ATE413178T1 - 2-phenoxy- und 2-phenylsulfanyl-benzenesulfonamid derivate mit ccr3 antagonistischer aktivität zur behandlung von asthma und anderen entzündlichen oder immunologischen erkrankungen - Google Patents
2-phenoxy- und 2-phenylsulfanyl-benzenesulfonamid derivate mit ccr3 antagonistischer aktivität zur behandlung von asthma und anderen entzündlichen oder immunologischen erkrankungenInfo
- Publication number
- ATE413178T1 ATE413178T1 AT04719389T AT04719389T ATE413178T1 AT E413178 T1 ATE413178 T1 AT E413178T1 AT 04719389 T AT04719389 T AT 04719389T AT 04719389 T AT04719389 T AT 04719389T AT E413178 T1 ATE413178 T1 AT E413178T1
- Authority
- AT
- Austria
- Prior art keywords
- phenylsulfanyl
- asthma
- phenoxy
- inflammatory
- treatment
- Prior art date
Links
- GCSIJZVYEPPSDF-UHFFFAOYSA-N 2-phenoxybenzenesulfonamide Chemical compound NS(=O)(=O)C1=CC=CC=C1OC1=CC=CC=C1 GCSIJZVYEPPSDF-UHFFFAOYSA-N 0.000 title 1
- URDPMPGGXZVVPD-UHFFFAOYSA-N 2-phenylsulfanylbenzenesulfonamide Chemical class NS(=O)(=O)C1=CC=CC=C1SC1=CC=CC=C1 URDPMPGGXZVVPD-UHFFFAOYSA-N 0.000 title 1
- 102100024167 C-C chemokine receptor type 3 Human genes 0.000 title 1
- 101710149862 C-C chemokine receptor type 3 Proteins 0.000 title 1
- 230000003042 antagnostic effect Effects 0.000 title 1
- 208000006673 asthma Diseases 0.000 title 1
- 208000026278 immune system disease Diseases 0.000 title 1
- 230000002757 inflammatory effect Effects 0.000 title 1
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- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
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- C—CHEMISTRY; METALLURGY
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- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
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| EP03006293 | 2003-03-24 |
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| ATE413178T1 true ATE413178T1 (de) | 2008-11-15 |
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| KR (1) | KR101109296B1 (de) |
| CN (2) | CN102146053A (de) |
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| AT (1) | ATE413178T1 (de) |
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| BR (1) | BRPI0408682A (de) |
| CA (1) | CA2520225C (de) |
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| PT (1) | PT1608374E (de) |
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| SI (1) | SI1608374T1 (de) |
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| UY (1) | UY28239A1 (de) |
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| HUP0500877A2 (en) * | 2005-09-22 | 2007-05-29 | Sanofi Aventis | Amide derivatives as ccr3 receptor ligands, process for producing them, pharmaceutical compositions containing them and their use and intermediates |
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| HUP0500886A2 (en) * | 2005-09-23 | 2007-05-29 | Sanofi Aventis | Amide derivatives as ccr3 receptor ligands, process for producing them, pharmaceutical compositions containing them and their use |
| BRPI0710512A2 (pt) * | 2006-04-20 | 2012-06-05 | Hoffmann La Roche | moduladores derivados de diazepan de receptores de quimiocinas |
| HUP0800478A2 (en) | 2008-07-31 | 2010-03-01 | Sanofi Aventis | Substituted pyrrolidinyl-[1,3]thiazolo[4,5-b]pyridin derivatives as ccr3 receptor ligands |
| EA020460B1 (ru) * | 2009-01-12 | 2014-11-28 | Пфайзер Лимитед | Производные сульфонамида |
| HUE025647T2 (en) | 2009-04-22 | 2016-04-28 | Axikin Pharmaceuticals Inc | Arylsulfonamide CCR3 antagonists |
| PL2421829T3 (pl) * | 2009-04-22 | 2016-03-31 | Axikin Pharmaceuticals Inc | 2,5-dipodstawione arylosulfonamidy jako antagoniści CCR3 |
| WO2010123959A2 (en) | 2009-04-22 | 2010-10-28 | Axikin Pharmaceuticals, Inc. | 2,5-disubstituted arylsulfonamide ccr3 antagonists |
| US10487148B2 (en) | 2010-01-28 | 2019-11-26 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for treating aging-associated impairments |
| WO2017120461A1 (en) * | 2016-01-08 | 2017-07-13 | The Board Of Trustees Of The Leland Stanford Junior University | Ccr3 modulation in the treatment of aging-associated impairments, and compositions for practicing the same |
| US20160208011A1 (en) * | 2010-01-28 | 2016-07-21 | The Board Of Trustees Of The Leland Stanford Junior University | Ccr3 modulation in the treatment of aging-associated impairments, and compositions for practicing the same |
| US20130040844A1 (en) * | 2010-01-28 | 2013-02-14 | The Board Of Trustees Of The Leland Stanford Junior University | Biomarkers of aging for detection and treatment of disorders |
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| US8741894B2 (en) | 2010-03-17 | 2014-06-03 | Axikin Pharmaceuticals, Inc. | Arylsulfonamide CCR3 antagonists |
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| ES2532356T3 (es) | 2010-07-09 | 2015-03-26 | Pfizer Limited | N-sulfonilbenzamidas como inhibidores de los canales de sodio dependientes de voltaje |
| US9096558B2 (en) | 2010-07-09 | 2015-08-04 | Pfizer Limited | N-sulfonylbenzamide compounds |
| EP2627635A1 (de) * | 2010-10-11 | 2013-08-21 | Axikin Pharmaceuticals, Inc. | Salze aus arylsulfonamid-ccr3-antagonisten |
| US9161968B2 (en) | 2011-04-08 | 2015-10-20 | The Board Of Trustees Of The Leland Stanford Junior University | Methods of neuroprotection involving macrophage colony stimulating factor receptor agonists |
| KR20150053906A (ko) | 2012-09-07 | 2015-05-19 | 액시킨 파마수티컬스 인코포레이티드 | 동위원소 농축 아릴설폰아미드 ccr3 길항제 |
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| EA035336B1 (ru) | 2013-12-09 | 2020-05-29 | Зе Боард Оф Трастиз Оф Зе Леланд Стэнфорд Джуниор Юниверсити | Способ лечения связанного со старением когнитивного расстройства или заболевания |
| US10905779B2 (en) | 2013-12-09 | 2021-02-02 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for screening human blood products comprising plasma using immunocompromised rodent models |
| MA39822A (fr) | 2014-04-03 | 2018-02-06 | Janssen Pharmaceutica Nv | Dérivés de pyrimidine bicycle |
| EA201692301A1 (ru) | 2014-07-01 | 2017-06-30 | Ремпекс Фармасьютикалз, Инк. | Производные бороновой кислоты и их терапевтическое применение |
| CN105884674B (zh) * | 2015-01-05 | 2019-07-26 | 南开大学 | 色氨酸衍生物及制备方法和在防治植物病毒、杀菌、杀虫方面的应用 |
| AU2016279804B2 (en) | 2015-06-15 | 2019-03-07 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for treating aging-associated conditions |
| WO2017189919A2 (en) | 2016-04-28 | 2017-11-02 | Alkahest, Inc. | Blood plasma and plasma fractions as therapy for tumor growth and progression |
| US10525107B2 (en) | 2016-08-18 | 2020-01-07 | Alkahest, Inc. | Blood plasma fractions as a treatment for aging-associated cognitive disorders |
| BR112019020798A2 (pt) | 2017-04-05 | 2020-04-28 | Alkahest Inc | métodos e composições para tratamento de danos associados ao envelhecimento usando inibidores de ccr3 |
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