ATE412902T1 - Reduktion der migrations-shift-assay-interferenz - Google Patents
Reduktion der migrations-shift-assay-interferenzInfo
- Publication number
- ATE412902T1 ATE412902T1 AT04759315T AT04759315T ATE412902T1 AT E412902 T1 ATE412902 T1 AT E412902T1 AT 04759315 T AT04759315 T AT 04759315T AT 04759315 T AT04759315 T AT 04759315T AT E412902 T1 ATE412902 T1 AT E412902T1
- Authority
- AT
- Austria
- Prior art keywords
- analyte
- shift assay
- reducing migration
- assay interference
- migration shift
- Prior art date
Links
- 238000003556 assay Methods 0.000 title 1
- 230000005012 migration Effects 0.000 title 1
- 238000013508 migration Methods 0.000 title 1
- 239000012491 analyte Substances 0.000 abstract 5
- 239000012141 concentrate Substances 0.000 abstract 1
- 230000035945 sensitivity Effects 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/86—Signal analysis
- G01N30/8624—Detection of slopes or peaks; baseline correction
- G01N30/8644—Data segmentation, e.g. time windows
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502753—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/5306—Improving reaction conditions, e.g. reduction of non-specific binding, promotion of specific binding
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
- G01N33/537—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody
- G01N33/538—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody by sorbent column, particles or resin strip, i.e. sorbent materials
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/558—Immunoassay; Biospecific binding assay; Materials therefor using diffusion or migration of antigen or antibody
- G01N33/561—Immunoelectrophoresis
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
- B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/28—Control of physical parameters of the fluid carrier
- G01N30/34—Control of physical parameters of the fluid carrier of fluid composition, e.g. gradient
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Electrochemistry (AREA)
- Dispersion Chemistry (AREA)
- Clinical Laboratory Science (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Peptides Or Proteins (AREA)
- Steroid Compounds (AREA)
- Instruments For Measurement Of Length By Optical Means (AREA)
- Radar Systems Or Details Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46263603P | 2003-04-14 | 2003-04-14 | |
| US50017703P | 2003-09-04 | 2003-09-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE412902T1 true ATE412902T1 (de) | 2008-11-15 |
Family
ID=33303093
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04759315T ATE412902T1 (de) | 2003-04-14 | 2004-04-08 | Reduktion der migrations-shift-assay-interferenz |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US9766216B2 (de) |
| EP (1) | EP1613962B1 (de) |
| JP (2) | JP4719669B2 (de) |
| AT (1) | ATE412902T1 (de) |
| AU (1) | AU2004230592B2 (de) |
| CA (1) | CA2515850A1 (de) |
| DE (1) | DE602004017443D1 (de) |
| ES (1) | ES2317016T3 (de) |
| WO (1) | WO2004092733A1 (de) |
Families Citing this family (134)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6048734A (en) | 1995-09-15 | 2000-04-11 | The Regents Of The University Of Michigan | Thermal microvalves in a fluid flow method |
| US6692700B2 (en) | 2001-02-14 | 2004-02-17 | Handylab, Inc. | Heat-reduction methods and systems related to microfluidic devices |
| US7323140B2 (en) | 2001-03-28 | 2008-01-29 | Handylab, Inc. | Moving microdroplets in a microfluidic device |
| US7829025B2 (en) | 2001-03-28 | 2010-11-09 | Venture Lending & Leasing Iv, Inc. | Systems and methods for thermal actuation of microfluidic devices |
| US7820030B2 (en) | 2003-04-16 | 2010-10-26 | Handylab, Inc. | System and method for electrochemical detection of biological compounds |
| EP3718635A1 (de) | 2003-07-31 | 2020-10-07 | Handylab, Inc. | Verarbeitung partikelhaltiger proben |
| JP4580180B2 (ja) | 2004-02-26 | 2010-11-10 | デンカ生研株式会社 | 免疫測定法用測定値低下抑制剤及びそれを用いた免疫測定法 |
| US8852862B2 (en) | 2004-05-03 | 2014-10-07 | Handylab, Inc. | Method for processing polynucleotide-containing samples |
| ES2553097T3 (es) | 2004-05-03 | 2015-12-04 | Handylab, Inc. | Procesamiento de muestras que contienen polinucleótidos |
| JP4677524B2 (ja) * | 2004-12-13 | 2011-04-27 | 独立行政法人産業技術総合研究所 | 微細管電気泳動による微生物分離用分離促進剤及び分析装置 |
| WO2007041692A2 (en) | 2005-10-04 | 2007-04-12 | Magic Technologies, Inc. | Microfluidic detection of analytes |
| WO2007066479A1 (ja) * | 2005-11-16 | 2007-06-14 | Mitsubishi Gas Chemical Company, Inc. | 二重鎖dna量の測定方法および測定用キット |
| US20070259376A1 (en) * | 2005-12-22 | 2007-11-08 | Toru Yoshimura | Homocysteine immunoassay |
| US7998708B2 (en) | 2006-03-24 | 2011-08-16 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
| ES2692380T3 (es) | 2006-03-24 | 2018-12-03 | Handylab, Inc. | Método para realizar PCR con un cartucho con varias pistas |
| US11806718B2 (en) | 2006-03-24 | 2023-11-07 | Handylab, Inc. | Fluorescence detector for microfluidic diagnostic system |
| US10900066B2 (en) | 2006-03-24 | 2021-01-26 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
| US20080003585A1 (en) * | 2006-06-29 | 2008-01-03 | Bio-Rad Laboratories, Inc., A Corporation Of The State Of Delaware | Purification and amplification of nucleic acids in a microfluidic device |
| KR100735142B1 (ko) | 2006-06-30 | 2007-07-03 | 부산대학교 산학협력단 | 페놀성 화합물 검출용 마이크로칩 및 이를 이용한 페놀성화합물 검출방법 |
| US8562804B2 (en) | 2006-07-20 | 2013-10-22 | The Board Of Trustees Of The Leland Stanford Junior University | Fluorescent finger prints for indirect detection in isotachophoresis |
| GB0619645D0 (en) * | 2006-10-05 | 2006-11-15 | Smiths Group Plc | Sensors and substances |
| US8765076B2 (en) | 2006-11-14 | 2014-07-01 | Handylab, Inc. | Microfluidic valve and method of making same |
| WO2008060604A2 (en) | 2006-11-14 | 2008-05-22 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
| US9081006B2 (en) | 2007-02-07 | 2015-07-14 | Lyzer Diagnostics, Inc. | Rapid homogeneous immunoassay using electrophoresis |
| US8133671B2 (en) | 2007-07-13 | 2012-03-13 | Handylab, Inc. | Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples |
| USD621060S1 (en) | 2008-07-14 | 2010-08-03 | Handylab, Inc. | Microfluidic cartridge |
| AU2008276211B2 (en) | 2007-07-13 | 2015-01-22 | Handylab, Inc. | Polynucleotide capture materials, and methods of using same |
| US20090136385A1 (en) | 2007-07-13 | 2009-05-28 | Handylab, Inc. | Reagent Tube |
| US8182763B2 (en) | 2007-07-13 | 2012-05-22 | Handylab, Inc. | Rack for sample tubes and reagent holders |
| US8105783B2 (en) | 2007-07-13 | 2012-01-31 | Handylab, Inc. | Microfluidic cartridge |
| US9618139B2 (en) | 2007-07-13 | 2017-04-11 | Handylab, Inc. | Integrated heater and magnetic separator |
| US9186677B2 (en) | 2007-07-13 | 2015-11-17 | Handylab, Inc. | Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples |
| US8287820B2 (en) | 2007-07-13 | 2012-10-16 | Handylab, Inc. | Automated pipetting apparatus having a combined liquid pump and pipette head system |
| US8016260B2 (en) | 2007-07-19 | 2011-09-13 | Formulatrix, Inc. | Metering assembly and method of dispensing fluid |
| US8617820B2 (en) | 2007-08-28 | 2013-12-31 | Ortho-Clinical Diagnostics, Inc. | Use of glycosaminoglycans to reduce non-specific binding in immunoassays |
| WO2009079028A1 (en) * | 2007-12-14 | 2009-06-25 | Johns Hopkins University | Purification and concentration of proteins and dna from a complex sample using isotachophoresis and a device to perform the purification |
| US8865401B2 (en) * | 2007-12-14 | 2014-10-21 | The Johns Hopkins University | Purification and concentration of proteins and DNA from a complex sample using isotachophoresis and a device to perform the purification |
| USD618820S1 (en) | 2008-07-11 | 2010-06-29 | Handylab, Inc. | Reagent holder |
| USD787087S1 (en) | 2008-07-14 | 2017-05-16 | Handylab, Inc. | Housing |
| KR100953353B1 (ko) | 2008-07-30 | 2010-04-20 | 부산대학교 산학협력단 | 식품에 함유된 염료분석방법 |
| EP2184606B1 (de) * | 2008-11-03 | 2015-06-24 | Helena Laboratories (UK) Ltd. | Immunverschiebungs-Elektrophorese |
| US8100293B2 (en) | 2009-01-23 | 2012-01-24 | Formulatrix, Inc. | Microfluidic dispensing assembly |
| US8846314B2 (en) * | 2009-03-03 | 2014-09-30 | The Board Of Trustees Of The Leland Stanford Junior University | Isotachophoretic focusing of nucleic acids |
| US9841401B2 (en) * | 2009-04-14 | 2017-12-12 | National Cheng Kung University | Capillary electrophoresis method for analyzing collagen |
| WO2010141131A1 (en) | 2009-06-04 | 2010-12-09 | Lockheed Martin Corporation | Multiple-sample microfluidic chip for dna analysis |
| JP2012529268A (ja) * | 2009-06-05 | 2012-11-22 | インテジェンクス,インコーポレイテッド | ユニバーサルサンプル調製システムおよび統合解析システムの使用方法 |
| US8721858B2 (en) * | 2010-03-12 | 2014-05-13 | The Board Of Trustees Of The Leland Stanford Junior University | Non-focusing tracers for indirect detection in electrophoretic displacement techniques |
| US8956859B1 (en) | 2010-08-13 | 2015-02-17 | Aviex Technologies Llc | Compositions and methods for determining successful immunization by one or more vaccines |
| EP2603795A1 (de) | 2010-08-13 | 2013-06-19 | Dentognostics Gmbh | Verfahren zur vermeidung von falsch-positiven ergebnissen bei einem nachweisverfahren eines entzündungsindikators in einer spüllösung für die aufnahme von saumepithelflüssigkeit des zahnfleisches |
| US8986529B2 (en) | 2010-09-13 | 2015-03-24 | The Board Of Trustees Of The Leland Stanford Junior University | Isotachophoresis having interacting anionic and cationic shock waves |
| GB2497501A (en) | 2010-10-15 | 2013-06-12 | Lockheed Corp | Micro fluidic optic design |
| US8524061B2 (en) | 2010-11-29 | 2013-09-03 | The Board Of Trustees Of The Leland Stanford Junior University | On-chip hybridization coupled with ITP based purification for fast sequence specific identification |
| EP3202903B1 (de) | 2010-12-22 | 2020-02-12 | President and Fellows of Harvard College | Kontinuierliche gerichtete evolution |
| JP5727218B2 (ja) * | 2010-12-24 | 2015-06-03 | 積水化学工業株式会社 | マイクロ流体デバイス、微生物夾雑物検出システム、並びに、微生物夾雑物の検出方法 |
| JP6088487B2 (ja) | 2011-04-15 | 2017-03-01 | ベクトン・ディキンソン・アンド・カンパニーBecton, Dickinson And Company | 走査リアルタイムマイクロ流体熱サイクラーと同期熱サイクリング及び走査光学検出の方法 |
| EP2724163B1 (de) * | 2011-06-24 | 2017-08-09 | The Regents of The University of California | Mikrofluidische vorrichtungen und verfahren zur trennung und detektion von komponenten einer flüssigkeitsprobe |
| US10641768B2 (en) * | 2011-07-08 | 2020-05-05 | Abbott Japan Co. Ltd. | Methods and kits for decreasing interferences from leukocytes in specific binding assays |
| JP6261500B2 (ja) | 2011-07-22 | 2018-01-17 | プレジデント アンド フェローズ オブ ハーバード カレッジ | ヌクレアーゼ切断特異性の評価および改善 |
| RU2622432C2 (ru) | 2011-09-30 | 2017-06-15 | Бектон, Дикинсон Энд Компани | Унифицированная полоска для реактивов |
| USD692162S1 (en) | 2011-09-30 | 2013-10-22 | Becton, Dickinson And Company | Single piece reagent holder |
| WO2013067202A1 (en) | 2011-11-04 | 2013-05-10 | Handylab, Inc. | Polynucleotide sample preparation device |
| JP5615306B2 (ja) * | 2012-02-03 | 2014-10-29 | シャープ株式会社 | 標的認識分子および標的認識分子を固定化する方法 |
| AU2013214849B2 (en) | 2012-02-03 | 2016-09-01 | Becton, Dickinson And Company | External files for distribution of molecular diagnostic tests and determination of compatibility between tests |
| US9322054B2 (en) | 2012-02-22 | 2016-04-26 | Lockheed Martin Corporation | Microfluidic cartridge |
| JP5694401B2 (ja) * | 2013-02-12 | 2015-04-01 | デンカ生研株式会社 | 免疫測定法用測定値低下抑制剤及びそれを用いた免疫測定法 |
| GB2517864B (en) | 2013-03-07 | 2015-12-09 | Univ California | Electrophoretic separation devices and methods for using the same |
| JP2013152247A (ja) * | 2013-04-12 | 2013-08-08 | Abbott Japan Co Ltd | 非特異的相互作用抑制剤及びその診断測定系への応用 |
| JP6174367B2 (ja) * | 2013-04-26 | 2017-08-02 | 株式会社Lsiメディエンス | トロンビン含有試薬及び測定方法 |
| CN105393119A (zh) * | 2013-07-30 | 2016-03-09 | 生物辐射实验室股份有限公司 | 用于免疫试验的多重封闭物珠 |
| US20150044192A1 (en) | 2013-08-09 | 2015-02-12 | President And Fellows Of Harvard College | Methods for identifying a target site of a cas9 nuclease |
| US9359599B2 (en) * | 2013-08-22 | 2016-06-07 | President And Fellows Of Harvard College | Engineered transcription activator-like effector (TALE) domains and uses thereof |
| US9388430B2 (en) | 2013-09-06 | 2016-07-12 | President And Fellows Of Harvard College | Cas9-recombinase fusion proteins and uses thereof |
| US9526784B2 (en) | 2013-09-06 | 2016-12-27 | President And Fellows Of Harvard College | Delivery system for functional nucleases |
| US9340799B2 (en) | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | MRNA-sensing switchable gRNAs |
| US20150165054A1 (en) | 2013-12-12 | 2015-06-18 | President And Fellows Of Harvard College | Methods for correcting caspase-9 point mutations |
| CN103713059B (zh) * | 2013-12-30 | 2015-07-08 | 上海微谱化工技术服务有限公司 | 聚酰胺工程塑料中聚酰胺树脂的定性定量方法 |
| US10179911B2 (en) | 2014-01-20 | 2019-01-15 | President And Fellows Of Harvard College | Negative selection and stringency modulation in continuous evolution systems |
| US9868555B2 (en) * | 2014-04-28 | 2018-01-16 | Robert F. LiVolsi | Systems and methods for filling inoculations |
| WO2016022363A2 (en) | 2014-07-30 | 2016-02-11 | President And Fellows Of Harvard College | Cas9 proteins including ligand-dependent inteins |
| US10920208B2 (en) | 2014-10-22 | 2021-02-16 | President And Fellows Of Harvard College | Evolution of proteases |
| GB2536293A (en) * | 2015-03-13 | 2016-09-14 | Agilent Technologies Inc | Artifact compensation due to different properties of fluid accommodation volumes in sample separation apparatus |
| JP6350349B2 (ja) * | 2015-03-19 | 2018-07-04 | 株式会社島津製作所 | キャピラリー電気泳動装置及びキャピラリー電気泳動による試料分析方法 |
| WO2016168631A1 (en) | 2015-04-17 | 2016-10-20 | President And Fellows Of Harvard College | Vector-based mutagenesis system |
| WO2017015545A1 (en) | 2015-07-22 | 2017-01-26 | President And Fellows Of Harvard College | Evolution of site-specific recombinases |
| US11524983B2 (en) | 2015-07-23 | 2022-12-13 | President And Fellows Of Harvard College | Evolution of Bt toxins |
| US10612011B2 (en) | 2015-07-30 | 2020-04-07 | President And Fellows Of Harvard College | Evolution of TALENs |
| JP7109784B2 (ja) | 2015-10-23 | 2022-08-01 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 遺伝子編集のための進化したCas9蛋白質 |
| EP3377654B1 (de) | 2015-11-16 | 2024-01-31 | Revere Biosensors, LLC | Systeme und methoden zur identifizierung und unterscheidung genetischer proben |
| EP3410118B1 (de) | 2016-01-27 | 2020-09-30 | FUJIFILM Wako Pure Chemical Corporation | Verfahren zur bestimmung eines prostatakarzinoms |
| JP7277050B2 (ja) | 2016-01-29 | 2023-05-18 | ピューリジェン バイオシステムズ, インコーポレイテッド | 核酸の精製のための等速電気泳動 |
| US11422128B2 (en) | 2016-04-13 | 2022-08-23 | Lsi Medience Corporation | Immunoassay employing sulfated polysaccharide |
| KR102547316B1 (ko) | 2016-08-03 | 2023-06-23 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 아데노신 핵염기 편집제 및 그의 용도 |
| US11661590B2 (en) | 2016-08-09 | 2023-05-30 | President And Fellows Of Harvard College | Programmable CAS9-recombinase fusion proteins and uses thereof |
| US11542509B2 (en) | 2016-08-24 | 2023-01-03 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
| EP3526320A1 (de) | 2016-10-14 | 2019-08-21 | President and Fellows of Harvard College | Aav-abgabe von nukleobasen-editoren |
| WO2018119359A1 (en) | 2016-12-23 | 2018-06-28 | President And Fellows Of Harvard College | Editing of ccr5 receptor gene to protect against hiv infection |
| JP2020510038A (ja) | 2017-03-09 | 2020-04-02 | プレジデント アンド フェローズ オブ ハーバード カレッジ | がんワクチン |
| EP3592853A1 (de) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Unterdrückung von schmerzen durch geneditierung |
| JP2020510439A (ja) | 2017-03-10 | 2020-04-09 | プレジデント アンド フェローズ オブ ハーバード カレッジ | シトシンからグアニンへの塩基編集因子 |
| KR20190126052A (ko) * | 2017-03-22 | 2019-11-08 | 후지필름 와코 준야쿠 가부시키가이샤 | 당쇄를 갖는 물질과 렉틴과의 복합체 형성 방법 |
| CA3057192A1 (en) | 2017-03-23 | 2018-09-27 | President And Fellows Of Harvard College | Nucleobase editors comprising nucleic acid programmable dna binding proteins |
| US20200110054A1 (en) * | 2017-04-03 | 2020-04-09 | Technion Research & Development Foundation Limited | Microfluidic devices and methods using the same |
| US11547997B2 (en) * | 2017-04-07 | 2023-01-10 | Arizona Board Of Regents On Behalf Of Arizona State University | Integrated diagnostic devices having embedded biomolecular computing systems and uses thereof |
| CN107037151B (zh) * | 2017-04-13 | 2019-10-15 | 宁波出入境检验检疫局检验检疫技术中心 | 一种食品接触材料中环氧氯丙烷迁移量的测定方法 |
| CN110869512A (zh) * | 2017-05-09 | 2020-03-06 | 雷瑞生物传感器有限责任公司 | 鉴别并区分遗传样品的系统及方法 |
| WO2018209320A1 (en) | 2017-05-12 | 2018-11-15 | President And Fellows Of Harvard College | Aptazyme-embedded guide rnas for use with crispr-cas9 in genome editing and transcriptional activation |
| US11447809B2 (en) | 2017-07-06 | 2022-09-20 | President And Fellows Of Harvard College | Evolution of tRNA synthetases |
| WO2019023680A1 (en) | 2017-07-28 | 2019-01-31 | President And Fellows Of Harvard College | METHODS AND COMPOSITIONS FOR EVOLUTION OF BASIC EDITORS USING PHAGE-ASSISTED CONTINUOUS EVOLUTION (PACE) |
| SG11202000871WA (en) | 2017-08-02 | 2020-02-27 | Purigen Biosystems Inc | Systems, devices, and methods for isotachophoresis |
| AU2018321405A1 (en) | 2017-08-25 | 2020-03-05 | Ipsen Biopharm Ltd. | Evolution of BoNT peptidases |
| EP3676376B1 (de) | 2017-08-30 | 2025-01-15 | President and Fellows of Harvard College | Hocheffiziente baseneditoren mit gam |
| US11624130B2 (en) | 2017-09-18 | 2023-04-11 | President And Fellows Of Harvard College | Continuous evolution for stabilized proteins |
| KR20250107288A (ko) | 2017-10-16 | 2025-07-11 | 더 브로드 인스티튜트, 인코퍼레이티드 | 아데노신 염기 편집제의 용도 |
| FR3072301B1 (fr) * | 2017-10-18 | 2022-01-07 | P M B | Cassette microfluidique de synthese d'un radio-traceur et procede de synthese d'un radio-traceur avec une telle cassette |
| WO2019118949A1 (en) | 2017-12-15 | 2019-06-20 | The Broad Institute, Inc. | Systems and methods for predicting repair outcomes in genetic engineering |
| KR102719728B1 (ko) | 2018-05-18 | 2024-10-18 | 후지필름 가부시키가이샤 | 전립선암을 판정하는 방법 |
| EP3797160A1 (de) | 2018-05-23 | 2021-03-31 | The Broad Institute Inc. | Baseneditoren und verwendungen davon |
| WO2019241649A1 (en) | 2018-06-14 | 2019-12-19 | President And Fellows Of Harvard College | Evolution of cytidine deaminases |
| US12522807B2 (en) | 2018-07-09 | 2026-01-13 | The Broad Institute, Inc. | RNA programmable epigenetic RNA modifiers and uses thereof |
| CN109374541A (zh) * | 2018-09-28 | 2019-02-22 | 江苏集萃智能传感技术研究所有限公司 | 基于微流控与表面等离共振激元的浓度检测系统及方法 |
| WO2020092453A1 (en) | 2018-10-29 | 2020-05-07 | The Broad Institute, Inc. | Nucleobase editors comprising geocas9 and uses thereof |
| US11485965B2 (en) * | 2018-11-02 | 2022-11-01 | Microsoft Technology Licensing, Llc | DNA data storage on two-dimensional support material |
| US12351837B2 (en) | 2019-01-23 | 2025-07-08 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
| CN111239403B (zh) * | 2019-02-13 | 2020-12-08 | 武汉生之源生物科技股份有限公司 | 一种β2微球蛋白胶乳增强免疫比浊试剂盒及应用 |
| US12565676B2 (en) | 2019-03-01 | 2026-03-03 | Revere Biosensors, Llc | Systems and methods for separating decoded arrays |
| JP7657726B2 (ja) | 2019-03-19 | 2025-04-07 | ザ ブロード インスティテュート,インコーポレーテッド | 編集ヌクレオチド配列を編集するための方法および組成物 |
| US12473543B2 (en) | 2019-04-17 | 2025-11-18 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
| WO2020241871A1 (ja) * | 2019-05-30 | 2020-12-03 | 国立大学法人北海道大学 | 物質検出装置 |
| US12435330B2 (en) | 2019-10-10 | 2025-10-07 | The Broad Institute, Inc. | Methods and compositions for prime editing RNA |
| CN110907638B (zh) * | 2020-02-14 | 2020-09-22 | 北京纳百生物科技有限公司 | 一种免疫胶体金均相标记用抗体分散剂及其应用 |
| EP4114568A1 (de) * | 2020-03-06 | 2023-01-11 | Cambridge Enterprise Limited | Hochempfindlicher nachweis und quantifizierung von biomolekülen |
| US20230160912A1 (en) * | 2020-03-31 | 2023-05-25 | Fujirebio Inc. | Method for immunoassay of amyloid beta in blood, and kit for same |
| DE112021002672T5 (de) | 2020-05-08 | 2023-04-13 | President And Fellows Of Harvard College | Vefahren und zusammensetzungen zum gleichzeitigen editieren beider stränge einer doppelsträngigen nukleotid-zielsequenz |
| WO2023157950A1 (ja) * | 2022-02-18 | 2023-08-24 | 株式会社Lsiメディエンス | 非特異反応抑制剤 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5165898A (en) * | 1986-08-13 | 1992-11-24 | The Board Of Trustees Of The Leland Stanford Junior University | Electrophoresis using contour-clamped electric fields |
| US5284558A (en) * | 1990-07-27 | 1994-02-08 | University Of Iowa Research Foundation | Electrophoresis-based sequencing of oligosaccharides |
| US5571680A (en) * | 1994-01-21 | 1996-11-05 | Beckman Instruments, Inc. | Homogeneous immunoassays and enzyme based assays of analytes using capillary electrophoresis |
| US5611903A (en) * | 1995-03-22 | 1997-03-18 | Analis S. A. | Capillary electrophoresis method using initialized capillary and polyanion-containing buffer and chemical kit therefor |
| US5630924A (en) | 1995-04-20 | 1997-05-20 | Perseptive Biosystems, Inc. | Compositions, methods and apparatus for ultrafast electroseparation analysis |
| US5830824A (en) * | 1997-02-28 | 1998-11-03 | Eastman Kodak Company | Plasticizers for dye-donor element used in thermal dye transfer |
| US6235471B1 (en) * | 1997-04-04 | 2001-05-22 | Caliper Technologies Corp. | Closed-loop biochemical analyzers |
| US5948227A (en) * | 1997-12-17 | 1999-09-07 | Caliper Technologies Corp. | Methods and systems for performing electrophoretic molecular separations |
| ATE419528T1 (de) * | 1999-04-28 | 2009-01-15 | Eidgenoess Tech Hochschule | Polyionische beschichtungen für analytische und sensor-vorrichtungen |
| JP2001004632A (ja) * | 1999-06-18 | 2001-01-12 | Wako Pure Chem Ind Ltd | 糖鎖構造の変異した癌胎児性抗原類の検出方法 |
| US6685813B2 (en) | 2000-02-11 | 2004-02-03 | Aclara Biosciences, Inc. | Tandem isotachophoresis/zone electrophoresis method and system |
| CA2402160C (en) * | 2000-03-08 | 2012-02-14 | Massachusetts Institute Of Technology | Heparinase iii and uses thereof |
| US6537433B1 (en) * | 2000-03-10 | 2003-03-25 | Applera Corporation | Methods and apparatus for the location and concentration of polar analytes using an alternating electric field |
| US6794493B2 (en) * | 2000-04-07 | 2004-09-21 | Wisys Technology Foundation, Inc. | Antithrombin H-helix mutants |
| CA2422856C (en) * | 2000-09-25 | 2012-02-07 | Abbott Laboratories | Methods and kits for decreasing interferences of assay samples containing plasma or serum in specific binding assays by using a large polycation |
| WO2002082083A1 (en) | 2001-04-04 | 2002-10-17 | Wako Pure Chemical Industries, Ltd. | Electrophoresis |
| AU2008247423B2 (en) * | 2007-05-04 | 2013-10-31 | Abbott Medical Optics Inc. | Methods and devices for measuring tear film and diagnosing tear disorders |
-
2004
- 2004-04-08 AT AT04759315T patent/ATE412902T1/de not_active IP Right Cessation
- 2004-04-08 JP JP2006501260A patent/JP4719669B2/ja not_active Expired - Lifetime
- 2004-04-08 US US10/821,657 patent/US9766216B2/en not_active Expired - Lifetime
- 2004-04-08 WO PCT/US2004/010914 patent/WO2004092733A1/en not_active Ceased
- 2004-04-08 AU AU2004230592A patent/AU2004230592B2/en not_active Ceased
- 2004-04-08 DE DE602004017443T patent/DE602004017443D1/de not_active Expired - Lifetime
- 2004-04-08 EP EP04759315A patent/EP1613962B1/de not_active Expired - Lifetime
- 2004-04-08 CA CA002515850A patent/CA2515850A1/en not_active Abandoned
- 2004-04-08 ES ES04759315T patent/ES2317016T3/es not_active Expired - Lifetime
-
2010
- 2010-12-14 JP JP2010277630A patent/JP4862093B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| AU2004230592B2 (en) | 2007-10-04 |
| JP2006524319A (ja) | 2006-10-26 |
| EP1613962B1 (de) | 2008-10-29 |
| CA2515850A1 (en) | 2004-10-28 |
| JP4862093B2 (ja) | 2012-01-25 |
| JP2011081011A (ja) | 2011-04-21 |
| JP4719669B2 (ja) | 2011-07-06 |
| AU2004230592A1 (en) | 2004-10-28 |
| EP1613962A1 (de) | 2006-01-11 |
| US9766216B2 (en) | 2017-09-19 |
| DE602004017443D1 (de) | 2008-12-11 |
| ES2317016T3 (es) | 2009-04-16 |
| US20050170362A1 (en) | 2005-08-04 |
| WO2004092733A1 (en) | 2004-10-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE412902T1 (de) | Reduktion der migrations-shift-assay-interferenz | |
| Zhuang et al. | DNAzyme-based magneto-controlled electronic switch for picomolar detection of lead (II) coupling with DNA-based hybridization chain reaction | |
| Lin et al. | A portable microchip for ultrasensitive and high-throughput assay of thrombin by rolling circle amplification and hemin/G-quadruplex system | |
| Ocaña et al. | Label free aptasensor for Lysozyme detection: A comparison of the analytical performance of two aptamers | |
| Yan et al. | A simple and sensitive electrochemical aptasensor for determination of Chloramphenicol in honey based on target-induced strand release | |
| Wang et al. | Target–aptamer binding triggered quadratic recycling amplification for highly specific and ultrasensitive detection of antibiotics at the attomole level | |
| Centi et al. | Polychlorinated biphenyls (PCBs) detection in milk samples by an electrochemical magneto-immunosensor (EMI) coupled to solid-phase extraction (SPE) and disposable low-density arrays | |
| Damiati et al. | Flex printed circuit board implemented graphene-based DNA sensor for detection of SARS-CoV-2 | |
| Ölcer et al. | Microfluidics and nanoparticles based amperometric biosensor for the detection of cyanobacteria (Planktothrix agardhii NIVA-CYA 116) DNA | |
| Cui et al. | Low-background and visual detection of antibiotic based on target-activated colorimetric split peroxidase DNAzyme coupled with dual nicking enzyme signal amplification | |
| ATE393914T1 (de) | Nachweis von biomolekülen unter verwendung poröser biosensoren und raman-spektroskopie | |
| BRPI0610092B8 (pt) | métodos para a detecção de um analito e de um ácido nucleico em uma amostra, e de sintetização de uma molécula de ácido nucleico ou de análogo de ácido nucleico, kit reagente, uso do mesmo, molécula de ácido nucleico ou de análogo de ácido nucleico e produto associado | |
| Zhang et al. | Label-free and sensitive electrochemiluminescence aptasensor for the determination of 17β-estradiol based on a competitive assay with cDNA amplification | |
| Wang et al. | Label-free bifunctional electrochemiluminescence aptasensor for detection of adenosine and lysozyme | |
| Rong et al. | A highly sensitive and colorimetric biosensor based on magnetic nano‐DNAzyme for detection of lead (II) ion in real water samples | |
| Chen et al. | Target-protecting dumbbell molecular probe against exonucleases digestion for sensitive detection of ATP and streptavidin | |
| Yan et al. | DNA aptamer folding on magnetic beads for sequential detection of adenosine and cocaine by substrate-resolved chemiluminescence technology | |
| Alhindawi et al. | Selection of ssDNA aptamers and construction of aptameric electrochemical biosensor for the detection of Giardia intestinalis trophozoite protein | |
| Zhou et al. | An electrochemiluminescent assay for high sensitive detection of mercury (II) based on isothermal rolling circular amplification | |
| CN106442480B (zh) | 基于hrp标记适体传感器的ota化学发光检测方法 | |
| CN106290320B (zh) | 一种基于无标记适体传感器的ota化学发光检测方法 | |
| Tomassetti et al. | New immunosensors operating in organic phase (OPIEs) for analysis of triazinic pesticides in olive oil | |
| CN104155289A (zh) | 一种检测汞离子的固态电化学发光传感器及其制备方法和应用 | |
| Martini et al. | Determination of traces of several pesticides in sunflower oil using organic phase immuno electrodes (OPIEs) | |
| Babu et al. | Label free luminescence strategy for sensitive detection of ATP using aptamer-Ru (II) complexes |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |