MA26837A1 - Heterocycles azotes bicycliques heteroalky-lamino substitues en tant qu'inhibiteurs de kinase de proteine p38. - Google Patents

Heterocycles azotes bicycliques heteroalky-lamino substitues en tant qu'inhibiteurs de kinase de proteine p38.

Info

Publication number: MA26837A1
Authority: MA; Morocco
Prior art keywords: heteroalky; lamino; protein kinase; kinase inhibitors; nitrogen heterocycles
Prior art date: 1999-10-21

Application number

MA26612A

Other languages

English (en)

Inventor

James Patrick Dunn

David Michael Goldstein

William Harris

Ian Edward David Smith

Teresa Rosanne Welch

Lawrence Emerson Fisher

Christopher Huw Hill

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-10-21

Filing date

2002-04-19

Publication date

2004-12-20

2002-04-19 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2004-12-20 Publication of MA26837A1 publication Critical patent/MA26837A1/fr

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Physical Education & Sports Medicine (AREA)
Pulmonology (AREA)
Virology (AREA)
Rheumatology (AREA)
Diabetes (AREA)
Oncology (AREA)
Neurosurgery (AREA)
Dermatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Hematology (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Communicable Diseases (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pain & Pain Management (AREA)
Ophthalmology & Optometry (AREA)
Tropical Medicine & Parasitology (AREA)
Reproductive Health (AREA)
Molecular Biology (AREA)
Endocrinology (AREA)
Urology & Nephrology (AREA)
Hospice & Palliative Care (AREA)
AIDS & HIV (AREA)

MA26612A 1999-10-21 2002-04-19 Heterocycles azotes bicycliques heteroalky-lamino substitues en tant qu'inhibiteurs de kinase de proteine p38. MA26837A1 (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US16080399P	1999-10-21	1999-10-21
US21374300P	2000-06-22	2000-06-22

Publications (1)

Publication Number	Publication Date
MA26837A1 true MA26837A1 (fr)	2004-12-20

Family

ID=26857240

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MA26612A MA26837A1 (fr)	1999-10-21	2002-04-19	Heterocycles azotes bicycliques heteroalky-lamino substitues en tant qu'inhibiteurs de kinase de proteine p38.

Country Status (26)

Country	Link
US (1)	US6451804B1 (fr)
EP (1)	EP1228070B1 (fr)
JP (1)	JP3961830B2 (fr)
KR (1)	KR100523120B1 (fr)
CN (1)	CN1171889C (fr)
AR (1)	AR026084A1 (fr)
AT (1)	ATE353329T1 (fr)
AU (1)	AU776250B2 (fr)
BR (1)	BR0015243A (fr)
CA (1)	CA2388142C (fr)
CZ (1)	CZ20021744A3 (fr)
DE (1)	DE60033307T2 (fr)
ES (1)	ES2280247T3 (fr)
HR (1)	HRP20020328A2 (fr)
HU (1)	HUP0203564A3 (fr)
IL (1)	IL149100A0 (fr)
MA (1)	MA26837A1 (fr)
MX (1)	MXPA02003950A (fr)
NO (1)	NO20021781L (fr)
NZ (1)	NZ518119A (fr)
PE (1)	PE20010758A1 (fr)
PL (1)	PL357502A1 (fr)
RU (1)	RU2265606C2 (fr)
TR (1)	TR200201057T2 (fr)
WO (1)	WO2001029042A1 (fr)
YU (1)	YU29102A (fr)

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JP2006503802A (ja) *	2002-04-03	2006-02-02	エフ．ホフマン−ラ　ロシュ　アーゲー	イミダゾ縮合化合物
KR20040103972A (ko) *	2002-04-19	2004-12-09	스미스클라인 비참 코포레이션	신규 화합물
ES2278170T3 (es)	2002-07-09	2007-08-01	BOEHRINGER INGELHEIM PHARMA GMBH & CO.KG	Composiciones farmaceuticas de anticolinergicos e inhibidores de la quinasa p38 en el tratamiento de enfermedades respiratorias.
US7196090B2 (en)	2002-07-25	2007-03-27	Warner-Lambert Company	Kinase inhibitors
AU2003251661A1 (en) *	2002-08-06	2004-02-25	F. Hoffmann-La Roche Ag	6-alkoxy-pyrido-pyrimidines as p-38 map kinase inhibitors
US7084270B2 (en) *	2002-08-14	2006-08-01	Hoffman-La Roche Inc.	Pyrimido compounds having antiproliferative activity
TW200413381A (en)	2002-11-04	2004-08-01	Hoffmann La Roche	Novel amino-substituted dihydropyrimido [4,5-d]pyrimidinone derivatives, their manufacture and use as pharmaceutical agents
US7112676B2 (en) *	2002-11-04	2006-09-26	Hoffmann-La Roche Inc.	Pyrimido compounds having antiproliferative activity
KR20050075028A (ko) *	2002-11-18	2005-07-19	에프. 호프만-라 로슈 아게	다이아지노피리미딘
WO2004089955A1 (fr) *	2003-04-10	2004-10-21	F.Hoffmann-La Roche Ag	Composes pyrimido
WO2005011597A2 (fr)	2003-07-29	2005-02-10	Irm Llc	Composes et compositions utilises en tant qu'inhibiteurs des proteines kinases
US20060035893A1 (en)	2004-08-07	2006-02-16	Boehringer Ingelheim International Gmbh	Pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders
AU2005279337A1 (en)	2004-08-31	2006-03-09	F. Hoffmann-La Roche Ag	Amide derivatives of 7-amino-3-phenyl-dihydropyrimido [4,5-d]pyrimidinones, their manufacture and use as pharmaceutical agents
JP2008510690A (ja)	2004-08-31	2008-04-10	エフ．ホフマン−ラロシュアーゲー	３−フェニル−ジヒドロピリミド［４，５−ｄ］ピリミジノンのアミド誘導体、これらの製造、及び医薬品としての使用
WO2006038112A1 (fr) *	2004-10-01	2006-04-13	Warner-Lambert Company Llc	Utilisation d'inhibiteurs de kinases pour favoriser la neochondrogenese
WO2006056863A1 (fr) *	2004-11-23	2006-06-01	Ranbaxy Laboratories Limited	Pyrido'2, 3-d!pyrimidines utilisees comme agents anti-inflammatoires
PE20060777A1 (es)	2004-12-24	2006-10-06	Boehringer Ingelheim Int	Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas
WO2006082492A1 (fr) *	2005-02-02	2006-08-10	Ranbaxy Laboratories Limited	Derives azabicyclo utilises comme agents anti-inflammatoires
CN101341116A (zh) *	2005-12-22	2009-01-07	巴斯夫欧洲公司	制备o-烷基化环状氨基醇的方法
ES2329419T3 (es)	2006-01-31	2009-11-25	F. Hoffmann-La Roche Ag	7h-pirido(3,4-d)pirimidin-8-onas, su preparacion y uso como inhibidores de proteinas cinasas.
ES2301380B1 (es)	2006-08-09	2009-06-08	Laboratorios Almirall S.A.	Nuevos derivados de 1,7-naftiridina.
ES2320955B1 (es)	2007-03-02	2010-03-16	Laboratorios Almirall S.A.	Nuevos derivados de 3-((1,2,4)triazolo(4,3-a)piridin-7-il)benzamida.
ES2329639B1 (es)	2007-04-26	2010-09-23	Laboratorios Almirall S.A.	Nuevos derivados de 4,8-difenilpoliazanaftaleno.
RU2340327C1 (ru) *	2007-05-03	2008-12-10	Лев Давидович Раснецов	Офтальмологический гель и способ его приготовления
EP1992344A1 (fr)	2007-05-18	2008-11-19	Institut Curie	P38 alpha comme cible therapeutique pour les maladies associées á une mutation de FGFR3
GB2452696B (en) *	2007-08-02	2009-09-23	Cambridge Entpr Ltd	3-(2',2'-dimethylpropanoylamino)-tetrahydropyridin-2-one and its use in pharmaceutical compositions
EP2108641A1 (fr)	2008-04-11	2009-10-14	Laboratorios Almirall, S.A.	Nouveaux dérivés substitués de spiro[cycloalkyl-1,3'-indo]-2'(1'H)-one et leur utilisation comme ihibiteurs de p38 mitogen-activated kinase
EP2113503A1 (fr)	2008-04-28	2009-11-04	Laboratorios Almirall, S.A.	Nouveaux dérivés d'indolin-2-one substitués et leur utilisation comme inhibiteurs de p38 mitogen-activated kinase
US8653304B2 (en)	2009-09-30	2014-02-18	Toray Industries, Inc.	2,3-dihydro-1H-indene-2-yl urea derivative and pharmaceutical application of same
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2000
- 2000-10-13 AU AU77873/00A patent/AU776250B2/en not_active Ceased
- 2000-10-13 ES ES00967864T patent/ES2280247T3/es not_active Expired - Lifetime
- 2000-10-13 CN CNB008146624A patent/CN1171889C/zh not_active Expired - Fee Related
- 2000-10-13 CA CA002388142A patent/CA2388142C/fr not_active Expired - Fee Related
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- 2000-10-13 KR KR10-2002-7005031A patent/KR100523120B1/ko not_active Expired - Fee Related
- 2000-10-13 RU RU2002112753/04A patent/RU2265606C2/ru not_active IP Right Cessation
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- 2000-10-13 PL PL00357502A patent/PL357502A1/xx not_active Application Discontinuation
- 2000-10-13 HU HU0203564A patent/HUP0203564A3/hu unknown
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- 2000-10-13 AT AT00967864T patent/ATE353329T1/de not_active IP Right Cessation
- 2000-10-13 WO PCT/EP2000/010088 patent/WO2001029042A1/fr not_active Ceased
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- 2000-10-13 DE DE60033307T patent/DE60033307T2/de not_active Expired - Fee Related
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- 2000-10-20 US US09/693,337 patent/US6451804B1/en not_active Expired - Fee Related
2002
- 2002-04-16 NO NO20021781A patent/NO20021781L/no not_active Application Discontinuation
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Also Published As

Publication number	Publication date
AU776250B2 (en)	2004-09-02
DE60033307T2 (de)	2007-07-12
MXPA02003950A (es)	2002-10-23
RU2002112753A (ru)	2004-01-20
HK1051039A1 (en)	2003-07-18
CN1171889C (zh)	2004-10-20
HRP20020328A2 (en)	2004-02-29
YU29102A (sh)	2004-12-31
IL149100A0 (en)	2002-11-10
HUP0203564A2 (hu)	2003-02-28
ES2280247T3 (es)	2007-09-16
JP2003512378A (ja)	2003-04-02
EP1228070A1 (fr)	2002-08-07
CZ20021744A3 (cs)	2002-08-14
EP1228070B1 (fr)	2007-02-07
CA2388142C (fr)	2008-12-09
RU2265606C2 (ru)	2005-12-10
KR100523120B1 (ko)	2005-10-20
ATE353329T1 (de)	2007-02-15
DE60033307D1 (en)	2007-03-22
AU7787300A (en)	2001-04-30
JP3961830B2 (ja)	2007-08-22
CA2388142A1 (fr)	2001-04-26
NO20021781L (no)	2002-04-18
CN1382144A (zh)	2002-11-27
WO2001029042A1 (fr)	2001-04-26
HUP0203564A3 (en)	2004-07-28
TR200201057T2 (tr)	2002-09-23
PE20010758A1 (es)	2001-07-21
AR026084A1 (es)	2002-12-26
PL357502A1 (en)	2004-07-26
BR0015243A (pt)	2002-07-16
KR20020038963A (ko)	2002-05-24
US6451804B1 (en)	2002-09-17
NO20021781D0 (no)	2002-04-16
NZ518119A (en)	2004-02-27

Publication	Publication Date	Title
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DE69718472D1 (de)	2003-02-20	Bicyclische heteroaromatische verbindungen als protein tyrosine kinase inhibitoren
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MA27083A1 (fr)	2004-12-20	Derives de nicotine ou d'isonicotine benzothiazole
MA25493A1 (fr)	2002-07-01	Derives de 3(5)-amino-pyrazole, procede pour leur preparation et leur utilisation en tant qu'agents antitumoraux.
DE60214428D1 (de)	2006-10-12	1, 4-dihydro-1, 4-diphenylpyridin-derivate
CU23053A3 (es)	2005-06-24	1,2,3,4-tetrahidroquinlinas 2-sustituidas 4-amino sustituidas
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FI962639A7 (fi)	1996-06-26	Diaryyli-5,6-fuusioituneita heterosyklisiä happoja leukotrieeniantagon isteina