ATE411337T1 - Verfahren zur herstellung acylierter polypeptide - Google Patents

Verfahren zur herstellung acylierter polypeptide

Info

Publication number
ATE411337T1
ATE411337T1 AT02750842T AT02750842T ATE411337T1 AT E411337 T1 ATE411337 T1 AT E411337T1 AT 02750842 T AT02750842 T AT 02750842T AT 02750842 T AT02750842 T AT 02750842T AT E411337 T1 ATE411337 T1 AT E411337T1
Authority
AT
Austria
Prior art keywords
polypeptides
acylated
certain
desired polypeptide
host cells
Prior art date
Application number
AT02750842T
Other languages
English (en)
Inventor
Ivan Diers
Per Balschmidt
Jan Markussen
Ib Jonassen
Michi Egel-Mitani
Thomas Kjeldsen
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Application granted granted Critical
Publication of ATE411337T1 publication Critical patent/ATE411337T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/006—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length of peptides containing derivatised side chain amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT02750842T 2001-07-24 2002-07-18 Verfahren zur herstellung acylierter polypeptide ATE411337T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DKPA200101141 2001-07-24

Publications (1)

Publication Number Publication Date
ATE411337T1 true ATE411337T1 (de) 2008-10-15

Family

ID=8160637

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02750842T ATE411337T1 (de) 2001-07-24 2002-07-18 Verfahren zur herstellung acylierter polypeptide

Country Status (15)

Country Link
EP (1) EP1421103B1 (de)
JP (1) JP4386722B2 (de)
KR (1) KR20040019361A (de)
CN (1) CN1558912A (de)
AT (1) ATE411337T1 (de)
AU (1) AU2002355161A1 (de)
BR (1) BR0211346A (de)
CA (1) CA2452735A1 (de)
DE (1) DE60229403D1 (de)
ES (1) ES2316588T3 (de)
HU (1) HUP0500057A3 (de)
IL (1) IL159623A0 (de)
PL (1) PL367687A1 (de)
RU (1) RU2004105155A (de)
WO (1) WO2003010186A2 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1687428A1 (de) 2003-11-14 2006-08-09 Novo Nordisk A/S Verfahren zur herstellung von acyliertem insulin
US20100317057A1 (en) * 2007-12-28 2010-12-16 Novo Nordisk A/S Semi-recombinant preparation of glp-1 analogues
ES2561208T3 (es) 2008-09-12 2016-02-25 Novo Nordisk A/S Método de acilación de un péptido o una proteína
CN107881187A (zh) * 2017-11-20 2018-04-06 珠海联邦制药股份有限公司 将大肠杆菌表达的融合蛋白转化为利拉鲁肽的制备方法及应用
CN111187760B (zh) * 2020-02-10 2022-09-13 中国海洋大学 一种具有酰基转移功能的酶及其应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6011007A (en) * 1993-09-17 2000-01-04 Novo Nordisk A/S Acylated insulin
US5646242A (en) * 1994-11-17 1997-07-08 Eli Lilly And Company Selective acylation of epsilon-amino groups
US5905140A (en) * 1996-07-11 1999-05-18 Novo Nordisk A/S, Novo Alle Selective acylation method
ES2258797T3 (es) * 1996-12-20 2006-09-01 Novo Nordisk A/S Proteinas con extension n-terminal expresadas en la levadura.
CZ20013018A3 (cs) * 1999-03-17 2002-02-13 Novo Nordisk A/S Způsob pro acylování aminoskupiny peptidu nebo proteinu a sloučenina

Also Published As

Publication number Publication date
KR20040019361A (ko) 2004-03-05
WO2003010186A2 (en) 2003-02-06
DE60229403D1 (de) 2008-11-27
WO2003010186A3 (en) 2004-03-25
ES2316588T3 (es) 2009-04-16
RU2004105155A (ru) 2005-04-20
IL159623A0 (en) 2004-06-01
HUP0500057A3 (en) 2006-01-30
CN1558912A (zh) 2004-12-29
CA2452735A1 (en) 2003-02-06
PL367687A1 (en) 2005-03-07
HUP0500057A2 (hu) 2005-04-28
EP1421103A2 (de) 2004-05-26
JP2005504527A (ja) 2005-02-17
AU2002355161A1 (en) 2003-02-17
BR0211346A (pt) 2004-09-21
EP1421103B1 (de) 2008-10-15
JP4386722B2 (ja) 2009-12-16

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Legal Events

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