NO20063989L - Fremgangsmater for a produsere 3-O-beskyttede morfinoner og 3-O-beskyttede morfinondienol-karboksylater - Google Patents

Fremgangsmater for a produsere 3-O-beskyttede morfinoner og 3-O-beskyttede morfinondienol-karboksylater

Info

Publication number
NO20063989L
NO20063989L NO20063989A NO20063989A NO20063989L NO 20063989 L NO20063989 L NO 20063989L NO 20063989 A NO20063989 A NO 20063989A NO 20063989 A NO20063989 A NO 20063989A NO 20063989 L NO20063989 L NO 20063989L
Authority
NO
Norway
Prior art keywords
protected
compound
carboxylates
formula
morphinondienol
Prior art date
Application number
NO20063989A
Other languages
English (en)
Inventor
Andreas Stumpe
Original Assignee
Euro Celtique Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34860329&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20063989(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Euro Celtique Sa filed Critical Euro Celtique Sa
Publication of NO20063989L publication Critical patent/NO20063989L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

Beskrevet er fremgangsmåter for fremstilling av aldehyder og ketoner som innbefatter omsetting av den korresponderende, primære eller sekundære alkoholen under nærvær av triklorisocyanursyre, en forbindelse med formel R1SR2 og en base. I en utførelsesform er alkoholen en forbindelse med formel (I), hvori R3 er en beskyttende gruppe. Også beskrevet er fremgangsmåter for fremstilling av 3-O-beskyttede morfindienolkarboksylater som innbefatter oksidasjon av en forbindelse med formel (I) under nærvær av en klorinneholdende forbindelse og en forbindelse med formel R1SR2; og omsetting av produktet oppnådd i oksidasjonstrinnet med et acyleringsmiddel.
NO20063989A 2004-02-06 2006-09-06 Fremgangsmater for a produsere 3-O-beskyttede morfinoner og 3-O-beskyttede morfinondienol-karboksylater NO20063989L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US54271104P 2004-02-06 2004-02-06
PCT/US2005/003390 WO2005077957A2 (en) 2004-02-06 2005-02-04 Methods for making 3-o-protected morphinones and 3-o-protected morphinone dienol carboxylates

Publications (1)

Publication Number Publication Date
NO20063989L true NO20063989L (no) 2006-10-31

Family

ID=34860329

Family Applications (2)

Application Number Title Priority Date Filing Date
NO20063989A NO20063989L (no) 2004-02-06 2006-09-06 Fremgangsmater for a produsere 3-O-beskyttede morfinoner og 3-O-beskyttede morfinondienol-karboksylater
NO20150276A NO339083B1 (no) 2004-02-06 2015-03-02 Fremgangsmåte for fremstilling av 3-O-beskyttede morfinoner og 3-O-beskyttede morfinondienolkarboksylater

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO20150276A NO339083B1 (no) 2004-02-06 2015-03-02 Fremgangsmåte for fremstilling av 3-O-beskyttede morfinoner og 3-O-beskyttede morfinondienolkarboksylater

Country Status (33)

Country Link
US (6) US8003793B2 (no)
EP (3) EP1864987B1 (no)
JP (1) JP4963968B2 (no)
KR (4) KR101011460B1 (no)
CN (1) CN1918168B (no)
AP (1) AP2006003716A0 (no)
AT (2) ATE451374T1 (no)
AU (1) AU2005212258B2 (no)
BR (1) BRPI0506607B8 (no)
CA (2) CA2555215C (no)
CR (1) CR8590A (no)
CY (2) CY1108506T1 (no)
DE (2) DE602005009321D1 (no)
DK (2) DK1864987T3 (no)
EA (2) EA016062B1 (no)
EC (1) ECSP066824A (no)
ES (2) ES2338054T3 (no)
GE (1) GEP20084454B (no)
HR (2) HRP20080618T3 (no)
IL (2) IL177281A (no)
MA (1) MA28346A1 (no)
MX (1) MXPA06008931A (no)
NO (2) NO20063989L (no)
NZ (2) NZ548786A (no)
PL (2) PL1864987T3 (no)
PT (2) PT1864987E (no)
RS (2) RS51317B (no)
SG (1) SG150500A1 (no)
SI (2) SI1711502T1 (no)
TN (1) TNSN06248A1 (no)
UA (2) UA88646C2 (no)
WO (1) WO2005077957A2 (no)
ZA (1) ZA200606252B (no)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1864987E (pt) 2004-02-06 2010-03-09 Euro Celtique Sa Processos para a produção de morfinonas protegidas em 3-o e carboxilatos de dienol e morfinonas protegidos em 3-o
NZ575620A (en) * 2006-09-20 2010-11-26 Mallinckrodt Inc Preparation of substituted morphinan-6-ones and salts and intermediates thereof
US9040726B2 (en) 2007-03-06 2015-05-26 Mallinckrodt Llc Process for the preparation of quaternary N-alkyl morphinan alkaloid salts
EP2137189B1 (en) * 2007-03-06 2015-05-06 Mallinckrodt LLC Process for the preparation of quaternary n-alkyl morphinan alkaloid salts
EP2285780B1 (en) 2008-05-27 2015-08-26 Mallinckrodt LLC Processes and compounds for the preparation of normorphinans
US9458109B2 (en) 2008-09-03 2016-10-04 Mallinckrodt Llc Substituted berbines and processes for their synthesis
NZ603173A (en) 2010-05-10 2014-10-31 Euro Celtique Sa Manufacturing of active-free granules and tablets comprising the same
KR20130030260A (ko) 2010-05-10 2013-03-26 유로-셀티큐 에스.에이. 히드로모르폰 및 날록손을 포함하는 제약 조성물
WO2011141490A1 (en) 2010-05-10 2011-11-17 Euro-Celtique S.A. Combination of active loaded granules with additional actives
EP3068397A1 (en) 2013-11-13 2016-09-21 Euro-Celtique S.A. Hydromorphone and naloxone for treatment of pain and opioid bowel dysfunction syndrome
JP6888550B2 (ja) * 2015-09-30 2021-06-16 富士フイルム和光純薬株式会社 有機化合物の製造方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2654756A (en) 1949-10-20 1953-10-06 Mallinckrodt Chemical Works Process of preparing codeinone, dihydrocodeinone, and dihydromorphinone
DE902257C (de) 1951-07-17 1954-01-21 Knoll Ag Verfahren zur Herstellung von Acylderivaten der Enolform des Codeinons
GB1495271A (en) * 1974-04-10 1977-12-14 Macfarlan Smith Ltd Dehydrohalogenation of codeinone derivatives
US4472253A (en) 1981-08-17 1984-09-18 The Florida Board Of Regents On Behalf Of The Florida State University Process for the preparation of an N-substituted 3-O-alkyl-14-hydroxynormorphinone derivative
US5112975A (en) 1984-03-27 1992-05-12 Mallinckrodt Specialty Chemicals Company Preparation of noroxymorphone from morphine
SE9003665D0 (sv) 1990-11-16 1990-11-16 Kabivitrum Ab Morphine prodrugs
GB9116909D0 (en) 1991-08-06 1991-09-18 Salford Ultrafine Chem & Res Morphine derivatives
US5821374A (en) 1995-11-21 1998-10-13 Hoffmann-La Roche Inc. Process for the oxidation of alcohols
US5869669A (en) * 1996-07-26 1999-02-09 Penick Corporation Preparation of 14-hydroxynormorphinones from normorphinone dienol acylates
GB9713703D0 (en) * 1997-06-30 1997-09-03 Johnson Matthey Plc Preparation of opiates
US6177567B1 (en) * 1999-10-15 2001-01-23 Boehringer Ingelheim Chemicals, Inc. Method for preparing oxycodone
US6596877B2 (en) 2001-10-17 2003-07-22 Novartis Ag Accelerated process for preparing O-methyl phenols, N-methyl heteroaromatic compounds, and methylated aminophenols
PT1864987E (pt) 2004-02-06 2010-03-09 Euro Celtique Sa Processos para a produção de morfinonas protegidas em 3-o e carboxilatos de dienol e morfinonas protegidos em 3-o

Also Published As

Publication number Publication date
IL177281A (en) 2012-02-29
KR100921696B1 (ko) 2009-10-15
UA87833C2 (uk) 2009-08-25
KR20090089486A (ko) 2009-08-21
US8003793B2 (en) 2011-08-23
JP2007520563A (ja) 2007-07-26
HK1103071A1 (en) 2007-12-14
CA2808199C (en) 2015-10-27
US9670218B2 (en) 2017-06-06
US8685996B2 (en) 2014-04-01
EA016062B1 (ru) 2012-01-30
UA88646C2 (uk) 2009-11-10
ATE406372T1 (de) 2008-09-15
EP2194059A2 (en) 2010-06-09
RS51317B (sr) 2010-12-31
DE602005009321D1 (de) 2008-10-09
HRP20080618T3 (hr) 2009-01-31
KR101011460B1 (ko) 2011-01-28
KR20070117701A (ko) 2007-12-12
RS50663B (sr) 2010-06-30
EP1864987A3 (en) 2008-02-20
BRPI0506607A (pt) 2007-05-02
DK1864987T3 (da) 2010-04-12
EA200601394A1 (ru) 2006-12-29
GEP20084454B (en) 2008-08-10
NZ565355A (en) 2008-09-26
ZA200606252B (en) 2007-11-28
DE602005018265D1 (de) 2010-01-21
PT1864987E (pt) 2010-03-09
HRP20100123T1 (hr) 2010-04-30
US20140171643A1 (en) 2014-06-19
NZ548786A (en) 2008-08-29
EP1864987A2 (en) 2007-12-12
HK1119160A1 (en) 2009-02-27
NO20150276L (no) 2006-10-31
US20120225902A1 (en) 2012-09-06
KR100921695B1 (ko) 2009-10-15
KR20070108956A (ko) 2007-11-13
US8975257B2 (en) 2015-03-10
SI1864987T1 (sl) 2010-04-30
BRPI0506607B1 (pt) 2018-01-16
AU2005212258B2 (en) 2008-05-22
US8198444B2 (en) 2012-06-12
SI1711502T1 (sl) 2009-02-28
PL1711502T3 (pl) 2009-02-27
BRPI0506607B8 (pt) 2021-05-25
CA2555215A1 (en) 2005-08-25
PL1864987T3 (pl) 2010-05-31
EP1711502A2 (en) 2006-10-18
DK1711502T3 (da) 2008-12-01
NO339083B1 (no) 2016-11-14
JP4963968B2 (ja) 2012-06-27
EP1711502B1 (en) 2008-08-27
ECSP066824A (es) 2006-12-29
EA012905B1 (ru) 2010-02-26
WO2005077957A2 (en) 2005-08-25
US20080146804A1 (en) 2008-06-19
IL205596A (en) 2011-11-30
US20150239898A1 (en) 2015-08-27
ES2313299T3 (es) 2009-03-01
ES2338054T3 (es) 2010-05-03
CR8590A (es) 2007-07-19
US20120022259A1 (en) 2012-01-26
PT1711502E (pt) 2008-11-20
MA28346A1 (fr) 2006-12-01
US20170233400A1 (en) 2017-08-17
KR20070026401A (ko) 2007-03-08
CN1918168A (zh) 2007-02-21
EP2194059A3 (en) 2010-09-22
IL177281A0 (en) 2006-12-10
CY1108506T1 (el) 2014-04-09
TNSN06248A1 (fr) 2007-12-03
ATE451374T1 (de) 2009-12-15
AP2006003716A0 (en) 2006-08-31
EA200801811A1 (ru) 2008-12-30
AU2005212258A1 (en) 2005-08-25
EP1864987B1 (en) 2009-12-09
CY1109838T1 (el) 2014-09-10
CN1918168B (zh) 2011-04-27
CA2808199A1 (en) 2005-08-25
SG150500A1 (en) 2009-03-30
MXPA06008931A (es) 2007-01-26
WO2005077957A3 (en) 2006-05-04
CA2555215C (en) 2013-05-21

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Legal Events

Date Code Title Description
CHAD Change of the owner's name or address (par. 44 patent law, par. patentforskriften)

Owner name: EURO-CELTIQUE SA, LU

FC2A Withdrawal, rejection or dismissal of laid open patent application