ATE414081T1 - Bizyklische heteroaromatische verbindungen als kinase hemmstoffe - Google Patents

Bizyklische heteroaromatische verbindungen als kinase hemmstoffe

Info

Publication number: ATE414081T1
Authority: AT; Austria
Prior art keywords: bizyclic; kinase inhibitors; heteroaromatic compounds; kinase; inhibitors
Prior art date: 2002-10-01

Application number

AT03753708T

Other languages

English (en)

Inventor

Daniel Christopher Brookings

Rachel Jane Cubbon

Jeremy Martin Davis

Barry John Langham

Original Assignee

Ucb Pharma Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-10-01

Filing date

2003-09-30

Publication date

2008-11-15

2003-09-30 Application filed by Ucb Pharma Sa filed Critical Ucb Pharma Sa

2008-11-15 Application granted granted Critical

2008-11-15 Publication of ATE414081T1 publication Critical patent/ATE414081T1/de

Links

150000002390 heteroarenes Chemical class 0.000 title 1
229940043355 kinase inhibitor Drugs 0.000 title 1
239000003757 phosphotransferase inhibitor Substances 0.000 title 1
FSHSBDMOHYYHRB-UHFFFAOYSA-N 1,4-dihydropyrrolo[3,2-b]pyridin-5-one Chemical group N1C(=O)C=CC2=C1C=CN2 FSHSBDMOHYYHRB-UHFFFAOYSA-N 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
208000026278 immune system disease Diseases 0.000 abstract 1
208000027866 inflammatory disease Diseases 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
102000002574 p38 Mitogen-Activated Protein Kinases Human genes 0.000 abstract 1
230000002265 prevention Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Virology (AREA)
Immunology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Neurology (AREA)
Diabetes (AREA)
Physical Education & Sports Medicine (AREA)
Neurosurgery (AREA)
Hematology (AREA)
Biomedical Technology (AREA)
Pulmonology (AREA)
Molecular Biology (AREA)
Rheumatology (AREA)
Dermatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Tropical Medicine & Parasitology (AREA)
Pain & Pain Management (AREA)
Urology & Nephrology (AREA)
AIDS & HIV (AREA)
Transplantation (AREA)
Vascular Medicine (AREA)
Ophthalmology & Optometry (AREA)
Hospice & Palliative Care (AREA)

AT03753708T 2002-10-01 2003-09-30 Bizyklische heteroaromatische verbindungen als kinase hemmstoffe ATE414081T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GBGB0222743.7A GB0222743D0 (en)	2002-10-01	2002-10-01	Chemical compounds

Publications (1)

Publication Number	Publication Date
ATE414081T1 true ATE414081T1 (de)	2008-11-15

Family

ID=9945093

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT03753708T ATE414081T1 (de)	2002-10-01	2003-09-30	Bizyklische heteroaromatische verbindungen als kinase hemmstoffe

Country Status (10)

Country	Link
US (1)	US7456286B2 (de)
EP (1)	EP1549648B1 (de)
JP (1)	JP2006504712A (de)
AT (1)	ATE414081T1 (de)
AU (1)	AU2003271870B2 (de)
CA (1)	CA2500844A1 (de)
DE (1)	DE60324696D1 (de)
ES (1)	ES2315527T3 (de)
GB (1)	GB0222743D0 (de)
WO (1)	WO2004031188A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB0224082D0 (en)	2002-10-16	2002-11-27	Celltech R&D Ltd	Biological products
ES2600460T3 (es)	2005-05-10	2017-02-09	Intermune, Inc.	Derivados de piridona-2-ona como moduladores del sistema de proteína cinasa activada por estrés
JP5580735B2 (ja) *	2007-06-12	2014-08-27	ジェネンテック，インコーポレイテッド	Ｎ−置換アザインドール類及び使用方法
CN102099036B (zh)	2008-06-03	2015-05-27	英特芒尼公司	用于治疗炎性疾患和纤维化疾患的化合物和方法
AR072008A1 (es) *	2008-06-13	2010-07-28	Merck & Co Inc	Compuestos heterobiciclicos como agentes de inhibicion de quinasa p38
AR092742A1 (es)	2012-10-02	2015-04-29	Intermune Inc	Piridinonas antifibroticas
GB201317363D0 (en)	2013-10-01	2013-11-13	Eisai Ltd	Novel compounds
MX382781B (es)	2014-04-02	2025-03-13	Intermune Inc	Piridinonas anti-fibroticas.
US20190060286A1 (en)	2016-02-29	2019-02-28	University Of Florida Research Foundation, Incorpo	Chemotherapeutic Methods
EP3515912B1 (de)	2016-09-26	2020-10-14	Centre National De La Recherche Scientifique	Verbindungen zur verwendung in der bildgebung, insbesondere zur diagnose von neurodegenerativen erkrankungen
WO2018119142A1 (en)	2016-12-21	2018-06-28	Amgen Inc.	Anti-tnf alpha antibody formulations

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2002517486A (ja) *	1998-06-12	2002-06-18	バーテックスファーマシューティカルズインコーポレイテッド	ｐ３８のインヒビター
GB0124848D0 (en) *	2001-10-16	2001-12-05	Celltech R&D Ltd	Chemical compounds
GB0218800D0 (en) *	2002-08-13	2002-09-18	Celltech R&D Ltd	Chemical compounds

2002
- 2002-10-01 GB GBGB0222743.7A patent/GB0222743D0/en not_active Ceased
2003
- 2003-09-30 EP EP03753708A patent/EP1549648B1/de not_active Expired - Lifetime
- 2003-09-30 CA CA002500844A patent/CA2500844A1/en not_active Abandoned
- 2003-09-30 ES ES03753708T patent/ES2315527T3/es not_active Expired - Lifetime
- 2003-09-30 AT AT03753708T patent/ATE414081T1/de not_active IP Right Cessation
- 2003-09-30 JP JP2004540940A patent/JP2006504712A/ja active Pending
- 2003-09-30 US US10/529,413 patent/US7456286B2/en not_active Expired - Fee Related
- 2003-09-30 WO PCT/GB2003/004214 patent/WO2004031188A1/en not_active Ceased
- 2003-09-30 DE DE60324696T patent/DE60324696D1/de not_active Expired - Lifetime
- 2003-09-30 AU AU2003271870A patent/AU2003271870B2/en not_active Ceased

Also Published As

Publication number	Publication date
AU2003271870A1 (en)	2004-04-23
WO2004031188A1 (en)	2004-04-15
DE60324696D1 (de)	2008-12-24
GB0222743D0 (en)	2002-11-06
CA2500844A1 (en)	2004-04-15
US7456286B2 (en)	2008-11-25
US20060122212A1 (en)	2006-06-08
JP2006504712A (ja)	2006-02-09
EP1549648A1 (de)	2005-07-06
ES2315527T3 (es)	2009-04-01
EP1549648B1 (de)	2008-11-12
AU2003271870B2 (en)	2009-08-27

Legal Events

Date	Code	Title	Description
2009-05-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
EA200600064A1 (ru)	2006-08-25	Производные тиенопиридона как ингибиторы киназ
MA26837A1 (fr)	2004-12-20	Heterocycles azotes bicycliques heteroalky-lamino substitues en tant qu'inhibiteurs de kinase de proteine p38.
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MXPA03006863A (es)	2003-11-13	Derivados de oxazolilpirazol com inhibidores de cinasa.
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