B2 (de) |
| CA (1) | CA2463179A1 (de) |
| DE (1) | DE60228875D1 (de) |
| ES (1) | ES2314118T3 (de) |
| WO (1) | WO2003044076A1 (de) |
Families Citing this family (79)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002520287A (ja) * | 1998-07-10 | 2002-07-09 | ザ・ユニバーシティ・オブ・シドニー | 黄斑変性における血管新生の予防的治療 |
| AUPQ496500A0 (en) * | 2000-01-06 | 2000-02-03 | University Of Sydney, The | Kit |
| US8088060B2 (en) | 2000-03-15 | 2012-01-03 | Orbusneich Medical, Inc. | Progenitor endothelial cell capturing with a drug eluting implantable medical device |
| US9522217B2 (en) | 2000-03-15 | 2016-12-20 | Orbusneich Medical, Inc. | Medical device with coating for capturing genetically-altered cells and methods for using same |
| US6613355B2 (en) * | 2000-05-11 | 2003-09-02 | A.P. Pharma, Inc. | Semi-solid delivery vehicle and pharmaceutical compositions |
| US20050042194A1 (en) | 2000-05-11 | 2005-02-24 | A.P. Pharma, Inc. | Semi-solid delivery vehicle and pharmaceutical compositions |
| DE10026698A1 (de) | 2000-05-30 | 2001-12-06 | Basf Ag | Selbstemulgierende Wirkstoffformulierung und Verwendung dieser Formulierung |
| AU2001288829A1 (en) * | 2000-09-06 | 2002-03-22 | Ap Pharma, Inc. | Degradable polyacetal polymers |
| US20030152630A1 (en) * | 2001-05-11 | 2003-08-14 | Ng Steven Y. | PEG-POE, PEG-POE-PEG, and POE-PEG-POE block copolymers |
| US6590059B2 (en) * | 2001-05-11 | 2003-07-08 | Ap Pharma, Inc. | Bioerodible polyorthoesters from dioxolane-based diketene acetals |
| US8403954B2 (en) | 2001-05-22 | 2013-03-26 | Sanostec Corp. | Nasal congestion, obstruction relief, and drug delivery |
| US6524606B1 (en) * | 2001-11-16 | 2003-02-25 | Ap Pharma, Inc. | Bioerodible polyorthoesters containing amine groups |
| US20040001889A1 (en) | 2002-06-25 | 2004-01-01 | Guohua Chen | Short duration depot formulations |
| US7354574B2 (en) * | 2002-11-07 | 2008-04-08 | Advanced Ocular Systems Limited | Treatment of ocular disease |
| US7045589B2 (en) * | 2002-11-15 | 2006-05-16 | A.P. Pharma, Inc. | Bioerodible poly(ortho esters) from dioxane-based di(ketene acetals), and block copolymers containing them |
| US7083802B2 (en) * | 2003-07-31 | 2006-08-01 | Advanced Ocular Systems Limited | Treatment of ocular disease |
| US8377952B2 (en) | 2003-08-28 | 2013-02-19 | Abbott Laboratories | Solid pharmaceutical dosage formulation |
| US8025899B2 (en) | 2003-08-28 | 2011-09-27 | Abbott Laboratories | Solid pharmaceutical dosage form |
| US7087237B2 (en) * | 2003-09-19 | 2006-08-08 | Advanced Ocular Systems Limited | Ocular solutions |
| US20050181018A1 (en) * | 2003-09-19 | 2005-08-18 | Peyman Gholam A. | Ocular drug delivery |
| US7083803B2 (en) * | 2003-09-19 | 2006-08-01 | Advanced Ocular Systems Limited | Ocular solutions |
| US7329413B1 (en) | 2003-11-06 | 2008-02-12 | Advanced Cardiovascular Systems, Inc. | Coatings for drug delivery devices having gradient of hydration and methods for fabricating thereof |
| US7976858B2 (en) | 2004-01-13 | 2011-07-12 | The Hospital For Special Surgery | Drug delivery to a joint |
| EP1711186A4 (de) * | 2004-02-04 | 2009-03-18 | Retmed Pty Ltd | Langsam freigesetzte steroidzusammensetzung |
| CA2557215A1 (en) * | 2004-02-26 | 2005-09-09 | Advanced Ocular Systems Limited | Tetracycline derivatives for the treatment of ocular pathologies |
| US20050192257A1 (en) * | 2004-02-26 | 2005-09-01 | Peyman Gholam A. | Predictors for patients at risk for glaucoma from steroid therapy |
| EP1755616B1 (de) | 2004-04-08 | 2013-08-14 | Advanced Ocular Systems Limited | Behandlung von exsudativer Retinopathie mit Mineralcorticoiden |
| WO2005102303A2 (en) * | 2004-04-21 | 2005-11-03 | Advanced Ocular Systems Limited | Antiprostaglandins for the treatment of ocular pathologies |
| US20080255492A1 (en) * | 2004-08-19 | 2008-10-16 | Jens Hoeg Truelsen | Absorbent Fiber Material and Use Thereof in Wound Dressings |
| US7350479B2 (en) * | 2004-09-10 | 2008-04-01 | United States Of America As Represented By The Secretary Of The Army | System and method for controlling growth of aquatic plants utilizing bio-eroding means implanted in triploid grass carp |
| US20060122152A1 (en) * | 2004-12-03 | 2006-06-08 | Peyman Gholam A | Heparin for the treatment of ocular pathologies |
| KR100732013B1 (ko) * | 2005-03-18 | 2007-06-25 | 성균관대학교산학협력단 | pH 민감성 블록 공중합체 및 이를 이용한 고분자 마이셀 |
| CA2601546A1 (en) * | 2005-03-31 | 2006-10-05 | Ap Pharma, Inc. | Peg-polyacetal diblock and triblock copolymers and pharmaceutical compositions |
| US20070014760A1 (en) * | 2005-07-18 | 2007-01-18 | Peyman Gholam A | Enhanced recovery following ocular surgery |
| CA2615990A1 (en) | 2005-07-18 | 2007-01-25 | Minu, L.L.C. | Enhanced ocular neuroprotection/neurostimulation |
| US7713916B2 (en) * | 2005-09-22 | 2010-05-11 | Halliburton Energy Services, Inc. | Orthoester-based surfactants and associated methods |
| CN103071209A (zh) | 2005-11-17 | 2013-05-01 | 周吉尼克斯股份有限公司 | 用无针注射递送粘稠制剂 |
| PL2374472T3 (pl) | 2006-03-16 | 2018-11-30 | Dyax Corp. | Kompozycje i sposoby leczenia zaburzeń okulistycznych |
| US20070264339A1 (en) * | 2006-05-12 | 2007-11-15 | Ap Pharma, Inc. | Base-stabilized polyorthoester formulations |
| US20070265329A1 (en) * | 2006-05-12 | 2007-11-15 | Devang Shah T | Methods for the prevention of acute and delayed chemotherapy-induced nausea and vomiting (CINV) |
| US20070264338A1 (en) * | 2006-05-12 | 2007-11-15 | Shah Devang T | Base-stabilized polyorthoester formulations |
| US7458953B2 (en) * | 2006-06-20 | 2008-12-02 | Gholam A. Peyman | Ocular drainage device |
| US7875697B2 (en) | 2006-06-29 | 2011-01-25 | Medtronic, Inc. | Poly(orthoester) polymers, and methods of making and using same |
| DK2046382T3 (en) * | 2006-07-10 | 2016-12-12 | Esbatech Alcon Biomed Res Unit | scFv Antibodies which passes through the epithelial and / or endothelial layer |
| WO2009091790A1 (en) | 2008-01-15 | 2009-07-23 | Invista Technologies S.A.R.L. | Hydrocyanation of pentenenitriles |
| US8940315B2 (en) * | 2008-04-18 | 2015-01-27 | Medtronic, Inc. | Benzodiazepine formulation in a polyorthoester carrier |
| US8722079B2 (en) * | 2008-04-18 | 2014-05-13 | Warsaw Orthopedic, Inc. | Methods for treating conditions such as dystonia and post-stroke spasticity with clonidine |
| US8956642B2 (en) * | 2008-04-18 | 2015-02-17 | Medtronic, Inc. | Bupivacaine formulation in a polyorthoester carrier |
| ES2563061T3 (es) | 2008-04-28 | 2016-03-10 | Zogenix, Inc. | Nuevas formulaciones para el tratamiento de la migraña |
| WO2009135246A1 (en) * | 2008-05-07 | 2009-11-12 | Obj Limited | Method and apparatus for enhanced transdermal diffusion |
| US9095404B2 (en) * | 2008-05-12 | 2015-08-04 | University Of Utah Research Foundation | Intraocular drug delivery device and associated methods |
| EP2326304A2 (de) | 2008-07-17 | 2011-06-01 | Merial Limited | Verfahren zur verbesserung der stabilität von polyorthoestern und ihren formulierungen |
| US20100028416A1 (en) * | 2008-07-30 | 2010-02-04 | Nitto Denko Corporation | Drug carriers |
| WO2010068827A1 (en) * | 2008-12-11 | 2010-06-17 | A.P. Pharma, Inc. | Methods for enhancing stability of polyorthoesters and their formulations |
| SG10201406420XA (en) | 2009-10-14 | 2014-11-27 | Univ Nanyang Tech | Antiproliferative agent |
| JP5809251B2 (ja) | 2010-05-25 | 2015-11-10 | インターナショナル・サイエンティフィック・プロプライエタリー・リミテッド | 口腔ケア製品の送達 |
| JP6046609B2 (ja) | 2010-06-17 | 2016-12-21 | インターナショナル・サイエンティフィック・プロプライエタリー・リミテッド | 皮膚ケア製品の送達 |
| US10179173B2 (en) | 2012-03-23 | 2019-01-15 | Regents Of The University Of Minnesota | Semi-solid delivery systems |
| US8945827B2 (en) | 2013-03-13 | 2015-02-03 | Awareness Technology, Inc. | Serological methods and diagnostic tests for syphilis antibodies |
| AU2014228313B2 (en) | 2013-03-15 | 2019-01-17 | Heron Therapeutics, Inc. | Compositions of a polyorthoester and an aprotic solvent |
| JP6232280B2 (ja) * | 2013-12-25 | 2017-11-15 | 株式会社ダイセル | 含酸素飽和ヘテロ環を有する重合体及びその製造方法 |
| WO2015103319A1 (en) * | 2013-12-31 | 2015-07-09 | Heron Therapeutics, Inc. | Polymer-based compositions for extended release of proteins |
| WO2015188223A1 (en) | 2014-06-11 | 2015-12-17 | International Scientific Pty Ltd | Device and method to treat or prevent joint degeneration |
| SG11201909478UA (en) | 2017-04-24 | 2019-11-28 | Cocrystal Pharma Inc | Pyrrolopyrimidine derivatives useful as inhibitors of influenza virus replication |
| CA3067558A1 (en) | 2017-06-16 | 2018-12-20 | Avery Therapeutics, Inc. | Three dimensional tissue compositions and methods of use |
| US10687023B1 (en) | 2017-08-14 | 2020-06-16 | Visualimits, Llc | Gaming table events detecting and processing |
| EP3829719B1 (de) | 2018-07-27 | 2025-04-02 | Cocrystal Pharma, Inc. | Pyrrolo[2,3-b]pyridinderivate als inhibitoren der influenzavirusreplikation |
| TWI844564B (zh) | 2018-09-10 | 2024-06-11 | 美商共結晶製藥公司 | 流感病毒複製之抑制劑 |
| PL3866778T3 (pl) | 2018-10-17 | 2023-03-27 | Cocrystal Pharma, Inc. | Kombinacje inhibitorów replikacji wirusa grypy |
| WO2020112716A1 (en) | 2018-11-26 | 2020-06-04 | Cocrystal Pharma, Inc. | Inhibitors of influenza virus replication |
| EP4090353A4 (de) | 2020-01-13 | 2023-08-09 | Durect Corporation | Arzneimittelabgabesysteme mit verzögerter freisetzung mit reduzierten verunreinigungen und verwandte verfahren |
| US20230151034A1 (en) | 2020-03-17 | 2023-05-18 | Cocrystal Pharma, Inc. | Peptidomimetic n5-methyl-n2-(nonanoyl-l-leucyl)-l-glutaminate derivatives, triazaspiro[4.14]nonadecane derivatives and similar compounds as inhibitors of norovirus and coronavirus replication |
| PH12022552486A1 (en) | 2020-04-10 | 2024-01-03 | Cocrystal Pharma Inc | Inhibitors of norovirus and coronavirus replication |
| US12558415B2 (en) | 2020-04-14 | 2026-02-24 | The Regents Of The University Of California | Broad-spectrum multi-antigen pan-coronavirus vaccine |
| WO2021211749A1 (en) | 2020-04-14 | 2021-10-21 | The Regents Of The University Of California | Multi-epitope pan-coronavirus vaccine compositions |
| JP2024503402A (ja) | 2021-01-12 | 2024-01-25 | デュレクト コーポレーション | 徐放性薬物送達システム及び関連の方法 |
| TW202321196A (zh) | 2021-08-03 | 2023-06-01 | 美商共結晶製藥公司 | 冠狀病毒抑制劑 |
| AR132416A1 (es) | 2023-04-12 | 2025-06-25 | Centennial Therapeutics Llc | Compuestos de pirimidina disustituidos para la inhibición de la cetohexoquinasa |
| KR20260022334A (ko) | 2023-05-31 | 2026-02-19 | 센테니얼 테라퓨틱스, 엘엘씨 | 케토헥소키나제 억제를 위한 이환식 화합물 |
Family Cites Families (152)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US82362A (en) * | 1868-09-22 | Samuel swes | ||
| US37300A (en) * | 1863-01-06 | Improvement in window-blind fastenings | ||
| US138474A (en) * | 1873-05-06 | Improvement in wave-powers | ||
| US90398A (en) * | 1869-05-25 | Improvement in tree-boxes | ||
| US176844A (en) * | 1876-05-02 | Improvement in beer-taps | ||
| US152630A (en) * | 1874-06-30 | Improvement in cars for transporting coal | ||
| US130472A (en) * | 1872-08-13 | Improvement in hinges for sewing-machine tables | ||
| US3268550A (en) * | 1963-08-26 | 1966-08-23 | Ibm | Nu-butenyl carbazoles |
| US4180064A (en) | 1972-12-27 | 1979-12-25 | Alza Corporation | System for delivering agent to environment of use over prolonged time |
| FR2238477B1 (de) | 1973-07-27 | 1976-12-03 | Roussel Uclaf | |
| US4014987A (en) * | 1974-06-04 | 1977-03-29 | Alza Corporation | Device for delivery of useful agent |
| US4180646A (en) | 1975-01-28 | 1979-12-25 | Alza Corporation | Novel orthoester polymers and orthocarbonate polymers |
| US4093709A (en) | 1975-01-28 | 1978-06-06 | Alza Corporation | Drug delivery devices manufactured from poly(orthoesters) and poly(orthocarbonates) |
| US4131648A (en) | 1975-01-28 | 1978-12-26 | Alza Corporation | Structured orthoester and orthocarbonate drug delivery devices |
| US4079038A (en) | 1976-03-05 | 1978-03-14 | Alza Corporation | Poly(carbonates) |
| FR2352547A1 (fr) | 1976-05-25 | 1977-12-23 | Viridis Ets | Nouvelle resine anionique a action hypocholesterolemiante, son procede de preparation et compositions therapeutiques la contenant |
| US4261969A (en) * | 1979-05-03 | 1981-04-14 | World Health Organization | Controlled drug release composition |
| US4249531A (en) * | 1979-07-05 | 1981-02-10 | Alza Corporation | Bioerodible system for delivering drug manufactured from poly(carboxylic acid) |
| US4304767A (en) | 1980-05-15 | 1981-12-08 | Sri International | Polymers of di- (and higher functionality) ketene acetals and polyols |
| US4502976A (en) * | 1982-10-25 | 1985-03-05 | Bend Research, Inc. | Water soluble polyesters |
| US4513143A (en) * | 1982-12-01 | 1985-04-23 | Sri International | Preparation of ketene acetals |
| US4532335A (en) | 1983-03-07 | 1985-07-30 | Sri International | Preparation of ketene acetals by rearrangement of allyl and substituted allyl acetals |
| US4690682A (en) * | 1983-04-15 | 1987-09-01 | Damon Biotech, Inc. | Sustained release |
| US5449670A (en) | 1983-05-20 | 1995-09-12 | Skinner; Wilfred A. | Composition and method for the transdermal delivery of bioactive peptides |
| US4710497A (en) | 1983-05-20 | 1987-12-01 | Nitto Electric Industrial Co., Ltd. | Method for percutaneously administering physiologically active agents |
| US5128376A (en) * | 1983-07-01 | 1992-07-07 | Nitto Denko Corporation | Method for percutaneously administering physiologically active agents using an adjuvant a solvent and a diol moderator |
| US4752612A (en) * | 1983-07-01 | 1988-06-21 | Nitto Electrical Industrial Co., Ltd. | Method and percutaneously administering physiologically active agents using an alcohol adjuvant and a solvent |
| US4590190A (en) * | 1983-07-01 | 1986-05-20 | Nitto Electric Industrial Co., Ltd. | Method for percutaneously administering physiologically active agents using an alcohol adjuvant and a solvent |
| US4548990A (en) | 1983-08-15 | 1985-10-22 | Ciba-Geigy Corporation | Crosslinked, porous polymers for controlled drug delivery |
| US4818542A (en) * | 1983-11-14 | 1989-04-04 | The University Of Kentucky Research Foundation | Porous microspheres for drug delivery and methods for making same |
| US4605670A (en) * | 1984-02-01 | 1986-08-12 | Nitto Electric Industrial Co., Ltd. | Method for percutaneously administering metoclopramide |
| US4765973A (en) * | 1984-06-06 | 1988-08-23 | Merck & Co., Inc. | Polymers containing pendant acid functionalities and labile backbone bonds |
| US4639366A (en) * | 1984-06-06 | 1987-01-27 | Merck & Co., Inc. | Polymers containing pendant acid functionalities and labile backbone bonds |
| GB8416234D0 (en) * | 1984-06-26 | 1984-08-01 | Ici Plc | Biodegradable amphipathic copolymers |
| US4549010A (en) | 1984-06-27 | 1985-10-22 | Merck & Co., Inc. | Bioerodible poly(ortho ester) thermoplastic elastomer from diketene diacetal |
| US4690825A (en) * | 1985-10-04 | 1987-09-01 | Advanced Polymer Systems, Inc. | Method for delivering an active ingredient by controlled time release utilizing a novel delivery vehicle which can be prepared by a process utilizing the active ingredient as a porogen |
| US4738932A (en) * | 1985-12-03 | 1988-04-19 | Advanced Polymer Systems, Inc. | Reaginic test for syphilis |
| US5955109A (en) | 1985-12-18 | 1999-09-21 | Advanced Polymer Systems, Inc. | Methods and compositions for topical delivery of retinoic acid |
| US5145675A (en) | 1986-03-31 | 1992-09-08 | Advanced Polymer Systems, Inc. | Two step method for preparation of controlled release formulations |
| US5879716A (en) * | 1985-12-18 | 1999-03-09 | Advanced Polymer Systems, Inc. | Methods and compositions for topical delivery of benzoyl peroxide |
| US4764364A (en) | 1986-02-25 | 1988-08-16 | S R I International | Method of preparing bioerodible polymers having pH sensitivity in the acid range and resulting product |
| US4855132A (en) | 1986-02-25 | 1989-08-08 | S R I International | Method of preparing bioerodible polymers having pH sensitivity in the acid range and resulting product |
| US4801457A (en) * | 1986-08-01 | 1989-01-31 | Sandoz Pharm. Corp. | Polyacetal hydrogels formed from divinyl ethers and polyols |
| US4713441A (en) | 1986-08-01 | 1987-12-15 | Sandoz Pharmaceuticals Corp. | Polyacetal hydrogels formed from divinyl ethers and polyols |
| JP2793188B2 (ja) | 1986-08-15 | 1998-09-03 | アドバンスト ポリマー システムズ,インコーポレイティド | ポリマー担体組成物の製造方法 |
| US4849426A (en) * | 1987-05-15 | 1989-07-18 | Pearlman Dale L | Method for treating actinic keratosis with cytotoxic agents |
| US5013553A (en) * | 1987-06-30 | 1991-05-07 | Vipont Pharmaceutical, Inc. | Drug delivery devices |
| US4855144A (en) * | 1987-10-23 | 1989-08-08 | Advanced Polymer Systems | Synthetic melanin aggregates |
| US4806360A (en) * | 1987-10-23 | 1989-02-21 | Advanced Polymer Systems | Synthetic melanin aggregates |
| US4923645A (en) * | 1987-11-16 | 1990-05-08 | Damon Biotech, Inc. | Sustained release of encapsulated molecules |
| SE8705136D0 (sv) | 1987-12-22 | 1987-12-22 | Pharmacia Ab | Oral doseringsenhet for lekemedel och dess anvendning och framstellning |
| US4898928A (en) * | 1988-03-07 | 1990-02-06 | Sandoz Pharmaceuticals Corp. | Polyacetal and polyketal hydrogels formed from acetals or ketals and polyols |
| ZA892859B (en) * | 1988-04-22 | 1989-12-27 | Advanced Polymer Systems Inc | Porous particles in preparations involving immiscible phases |
| US5041713A (en) | 1988-05-13 | 1991-08-20 | Marinelon, Inc. | Apparatus and method for applying plasma flame sprayed polymers |
| AU4059489A (en) | 1988-05-13 | 1989-11-29 | Advanced Polymer Systems Inc. | Protective coating for boat hulls and method of applying the same |
| US4957998A (en) | 1988-08-22 | 1990-09-18 | Pharmaceutical Delivery Systems, Inc. | Polymers containing acetal, carboxy-acetal, ortho ester and carboxyortho ester linkages |
| US5702716A (en) | 1988-10-03 | 1997-12-30 | Atrix Laboratories, Inc. | Polymeric compositions useful as controlled release implants |
| US5632727A (en) * | 1988-10-03 | 1997-05-27 | Atrix Laboratories, Inc. | Biodegradable film dressing and method for its formation |
| US5725491A (en) * | 1988-10-03 | 1998-03-10 | Atrix Laboratories, Inc. | Method of forming a biodegradable film dressing on tissue |
| US4938763B1 (en) * | 1988-10-03 | 1995-07-04 | Atrix Lab Inc | Biodegradable in-situ forming implants and method of producing the same |
| US5840293A (en) | 1988-11-16 | 1998-11-24 | Advanced Polymer Systems, Inc. | Ionic beads for controlled release and adsorption |
| US5324520A (en) * | 1988-12-19 | 1994-06-28 | Vipont Pharmaceutical, Inc. | Intragingival delivery systems for treatment of periodontal disease |
| US4963369A (en) | 1989-01-19 | 1990-10-16 | Wm. Wrigley Jr. Co. | Gum composition containing dispersed porous beads containing active chewing gum ingredients and method |
| US5287588A (en) * | 1989-01-31 | 1994-02-22 | U.S. Products, Inc. | Upholstery and carpet cleaning equipment including external heat exchanger |
| US5108755A (en) * | 1989-04-27 | 1992-04-28 | Sri International | Biodegradable composites for internal medical use |
| ES2084698T5 (es) | 1989-05-04 | 2005-03-01 | Southern Research Institute | Procedimiento de encapsulacion. |
| US5028435A (en) * | 1989-05-22 | 1991-07-02 | Advanced Polymer Systems, Inc. | System and method for transdermal drug delivery |
| US4946931A (en) | 1989-06-14 | 1990-08-07 | Pharmaceutical Delivery Systems, Inc. | Polymers containing carboxy-ortho ester and ortho ester linkages |
| US5013821A (en) * | 1989-06-15 | 1991-05-07 | Pharmaceutical Delivery Systems, Inc. | Ortho and thio-ortho ester polymer |
| US5324519A (en) * | 1989-07-24 | 1994-06-28 | Atrix Laboratories, Inc. | Biodegradable polymer composition |
| US5077049A (en) | 1989-07-24 | 1991-12-31 | Vipont Pharmaceutical, Inc. | Biodegradable system for regenerating the periodontium |
| US5487897A (en) * | 1989-07-24 | 1996-01-30 | Atrix Laboratories, Inc. | Biodegradable implant precursor |
| US5030457A (en) * | 1989-08-28 | 1991-07-09 | Pharmaceutical Delivery Systems, Inc. | Bioerodible polymers useful for the controlled release of therapeutic agents |
| WO1991003510A1 (en) | 1989-08-28 | 1991-03-21 | Pharmaceutical Delivery Systems, Inc. | Bioerodible polymers useful for the controlled release of therapeutic agents |
| US5217712A (en) * | 1989-09-20 | 1993-06-08 | Merck & Co., Inc. | Bioerodible thermoset elastomers |
| US5047464A (en) | 1989-09-20 | 1991-09-10 | Merck & Co., Inc. | Bioerodible thermoset elastomers |
| WO1991004732A1 (en) | 1989-10-03 | 1991-04-18 | Advanced Polymer Systems, Inc. | Erodible macroporous hydrogel particles and preparation thereof |
| JP2641620B2 (ja) | 1989-11-09 | 1997-08-20 | アドバンスト ポリマー システムズ,インコーポレイティド | 経口導入製品に味付けする方法及び組成物 |
| IL98087A (en) * | 1990-05-04 | 1996-11-14 | Perio Prod Ltd | Preparation for dispensing drugs in the colon |
| JP2579711B2 (ja) | 1990-05-14 | 1997-02-12 | アドバンスト ポリマー システムズ,インコーポレイティド | 変色メラニン及びそれらの調製方法及び使用 |
| US5240715A (en) * | 1990-05-14 | 1993-08-31 | Advanced Polymer Systems | Color modified melanins and methods for their preparation and use |
| US5188844A (en) * | 1990-05-14 | 1993-02-23 | Advanced Polymer Systems, Inc. | Color modified melanins and methods for their preparation and use |
| JP3286315B2 (ja) * | 1990-06-20 | 2002-05-27 | アドバンスト ポリマー システムズ,インコーポレイティド | 可溶性活性物質の調節された放出のための組成物及び方法 |
| SE9002339L (sv) | 1990-07-04 | 1992-01-05 | Kabi Pharmacia Ab | Terapeutisk komposition och foerfarande foer dess framstaellning |
| JP2773959B2 (ja) | 1990-07-10 | 1998-07-09 | 信越化学工業株式会社 | 大腸内放出性固形製剤 |
| NZ239370A (en) | 1990-08-22 | 1994-04-27 | Merck & Co Inc | Bioerodible implantable controlled release dosage form comprising a poly(ortho ester) or a polyacetal with an active agent incorporated into the chain backbone |
| ZA918526B (en) * | 1990-10-30 | 1992-08-26 | Alza Corp | Drug delivery system and method |
| US5422121A (en) * | 1990-11-14 | 1995-06-06 | Rohm Gmbh | Oral dosage unit form |
| DE9015551U1 (de) | 1990-11-14 | 1992-03-12 | Röhm GmbH, 6100 Darmstadt | Orale Arzneiform und Überzugsmittel, enthaltend ein im Colon abbaubares Polysaccarid |
| WO1992018222A1 (en) | 1991-04-18 | 1992-10-29 | Advanced Polymer Systems, Inc. | Preparation and use of solid beads having controlled characteristics |
| WO1993000383A1 (en) | 1991-06-20 | 1993-01-07 | Pharmaceutical Delivery Systems, Inc. | Pulsed release of high molecular weight therapeutic agents from bioerodible polymer compositions |
| JP3000732B2 (ja) | 1991-07-05 | 2000-01-17 | 富士ゼロックス株式会社 | コロナ放電装置 |
| US5211951A (en) | 1991-07-24 | 1993-05-18 | Merck & Co., Inc. | Process for the manufacture of bioerodible poly (orthoester)s and polyacetals |
| US5261169A (en) | 1991-10-11 | 1993-11-16 | Advanced Polymer Systems, Inc. | System and method for deodorant delivery in footwear |
| AU2605592A (en) * | 1991-10-15 | 1993-04-22 | Atrix Laboratories, Inc. | Polymeric compositions useful as controlled release implants |
| CA2121687A1 (en) | 1991-10-21 | 1993-04-29 | Sergio Nacht | Ionic beads useful for controlled release and adsorption |
| US5256400A (en) | 1991-12-04 | 1993-10-26 | Advanced Polymer Systems, Inc. | Pressurized product delivery systems |
| EP0560014A1 (de) * | 1992-03-12 | 1993-09-15 | Atrix Laboratories, Inc. | Biologisch abbaubarer Wundverband in Form eines Sprühfilms und Verfahren zu seiner Herstellung |
| ZA932272B (en) * | 1992-03-30 | 1993-10-19 | Alza Corp | Viscous suspensions of controlled-release drug particles |
| US5334640A (en) * | 1992-04-08 | 1994-08-02 | Clover Consolidated, Ltd. | Ionically covalently crosslinked and crosslinkable biocompatible encapsulation compositions and methods |
| US5461140A (en) | 1992-04-30 | 1995-10-24 | Pharmaceutical Delivery Systems | Bioerodible polymers for solid controlled release pharmaceutical compositions |
| US5518730A (en) | 1992-06-03 | 1996-05-21 | Fuisz Technologies Ltd. | Biodegradable controlled release flash flow melt-spun delivery system |
| AU4538393A (en) | 1992-06-17 | 1994-01-04 | Advanced Polymer Systems Inc. | Antimicrobial dry paper product |
| MY113268A (en) | 1992-12-29 | 2002-01-31 | Insite Vision Incorporated | Plasticized bioerodible controlled delivery system |
| GB2273874A (en) | 1992-12-31 | 1994-07-06 | Pertti Olavi Toermaelae | Preparation of pharmaceuticals in a polymer matrix |
| IL110787A0 (en) * | 1993-08-27 | 1994-11-11 | Sandoz Ag | Biodegradable polymer, its preparation and pharmaceutical composition containing it |
| US5681873A (en) | 1993-10-14 | 1997-10-28 | Atrix Laboratories, Inc. | Biodegradable polymeric composition |
| ATE191444T1 (de) | 1993-12-15 | 2000-04-15 | Avon Prod Inc | Neue retinoidkonjugate zur behandlung von alterserscheinungen der haut |
| DK0754032T3 (da) * | 1994-04-08 | 2002-04-02 | Atrix Lab Inc | Flydende frigivelsessammensætninger |
| DE4415204A1 (de) | 1994-04-30 | 1995-11-02 | Carl Heinrich Dr Weischer | Neue Retinol (Vitamin A) -Derivate, deren Herstellung und Verwendung als Arzneimittel und Kosmetika |
| JP3005419U (ja) | 1994-06-20 | 1994-12-20 | 精 武田 | スナップファスナーの雌型嵌合体 |
| US6007845A (en) | 1994-07-22 | 1999-12-28 | Massachusetts Institute Of Technology | Nanoparticles and microparticles of non-linear hydrophilic-hydrophobic multiblock copolymers |
| US5849327A (en) | 1994-07-29 | 1998-12-15 | Advanced Polymer Systems, Inc. | Delivery of drugs to the lower gastrointestinal tract |
| US5607686A (en) * | 1994-11-22 | 1997-03-04 | United States Surgical Corporation | Polymeric composition |
| US6281015B1 (en) * | 1994-12-16 | 2001-08-28 | Children's Medical Center Corp. | Localized delivery of factors enhancing survival of transplanted cells |
| US5627187A (en) * | 1995-04-12 | 1997-05-06 | Katz; Bruce E. | 5-FU for treating actinic kerotoses |
| US5811510A (en) | 1995-04-14 | 1998-09-22 | General Hospital Corporation | Biodegradable polyacetal polymers and methods for their formation and use |
| US6413536B1 (en) | 1995-06-07 | 2002-07-02 | Southern Biosystems, Inc. | High viscosity liquid controlled delivery system and medical or surgical device |
| US6096344A (en) * | 1995-07-28 | 2000-08-01 | Advanced Polymer Systems, Inc. | Bioerodible porous compositions |
| AU710347B2 (en) * | 1995-08-31 | 1999-09-16 | Alkermes Controlled Therapeutics, Inc. | Composition for sustained release of an agent |
| AU1284897A (en) | 1995-12-04 | 1997-06-27 | Advanced Polymer Systems Inc. | Retinyl esters of alpha-hydroxy acids for topical improvement of skin function and appearance |
| US5851538A (en) | 1995-12-29 | 1998-12-22 | Advanced Polymer Systems, Inc. | Retinoid formulations in porous microspheres for reduced irritation and enhanced stability |
| US5968543A (en) | 1996-01-05 | 1999-10-19 | Advanced Polymer Systems, Inc. | Polymers with controlled physical state and bioerodibility |
| ATE197310T1 (de) | 1996-01-05 | 2000-11-15 | Advanced Polymer Systems Inc | Polymere mit kontrolliertem physikalischen zustand und bioerodierbarkeit |
| KR19990077278A (ko) | 1996-01-16 | 1999-10-25 | 마이클 오코넬 | 약물의 하부 위장관으로의 국소적 전달 |
| AU1751997A (en) | 1996-01-30 | 1997-08-22 | Advanced Polymer Systems Inc. | Targeted delivery of drugs to the lower gastrointestinal tract |
| AU2804297A (en) | 1996-04-22 | 1997-11-12 | Advanced Polymer Systems Inc. | Method of and composition for treating disorders of the skin using vitamin k |
| IL118235A0 (en) * | 1996-05-13 | 1996-09-12 | Univ Ben Gurion | Composition and method for forming biodegradable implants in situ and uses of these implants |
| ES2256898T3 (es) | 1996-12-20 | 2006-07-16 | Alza Corporation | Composicion de gel y procedimientos. |
| US5993856A (en) | 1997-01-24 | 1999-11-30 | Femmepharma | Pharmaceutical preparations and methods for their administration |
| UA54505C2 (uk) | 1997-04-03 | 2003-03-17 | Гілфорд Фармасьютікалз Інк. | Полімери, що біологічно розкладаються, зшиті фосфатами, композиції, вироби і способи для їх виготовлення і використання |
| US6193991B1 (en) * | 1997-10-29 | 2001-02-27 | Atul J. Shukla | Biodegradable delivery systems of biologically active substances |
| US5891470A (en) * | 1998-04-17 | 1999-04-06 | Advanced Polymer Systems, Inc. | Softgel formulation containing retinol |
| US6228894B1 (en) | 1998-04-17 | 2001-05-08 | Enhanced Derm Technologies, Inc. | Softgel-compatible composition containing retinol |
| US5939453A (en) | 1998-06-04 | 1999-08-17 | Advanced Polymer Systems, Inc. | PEG-POE, PEG-POE-PEG, and POE-PEG-POE block copolymers |
| AU4717399A (en) | 1998-06-26 | 2000-01-17 | Dermik Laboratories Inc. | Method of treatment for dermatological disorders and compositions therefor |
| US6245345B1 (en) * | 1998-07-07 | 2001-06-12 | Atrix Laboratories, Inc. | Filamentous porous films and methods for producing the same |
| US6261583B1 (en) * | 1998-07-28 | 2001-07-17 | Atrix Laboratories, Inc. | Moldable solid delivery system |
| US6143314A (en) | 1998-10-28 | 2000-11-07 | Atrix Laboratories, Inc. | Controlled release liquid delivery compositions with low initial drug burst |
| US6159491A (en) | 1999-02-12 | 2000-12-12 | Biovector Technologies, Inc. | Prolonged release bioadhesive vaginal gel dosage form |
| US6217895B1 (en) * | 1999-03-22 | 2001-04-17 | Control Delivery Systems | Method for treating and/or preventing retinal diseases with sustained release corticosteroids |
| US6287588B1 (en) | 1999-04-29 | 2001-09-11 | Macromed, Inc. | Agent delivering system comprised of microparticle and biodegradable gel with an improved releasing profile and methods of use thereof |
| US6461631B1 (en) | 1999-11-16 | 2002-10-08 | Atrix Laboratories, Inc. | Biodegradable polymer composition |
| EP1142596A1 (de) | 2000-04-03 | 2001-10-10 | Universiteit Gent | Zusammensetzung von vernetzbaren Prepolymeren zum Gebrauch in therapeutisch aktiven, bioabbaubaren Implantaten |
| AU2001261516A1 (en) | 2000-05-11 | 2001-11-20 | Advanced Polymer Systems Inc. | Semi-solid delivery vehicle and pharmaceutical compositions |
| US6613355B2 (en) | 2000-05-11 | 2003-09-02 | A.P. Pharma, Inc. | Semi-solid delivery vehicle and pharmaceutical compositions |
| AU2001288829A1 (en) | 2000-09-06 | 2002-03-22 | Ap Pharma, Inc. | Degradable polyacetal polymers |
| US6590059B2 (en) * | 2001-05-11 | 2003-07-08 | Ap Pharma, Inc. | Bioerodible polyorthoesters from dioxolane-based diketene acetals |
| EP1395626A1 (de) | 2001-05-11 | 2004-03-10 | AP Pharma, Inc. | Peg-poe, peg-poe-peg, und oe-peg-poe- blockcopolymere |
| US20020176844A1 (en) | 2001-05-11 | 2002-11-28 | Ng Steven Y. | Bioerodible polyorthoesters containing hydrogen bonding groups |
| US6524606B1 (en) * | 2001-11-16 | 2003-02-25 | Ap Pharma, Inc. | Bioerodible polyorthoesters containing amine groups |
| DE10157163A1 (de) | 2001-11-22 | 2003-06-18 | Gfe Gmbh & Co Kg Ges Fuer Ents | Verfahren und Vorrichtung zur Entsorgung von hochenergetische Stoffe enthaltenden Materialien, insbesondere von Granaten |
-
2001
- 2001-11-16 US US09/991,537 patent/US6524606B1/en not_active Expired - Fee Related
-
2002
- 2002-11-14 US US10/295,766 patent/US6667371B2/en not_active Expired - Fee Related
- 2002-11-15 DE DE60228875T patent/DE60228875D1/de not_active Expired - Fee Related
- 2002-11-15 CA CA002463179A patent/CA2463179A1/en not_active Abandoned
- 2002-11-15 JP JP2003545710A patent/JP2005509709A/ja active Pending
- 2002-11-15 AU AU2002352743A patent/AU2002352743B2/en not_active Ceased
- 2002-11-15 EP EP02789694A patent/EP1448666B1/de not_active Expired - Lifetime
- 2002-11-15 ES ES02789694T patent/ES2314118T3/es not_active Expired - Lifetime
- 2002-11-15 AT AT02789694T patent/ATE407963T1/de not_active IP Right Cessation
- 2002-11-15 WO PCT/US2002/036775 patent/WO2003044076A1/en not_active Ceased
- 2002-11-15 KR KR10-2004-7007476A patent/KR20040066818A/ko not_active Ceased
-
2003
- 2003-07-24 US US10/627,297 patent/US6946145B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP2005509709A (ja) | 2005-04-14 |
| ES2314118T3 (es) | 2009-03-16 |
| US6524606B1 (en) | 2003-02-25 |
| US20040146550A1 (en) | 2004-07-29 |
| KR20040066818A (ko) | 2004-07-27 |
| US20030138474A1 (en) | 2003-07-24 |
| WO2003044076A1 (en) | 2003-05-30 |
| CA2463179A1 (en) | 2003-05-30 |
| US6946145B2 (en) | 2005-09-20 |
| EP1448666B1 (de) | 2008-09-10 |
| AU2002352743A1 (en) | 2003-06-10 |
| WO2003044076A8 (en) | 2004-07-29 |
| AU2002352743B2 (en) | 2008-10-23 |
| EP1448666A1 (de) | 2004-08-25 |
| US6667371B2 (en) | 2003-12-23 |
| DE60228875D1 (de) | 2008-10-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE407963T1 (de) | Biologisch abbaubare amin-enthaltende polyorthoester und blockcopolymere daraus | |
| CA2355657A1 (en) | Biodegradable ph/thermosensitive hydrogels for sustained delivery of biologically active agents | |
| EP1569664A4 (de) | Biologisch abbaubare poly(ortho-ester) von di(ketenacetalen) auf dioxangrundlage, sowie sie enthaltende blockcopolymere | |
| EP1334731A4 (de) | Mittel zur prävention oder behandlung von psoriasis mit einem il-6-antagonist als wirkstoff | |
| BR0111016A (pt) | Composições farmacêuticas de liberação sustentada para a administração parenteral de compostos hidrófilos biologicamente ativos | |
| ATE461961T1 (de) | Mehrarmige polypeptid-poly(ethylenglykol)- blockcopolymere als arzneistoffzufuhrvehikel | |
| BR0210335A (pt) | Copolìmero de blocos, e, composição | |
| WO2000040203A3 (en) | Polymeric delivery agents and delivery agent compounds | |
| CY1105953T1 (el) | Συνθεσεις για απελευθερωση συνδυασμων φαρμακων | |
| BR0212475A (pt) | Composições farmacêuticas | |
| ATE302616T1 (de) | Oral anzuwendende arzneizusammensetzungen mit gesteuerter wirkstoffabgabe | |
| DE60208172D1 (de) | Mehrarmige blockcopolymere und pharmazeutische zusammensetzung | |
| PT1313453E (pt) | Vectores particulados destinados a melhorar a absorção oral de princípios activos | |
| WO2004104021A3 (en) | Controlled release of active agents utilizing repeat sequence protein polymers | |
| AU2003226059A8 (en) | Biodegradable peg-based polymer formulations in ocular applications | |
| WO2002058672A3 (en) | Microparticles of biodegradable polymer encapsulating a biologically active substance | |
| DE60124335D1 (de) | Alkylmethylsiloxan- Dimethylsiloxan- Polyalkylenoxid- Copolymere | |
| PT1195160E (pt) | Composições farmacêuticas de trimetazidina de libertação sustentada e método para a sua preparação | |
| ITTO20010321A0 (it) | Procedimento per la trasmissione di messaggi sms con identita' protetta. | |
| AR018451A1 (es) | Composiciones para el cuidado de cabello y metodo para depositar particulas de polimeros expandidos sobre el cabello | |
| BR9917195A (pt) | Nucleadores para polìmeros termoplásticoscristalizáveis | |
| TW200624464A (en) | Amphiphilic block copolymer and pharmaceutical formulation comprising the same | |
| BR0210632A (pt) | Tratamento de doença parasìtica | |
| NO20040134L (no) | Biologisk aktive peptider | |
| SE0001916D0 (sv) | Novel formulation |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |