ATE412902T1 - Reduktion der migrations-shift-assay-interferenz - Google Patents

Reduktion der migrations-shift-assay-interferenz

Info

Publication number
ATE412902T1
ATE412902T1 AT04759315T AT04759315T ATE412902T1 AT E412902 T1 ATE412902 T1 AT E412902T1 AT 04759315 T AT04759315 T AT 04759315T AT 04759315 T AT04759315 T AT 04759315T AT E412902 T1 ATE412902 T1 AT E412902T1
Authority
AT
Austria
Prior art keywords
analyte
shift assay
reducing migration
assay interference
migration shift
Prior art date
Application number
AT04759315T
Other languages
English (en)
Inventor
H Wada
Irina Kazakova
Miki Yutaka
Toshinari Ohashi
Futoshi Kanke
Original Assignee
Caliper Life Sciences Inc
Wako Pure Chem Ind Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Caliper Life Sciences Inc, Wako Pure Chem Ind Ltd filed Critical Caliper Life Sciences Inc
Application granted granted Critical
Publication of ATE412902T1 publication Critical patent/ATE412902T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/86—Signal analysis
    • G01N30/8624—Detection of slopes or peaks; baseline correction
    • G01N30/8644—Data segmentation, e.g. time windows
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502753—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5306—Improving reaction conditions, e.g. reduction of non-specific binding, promotion of specific binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/537—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody
    • G01N33/538—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody by sorbent column, particles or resin strip, i.e. sorbent materials
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/558—Immunoassay; Biospecific binding assay; Materials therefor using diffusion or migration of antigen or antibody
    • G01N33/561—Immunoelectrophoresis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/28—Control of physical parameters of the fluid carrier
    • G01N30/34—Control of physical parameters of the fluid carrier of fluid composition, e.g. gradient

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Electrochemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Instruments For Measurement Of Length By Optical Means (AREA)
  • Radar Systems Or Details Thereof (AREA)
  • Steroid Compounds (AREA)
AT04759315T 2003-04-14 2004-04-08 Reduktion der migrations-shift-assay-interferenz ATE412902T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46263603P 2003-04-14 2003-04-14
US50017703P 2003-09-04 2003-09-04

Publications (1)

Publication Number Publication Date
ATE412902T1 true ATE412902T1 (de) 2008-11-15

Family

ID=33303093

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04759315T ATE412902T1 (de) 2003-04-14 2004-04-08 Reduktion der migrations-shift-assay-interferenz

Country Status (9)

Country Link
US (1) US9766216B2 (de)
EP (1) EP1613962B1 (de)
JP (2) JP4719669B2 (de)
AT (1) ATE412902T1 (de)
AU (1) AU2004230592B2 (de)
CA (1) CA2515850A1 (de)
DE (1) DE602004017443D1 (de)
ES (1) ES2317016T3 (de)
WO (1) WO2004092733A1 (de)

Families Citing this family (134)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6048734A (en) 1995-09-15 2000-04-11 The Regents Of The University Of Michigan Thermal microvalves in a fluid flow method
US6692700B2 (en) 2001-02-14 2004-02-17 Handylab, Inc. Heat-reduction methods and systems related to microfluidic devices
US7829025B2 (en) 2001-03-28 2010-11-09 Venture Lending & Leasing Iv, Inc. Systems and methods for thermal actuation of microfluidic devices
US7323140B2 (en) 2001-03-28 2008-01-29 Handylab, Inc. Moving microdroplets in a microfluidic device
WO2004094986A2 (en) 2003-04-16 2004-11-04 Handylab, Inc. System and method for electrochemical detection of biological compounds
WO2005011867A2 (en) 2003-07-31 2005-02-10 Handylab, Inc. Processing particle-containing samples
JP4580180B2 (ja) * 2004-02-26 2010-11-10 デンカ生研株式会社 免疫測定法用測定値低下抑制剤及びそれを用いた免疫測定法
US8852862B2 (en) 2004-05-03 2014-10-07 Handylab, Inc. Method for processing polynucleotide-containing samples
ES2572382T3 (es) 2004-05-03 2016-05-31 Handylab Inc Un dispositivo microfluídico para el procesamiento de muestras que contienen polinucleótidos
JP4677524B2 (ja) * 2004-12-13 2011-04-27 独立行政法人産業技術総合研究所 微細管電気泳動による微生物分離用分離促進剤及び分析装置
JP5592606B2 (ja) * 2005-10-04 2014-09-17 ヘッドウェイ テクノロジーズ，インク． 被分析物のマイクロ流体的検出
CN101310176B (zh) * 2005-11-16 2013-05-01 三菱瓦斯化学株式会社 双链dna量的测定方法以及用于测定的试剂盒
US20070259376A1 (en) * 2005-12-22 2007-11-08 Toru Yoshimura Homocysteine immunoassay
US11806718B2 (en) 2006-03-24 2023-11-07 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
US10900066B2 (en) 2006-03-24 2021-01-26 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US7998708B2 (en) 2006-03-24 2011-08-16 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
DK3088083T3 (en) 2006-03-24 2018-11-26 Handylab Inc Method of carrying out PCR down a multi-track cartridge
US20080003585A1 (en) * 2006-06-29 2008-01-03 Bio-Rad Laboratories, Inc., A Corporation Of The State Of Delaware Purification and amplification of nucleic acids in a microfluidic device
KR100735142B1 (ko) 2006-06-30 2007-07-03 부산대학교 산학협력단 페놀성 화합물 검출용 마이크로칩 및 이를 이용한 페놀성화합물 검출방법
US8562804B2 (en) 2006-07-20 2013-10-22 The Board Of Trustees Of The Leland Stanford Junior University Fluorescent finger prints for indirect detection in isotachophoresis
GB0619645D0 (en) * 2006-10-05 2006-11-15 Smiths Group Plc Sensors and substances
US8709787B2 (en) 2006-11-14 2014-04-29 Handylab, Inc. Microfluidic cartridge and method of using same
WO2008060604A2 (en) 2006-11-14 2008-05-22 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
EP2115455B1 (de) * 2007-02-07 2012-02-22 Lyzer Diagnostics, Inc. Schnelles homogenes immunoassay unter verwendung von elektrophorese
US9186677B2 (en) 2007-07-13 2015-11-17 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
USD621060S1 (en) 2008-07-14 2010-08-03 Handylab, Inc. Microfluidic cartridge
US8287820B2 (en) 2007-07-13 2012-10-16 Handylab, Inc. Automated pipetting apparatus having a combined liquid pump and pipette head system
US9618139B2 (en) 2007-07-13 2017-04-11 Handylab, Inc. Integrated heater and magnetic separator
US8133671B2 (en) 2007-07-13 2012-03-13 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US20090136385A1 (en) 2007-07-13 2009-05-28 Handylab, Inc. Reagent Tube
US8105783B2 (en) 2007-07-13 2012-01-31 Handylab, Inc. Microfluidic cartridge
AU2008276211B2 (en) 2007-07-13 2015-01-22 Handylab, Inc. Polynucleotide capture materials, and methods of using same
US8182763B2 (en) 2007-07-13 2012-05-22 Handylab, Inc. Rack for sample tubes and reagent holders
US8016260B2 (en) 2007-07-19 2011-09-13 Formulatrix, Inc. Metering assembly and method of dispensing fluid
US8617820B2 (en) * 2007-08-28 2013-12-31 Ortho-Clinical Diagnostics, Inc. Use of glycosaminoglycans to reduce non-specific binding in immunoassays
WO2009079028A1 (en) * 2007-12-14 2009-06-25 Johns Hopkins University Purification and concentration of proteins and dna from a complex sample using isotachophoresis and a device to perform the purification
US8865401B2 (en) * 2007-12-14 2014-10-21 The Johns Hopkins University Purification and concentration of proteins and DNA from a complex sample using isotachophoresis and a device to perform the purification
USD618820S1 (en) 2008-07-11 2010-06-29 Handylab, Inc. Reagent holder
USD787087S1 (en) 2008-07-14 2017-05-16 Handylab, Inc. Housing
KR100953353B1 (ko) 2008-07-30 2010-04-20 부산대학교 산학협력단 식품에 함유된 염료분석방법
EP2184606B1 (de) * 2008-11-03 2015-06-24 Helena Laboratories (UK) Ltd. Immunverschiebungs-Elektrophorese
US8100293B2 (en) 2009-01-23 2012-01-24 Formulatrix, Inc. Microfluidic dispensing assembly
US8846314B2 (en) * 2009-03-03 2014-09-30 The Board Of Trustees Of The Leland Stanford Junior University Isotachophoretic focusing of nucleic acids
US9841401B2 (en) * 2009-04-14 2017-12-12 National Cheng Kung University Capillary electrophoresis method for analyzing collagen
DE112010002222B4 (de) 2009-06-04 2024-01-25 Leidos Innovations Technology, Inc. (n.d.Ges.d. Staates Delaware) Mehr-Proben-Mikrofluidchip fur DNA-Analyse
EP3586945A3 (de) * 2009-06-05 2020-03-04 IntegenX Inc. Universelles probenvorbereitungssystem und verwendung in einem integrierten analysesystem
US8721858B2 (en) * 2010-03-12 2014-05-13 The Board Of Trustees Of The Leland Stanford Junior University Non-focusing tracers for indirect detection in electrophoretic displacement techniques
US20130217034A1 (en) 2010-08-13 2013-08-22 Dentognostics Gmbh Process for avoiding false positive results in a detecting process of an inflammation indicator in a rinse solution for taking up gingival crevicular fluid
US8956859B1 (en) 2010-08-13 2015-02-17 Aviex Technologies Llc Compositions and methods for determining successful immunization by one or more vaccines
US8986529B2 (en) 2010-09-13 2015-03-24 The Board Of Trustees Of The Leland Stanford Junior University Isotachophoresis having interacting anionic and cationic shock waves
GB2497501A (en) 2010-10-15 2013-06-12 Lockheed Corp Micro fluidic optic design
US8524061B2 (en) 2010-11-29 2013-09-03 The Board Of Trustees Of The Leland Stanford Junior University On-chip hybridization coupled with ITP based purification for fast sequence specific identification
CA2825370A1 (en) 2010-12-22 2012-06-28 President And Fellows Of Harvard College Continuous directed evolution
JP5727218B2 (ja) * 2010-12-24 2015-06-03 積水化学工業株式会社 マイクロ流体デバイス、微生物夾雑物検出システム、並びに、微生物夾雑物の検出方法
ES2769028T3 (es) 2011-04-15 2020-06-24 Becton Dickinson Co Termociclador microfluídico de barrido en tiempo real
EP2724163B1 (de) * 2011-06-24 2017-08-09 The Regents of The University of California Mikrofluidische vorrichtungen und verfahren zur trennung und detektion von komponenten einer flüssigkeitsprobe
US10641768B2 (en) * 2011-07-08 2020-05-05 Abbott Japan Co. Ltd. Methods and kits for decreasing interferences from leukocytes in specific binding assays
US10323236B2 (en) 2011-07-22 2019-06-18 President And Fellows Of Harvard College Evaluation and improvement of nuclease cleavage specificity
ES2645966T3 (es) 2011-09-30 2017-12-11 Becton, Dickinson And Company Tira reactiva unificada
USD692162S1 (en) 2011-09-30 2013-10-22 Becton, Dickinson And Company Single piece reagent holder
CN104040238B (zh) 2011-11-04 2017-06-27 汉迪拉布公司 多核苷酸样品制备装置
AU2013214849B2 (en) 2012-02-03 2016-09-01 Becton, Dickinson And Company External files for distribution of molecular diagnostic tests and determination of compatibility between tests
JP5615306B2 (ja) * 2012-02-03 2014-10-29 シャープ株式会社 標的認識分子および標的認識分子を固定化する方法
US9322054B2 (en) 2012-02-22 2016-04-26 Lockheed Martin Corporation Microfluidic cartridge
JP5694401B2 (ja) * 2013-02-12 2015-04-01 デンカ生研株式会社 免疫測定法用測定値低下抑制剤及びそれを用いた免疫測定法
EP2965083B1 (de) 2013-03-07 2019-07-03 The Regents of The University of California Elektrophoretische trennvorrichtungen und verfahren zur verwendung davon
JP2013152247A (ja) * 2013-04-12 2013-08-08 Abbott Japan Co Ltd 非特異的相互作用抑制剤及びその診断測定系への応用
JP6174367B2 (ja) * 2013-04-26 2017-08-02 株式会社Ｌｓｉメディエンス トロンビン含有試薬及び測定方法
EP3028043A4 (de) * 2013-07-30 2017-04-19 Bio-rad Laboratories, Inc. Multiplexblockerkügelchen für immunoassays
US9163284B2 (en) 2013-08-09 2015-10-20 President And Fellows Of Harvard College Methods for identifying a target site of a Cas9 nuclease
US9359599B2 (en) * 2013-08-22 2016-06-07 President And Fellows Of Harvard College Engineered transcription activator-like effector (TALE) domains and uses thereof
US9526784B2 (en) 2013-09-06 2016-12-27 President And Fellows Of Harvard College Delivery system for functional nucleases
US9322037B2 (en) 2013-09-06 2016-04-26 President And Fellows Of Harvard College Cas9-FokI fusion proteins and uses thereof
US9228207B2 (en) 2013-09-06 2016-01-05 President And Fellows Of Harvard College Switchable gRNAs comprising aptamers
US20150165054A1 (en) 2013-12-12 2015-06-18 President And Fellows Of Harvard College Methods for correcting caspase-9 point mutations
CN103713059B (zh) * 2013-12-30 2015-07-08 上海微谱化工技术服务有限公司 聚酰胺工程塑料中聚酰胺树脂的定性定量方法
WO2015134121A2 (en) 2014-01-20 2015-09-11 President And Fellows Of Harvard College Negative selection and stringency modulation in continuous evolution systems
US9868555B2 (en) * 2014-04-28 2018-01-16 Robert F. LiVolsi Systems and methods for filling inoculations
US10077453B2 (en) 2014-07-30 2018-09-18 President And Fellows Of Harvard College CAS9 proteins including ligand-dependent inteins
WO2016077052A2 (en) 2014-10-22 2016-05-19 President And Fellows Of Harvard College Evolution of proteases
GB2536293A (en) * 2015-03-13 2016-09-14 Agilent Technologies Inc Artifact compensation due to different properties of fluid accommodation volumes in sample separation apparatus
JP6350349B2 (ja) * 2015-03-19 2018-07-04 株式会社島津製作所 キャピラリー電気泳動装置及びキャピラリー電気泳動による試料分析方法
WO2016168631A1 (en) 2015-04-17 2016-10-20 President And Fellows Of Harvard College Vector-based mutagenesis system
WO2017015545A1 (en) 2015-07-22 2017-01-26 President And Fellows Of Harvard College Evolution of site-specific recombinases
US11524983B2 (en) 2015-07-23 2022-12-13 President And Fellows Of Harvard College Evolution of Bt toxins
WO2017019895A1 (en) 2015-07-30 2017-02-02 President And Fellows Of Harvard College Evolution of talens
IL310721B2 (en) 2015-10-23 2025-11-01 Harvard College Nucleobase editors and uses thereof
EP3377654B1 (de) 2015-11-16 2024-01-31 Revere Biosensors, LLC Systeme und methoden zur identifizierung und unterscheidung genetischer proben
CN108603883A (zh) 2016-01-27 2018-09-28 富士胶片和光纯药株式会社 前列腺癌的判定方法
EP3916090B1 (de) 2016-01-29 2025-07-23 Purigen Biosystems, Inc. Isotachophorese zur reinigung von nukleinsäuren
WO2017179611A1 (ja) 2016-04-13 2017-10-19 株式会社Ｌｓｉメディエンス 硫酸化多糖類を用いた免疫学的測定法
CN110214183A (zh) 2016-08-03 2019-09-06 哈佛大学的校长及成员们 腺苷核碱基编辑器及其用途
WO2018031683A1 (en) 2016-08-09 2018-02-15 President And Fellows Of Harvard College Programmable cas9-recombinase fusion proteins and uses thereof
US11542509B2 (en) 2016-08-24 2023-01-03 President And Fellows Of Harvard College Incorporation of unnatural amino acids into proteins using base editing
KR102622411B1 (ko) 2016-10-14 2024-01-10 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 핵염기 에디터의 aav 전달
WO2018119359A1 (en) 2016-12-23 2018-06-28 President And Fellows Of Harvard College Editing of ccr5 receptor gene to protect against hiv infection
EP3592853A1 (de) 2017-03-09 2020-01-15 President and Fellows of Harvard College Unterdrückung von schmerzen durch geneditierung
US12390514B2 (en) 2017-03-09 2025-08-19 President And Fellows Of Harvard College Cancer vaccine
US11542496B2 (en) 2017-03-10 2023-01-03 President And Fellows Of Harvard College Cytosine to guanine base editor
US20200048723A1 (en) * 2017-03-22 2020-02-13 Fujifilm Wako Pure Chemical Corporation Method for forming complex of substance having sugar chain and lectin
KR20240116572A (ko) 2017-03-23 2024-07-29 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 핵산 프로그램가능한 dna 결합 단백질을 포함하는 핵염기 편집제
US20200110054A1 (en) * 2017-04-03 2020-04-09 Technion Research & Development Foundation Limited Microfluidic devices and methods using the same
WO2018187687A1 (en) * 2017-04-07 2018-10-11 Arizona Board Regents On Behalf Of Arizona State University Integrated diagnostic devices having embedded biomolecular computing systems and uses thereof
CN107037151B (zh) * 2017-04-13 2019-10-15 宁波出入境检验检疫局检验检疫技术中心 一种食品接触材料中环氧氯丙烷迁移量的测定方法
CN110869512A (zh) * 2017-05-09 2020-03-06 雷瑞生物传感器有限责任公司 鉴别并区分遗传样品的系统及方法
US11560566B2 (en) 2017-05-12 2023-01-24 President And Fellows Of Harvard College Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation
US11447809B2 (en) 2017-07-06 2022-09-20 President And Fellows Of Harvard College Evolution of tRNA synthetases
CN111801345A (zh) 2017-07-28 2020-10-20 哈佛大学的校长及成员们 使用噬菌体辅助连续进化(pace)的进化碱基编辑器的方法和组合物
SG11202000871WA (en) 2017-08-02 2020-02-27 Purigen Biosystems Inc Systems, devices, and methods for isotachophoresis
US12060553B2 (en) 2017-08-25 2024-08-13 President And Fellows Of Harvard College Evolution of BoNT peptidases
EP3676376B1 (de) 2017-08-30 2025-01-15 President and Fellows of Harvard College Hocheffiziente baseneditoren mit gam
WO2019056002A1 (en) 2017-09-18 2019-03-21 President And Fellows Of Harvard College CONTINUOUS EVOLUTION FOR STABILIZED PROTEINS
KR20250107288A (ko) 2017-10-16 2025-07-11 더 브로드 인스티튜트, 인코퍼레이티드 아데노신 염기 편집제의 용도
FR3072301B1 (fr) 2017-10-18 2022-01-07 P M B Cassette microfluidique de synthese d'un radio-traceur et procede de synthese d'un radio-traceur avec une telle cassette
US12406749B2 (en) 2017-12-15 2025-09-02 The Broad Institute, Inc. Systems and methods for predicting repair outcomes in genetic engineering
CN112136047A (zh) 2018-05-18 2020-12-25 富士胶片和光纯药株式会社 判断前列腺癌的方法
US12157760B2 (en) 2018-05-23 2024-12-03 The Broad Institute, Inc. Base editors and uses thereof
WO2019241649A1 (en) 2018-06-14 2019-12-19 President And Fellows Of Harvard College Evolution of cytidine deaminases
US12522807B2 (en) 2018-07-09 2026-01-13 The Broad Institute, Inc. RNA programmable epigenetic RNA modifiers and uses thereof
CN109374541A (zh) * 2018-09-28 2019-02-22 江苏集萃智能传感技术研究所有限公司 基于微流控与表面等离共振激元的浓度检测系统及方法
WO2020092453A1 (en) 2018-10-29 2020-05-07 The Broad Institute, Inc. Nucleobase editors comprising geocas9 and uses thereof
US11485965B2 (en) * 2018-11-02 2022-11-01 Microsoft Technology Licensing, Llc DNA data storage on two-dimensional support material
US12351837B2 (en) 2019-01-23 2025-07-08 The Broad Institute, Inc. Supernegatively charged proteins and uses thereof
CN111239403B (zh) * 2019-02-13 2020-12-08 武汉生之源生物科技股份有限公司 一种β2微球蛋白胶乳增强免疫比浊试剂盒及应用
US12565676B2 (en) 2019-03-01 2026-03-03 Revere Biosensors, Llc Systems and methods for separating decoded arrays
WO2020191233A1 (en) 2019-03-19 2020-09-24 The Broad Institute, Inc. Methods and compositions for editing nucleotide sequences
US12473543B2 (en) 2019-04-17 2025-11-18 The Broad Institute, Inc. Adenine base editors with reduced off-target effects
JP7350268B2 (ja) * 2019-05-30 2023-09-26 国立大学法人北海道大学 物質検出装置
US12435330B2 (en) 2019-10-10 2025-10-07 The Broad Institute, Inc. Methods and compositions for prime editing RNA
CN110907638B (zh) * 2020-02-14 2020-09-22 北京纳百生物科技有限公司 一种免疫胶体金均相标记用抗体分散剂及其应用
WO2021176065A1 (en) * 2020-03-06 2021-09-10 Cambridge Enterprise Limited Highly sensitive biomolecule detection and quantification
US20230160912A1 (en) * 2020-03-31 2023-05-25 Fujirebio Inc. Method for immunoassay of amyloid beta in blood, and kit for same
IL297761A (en) 2020-05-08 2022-12-01 Broad Inst Inc Methods and compositions for simultaneously editing two helices of a designated double-helix nucleotide sequence
JPWO2023157950A1 (de) * 2022-02-18 2023-08-24

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5165898A (en) * 1986-08-13 1992-11-24 The Board Of Trustees Of The Leland Stanford Junior University Electrophoresis using contour-clamped electric fields
US5284558A (en) * 1990-07-27 1994-02-08 University Of Iowa Research Foundation Electrophoresis-based sequencing of oligosaccharides
US5571680A (en) * 1994-01-21 1996-11-05 Beckman Instruments, Inc. Homogeneous immunoassays and enzyme based assays of analytes using capillary electrophoresis
US5611903A (en) * 1995-03-22 1997-03-18 Analis S. A. Capillary electrophoresis method using initialized capillary and polyanion-containing buffer and chemical kit therefor
US5630924A (en) 1995-04-20 1997-05-20 Perseptive Biosystems, Inc. Compositions, methods and apparatus for ultrafast electroseparation analysis
US5830824A (en) * 1997-02-28 1998-11-03 Eastman Kodak Company Plasticizers for dye-donor element used in thermal dye transfer
US6235471B1 (en) * 1997-04-04 2001-05-22 Caliper Technologies Corp. Closed-loop biochemical analyzers
US5948227A (en) * 1997-12-17 1999-09-07 Caliper Technologies Corp. Methods and systems for performing electrophoretic molecular separations
DE60041255D1 (de) * 1999-04-28 2009-02-12 Eidgenoess Tech Hochschule Polyionische beschichtungen für analytische und sensor-vorrichtungen
JP2001004632A (ja) * 1999-06-18 2001-01-12 Wako Pure Chem Ind Ltd 糖鎖構造の変異した癌胎児性抗原類の検出方法
US6685813B2 (en) * 2000-02-11 2004-02-03 Aclara Biosciences, Inc. Tandem isotachophoresis/zone electrophoresis method and system
WO2001066772A2 (en) * 2000-03-08 2001-09-13 Massachusetts Institute Of Technology Heparinase iii and uses thereof
US6537433B1 (en) * 2000-03-10 2003-03-25 Applera Corporation Methods and apparatus for the location and concentration of polar analytes using an alternating electric field
US6794493B2 (en) * 2000-04-07 2004-09-21 Wisys Technology Foundation, Inc. Antithrombin H-helix mutants
CA2422856C (en) * 2000-09-25 2012-02-07 Abbott Laboratories Methods and kits for decreasing interferences of assay samples containing plasma or serum in specific binding assays by using a large polycation
WO2002082083A1 (en) * 2001-04-04 2002-10-17 Wako Pure Chemical Industries, Ltd. Electrophoresis
WO2008137863A2 (en) * 2007-05-04 2008-11-13 Advanced Medical Optics, Inc. Methods and devices for measuring tear film and diagnosing tear disorders

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