ATE411998T1 - Verfahren zur herstellung der kristallform i von clopidogrel-hydrogensulphat - Google Patents

Verfahren zur herstellung der kristallform i von clopidogrel-hydrogensulphat

Info

Publication number
ATE411998T1
ATE411998T1 AT03750270T AT03750270T ATE411998T1 AT E411998 T1 ATE411998 T1 AT E411998T1 AT 03750270 T AT03750270 T AT 03750270T AT 03750270 T AT03750270 T AT 03750270T AT E411998 T1 ATE411998 T1 AT E411998T1
Authority
AT
Austria
Prior art keywords
clopidogrel
crystal form
preparing crystal
alpha
formula
Prior art date
Application number
AT03750270T
Other languages
English (en)
Inventor
Miroslav Veverka
Stefan Vodny
Eva Veverkova
Josef Hajicek
Hana Stepankova
Original Assignee
Zentiva As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=31954588&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE411998(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Zentiva As filed Critical Zentiva As
Application granted granted Critical
Publication of ATE411998T1 publication Critical patent/ATE411998T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Liquid Crystal Substances (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT03750270T 2002-08-27 2003-08-26 Verfahren zur herstellung der kristallform i von clopidogrel-hydrogensulphat ATE411998T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CZ20022906A CZ297472B6 (cs) 2002-08-27 2002-08-27 Zpusob výroby clopidogrelu hydrogensulfátu krystalické formy I

Publications (1)

Publication Number Publication Date
ATE411998T1 true ATE411998T1 (de) 2008-11-15

Family

ID=31954588

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03750270T ATE411998T1 (de) 2002-08-27 2003-08-26 Verfahren zur herstellung der kristallform i von clopidogrel-hydrogensulphat

Country Status (12)

Country Link
US (1) US7714133B2 (de)
EP (1) EP1554284B1 (de)
JP (1) JP2006502238A (de)
KR (1) KR20050058492A (de)
AT (1) ATE411998T1 (de)
AU (1) AU2003269673A1 (de)
CA (1) CA2495823A1 (de)
CZ (1) CZ297472B6 (de)
DE (1) DE60324301D1 (de)
EA (1) EA007977B1 (de)
PL (1) PL373578A1 (de)
WO (1) WO2004020443A1 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2534893A1 (en) * 2003-08-04 2005-02-10 Wockhardt Limited A novel process for the manufacture of (+)-(s)-clopidogrel bisulfate form-i
DE10337773A1 (de) * 2003-08-13 2005-03-24 Krka Tovarna Zdravil, D.D. Kristallisation von festen Formen von Clopidogrel-Additionssalzen
PT1680430E (pt) * 2003-11-03 2010-04-26 Cadila Healthcare Ltd Processos para a preparação da forma i de bissulfato de (s)-(+)-clopidogrel
CN1938319B (zh) * 2004-04-09 2010-05-12 韩美药品株式会社 结晶氯吡格雷萘磺酸盐或其水合物、其制备方法及含其的药物组合物
EP1740593B1 (de) 2004-04-19 2016-04-06 KRKA, tovarna zdravil, d.d., Novo mesto Verfahren zur herstellung der polymorphen form i von clopidogrelhydrogensulfat
KR20070012675A (ko) * 2004-04-20 2007-01-26 사노피-아벤티스 메틸(+)-(Ｓ)-α-(2-클로로페닐)-6,7-디히드로티에노[3,2-Ｃ]피리딘-5(4Ｈ) 아세테이트 히드로브로마이드, 클로피도그렐히드로브로마이드의 다형성 형태
CA2561006A1 (en) * 2004-04-20 2005-11-03 Sanofi-Aventis Clopidogrel salt and polymorphic forms thereof
EP1693375A1 (de) * 2005-02-21 2006-08-23 KRKA, tovarna zdravil, d.d., Novo mesto Verfahren zur Herstellung von Clopidrogel hydrogen sulfat in Form I
US7772398B2 (en) * 2005-03-11 2010-08-10 Dr. Reddy's Laboratories, Inc. Process for making crystalline form I of clopidogrel hydrogen sulphate
WO2007017886A1 (en) * 2005-08-11 2007-02-15 Arch Pharmalabs Limited Novel process for preparation of clopidogrel bisulphate polymorphic form i
WO2007035028A1 (en) 2005-09-21 2007-03-29 Chong Kun Dang Pharmaceutical Corp. Novel resinate complex of s-clopidogrel and production method thereof
EP2114957A4 (de) * 2007-01-29 2011-06-08 Ipca Lab Ltd Verfahren zur herstellung von kristallinem clopidogrelhydrogensulfat der form i
US20080188663A1 (en) * 2007-01-29 2008-08-07 Ashok Kumar Process for the preparation of crystalline clopidogrel hydrogen sulphate Form I
CN101686681B (zh) 2007-04-27 2015-04-01 锡德克斯药物公司 包含氯吡格雷和磺基烷基醚环糊精的制剂和其使用方法
EP2107061A1 (de) * 2008-04-02 2009-10-07 Krka Tovarna Zdravil, D.D., Novo Mesto Herstellungsverfahren für optisch angereichertes Clopidogrel
AU2009264395B2 (en) * 2008-06-24 2013-12-05 Zach System S.P.A. Process for the preparation of clopidogrel hydrogen sulfate crystalline form I
PL3100728T3 (pl) 2009-05-13 2020-05-18 Cydex Pharmaceuticals, Inc. Kompozycje farmaceutyczne zawierające prasugrel i pochodne cyklodekstryny oraz sposoby ich wytwarzania i zastosowania
WO2011042804A2 (en) * 2009-10-08 2011-04-14 Jubliant Life Sciences Limited An improved process for the preparation of clopidogrel hydrogen sulfate form i
KR101130445B1 (ko) * 2009-10-29 2012-03-27 동아제약주식회사 클로피도그랠 황산수소염 ⅰ형 제조방법
WO2011051976A2 (en) 2009-10-30 2011-05-05 Matrix Laboratories Ltd An improved process for the preparation of clopidogrel bisulfate form i
US20120232274A1 (en) * 2009-11-09 2012-09-13 Pharmazell Gmbh Process for preparation of clopiodogrel bisulfate form-1
WO2011125069A1 (en) 2010-03-22 2011-10-13 Rpg Life Sciences Limited A process for preparation of crystalline form i of clopidogrel bisulfate
CN102558194A (zh) * 2010-12-11 2012-07-11 山东方明药业股份有限公司 一种硫酸氢氯吡格雷i型的制备方法
CN102875568B (zh) * 2012-09-06 2015-12-09 苏州晶云药物科技有限公司 制备(+)-(s)-氯吡格雷硫酸氢盐纯晶型i的方法
KR101710922B1 (ko) 2015-06-03 2017-02-28 경동제약 주식회사 클로피도그렐 황산염 결정형 i형의 제조방법
CN107118221B (zh) * 2017-05-24 2021-09-07 常州制药厂有限公司 一种硫酸氢氯吡格雷晶型i制备方法
CN107163060B (zh) * 2017-05-24 2021-03-02 常州制药厂有限公司 一种硫酸氢氯吡格雷晶型ii制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2623810B2 (fr) * 1987-02-17 1992-01-24 Sanofi Sa Sels de l'alpha-(tetrahydro-4,5,6,7 thieno(3,2-c) pyridyl-5) (chloro-2 phenyl) -acetate de methyle dextrogyre et compositions pharmaceutiques en contenant
FR2779726B1 (fr) * 1998-06-15 2001-05-18 Sanofi Sa Forme polymorphe de l'hydrogenosulfate de clopidogrel
GB0125708D0 (en) 2001-10-26 2001-12-19 Generics Uk Ltd Novel compounds and processes
AU2002366383B2 (en) 2001-12-18 2007-06-14 Teva Pharmaceutical Industries Ltd. Polymorphs of clopidogrel hydrogensulfate
US6767913B2 (en) * 2001-12-18 2004-07-27 Teva Pharmaceutical Industries Ltd. Crystal forms iii, iv, v, and novel amorphous form of clopidogrel hydrogensulfate, processes for their preparation, processes for the preparation of form i, compositions containing the new forms and methods of administering the new forms
US7074928B2 (en) * 2002-01-11 2006-07-11 Teva Pharmaceutical Industries, Ltd. Polymorphs of clopidogrel hydrogensulfate
JP4072005B2 (ja) * 2002-06-12 2008-04-02 日本電波工業株式会社 温度補償水晶発振器
CA2534893A1 (en) * 2003-08-04 2005-02-10 Wockhardt Limited A novel process for the manufacture of (+)-(s)-clopidogrel bisulfate form-i

Also Published As

Publication number Publication date
KR20050058492A (ko) 2005-06-16
CA2495823A1 (en) 2004-03-11
JP2006502238A (ja) 2006-01-19
PL373578A1 (en) 2005-09-05
EP1554284B1 (de) 2008-10-22
EA007977B1 (ru) 2007-02-27
CZ20022906A3 (en) 2004-05-12
CZ297472B6 (cs) 2006-12-13
US20060041136A1 (en) 2006-02-23
US7714133B2 (en) 2010-05-11
WO2004020443A1 (en) 2004-03-11
AU2003269673A1 (en) 2004-03-19
DE60324301D1 (de) 2008-12-04
EP1554284A1 (de) 2005-07-20
EA200500310A1 (ru) 2005-08-25

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