ATE416190T1 - Polypeptide mit bindungsaffinität für her2 - Google Patents

Polypeptide mit bindungsaffinität für her2

Info

Publication number
ATE416190T1
ATE416190T1 AT04749087T AT04749087T ATE416190T1 AT E416190 T1 ATE416190 T1 AT E416190T1 AT 04749087 T AT04749087 T AT 04749087T AT 04749087 T AT04749087 T AT 04749087T AT E416190 T1 ATE416190 T1 AT E416190T1
Authority
AT
Austria
Prior art keywords
polypeptide
her2
methods
binding affinity
polypeptides
Prior art date
Application number
AT04749087T
Other languages
English (en)
Inventor
Joergen Carlsson
Stefan Stahl
Tove Eriksson
Elin Gunneriusson
Fredrik Nilsson
Original Assignee
Affibody Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE0301987A external-priority patent/SE0301987D0/xx
Priority claimed from SE0400275A external-priority patent/SE0400275D0/xx
Application filed by Affibody Ab filed Critical Affibody Ab
Application granted granted Critical
Publication of ATE416190T1 publication Critical patent/ATE416190T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/305Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
    • C07K14/31Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/20Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/20Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/21Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/20Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/22Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a Strep-tag

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicinal Preparation (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
AT04749087T 2003-07-04 2004-06-30 Polypeptide mit bindungsaffinität für her2 ATE416190T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0301987A SE0301987D0 (sv) 2003-07-04 2003-07-04 New polypeptide
SE0400275A SE0400275D0 (sv) 2004-02-09 2004-02-09 New polypeptide

Publications (1)

Publication Number Publication Date
ATE416190T1 true ATE416190T1 (de) 2008-12-15

Family

ID=33566900

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04749087T ATE416190T1 (de) 2003-07-04 2004-06-30 Polypeptide mit bindungsaffinität für her2

Country Status (10)

Country Link
US (1) US7993650B2 (de)
EP (1) EP1641818B1 (de)
JP (2) JP4871126B2 (de)
AT (1) ATE416190T1 (de)
AU (1) AU2004253835B2 (de)
CA (1) CA2531238C (de)
DE (1) DE602004018141D1 (de)
DK (1) DK1641818T3 (de)
ES (1) ES2319426T3 (de)
WO (1) WO2005003156A1 (de)

Families Citing this family (155)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0200943D0 (sv) * 2002-03-25 2002-03-25 Amersham Biosciences Ab Mutant protein
US7993848B2 (en) 2005-03-01 2011-08-09 Affibody Ab Staphylococcus protein A domain mutants that bind to TNF-α
CN1908015B (zh) * 2005-10-18 2010-09-08 中国人民解放军军事医学科学院基础医学研究所 能抑制her2高表达肿瘤细胞增殖的稳定的小分子多肽
GB0524788D0 (en) * 2005-12-05 2006-01-11 Affibody Ab Polypeptides
US7993560B2 (en) 2006-04-20 2011-08-09 Curwood, Inc. Process for introducing an additive into a polymer melt
US7989216B2 (en) 2006-12-08 2011-08-02 General Electric Company Two helix binders
US7981691B2 (en) 2006-12-08 2011-07-19 General Electric Company Two helix binders
US7977118B2 (en) 2006-12-08 2011-07-12 General Electric Company Two helix binders
US8198043B2 (en) 2006-12-08 2012-06-12 General Electric Company Two helix binders
US20100255514A1 (en) 2007-08-16 2010-10-07 The Royal Institution For The Advancement Of Learning/Mcgill University Tumor cell-derived microvesicles
JP5769417B2 (ja) * 2007-08-16 2015-08-26 ザ ロイヤル インスティチューション フォー ザ アドバンスメント オブ ラーニング/マギル ユニバーシティ 腫瘍細胞由来微小胞
EP2641919A3 (de) 2007-11-30 2014-05-07 Glaxo Group Limited Antigenbindende Konstrukte
US9187535B2 (en) 2007-12-19 2015-11-17 Affibody Ab Polypeptide derived from protein A and able to bind PDGF
EP2077272A1 (de) * 2007-12-21 2009-07-08 Affibody AB Polypeptid-Bibliothek mit vorbestimmtem Gerüst
EP2072525A1 (de) * 2007-12-21 2009-06-24 Affibody AB Neue Polypeptide mit Bindungsaffinität für HER2
AR072359A1 (es) 2008-05-06 2010-08-25 Glaxo Group Ltd Encapsulacion de agentes biologicamente activos
US8592555B2 (en) 2008-08-11 2013-11-26 Emd Millipore Corporation Immunoglobulin-binding proteins with improved specificity
JP5588983B2 (ja) 2008-08-11 2014-09-10 ウェルズ ファーゴ バンク ナショナル アソシエイション マルチアームポリマーアルカノエートコンジュゲート
UY32341A (es) 2008-12-19 2010-07-30 Glaxo Group Ltd Proteínas de unión antígeno novedosas
US20120165650A1 (en) 2010-12-22 2012-06-28 General Electric Company Her2 binders
SG195555A1 (en) * 2008-12-24 2013-12-30 Emd Millipore Corp Caustic stable chromatography ligands
EP2401296A1 (de) 2009-02-24 2012-01-04 Glaxo Group Limited Multivalente und/oder multispezifische rankl-bindende konstrukte
CA2753287A1 (en) 2009-02-24 2010-09-02 Glaxo Group Limited Antigen-binding constructs
WO2010097386A1 (en) 2009-02-24 2010-09-02 Glaxo Group Limited Antigen-binding constructs
JP2012519170A (ja) 2009-02-26 2012-08-23 オーエスアイ・ファーマシューティカルズ,エルエルシー 生体内の腫瘍細胞のemtステータスをモニターするためのinsitu法
WO2010120514A2 (en) * 2009-03-31 2010-10-21 The Trustees Of The University Of Pennsylvania Antigen-binding proteins comprising recombinant protein scaffolds
WO2011012646A2 (en) 2009-07-28 2011-02-03 F. Hoffmann-La Roche Ag Non-invasive in vivo optical imaging method
JP5960598B2 (ja) * 2009-11-04 2016-08-02 アフィボディ・アーベー Her3結合ポリペプチド
TWI377954B (en) * 2009-11-25 2012-12-01 Univ China Medical Oil body carriers, uses in target therapy and/or detection of the same, and fusion proteins comprised therein
US8940303B2 (en) 2010-01-28 2015-01-27 Glaxo Group Limited CD127 binding proteins
US10745467B2 (en) 2010-03-26 2020-08-18 The Trustees Of Dartmouth College VISTA-Ig for treatment of autoimmune, allergic and inflammatory disorders
EP2552947A4 (de) 2010-03-26 2013-11-13 Dartmouth College Vista-regulatorisches t-zellen-mediator-protein, vista-bindende wirkstoffe und verwendung davon
US20150231215A1 (en) 2012-06-22 2015-08-20 Randolph J. Noelle VISTA Antagonist and Methods of Use
KR20130036012A (ko) 2010-05-07 2013-04-09 에프. 호프만-라 로슈 아게 생체외 세포의 검출을 위한 진단 방법
UY33421A (es) 2010-06-03 2011-12-30 Glaxo Wellcome House Proteinas de union al antígeno humanizados
DE102010026061A1 (de) 2010-06-30 2012-01-05 Siemens Aktiengesellschaft 11C-markiertes Peptid zur Detektion eines Tumors, der einen Her2/neu-Rezeptor exprimiert
WO2012069433A2 (en) 2010-11-23 2012-05-31 Glaxo Group Limited Antigen binding proteins
JP2014501725A (ja) 2010-11-24 2014-01-23 グラクソ グループ リミテッド Hgfを標的とする多特異的抗原結合タンパク質
EP2654915B1 (de) * 2010-12-20 2018-10-24 GE Healthcare BioProcess R&D AB Affinitätschromatographiematrix
WO2012088422A1 (en) 2010-12-22 2012-06-28 Nektar Therapeutics Multi-arm polymeric prodrug conjugates of taxane-based compounds
AU2011349482A1 (en) * 2010-12-22 2013-07-25 Ge Healthcare Limited HER2 binding peptides labeled with aluminium-(18) fluoride complexed by NOTA
US10894087B2 (en) 2010-12-22 2021-01-19 Nektar Therapeutics Multi-arm polymeric prodrug conjugates of cabazitaxel-based compounds
US9061080B2 (en) 2010-12-22 2015-06-23 Ge Healthcare Limited HER2 binding peptides labeled with aluminium-[18] fluoride complexed by NOTA
SG191338A1 (en) * 2010-12-22 2013-07-31 Ge Healthcare Ltd Her2 binding peptides labelled with a 18f - containing organosilicon compound
KR20140029446A (ko) 2011-04-15 2014-03-10 컴퓨젠 엘티디. 면역 관련 장애 및 암의 치료를 위한 폴리펩티드 및 폴리뉴클레오티드, 및 이들의 용도
SG194176A1 (en) 2011-05-27 2013-12-30 Glaxo Group Ltd Bcma (cd269/tnfrsf17) -binding proteins
WO2012166555A1 (en) 2011-05-27 2012-12-06 Nektar Therapeutics Water - soluble polymer - linked binding moiety and drug compounds
SG186552A1 (en) 2011-06-08 2013-01-30 Emd Millipore Corp Chromatography matrices including novel staphylococcus aureus protein a based ligands
BR112013031943B1 (pt) 2011-06-13 2021-10-13 Csl Limited Composição que compreende proteínas e anticorpos contra g-csfr
AU2012327878A1 (en) 2011-10-28 2014-05-29 Patrys Limited PAT-LM1 epitopes and methods for using same
DK2814843T3 (da) 2012-02-13 2020-06-22 Agency Science Tech & Res IL-ß-NEUTRALISERENDE HUMANE MONOKLONALE ANTISTOFFER
JP6420756B2 (ja) * 2012-03-28 2018-11-07 ジーイー・ヘルスケア・バイオプロセス・アールアンドディ・アクチボラグ アフィニティークロマトグラフィーマトリックス
GB2502127A (en) 2012-05-17 2013-11-20 Kymab Ltd Multivalent antibodies and in vivo methods for their production
US9890215B2 (en) 2012-06-22 2018-02-13 King's College London Vista modulators for diagnosis and treatment of cancer
TWI705073B (zh) 2012-06-22 2020-09-21 達特茅斯學院基金會 新穎之vista-ig構築體及vista-ig用於治療自體免疫、過敏及發炎病症之用途
WO2014013016A1 (en) 2012-07-20 2014-01-23 Affibody Ab Method for determining the her2 status of a malignancy
JP6368308B2 (ja) 2012-09-07 2018-08-01 トラスティーズ・オブ・ダートマス・カレッジ 癌の診断および治療のためのvista調節剤
WO2014053586A1 (en) 2012-10-05 2014-04-10 Affibody Ab Her3 binding polypeptides
EP2917243B1 (de) 2012-11-08 2018-03-14 F.Hoffmann-La Roche Ag Die beta-haarnadel von her3 bindende her3-antikörper
WO2014076179A1 (en) 2012-11-14 2014-05-22 Affibody Ab New polypeptide
JP6146797B2 (ja) * 2013-02-15 2017-06-14 国立大学法人九州大学 Her2タンパク質検出プローブ、her2タンパク質検出プローブの製造方法およびher2タンパク質の検出方法
US9896486B2 (en) * 2013-07-10 2018-02-20 Ge Healthcare Bioprocess R&D Ab Mutated immunoglobulin-binding polypeptides
JP6584012B2 (ja) 2013-10-06 2019-10-02 アメリカ合衆国 改変シュードモナス外毒素a
CA2932465C (en) 2013-12-18 2023-08-22 Csl Limited Methods of treating wounds in a diabetic subject
RS63295B1 (sr) 2013-12-24 2022-06-30 Janssen Pharmaceutica Nv Anti-vista antitela i fragmenti
US11014987B2 (en) 2013-12-24 2021-05-25 Janssen Pharmaceutics Nv Anti-vista antibodies and fragments, uses thereof, and methods of identifying same
EP3872090A1 (de) 2014-03-11 2021-09-01 Molecular Templates, Inc. Proteine mit aminoterminalen proximalen shiga-toxin-a-untereinheiteneffektorregionen und gegen zellen gerichteten immunglobulinbindungsregionen
WO2015138435A1 (en) 2014-03-11 2015-09-17 Molecular Templates, Inc. Proteins comprising binding regions, shiga toxin a subunit effector regions, and carboxy-terminal, endoplasmic reticulum localization signal motifs
JP6997619B2 (ja) 2014-06-11 2022-01-17 キャシー・エイ・グリーン 液性免疫の抑制または増進のための、vistaアゴニスト及びvistaアンタゴニストの使用
EP3173482B1 (de) * 2014-07-09 2020-01-01 Kyoto University Rna-protein-komplex und rna- und proteinabgabesystem damit
CN104130315B (zh) * 2014-07-25 2017-04-05 国家纳米科学中心 一种特异靶向her2蛋白的多肽
CN106795202B (zh) * 2014-09-29 2020-10-30 富士胶片株式会社 抗体结合多肽、抗体结合融合多肽及吸附材料
CA2962783A1 (en) 2014-10-01 2016-04-07 Medimmune, Llc Method of conjugating a polypeptide
WO2016059602A2 (en) 2014-10-16 2016-04-21 Glaxo Group Limited Methods of treating cancer and related compositions
HK1243333A1 (zh) 2014-10-31 2018-07-13 The Trustees Of The University Of Pennsylvania 用於修饰的t细胞的方法和组合物
DK3489256T3 (da) 2014-11-14 2021-05-25 Hoffmann La Roche Antigenbindende molekyler omfattende en TNF-familieligandtrimer
EP3226900A4 (de) 2014-12-05 2018-09-19 Immunext, Inc. Identifizierung von vsig8 als vermeintlicher vista-rezeptor und dessen verwendung zur herstellung von vista/vsig8-modulatoren
JP6771492B2 (ja) 2015-05-30 2020-10-21 モレキュラー テンプレーツ, インク.Molecular Templates, Inc. 脱免疫化された志賀毒素aサブユニット足場及びそれを含む細胞標的化分子
CN107922497B (zh) 2015-06-24 2022-04-12 詹森药业有限公司 抗vista抗体和片段
MX2018001208A (es) 2015-07-26 2018-03-26 Molecular Templates Inc Moleculas con direccion a las celulas que comprenden efectores de la subunidad a de la toxina shiga y epitopos de celulas-t cd8+.
CN105085631B (zh) * 2015-09-14 2019-01-25 国家纳米科学中心 一种特异靶向her2蛋白的多肽及其应用
CN105085632B (zh) * 2015-09-14 2019-01-25 国家纳米科学中心 一种特异靶向egfr蛋白的多肽及其应用
AR106188A1 (es) 2015-10-01 2017-12-20 Hoffmann La Roche Anticuerpos anti-cd19 humano humanizados y métodos de utilización
MA43017A (fr) 2015-10-02 2018-08-08 Hoffmann La Roche Anticorps bispécifiques spécifiques d'un récepteur de co-stimulation du tnf
SMT202100506T1 (it) 2015-10-02 2021-11-12 Hoffmann La Roche Anticorpi bispecifici specifici per pd1 e tim3
AU2016334623A1 (en) 2015-10-07 2018-02-15 F. Hoffmann-La Roche Ag Bispecific antibodies with tetravalency for a costimulatory TNF receptor
KR102802396B1 (ko) 2015-11-27 2025-05-07 씨에스엘 리미티드 Cd131 결합 단백질 및 이의 용도
CN109069626A (zh) 2016-02-12 2018-12-21 詹森药业有限公司 抗-vista(b7h5)抗体
GB201615588D0 (en) 2016-09-14 2016-10-26 Glaxosmithkline Ip Dev Ltd TSLP Binding Proteins
EP3231813A1 (de) 2016-03-29 2017-10-18 F. Hoffmann-La Roche AG Trimere kostimulatorische tnf-familien-ligandenhaltige antigenbindende moleküle
US11649283B2 (en) 2016-04-15 2023-05-16 Immunext, Inc. Anti-human vista antibodies and use thereof
JP7285076B2 (ja) 2016-05-11 2023-06-01 エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト Tnfファミリーリガンドトリマーとテネイシン結合部分とを含む抗原結合分子
EP3243832A1 (de) 2016-05-13 2017-11-15 F. Hoffmann-La Roche AG Antigenbindende moleküle mit einem ligandentrimer der tnf-familie und pd1-bindungsteil
JP2020501508A (ja) 2016-09-15 2020-01-23 クアドルセプト バイオ リミテッド 多量体、四量体および八量体
AU2017331739A1 (en) 2016-09-23 2019-03-07 Csl Limited Coagulation factor binding proteins and uses thereof
WO2018083087A2 (en) 2016-11-02 2018-05-11 Glaxosmithkline Intellectual Property (No.2) Limited Binding proteins
EP3565843A1 (de) 2017-01-03 2019-11-13 H. Hoffnabb-La Roche Ag Bispezifische antigenbindende moleküle mit anti-4-1bb-klon 20h4.9
KR102590672B1 (ko) 2017-01-25 2023-10-18 몰레큘러 템플레이츠, 인코퍼레이션. 탈면역된 시가 독소 a 서브유닛 이펙터 및 cd8+ t-세포 에피토프를 포함하는 세포-표적화 분자
WO2018178074A1 (en) 2017-03-29 2018-10-04 F. Hoffmann-La Roche Ag Trimeric antigen binding molecules specific for a costimulatory tnf receptor
WO2018178055A1 (en) 2017-03-29 2018-10-04 F. Hoffmann-La Roche Ag Bispecific antigen binding molecule for a costimulatory tnf receptor
WO2018178076A1 (en) 2017-03-29 2018-10-04 F. Hoffmann-La Roche Ag Bispecific antigen binding molecule for a costimulatory tnf receptor
UY37651A (es) * 2017-03-31 2018-10-31 Swedish Orphan Biovitrum Ab Publ Polipéptido de unión al il-1r-i
MA49039A (fr) 2017-04-04 2020-02-12 Hoffmann La Roche Nouvelles molécules bispécifiques de liaison à l'antigène capables de se lier spécifiquement à cd40 et à fap
PL3606955T3 (pl) 2017-04-05 2025-02-24 F. Hoffmann-La Roche Ag Przeciwciała dwuswoiste swoiście wiążące się z PD1 i LAG3
AR111963A1 (es) 2017-05-26 2019-09-04 Univ California Método y moléculas
EP4512469A3 (de) 2017-09-11 2025-05-21 Monash University Bindung von proteinen an den menschlichen thrombinrezeptor par4
AU2018350370B2 (en) 2017-10-18 2023-05-04 Csl Limited Human serum albumin variants and uses thereof
MY205342A (en) 2017-11-01 2024-10-16 Hoffmann La Roche Bispecific 2+1 contorsbodies
CN111246884A (zh) 2017-11-01 2020-06-05 豪夫迈·罗氏有限公司 新颖的含有tnf家族配体三聚体的抗原结合分子
ES2939461T3 (es) 2017-11-29 2023-04-24 Csl Ltd Método para tratar o prevenir la lesión por isquemia-reperfusión
EP3502140A1 (de) 2017-12-21 2019-06-26 F. Hoffmann-La Roche AG Kombinationstherapie von tumorabgezielten icos-agonisten mit t-zellenbispezifischen molekülen
WO2019197600A1 (en) 2018-04-13 2019-10-17 F. Hoffmann-La Roche Ag Her2-targeting antigen binding molecules comprising 4-1bbl
MX2019009726A (es) 2018-04-17 2020-02-05 Molecular Templates Inc Moleculas con direccion hacia her2 que comprenden andamiajes de la sub-unidad a de la toxina shiga desinmunizados.
CN112424228B (zh) 2018-07-04 2024-08-09 豪夫迈·罗氏有限公司 新型双特异性激动性4-1bb抗原结合分子
CN109182364A (zh) * 2018-08-30 2019-01-11 武汉百意欣生物技术有限公司 一种特异性识别蛋白a的多克隆抗体及其制备方法和应用
CN112654641A (zh) 2018-10-01 2021-04-13 豪夫迈·罗氏有限公司 具有与cd40的三价结合的双特异性抗原结合分子
PE20211863A1 (es) 2018-10-01 2021-09-21 Hoffmann La Roche Moleculas de union a antigeno biespecificas que comprenden el clon 212 anti-fap
WO2020127618A1 (en) 2018-12-21 2020-06-25 F. Hoffmann-La Roche Ag Tumor-targeted agonistic cd28 antigen binding molecules
JP2022513495A (ja) 2018-12-21 2022-02-08 エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト 腫瘍標的化スーパーアゴニストcd28抗原結合分子
GB201903767D0 (en) 2019-03-19 2019-05-01 Quadrucept Bio Ltd Multimers, tetramers & octamers
CN110144003B (zh) * 2019-03-22 2023-04-07 温州医科大学 一种对eb病毒lmp2a蛋白n端胞浆区特异性结合的多肽及其应用
EP3952996A1 (de) 2019-04-12 2022-02-16 F. Hoffmann-La Roche AG Bispezifische antigenbindende moleküle mit lipocalinmuteinen
WO2020260329A1 (en) 2019-06-26 2020-12-30 F. Hoffmann-La Roche Ag Fusion of an antibody binding cea and 4-1bbl
EP3990492A1 (de) 2019-06-27 2022-05-04 F. Hoffmann-La Roche AG Neuartige icos-antikörper und tumorspezifische antigenbindende moleküle damit
AU2020374942A1 (en) * 2019-11-01 2022-05-26 University Of Houston System Oncolytic virotherapy with induced anti-tumor immunity
WO2021122729A1 (en) * 2019-12-18 2021-06-24 Bracco Imaging Spa Anti-her2 polypeptides derivatives as new diagnostic molecular probes
CN114829388B (zh) * 2019-12-18 2026-02-03 伯拉考成像股份公司 抗her2多肽衍生物作为新的诊断分子探针
JP7807372B2 (ja) 2019-12-20 2026-01-27 ハドソン インスティチュート オブ メディカル リサーチ Cxcl10結合タンパク質及びその使用
WO2021190980A1 (en) 2020-03-22 2021-09-30 Quadrucept Bio Limited Multimers for viral strain evolution
AR121706A1 (es) 2020-04-01 2022-06-29 Hoffmann La Roche Moléculas de unión a antígeno biespecíficas dirigidas a ox40 y fap
CN111592584B (zh) * 2020-05-27 2021-06-29 北京市肿瘤防治研究所 Her2亲和体和诊疗核素标记物及其制备方法与应用
IL297880A (en) 2020-06-23 2023-01-01 Hoffmann La Roche Agonistic cd28 antigen binding molecules targeting her2
CN115916830A (zh) 2020-06-25 2023-04-04 豪夫迈·罗氏有限公司 抗cd3/抗cd28双特异性抗原结合分子
KR102350655B1 (ko) * 2020-10-13 2022-01-12 인센 주식회사 테스토스테론-특이적 어피바디 및 이의 용도
US20240148917A1 (en) 2020-10-16 2024-05-09 Zytox Therapeutics Ab Pna probes for pretargeted imaging and therapy
WO2022101458A1 (en) 2020-11-16 2022-05-19 F. Hoffmann-La Roche Ag Combination therapy with fap-targeted cd40 agonists
MX2023007846A (es) 2021-01-06 2023-07-07 Hoffmann La Roche Tratamiento conjunto que usa un anticuerpo biespecifico contra pd1-lag3 y un anticuerpo biespecifico de linfocitos t cd20.
WO2022171892A1 (en) 2021-02-15 2022-08-18 Affibody Ab New her2-binding polypeptide
WO2022184659A1 (en) 2021-03-01 2022-09-09 Quadrucept Bio Limited Antibody domains & multimers
WO2022243261A1 (en) 2021-05-19 2022-11-24 F. Hoffmann-La Roche Ag Agonistic cd40 antigen binding molecules targeting cea
AR126009A1 (es) 2021-06-02 2023-08-30 Hoffmann La Roche Moléculas agonistas de unión al antígeno cd28 que se dirigen a epcam
TW202309078A (zh) 2021-07-02 2023-03-01 美商建南德克公司 治療癌症之方法及組成物
CR20240246A (es) 2021-12-20 2024-07-19 Hoffmann La Roche Anticuerpos agonistas anti-ltbr y anticuerpos biespecificos que los comprenden
JP2025511000A (ja) 2022-03-28 2025-04-15 エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト インターフェロンガンマバリアントおよびこれを含む抗原結合分子
JP2025518548A (ja) * 2022-05-18 2025-06-17 ケーエムディー バイオ カンパニー リミテッド Her2-gst-sn-38複合体およびそれを含む増殖性疾患の予防または治療用医薬組成物
CN119998330A (zh) 2022-09-15 2025-05-13 艾维迪治疗知识产权有限公司 用于刺激nk细胞的多特异性抗原结合蛋白及其用途
GB202216503D0 (en) 2022-11-05 2022-12-21 Quadrucept Bio Ltd Non-human vertebrates & cells
EP4680635A1 (de) 2023-03-13 2026-01-21 F. Hoffmann-La Roche AG Kombinationstherapie mit einem pd1-lag3-bispezifischen antikörper und einem bispezifischen hla-g-t-zellantikörper
CN121241068A (zh) 2023-06-01 2025-12-30 豪夫迈·罗氏有限公司 靶向bcma和cd28的双特异性抗体
AR132805A1 (es) 2023-06-01 2025-07-30 Hoffmann La Roche Moléculas de unión al antígeno inmunoestimuladoras que se unen específicamente a bcma
WO2025007195A1 (en) 2023-07-05 2025-01-09 CSL Innovation Pty Ltd Methods of treating or preventing a complication of sickle cell disease
WO2025149633A1 (en) 2024-01-12 2025-07-17 Laigo Bio B.V. Bispecific antigen binding proteins
WO2025191136A1 (en) 2024-03-15 2025-09-18 Avidicure Ip B.V. Muteins of 4-1bb ligand extracellular domain, fusion proteins comprising the same and uses thereof
WO2025191137A1 (en) 2024-03-15 2025-09-18 Avidicure Ip B.V. Conjugates of trop2-specific antigen binding proteins and cytokines
WO2025191133A1 (en) 2024-03-15 2025-09-18 Avidicure Ip B.V. Il-21 muteins, fusion proteins comprising the same and uses thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989006692A1 (en) 1988-01-12 1989-07-27 Genentech, Inc. Method of treating tumor cells by inhibiting growth factor receptor function
SE9400088D0 (sv) * 1994-01-14 1994-01-14 Kabi Pharmacia Ab Bacterial receptor structures
GB9823071D0 (en) * 1998-10-21 1998-12-16 Affibody Technology Ab A method
SE9901379D0 (sv) * 1999-04-19 1999-04-19 Pharmacia & Upjohn Ab Receptor structures
EP1189931B1 (de) 1999-07-02 2006-06-21 Genentech, Inc. An her2 bindende peptidverbindungen
ES2637801T3 (es) * 2000-04-11 2017-10-17 Genentech, Inc. Anticuerpos multivalentes y usos de los mismos
GB0017720D0 (en) * 2000-07-19 2000-09-06 Got A Gene Ab Modified virus
US7939087B2 (en) 2000-10-27 2011-05-10 Novartis Vaccines And Diagnostics, Inc. Nucleic acids and proteins from Streptococcus groups A & B

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