ATE411994T1 - Herstellung eines substituierten chinoxalins von hoher reinheit - Google Patents
Herstellung eines substituierten chinoxalins von hoher reinheitInfo
- Publication number
- ATE411994T1 ATE411994T1 AT06710423T AT06710423T ATE411994T1 AT E411994 T1 ATE411994 T1 AT E411994T1 AT 06710423 T AT06710423 T AT 06710423T AT 06710423 T AT06710423 T AT 06710423T AT E411994 T1 ATE411994 T1 AT E411994T1
- Authority
- AT
- Austria
- Prior art keywords
- preparation
- high purity
- substituted quinoxaline
- purity substituted
- quinoxaline
- Prior art date
Links
- XSCHRSMBECNVNS-UHFFFAOYSA-N quinoxaline Chemical class N1=CC=NC2=CC=CC=C21 XSCHRSMBECNVNS-UHFFFAOYSA-N 0.000 title abstract 3
- QGMGHALXLXKCBD-UHFFFAOYSA-N 4-amino-n-(2-aminophenyl)benzamide Chemical compound C1=CC(N)=CC=C1C(=O)NC1=CC=CC=C1N QGMGHALXLXKCBD-UHFFFAOYSA-N 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000001567 quinoxalinyl group Chemical class N1=C(C=NC2=CC=CC=C12)* 0.000 abstract 1
- 238000007363 ring formation reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Psychology (AREA)
- Diabetes (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Child & Adolescent Psychology (AREA)
- Anesthesiology (AREA)
- Obesity (AREA)
- Physical Education & Sports Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US65629605P | 2005-02-24 | 2005-02-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE411994T1 true ATE411994T1 (de) | 2008-11-15 |
Family
ID=36405938
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06710423T ATE411994T1 (de) | 2005-02-24 | 2006-02-21 | Herstellung eines substituierten chinoxalins von hoher reinheit |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20080275051A1 (de) |
| EP (1) | EP1866308B1 (de) |
| JP (1) | JP2008531540A (de) |
| KR (1) | KR20070098942A (de) |
| CN (1) | CN101128462A (de) |
| AT (1) | ATE411994T1 (de) |
| AU (1) | AU2006217616A1 (de) |
| BR (1) | BRPI0607838A2 (de) |
| CA (1) | CA2598533A1 (de) |
| DE (1) | DE602006003320D1 (de) |
| ES (1) | ES2313625T3 (de) |
| IL (1) | IL185013A0 (de) |
| MX (1) | MX2007010375A (de) |
| RU (1) | RU2007131535A (de) |
| WO (1) | WO2006090236A1 (de) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2007319951A1 (en) | 2006-11-09 | 2008-05-22 | Pfizer Products Inc. | Polymorphs of nicotinic intermediates |
| WO2009065872A2 (en) * | 2007-11-20 | 2009-05-28 | Medichem, S.A. | Improved processes for the synthesis of varenicline l-tartrate |
| US8039620B2 (en) | 2008-05-22 | 2011-10-18 | Teva Pharmaceutical Industries Ltd. | Varenicline tosylate, an intermediate in the preparation process of varenicline L-tartrate |
| WO2009155403A2 (en) * | 2008-06-19 | 2009-12-23 | Teva Pharmaceutical Industries Ltd. | Processes for the preparation of varenicline and intermediates thereof |
| US20100010221A1 (en) * | 2008-07-10 | 2010-01-14 | Revital Lifshitz-Liron | Processes for purifying varenicline l-tartrate salt and preparing crystalline forms of varenicline l-tartrate salt |
| US8178537B2 (en) | 2009-06-22 | 2012-05-15 | Teva Pharmaceutical Industries Ltd. | Solid state forms of varenicline salts and processes for preparation thereof |
| US20120277433A1 (en) * | 2009-12-29 | 2012-11-01 | Mahendranath Rao Narasimha Rao | Process for the preparation of substituted quinoxalines |
| AU2011225747A1 (en) * | 2010-03-09 | 2012-09-27 | Actavis Group Ptc Ehf | Highly pure varenicline or a pharmaceutically acceptable salt thereof substantially free of methylvarenicline impurity |
| US20120004239A1 (en) * | 2010-06-11 | 2012-01-05 | Medichem, S.A. | Process for Preparing Quinoxaline Derivatives |
| CN113956255A (zh) * | 2020-07-20 | 2022-01-21 | 威智医药有限公司 | 一种伐尼克兰中间体、伐尼克兰及其盐的制备方法 |
| WO2022035434A1 (en) | 2020-08-14 | 2022-02-17 | Almatica Pharma Llc | Cocrystal of varenicline and oxalic acid, pharmaceutical composition thereof, and methods of use thereof |
| WO2022222019A1 (en) * | 2021-04-20 | 2022-10-27 | Suzhou Fude Zhaofeng Biochemical Technology Co., Ltd | Total synthesis of varenicline |
| CN115894488A (zh) * | 2021-08-20 | 2023-04-04 | 威智医药有限公司 | 低亚硝胺杂质含量的酒石酸伐尼克兰原料药及其制备方法 |
| CN114349701B (zh) * | 2022-01-07 | 2024-04-05 | 江苏豪森药业集团有限公司 | 一种酒石酸伐尼克兰中间体的制备方法 |
| US11602537B2 (en) | 2022-03-11 | 2023-03-14 | Par Pharmaceutical, Inc. | Varenicline compound and process of manufacture thereof |
| EP4241775A1 (de) | 2022-03-11 | 2023-09-13 | Par Pharmaceutical, Inc. | Tablette mit vareniclin und verfahren zur herstellung davon |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6605610B1 (en) * | 1997-12-31 | 2003-08-12 | Pfizer Inc | Aryl fused azapolycyclic compounds |
| IL136727A0 (en) * | 1997-12-31 | 2001-06-14 | Pfizer Prod Inc | Aryl fused azapolycyclic compounds |
| OA12599A (en) * | 2001-05-14 | 2006-06-08 | Pfizer Prod Inc | Tartrate salts of 5,8, 14-triazatetracyclo Ä10.3.1.o2,11.o4.9Ü-hexadeca2(11),3,5,7,9-pentaene and pharmaceutical compositions thereof. |
| WO2004108725A1 (en) * | 2003-06-04 | 2004-12-16 | Pfizer Products Inc. | Preparation of substituted quinoxalines from the dianline with 2,3-dihydroxy-1,4-dioxane |
-
2006
- 2006-02-21 AU AU2006217616A patent/AU2006217616A1/en not_active Abandoned
- 2006-02-21 KR KR1020077019287A patent/KR20070098942A/ko not_active Ceased
- 2006-02-21 CN CNA2006800060133A patent/CN101128462A/zh active Pending
- 2006-02-21 RU RU2007131535/04A patent/RU2007131535A/ru not_active Application Discontinuation
- 2006-02-21 EP EP06710423A patent/EP1866308B1/de not_active Expired - Lifetime
- 2006-02-21 BR BRPI0607838-9A patent/BRPI0607838A2/pt not_active IP Right Cessation
- 2006-02-21 CA CA002598533A patent/CA2598533A1/en not_active Abandoned
- 2006-02-21 US US11/722,817 patent/US20080275051A1/en not_active Abandoned
- 2006-02-21 JP JP2007556673A patent/JP2008531540A/ja active Pending
- 2006-02-21 AT AT06710423T patent/ATE411994T1/de not_active IP Right Cessation
- 2006-02-21 WO PCT/IB2006/000351 patent/WO2006090236A1/en not_active Ceased
- 2006-02-21 DE DE602006003320T patent/DE602006003320D1/de not_active Expired - Fee Related
- 2006-02-21 MX MX2007010375A patent/MX2007010375A/es not_active Application Discontinuation
- 2006-02-21 ES ES06710423T patent/ES2313625T3/es not_active Expired - Lifetime
-
2007
- 2007-08-02 IL IL185013A patent/IL185013A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2006090236A1 (en) | 2006-08-31 |
| CA2598533A1 (en) | 2006-08-31 |
| US20080275051A1 (en) | 2008-11-06 |
| EP1866308B1 (de) | 2008-10-22 |
| ES2313625T3 (es) | 2009-03-01 |
| JP2008531540A (ja) | 2008-08-14 |
| EP1866308A1 (de) | 2007-12-19 |
| RU2007131535A (ru) | 2009-03-27 |
| IL185013A0 (en) | 2007-12-03 |
| BRPI0607838A2 (pt) | 2009-06-13 |
| AU2006217616A1 (en) | 2006-08-31 |
| CN101128462A (zh) | 2008-02-20 |
| DE602006003320D1 (de) | 2008-12-04 |
| KR20070098942A (ko) | 2007-10-05 |
| MX2007010375A (es) | 2007-09-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |