ATE415631T1 - AFFINITÄTSSCREENING MITTELS BIBLIOTHEKEN DES TYPS ßEINE-VERBINDUNG-PRO-KÜGELCHENß - Google Patents

AFFINITÄTSSCREENING MITTELS BIBLIOTHEKEN DES TYPS ßEINE-VERBINDUNG-PRO-KÜGELCHENß

Info

Publication number
ATE415631T1
ATE415631T1 AT04702645T AT04702645T ATE415631T1 AT E415631 T1 ATE415631 T1 AT E415631T1 AT 04702645 T AT04702645 T AT 04702645T AT 04702645 T AT04702645 T AT 04702645T AT E415631 T1 ATE415631 T1 AT E415631T1
Authority
AT
Austria
Prior art keywords
protein
libraries
ligand binding
binding pairs
comound
Prior art date
Application number
AT04702645T
Other languages
English (en)
Inventor
St Hilaire
Haifeng Yin
Sheryl Surve
Martin Wenckens
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Application granted granted Critical
Publication of ATE415631T1 publication Critical patent/ATE415631T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/11—Compounds covalently bound to a solid support
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT04702645T 2003-01-16 2004-01-16 AFFINITÄTSSCREENING MITTELS BIBLIOTHEKEN DES TYPS ßEINE-VERBINDUNG-PRO-KÜGELCHENß ATE415631T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/346,737 US20040142379A1 (en) 2003-01-16 2003-01-16 Affinity fishing for ligands and proteins receptors
DKPA200300749 2003-05-19

Publications (1)

Publication Number Publication Date
ATE415631T1 true ATE415631T1 (de) 2008-12-15

Family

ID=32714977

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04702645T ATE415631T1 (de) 2003-01-16 2004-01-16 AFFINITÄTSSCREENING MITTELS BIBLIOTHEKEN DES TYPS ßEINE-VERBINDUNG-PRO-KÜGELCHENß

Country Status (8)

Country Link
US (2) US20040142379A1 (de)
EP (2) EP1588173B1 (de)
AT (1) ATE415631T1 (de)
AU (1) AU2004204276A1 (de)
CA (1) CA2551593A1 (de)
DE (1) DE602004017960D1 (de)
ES (1) ES2318266T3 (de)
WO (1) WO2004062553A2 (de)

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US20050287552A1 (en) * 2003-02-19 2005-12-29 Academia Sinica, Office Of Public Affairs (Technology Transfer) Carbohydrate encapsulated nanoparticle based affinity mass spectrometry
US7329725B1 (en) * 2003-10-29 2008-02-12 Nastech Pharmaceutical Company Inc. Phage displayed Trp cage ligands
US20080176753A1 (en) * 2004-11-08 2008-07-24 Kunihiro Ohta Method of Efficiently Screening Protein Capable of Specific Binding to Ligand
US7704953B2 (en) * 2006-02-17 2010-04-27 Mdrna, Inc. Phage displayed cell binding peptides
US7879799B2 (en) * 2006-08-10 2011-02-01 Institute For Systems Biology Methods for characterizing glycoproteins and generating antibodies for same
CA2722704A1 (en) * 2008-04-28 2009-11-05 Zalicus Pharmaceuticals Ltd. Cyclylamine derivatives as calcium channel blockers
JP2010051764A (ja) * 2008-07-29 2010-03-11 Fujifilm Corp 有害物質除去材及び有害物質除去方法
SG176009A1 (en) 2009-05-28 2011-12-29 Novartis Ag Substituted aminopropionic derivatives as neprilysin inhibitors
JP5466759B2 (ja) 2009-05-28 2014-04-09 ノバルティス アーゲー ネプリライシン阻害剤としての置換アミノ酪酸誘導体
US8574835B2 (en) * 2009-05-29 2013-11-05 Life Technologies Corporation Scaffolded nucleic acid polymer particles and methods of making and using
JO2967B1 (en) 2009-11-20 2016-03-15 نوفارتس ايه جي Acetic acid derivatives of carbamoyl methyl amino are substituted as new NEP inhibitors
CN102812003B (zh) 2009-12-18 2015-01-21 欧洲筛选有限公司 吡咯烷羧酸衍生物、药物组合物以及在代谢紊乱中作为g-蛋白偶联受体43(gpr43)激动剂使用的方法
JP2013531687A (ja) 2010-07-16 2013-08-08 パーデュー、ファーマ、リミテッド、パートナーシップ ナトリウムチャネル遮断剤としてのピリジン化合物
AU2011303597A1 (en) 2010-09-17 2013-04-11 Purdue Pharma L.P. Pyridine compounds and the uses thereof
US9200251B1 (en) 2011-03-31 2015-12-01 David Gordon Bermudes Bacterial methionine analogue and methionine synthesis inhibitor anticancer, antiinfective and coronary heart disease protective microcins and methods of treatment therewith
WO2013136170A1 (en) 2012-03-16 2013-09-19 Purdue Pharma L.P. Substituted pyridines as sodium channel blockers
EP2935257B1 (de) 2012-12-20 2018-02-07 Purdue Pharma LP Cyclische sulfonamide als natriumkanalblocker
TR201808541T4 (tr) 2013-02-14 2018-07-23 Novartis Ag Nep (nötr endopeptidaz) inhibitörleri olarak ikame edilmiş bisfenil butanoik fosfonik asit türevleri.
JP6301371B2 (ja) 2013-02-14 2018-04-11 ノバルティス アーゲー インビボ効力が改善されたｎｅｐ阻害剤としての置換ビスフェニルブタン酸誘導体
GB201315335D0 (en) 2013-08-29 2013-10-09 Of Singapore Amino diacids containing peptide modifiers
CN105916500A (zh) * 2013-11-27 2016-08-31 欧洲筛选有限公司 用于治疗炎性疾病的化合物、药物组合物和方法
US10730866B2 (en) 2014-04-07 2020-08-04 Purdue Pharma L.P. Indole derivatives and use thereof
CN103976994B (zh) * 2014-05-09 2016-03-16 中国药科大学 一种肿瘤相关疾病药物靶点及其应用
CN115043943A (zh) 2015-05-15 2022-09-13 综合医院公司 拮抗性抗肿瘤坏死因子受体超家族抗体
CN109563133B (zh) * 2016-09-27 2020-09-11 四川科伦博泰生物医药股份有限公司 多酰胺化合物及其用途
EP3853252A1 (de) 2018-09-18 2021-07-28 Merrimack Pharmaceuticals, Inc. Anti-tnfr2-antikörper und verwendungen davon
CA3131953A1 (en) 2019-03-01 2020-09-10 Merrimack Pharmaceuticals, Inc. Anti-tnfr2 antibodies and uses thereof
CN110331124B (zh) * 2019-06-14 2022-03-22 浙江大学 一种导电聚吡咯/细胞外基质复合薄膜及其制备方法
WO2025049272A1 (en) 2023-08-25 2025-03-06 The Broad Institute, Inc. Card9 variant polypeptide and antibodies directed thereto
WO2026052582A1 (en) 2024-09-04 2026-03-12 Red Ridge Bio Ag Biparatopic antibodies that specifically bind fms related receptor tyrosine kinase 3

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US5185446A (en) * 1990-09-04 1993-02-09 Neurogen Corporation Certain cycloalkyl imidazopyrimidines; a new class of gaba brainreceptor ligands
US5733740A (en) 1992-10-13 1998-03-31 Vanderbilt University Taga gene and methods for detecting predisposition to peptic ulceration and gastric carcinoma
US5834318A (en) 1995-05-10 1998-11-10 Bayer Corporation Screening of combinatorial peptide libraries for selection of peptide ligand useful in affinity purification of target proteins
WO1996038553A1 (en) 1995-06-02 1996-12-05 M&E Biotech A/S A method for identification of biologically active peptides and nucleic acids
US6068829A (en) * 1995-09-11 2000-05-30 The Burnham Institute Method of identifying molecules that home to a selected organ in vivo
US5622699A (en) * 1995-09-11 1997-04-22 La Jolla Cancer Research Foundation Method of identifying molecules that home to a selected organ in vivo
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US5783663A (en) 1998-01-23 1998-07-21 Bayer Corporation Peptide ligands for affinity purification of fibrinogen
JP4278872B2 (ja) * 1998-08-17 2009-06-17 フィロス インク． 蛋白質・核酸融合分子ライブラリーを用いた化合物・蛋白質相互作用の同定
EP1169649A2 (de) * 1999-04-15 2002-01-09 The Board Of Trustees Of The Leland Stanford Junior University Mikromatrizen für polypeptiden
EP1169641B1 (de) * 1999-04-15 2007-10-17 The University Of Virginia Patent Foundation Proteomabbau
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US7153682B2 (en) * 2000-06-05 2006-12-26 Chiron Corporation Microarrays on mirrored substrates for performing proteomic analyses
US20020115068A1 (en) * 2000-06-23 2002-08-22 Ian Tomlinson Matrix screening method
WO2003060460A2 (en) * 2002-01-03 2003-07-24 Furka Arpad Multi-target screening
WO2003062831A1 (en) * 2002-01-24 2003-07-31 The Regents Of The University Of California Method for determining differences in molecular interactions and for screening a combinatorial library
US7485414B2 (en) * 2002-08-30 2009-02-03 Rigel Pharmaceuticals, Inc. Modulators of angiogenesis

Also Published As

Publication number Publication date
US20060257875A1 (en) 2006-11-16
US20040142379A1 (en) 2004-07-22
CA2551593A1 (en) 2004-07-29
DE602004017960D1 (de) 2009-01-08
WO2004062553A2 (en) 2004-07-29
ES2318266T3 (es) 2009-05-01
EP2053403A3 (de) 2009-07-15
WO2004062553A3 (en) 2005-01-27
EP1588173A2 (de) 2005-10-26
AU2004204276A1 (en) 2004-07-29
EP2053403A2 (de) 2009-04-29
EP1588173B1 (de) 2008-11-26

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