ATE414704T1 - Verfahren zur synthese von pergolid - Google Patents

Verfahren zur synthese von pergolid

Info

Publication number: ATE414704T1
Authority: AT; Austria
Prior art keywords: pergolide; synthesis; dihydrolysergic; intermediates; isolating
Prior art date: 2002-03-15

Application number

AT03717204T

Other languages

English (en)

Inventor

Walter Cabri

Paolo Paissoni

Jacopo Roletto

Piera Fonte

Sara Olmo

Original Assignee

Antibioticos Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-03-15

Filing date

2003-03-10

Publication date

2008-12-15

2002-03-15 Priority claimed from IT2002MI000555A external-priority patent/ITMI20020555A1/it

2002-10-08 Priority claimed from ITMI20022133 external-priority patent/ITMI20022133A1/it

2003-03-10 Application filed by Antibioticos Spa filed Critical Antibioticos Spa

2008-12-15 Application granted granted Critical

2008-12-15 Publication of ATE414704T1 publication Critical patent/ATE414704T1/de

Links

238000000034 method Methods 0.000 title abstract 3
229960004851 pergolide Drugs 0.000 title abstract 3
YEHCICAEULNIGD-MZMPZRCHSA-N pergolide Chemical compound C1=CC([C@H]2C[C@@H](CSC)CN([C@@H]2C2)CCC)=C3C2=CNC3=C1 YEHCICAEULNIGD-MZMPZRCHSA-N 0.000 title abstract 3
230000015572 biosynthetic process Effects 0.000 title abstract 2
238000003786 synthesis reaction Methods 0.000 title abstract 2
239000002253 acid Substances 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
229960001511 pergolide mesylate Drugs 0.000 abstract 1
UWCVGPLTGZWHGS-ZORIOUSZSA-N pergolide mesylate Chemical compound CS(O)(=O)=O.C1=CC([C@H]2C[C@@H](CSC)CN([C@@H]2C2)CCC)=C3C2=CNC3=C1 UWCVGPLTGZWHGS-ZORIOUSZSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT03717204T 2002-03-15 2003-03-10 Verfahren zur synthese von pergolid ATE414704T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT2002MI000555A ITMI20020555A1 (it)	2002-03-15	2002-03-15	Processo per la sintesi del pergolide
ITMI20022133 ITMI20022133A1 (it)	2002-10-08	2002-10-08	Procedimento per la preparazione del pergolide.

Publications (1)

Publication Number	Publication Date
ATE414704T1 true ATE414704T1 (de)	2008-12-15

Family

ID=28043508

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT03717204T ATE414704T1 (de)	2002-03-15	2003-03-10	Verfahren zur synthese von pergolid

Country Status (7)

Country	Link
US (1)	US7019140B2 (de)
EP (1)	EP1485382B1 (de)
JP (1)	JP2005520833A (de)
AT (1)	ATE414704T1 (de)
AU (1)	AU2003221494A1 (de)
DE (1)	DE60324776D1 (de)
WO (1)	WO2003078432A2 (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BRPI1011322A2 (pt)	2009-04-17	2018-09-18	Merz Pharma Gmbh & Co Kgaa	1-amino-1,3,3,5,5-pentametilciclohexano mesilato, seu processo de fabricação, suas partículas e seus cristais, uso de anisol ou uma mistura de anisol e pelo menos um dos solventes, e composição farmacêutica.

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3901894A (en) *	1974-06-06	1975-08-26	Lilly Co Eli	8-thiomethylergolines
US4166182A (en) *	1978-02-08	1979-08-28	Eli Lilly And Company	6-n-propyl-8-methoxymethyl or methylmercaptomethylergolines and related compounds
US4246265A (en)	1979-10-01	1981-01-20	Eli Lilly And Company	6-n-Propyl-8α-methoxymethyl or methylmercaptomethylergolines and related compounds
US5463060A (en) *	1992-05-21	1995-10-31	Eli Lilly And Company	One-pot process
IT1307934B1 (it)	1999-01-27	2001-11-29	Poli Ind Chimica Spa	Processo per la preparazione di derivati alchimercaptometilergolinici.
CZ287962B6 (cs)	1999-06-15	2001-03-14	Galena A. S.	Způsob přípravy 8ß-methylthiomethyl derivátů ergolinu

2003
- 2003-03-10 JP JP2003576437A patent/JP2005520833A/ja active Pending
- 2003-03-10 DE DE60324776T patent/DE60324776D1/de not_active Expired - Fee Related
- 2003-03-10 AT AT03717204T patent/ATE414704T1/de not_active IP Right Cessation
- 2003-03-10 WO PCT/EP2003/002423 patent/WO2003078432A2/en not_active Ceased
- 2003-03-10 US US10/507,620 patent/US7019140B2/en not_active Expired - Fee Related
- 2003-03-10 EP EP03717204A patent/EP1485382B1/de not_active Expired - Lifetime
- 2003-03-10 AU AU2003221494A patent/AU2003221494A1/en not_active Abandoned

Also Published As

Publication number	Publication date
EP1485382A2 (de)	2004-12-15
AU2003221494A1 (en)	2003-09-29
DE60324776D1 (de)	2009-01-02
WO2003078432A3 (en)	2004-01-15
US20050124812A1 (en)	2005-06-09
WO2003078432A2 (en)	2003-09-25
US7019140B2 (en)	2006-03-28
EP1485382B1 (de)	2008-11-19
JP2005520833A (ja)	2005-07-14

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Legal Events

Date	Code	Title	Description
2009-05-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties