ES2572382T3 - Un dispositivo microfluídico para el procesamiento de muestras que contienen polinucleótidos - Google Patents

Un dispositivo microfluídico para el procesamiento de muestras que contienen polinucleótidos

Info

Publication number
ES2572382T3
ES2572382T3 ES11153427T ES11153427T ES2572382T3 ES 2572382 T3 ES2572382 T3 ES 2572382T3 ES 11153427 T ES11153427 T ES 11153427T ES 11153427 T ES11153427 T ES 11153427T ES 2572382 T3 ES2572382 T3 ES 2572382T3
Authority
ES
Spain
Prior art keywords
polynucleotides
retention
processing region
microfluidic device
retention member
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES11153427T
Other languages
English (en)
Other versions
ES2572382T8 (es
Inventor
Betty Wu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
HandyLab Inc
Original Assignee
HandyLab Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by HandyLab Inc filed Critical HandyLab Inc
Application granted granted Critical
Publication of ES2572382T3 publication Critical patent/ES2572382T3/es
Publication of ES2572382T8 publication Critical patent/ES2572382T8/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/686—Polymerase chain reaction [PCR]
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    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K2099/0082—Microvalves adapted for a particular use
    • F16K2099/0084—Chemistry or biology, e.g. "lab-on-a-chip" technology
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0034—Operating means specially adapted for microvalves

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Abstract

Un dispositivo microfluídico, que comprende: una primera región de procesamiento; estando dicho miembro de retención configurado para retener preferentemente uno o más polinucleótidos en una muestra, en comparación con los inhibidores de la reacción en cadena de la polimerasa en la muestra, donde dicho miembro de retención comprende una pluralidad de partículas de retención de polinucleótidos, y comprendiendo dicha pluralidad de retención al menos un ligando que comprende una poliamida poli-catiónica, donde además el miembro de retención se configura para retener polinucleótidos a un primer pH y liberar polinucleótidos a un segundo pH, donde el segundo pH es al menos aproximadamente 10; un reservorio de fluido que comprende un líquido de liberación que tiene un pH de al menos aproximadamente 10, donde el dispositivo se configura para poner en contacto el miembro de retención con el líquido; una segunda región de procesamiento para recibir los polinucleótidos liberados de las partículas de retención en la primera región de procesamiento, comprendiendo la segunda región de procesamiento una o más partículas liofilizadas que contienen uno o más reactivos de la PCR; y una región de detección.
ES11153427T 2004-05-03 2005-05-03 Un dispositivo microfluídico para el procesamiento de muestras que contienen polinucleótidos Expired - Lifetime ES2572382T3 (es)

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