ATE412771T1 - Verfahren zur modulation der tubulindeacetylase- aktivität - Google Patents
Verfahren zur modulation der tubulindeacetylase- aktivitätInfo
- Publication number
- ATE412771T1 ATE412771T1 AT03726921T AT03726921T ATE412771T1 AT E412771 T1 ATE412771 T1 AT E412771T1 AT 03726921 T AT03726921 T AT 03726921T AT 03726921 T AT03726921 T AT 03726921T AT E412771 T1 ATE412771 T1 AT E412771T1
- Authority
- AT
- Austria
- Prior art keywords
- deacetylase activity
- tubulin deacetylase
- modulating
- modulating tubulin
- ribavirin
- Prior art date
Links
- 102000004243 Tubulin Human genes 0.000 title 1
- 108090000704 Tubulin Proteins 0.000 title 1
- IWUCXVSUMQZMFG-AFCXAGJDSA-N Ribavirin Chemical compound N1=C(C(=O)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 IWUCXVSUMQZMFG-AFCXAGJDSA-N 0.000 abstract 2
- 229960000329 ribavirin Drugs 0.000 abstract 2
- HZCAHMRRMINHDJ-DBRKOABJSA-N ribavirin Natural products O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1N=CN=C1 HZCAHMRRMINHDJ-DBRKOABJSA-N 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
- C12Q1/32—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving dehydrogenase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/978—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
- G01N2333/98—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38221802P | 2002-05-20 | 2002-05-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE412771T1 true ATE412771T1 (de) | 2008-11-15 |
Family
ID=29584377
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03726921T ATE412771T1 (de) | 2002-05-20 | 2003-05-20 | Verfahren zur modulation der tubulindeacetylase- aktivität |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US7351542B2 (de) |
| EP (2) | EP1982720A1 (de) |
| AT (1) | ATE412771T1 (de) |
| AU (1) | AU2003229329B2 (de) |
| CA (1) | CA2485988C (de) |
| DE (1) | DE60324427D1 (de) |
| ES (1) | ES2318131T3 (de) |
| WO (1) | WO2003099210A2 (de) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003100089A1 (en) * | 2002-05-23 | 2003-12-04 | The Regents Of The University Of California | Methods of modulating mitochondrial nad-dependent deacetylase |
| US7154002B1 (en) | 2002-10-08 | 2006-12-26 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| US7381825B2 (en) * | 2003-03-17 | 2008-06-03 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| JP2007530417A (ja) * | 2003-07-01 | 2007-11-01 | プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ | 細胞及び生物の寿命及びストレス応答を操作するための組成物 |
| US20060025337A1 (en) * | 2003-07-01 | 2006-02-02 | President And Fellows Of Harvard College | Sirtuin related therapeutics and diagnostics for neurodegenerative diseases |
| US20050159470A1 (en) * | 2003-12-19 | 2005-07-21 | Syrrx, Inc. | Histone deacetylase inhibitors |
| US20050137234A1 (en) * | 2003-12-19 | 2005-06-23 | Syrrx, Inc. | Histone deacetylase inhibitors |
| US8017634B2 (en) | 2003-12-29 | 2011-09-13 | President And Fellows Of Harvard College | Compositions for treating obesity and insulin resistance disorders |
| US20050171027A1 (en) | 2003-12-29 | 2005-08-04 | President And Fellows Of Harvard College | Compositions for treating or preventing obesity and insulin resistance disorders |
| CA2553670A1 (en) * | 2004-01-29 | 2005-08-11 | Elixir Pharmaceuticals, Inc. | Anti-viral therapeutics |
| EP1734950A4 (de) * | 2004-01-29 | 2010-06-16 | Elixir Pharmaceuticals Inc | Behandlung einer viruserkrankung |
| PT1720540E (pt) | 2004-02-18 | 2008-09-10 | Gpc Biotech Ag | Métodos de tratamento de tumores resistentes ou refractários |
| EP2298291A3 (de) | 2004-06-18 | 2011-08-03 | Agennix USA Inc. | Kinasehemmer zur Behandlung von Krebs |
| US20060014705A1 (en) * | 2004-06-30 | 2006-01-19 | Howitz Konrad T | Compositions and methods for selectively activating human sirtuins |
| EP1824831A2 (de) * | 2004-12-16 | 2007-08-29 | Takeda San Diego, Inc. | Histondeacetylase-inhibitoren |
| ATE544071T1 (de) * | 2005-03-03 | 2012-02-15 | Sirtris Pharmaceuticals Inc | Fluoreszenzpolarisationstests für die acetyltransferase-deacetylase-aktivität |
| EP1896436A2 (de) * | 2005-05-11 | 2008-03-12 | Takeda San Diego, Inc. | Inhibitoren der histondeacetylase |
| WO2006138418A2 (en) * | 2005-06-14 | 2006-12-28 | President And Fellows Of Harvard College | Improvement of cognitive performance with sirtuin activators |
| US7838503B2 (en) * | 2005-06-15 | 2010-11-23 | Children's Medical Center Corporation | Methods for extending the replicative lifespan of cells |
| EA200800321A1 (ru) * | 2005-07-14 | 2008-06-30 | Такеда Сан Диего, Инк. | Ингибиторы гистондеацетилазы |
| EP1955077B1 (de) * | 2005-12-02 | 2012-06-13 | Sirtris Pharmaceuticals, Inc. | Massen-spektronomie-tests für die acetyltransferase-deacetylase-aktivität |
| JP2009525955A (ja) * | 2006-01-13 | 2009-07-16 | タケダ サン ディエゴ インコーポレイテッド | ヒストンデアセチラーゼ阻害剤 |
| US8518635B2 (en) * | 2006-06-12 | 2013-08-27 | The J. David Gladstone Institutes | Regulation of protein activity by reversible acetylation |
| WO2009026234A1 (en) * | 2007-08-17 | 2009-02-26 | Allos Therapeutics, Inc. | Combination of 10-propargyl-10-deazaaminopterin and erlotinib for the treatment of non-small cell lung cancer |
| US9901578B2 (en) | 2007-08-17 | 2018-02-27 | Allos Therapeutics, Inc. | Combination of 10-propargyl-10-deazaaminopterin and erlotinib for the treatment of non-small cell lung cancer |
| US20100248249A1 (en) * | 2007-08-17 | 2010-09-30 | Allos Therapeutics, Inc. | Methods for Assessing Cancer for Increased Sensitivity to 10-Propargyl-10-Deazaaminopterin by Assessing Egfr Levels |
| GB0909912D0 (en) | 2009-06-09 | 2009-07-22 | Univ Dundee | Compounds |
| US20110190305A1 (en) | 2010-02-02 | 2011-08-04 | Allos Therapeutics, Inc. | Optically Pure Diastereomers of 10-Propargyl-10-Deazaaminopterin and Methods of Using Same |
| WO2011146636A2 (en) * | 2010-05-18 | 2011-11-24 | Cornell University | Reagents and methods for sirtuin capture |
| JP5947623B2 (ja) * | 2012-06-04 | 2016-07-06 | インフォコム株式会社 | 抗がん剤の効果増強剤 |
| FR3086493B1 (fr) * | 2018-09-20 | 2020-08-28 | Renault Sas | Procede de reattribution d’un serveur peripherique de traitement de donnees |
| WO2024158914A1 (en) * | 2023-01-24 | 2024-08-02 | Beth Israel Deaconess Medical Center, Inc. | Optical sensor probes |
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|---|---|---|---|---|
| US4211771A (en) | 1971-06-01 | 1980-07-08 | Robins Ronald K | Treatment of human viral diseases with 1-B-D-ribofuranosyl-1,2,4-triazole-3-carboxamide |
| US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| JPS6023084B2 (ja) | 1979-07-11 | 1985-06-05 | 味の素株式会社 | 代用血液 |
| US4640835A (en) | 1981-10-30 | 1987-02-03 | Nippon Chemiphar Company, Ltd. | Plasminogen activator derivatives |
| US4496689A (en) | 1983-12-27 | 1985-01-29 | Miles Laboratories, Inc. | Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer |
| US5034506A (en) | 1985-03-15 | 1991-07-23 | Anti-Gene Development Group | Uncharged morpholino-based polymers having achiral intersubunit linkages |
| EP0206448B1 (de) | 1985-06-19 | 1990-11-14 | Ajinomoto Co., Inc. | Hämoglobin, das an ein Poly(alkenylenoxid) gebunden ist |
| US4791192A (en) | 1986-06-26 | 1988-12-13 | Takeda Chemical Industries, Ltd. | Chemically modified protein with polyethyleneglycol |
| GB8800276D0 (en) | 1988-01-07 | 1988-02-10 | Univ Liverpool | Medical treatment |
| US6552170B1 (en) | 1990-04-06 | 2003-04-22 | Amgen Inc. | PEGylation reagents and compounds formed therewith |
| TW197439B (de) | 1991-04-04 | 1993-01-01 | Ueno Pharmaceutics Applic Res Co Ltd | |
| US5283253A (en) | 1991-09-23 | 1994-02-01 | Florida State University | Furyl or thienyl carbonyl substituted taxanes and pharmaceutical compositions containing them |
| WO1993010076A1 (en) | 1991-11-22 | 1993-05-27 | The University Of Mississippi | Synthesis and optical resolution of the taxol side chain and related compounds |
| US5200534A (en) | 1992-03-13 | 1993-04-06 | University Of Florida | Process for the preparation of taxol and 10-deacetyltaxol |
| JPH08500973A (ja) | 1992-05-21 | 1996-02-06 | ザ ペン ステイト リサーチ ファウンデーション | タキソール、関連タキサン及び他の新規な抗癌／抗ウイルス性化合物原料としてのイチイ培養組織 |
| US5274137A (en) | 1992-06-23 | 1993-12-28 | Nicolaou K C | Intermediates for preparation of taxols |
| US5294637A (en) | 1992-07-01 | 1994-03-15 | Bristol-Myers Squibb Company | Fluoro taxols |
| US5202448A (en) | 1992-08-14 | 1993-04-13 | Napro Biotherapeutics, Inc. | Processes of converting taxanes into baccatin III |
| CA2100808A1 (en) | 1992-10-01 | 1994-04-02 | Vittorio Farina | Deoxy paclitaxels |
| FR2696458B1 (fr) | 1992-10-05 | 1994-11-10 | Rhone Poulenc Rorer Sa | Procédé de préparation de dérivés du taxane. |
| FR2696461B1 (fr) | 1992-10-05 | 1994-11-10 | Rhone Poulenc Rorer Sa | Nouveaux dérivés d'analogues du taxol, leur préparation et les compositions qui les contiennent. |
| FR2696463B1 (fr) | 1992-10-05 | 1994-11-25 | Rhone Poulenc Rorer Sa | Procédé d'obtention de la désacétyl-10 baccatine III. |
| FR2696464B1 (fr) | 1992-10-05 | 1994-11-10 | Rhone Poulenc Rorer Sa | Nouveau procédé d'estérification de la baccatine III et de la désacétyl-10 baccatine III. |
| FR2696462B1 (fr) | 1992-10-05 | 1994-11-25 | Rhone Poulenc Rorer Sa | Procédé d'obtention de la désacétyl-10 baccatine III. |
| US5279949A (en) | 1992-12-07 | 1994-01-18 | Board Of Trustees Operating Michigan State University | Process for the isolation and purification of taxol and taxanes from Taxus spp |
| WO1995006764A2 (en) | 1993-09-03 | 1995-03-09 | Vpi Holdings Ltd. | Oligonucleotides with rna cleavage activity |
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| US5976796A (en) | 1996-10-04 | 1999-11-02 | Loma Linda University | Construction and expression of renilla luciferase and green fluorescent protein fusion genes |
| TW371617B (en) | 1996-10-09 | 1999-10-11 | Of Animal And Plant Health Inspection And Quarantine Council Of Agriculture Executive Yuan Bureau | Method to transplant GFP into autographa californica multiple nuclear polyhedrosis virus for inflicting pest in an attempt to detect and flow up it existence and to improve life span against UV |
| AU4966597A (en) | 1996-11-19 | 1998-06-10 | Daiichi Pharmaceutical Co., Ltd. | Taxol derivatives |
| US5977386A (en) | 1996-12-24 | 1999-11-02 | Bristol-Myers Squibb Company | 6-thio-substituted paclitaxels |
| JP2002505682A (ja) | 1997-06-20 | 2002-02-19 | ベーカー ノートン ファーマシューティカルズ インコーポレイテッド | パクリタクセルの可溶性プロドラッグ |
| US7288665B1 (en) | 1997-08-18 | 2007-10-30 | Florida State University | Process for selective derivatization of taxanes |
| JPH1192468A (ja) | 1997-09-17 | 1999-04-06 | Yakult Honsha Co Ltd | 新規なタキサン誘導体 |
| WO1999018113A1 (fr) | 1997-10-08 | 1999-04-15 | Bio Research Corporation Of Yokohama | Derives taxoides et leur procede de production |
| US6506559B1 (en) | 1997-12-23 | 2003-01-14 | Carnegie Institute Of Washington | Genetic inhibition by double-stranded RNA |
| JP2002507410A (ja) | 1998-03-27 | 2002-03-12 | プロルーム・リミテッド | ルシフェラーゼ、蛍光タンパク質、ルシフェラーゼおよび蛍光タンパク質をコードする核酸および、診断、高処理スクリーニングおよび新規アイテムにおけるその使用 |
| US5985577A (en) | 1998-10-14 | 1999-11-16 | The Trustees Of Columbia University In The City Of New York | Protein conjugates containing multimers of green fluorescent protein |
| US6277830B1 (en) | 1998-10-16 | 2001-08-21 | Schering Corporation | 5′-amino acid esters of ribavirin and the use of same to treat hepatitis C with interferon |
| WO2003004621A2 (en) * | 2001-07-06 | 2003-01-16 | Elixir Pharmaceuticals, Inc. | Sir2 activity |
| AU2002362030A1 (en) * | 2001-11-27 | 2003-06-10 | Fred Hutchinson Cancer Research Center | Methods for inhibiting deacetylase activity |
-
2003
- 2003-05-19 US US10/441,854 patent/US7351542B2/en not_active Expired - Fee Related
- 2003-05-20 DE DE60324427T patent/DE60324427D1/de not_active Expired - Lifetime
- 2003-05-20 AU AU2003229329A patent/AU2003229329B2/en not_active Ceased
- 2003-05-20 EP EP08012756A patent/EP1982720A1/de not_active Withdrawn
- 2003-05-20 CA CA2485988A patent/CA2485988C/en not_active Expired - Fee Related
- 2003-05-20 AT AT03726921T patent/ATE412771T1/de not_active IP Right Cessation
- 2003-05-20 EP EP03726921A patent/EP1514105B1/de not_active Expired - Lifetime
- 2003-05-20 WO PCT/US2003/015813 patent/WO2003099210A2/en not_active Ceased
- 2003-05-20 ES ES03726921T patent/ES2318131T3/es not_active Expired - Lifetime
-
2008
- 2008-02-11 US US12/029,333 patent/US7884081B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| WO2003099210A2 (en) | 2003-12-04 |
| US20090005328A1 (en) | 2009-01-01 |
| ES2318131T3 (es) | 2009-05-01 |
| EP1982720A1 (de) | 2008-10-22 |
| DE60324427D1 (de) | 2008-12-11 |
| EP1514105A2 (de) | 2005-03-16 |
| CA2485988A1 (en) | 2003-12-04 |
| US7351542B2 (en) | 2008-04-01 |
| AU2003229329B2 (en) | 2009-08-06 |
| US7884081B2 (en) | 2011-02-08 |
| WO2003099210A3 (en) | 2004-03-18 |
| EP1514105B1 (de) | 2008-10-29 |
| CA2485988C (en) | 2013-12-24 |
| AU2003229329A1 (en) | 2003-12-12 |
| EP1514105A4 (de) | 2006-05-17 |
| US20040028607A1 (en) | 2004-02-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |