ATE414081T1 - Bizyklische heteroaromatische verbindungen als kinase hemmstoffe - Google Patents

Bizyklische heteroaromatische verbindungen als kinase hemmstoffe

Info

Publication number: ATE414081T1
Authority: AT; Austria
Prior art keywords: bizyclic; kinase inhibitors; heteroaromatic compounds; kinase; inhibitors
Prior art date: 2002-10-01

Application number

AT03753708T

Other languages

English (en)

Inventor

Daniel Christopher Brookings

Rachel Jane Cubbon

Jeremy Martin Davis

Barry John Langham

Original Assignee

Ucb Pharma Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-10-01

Filing date

2003-09-30

Publication date

2008-11-15

2003-09-30 Application filed by Ucb Pharma Sa filed Critical Ucb Pharma Sa

2008-11-15 Application granted granted Critical

2008-11-15 Publication of ATE414081T1 publication Critical patent/ATE414081T1/de

Links

150000002390 heteroarenes Chemical class 0.000 title 1
229940043355 kinase inhibitor Drugs 0.000 title 1
239000003757 phosphotransferase inhibitor Substances 0.000 title 1
FSHSBDMOHYYHRB-UHFFFAOYSA-N 1,4-dihydropyrrolo[3,2-b]pyridin-5-one Chemical group N1C(=O)C=CC2=C1C=CN2 FSHSBDMOHYYHRB-UHFFFAOYSA-N 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
208000026278 immune system disease Diseases 0.000 abstract 1
208000027866 inflammatory disease Diseases 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
102000002574 p38 Mitogen-Activated Protein Kinases Human genes 0.000 abstract 1
230000002265 prevention Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Virology (AREA)
Oncology (AREA)
Diabetes (AREA)
Neurology (AREA)
Communicable Diseases (AREA)
Neurosurgery (AREA)
Hematology (AREA)
Physical Education & Sports Medicine (AREA)
Biomedical Technology (AREA)
Pulmonology (AREA)
Dermatology (AREA)
Molecular Biology (AREA)
Rheumatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Tropical Medicine & Parasitology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Endocrinology (AREA)
Ophthalmology & Optometry (AREA)
Biotechnology (AREA)
Vascular Medicine (AREA)
AIDS & HIV (AREA)
Urology & Nephrology (AREA)
Hospice & Palliative Care (AREA)

AT03753708T 2002-10-01 2003-09-30 Bizyklische heteroaromatische verbindungen als kinase hemmstoffe ATE414081T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GBGB0222743.7A GB0222743D0 (en)	2002-10-01	2002-10-01	Chemical compounds

Publications (1)

Publication Number	Publication Date
ATE414081T1 true ATE414081T1 (de)	2008-11-15

Family

ID=9945093

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT03753708T ATE414081T1 (de)	2002-10-01	2003-09-30	Bizyklische heteroaromatische verbindungen als kinase hemmstoffe

Country Status (10)

Country	Link
US (1)	US7456286B2 (de)
EP (1)	EP1549648B1 (de)
JP (1)	JP2006504712A (de)
AT (1)	ATE414081T1 (de)
AU (1)	AU2003271870B2 (de)
CA (1)	CA2500844A1 (de)
DE (1)	DE60324696D1 (de)
ES (1)	ES2315527T3 (de)
GB (1)	GB0222743D0 (de)
WO (1)	WO2004031188A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB0224082D0 (en)	2002-10-16	2002-11-27	Celltech R&D Ltd	Biological products
RS53599B1 (sr)	2005-05-10	2015-02-27	Intermune, Inc.	Piridon derivati za modulaciju stresom aktiviranog sistema proteinskih kinaza
WO2008157179A2 (en) *	2007-06-12	2008-12-24	Genentech, Inc.	N-substituted azaindoles and methods of use
JP5627574B2 (ja)	2008-06-03	2014-11-19	インターミューン，インコーポレイテッド	炎症性および線維性疾患を治療するための化合物および方法
AR072008A1 (es)	2008-06-13	2010-07-28	Merck & Co Inc	Compuestos heterobiciclicos como agentes de inhibicion de quinasa p38
AR092742A1 (es)	2012-10-02	2015-04-29	Intermune Inc	Piridinonas antifibroticas
GB201317363D0 (en)	2013-10-01	2013-11-13	Eisai Ltd	Novel compounds
CN106459042B (zh)	2014-04-02	2019-06-28	英特穆恩公司	抗纤维化吡啶酮类
US20190060286A1 (en)	2016-02-29	2019-02-28	University Of Florida Research Foundation, Incorpo	Chemotherapeutic Methods
US10906900B2 (en)	2016-09-26	2021-02-02	Centre National De La Recherche Scientifique	Compounds for using in imaging and particularly for the diagnosis of neurodegenerative diseases
EP3824906A1 (de)	2016-12-21	2021-05-26	Amgen Inc.	Anti-tnf alpha antikörperformulierungen

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2002517486A (ja) *	1998-06-12	2002-06-18	バーテックスファーマシューティカルズインコーポレイテッド	ｐ３８のインヒビター
GB0124848D0 (en) *	2001-10-16	2001-12-05	Celltech R&D Ltd	Chemical compounds
GB0218800D0 (en) *	2002-08-13	2002-09-18	Celltech R&D Ltd	Chemical compounds

2002
- 2002-10-01 GB GBGB0222743.7A patent/GB0222743D0/en not_active Ceased
2003
- 2003-09-30 JP JP2004540940A patent/JP2006504712A/ja active Pending
- 2003-09-30 AU AU2003271870A patent/AU2003271870B2/en not_active Ceased
- 2003-09-30 ES ES03753708T patent/ES2315527T3/es not_active Expired - Lifetime
- 2003-09-30 CA CA002500844A patent/CA2500844A1/en not_active Abandoned
- 2003-09-30 AT AT03753708T patent/ATE414081T1/de not_active IP Right Cessation
- 2003-09-30 WO PCT/GB2003/004214 patent/WO2004031188A1/en not_active Ceased
- 2003-09-30 US US10/529,413 patent/US7456286B2/en not_active Expired - Fee Related
- 2003-09-30 DE DE60324696T patent/DE60324696D1/de not_active Expired - Lifetime
- 2003-09-30 EP EP03753708A patent/EP1549648B1/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
WO2004031188A1 (en)	2004-04-15
AU2003271870A1 (en)	2004-04-23
EP1549648B1 (de)	2008-11-12
AU2003271870B2 (en)	2009-08-27
GB0222743D0 (en)	2002-11-06
ES2315527T3 (es)	2009-04-01
CA2500844A1 (en)	2004-04-15
DE60324696D1 (de)	2008-12-24
US20060122212A1 (en)	2006-06-08
JP2006504712A (ja)	2006-02-09
EP1549648A1 (de)	2005-07-06
US7456286B2 (en)	2008-11-25

Legal Events

Date	Code	Title	Description
2009-05-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
EA200600064A1 (ru)	2006-08-25	Производные тиенопиридона как ингибиторы киназ
MA26836A1 (fr)	2004-12-20	Heterocycles azotes bicycliques alkylamino substitues en tant qu'inhibiteurs de kinase de proteine p38.
MA26837A1 (fr)	2004-12-20	Heterocycles azotes bicycliques heteroalky-lamino substitues en tant qu'inhibiteurs de kinase de proteine p38.
TNSN06053A1 (en)	2007-10-03	6-substituted anilino purines as rtk inhibitors
MXPA06001134A (es)	2006-04-11	Inhibidores de la actividad de la proteina cinasa b.
BRPI0418112A (pt)	2007-04-17	inibidores de p-38 quinase bicìclico heterocìclicos
NO20044261L (no)	2004-11-25	Indazoler substituerte med en anticanceros aktivitet
DK1539166T3 (da)	2008-10-20	Farmaceutiske sammensætninger indeholdende dextromethorphan og quinidin til behandling af neurologiske sygdomme
DE69808765D1 (de)	2002-11-21	Verbindungen
ATE458735T1 (de)	2010-03-15	Pyridino[1,2-a pyrimidin-4-onverbindungen als mittel gegen krebs
NO20093060L (no)	2005-06-07	Spirosykliske sykloheksanderivater
HUP0201900A3 (en)	2003-02-28	Bicyclic heterocycles, pharmaceutical compositions containing them, their use and methods for the production thereof
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